DE69032133T2 - Dna-abschnitt, der für ein gen für den mit dem epidermalen wachstumsfaktorrezeptor verwandten rezeptor kodiert - Google Patents

Dna-abschnitt, der für ein gen für den mit dem epidermalen wachstumsfaktorrezeptor verwandten rezeptor kodiert

Info

Publication number
DE69032133T2
DE69032133T2 DE69032133T DE69032133T DE69032133T2 DE 69032133 T2 DE69032133 T2 DE 69032133T2 DE 69032133 T DE69032133 T DE 69032133T DE 69032133 T DE69032133 T DE 69032133T DE 69032133 T2 DE69032133 T2 DE 69032133T2
Authority
DE
Germany
Prior art keywords
erbb
human
gp180erbb
receptor
egfr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69032133T
Other languages
English (en)
Other versions
DE69032133D1 (de
Inventor
Matthias Kraus
Stuart Aaronson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
US Department of Commerce
Original Assignee
US Department of Health and Human Services
US Department of Commerce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services, US Department of Commerce filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69032133D1 publication Critical patent/DE69032133D1/de
Publication of DE69032133T2 publication Critical patent/DE69032133T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6843Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5748Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
DE69032133T 1989-12-01 1990-11-30 Dna-abschnitt, der für ein gen für den mit dem epidermalen wachstumsfaktorrezeptor verwandten rezeptor kodiert Expired - Lifetime DE69032133T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/444,406 US5183884A (en) 1989-12-01 1989-12-01 Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
PCT/US1990/007025 WO1991008214A1 (en) 1989-12-01 1990-11-30 Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor

Publications (2)

Publication Number Publication Date
DE69032133D1 DE69032133D1 (de) 1998-04-16
DE69032133T2 true DE69032133T2 (de) 1998-07-02

Family

ID=23764745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69032133T Expired - Lifetime DE69032133T2 (de) 1989-12-01 1990-11-30 Dna-abschnitt, der für ein gen für den mit dem epidermalen wachstumsfaktorrezeptor verwandten rezeptor kodiert

Country Status (10)

Country Link
US (6) US5183884A (de)
EP (1) EP0502927B1 (de)
JP (2) JP3196079B2 (de)
AT (1) ATE163970T1 (de)
AU (1) AU654805B2 (de)
CA (1) CA2069900C (de)
DE (1) DE69032133T2 (de)
DK (1) DK0502927T3 (de)
ES (1) ES2113877T3 (de)
WO (1) WO1991008214A1 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE155813T1 (de) * 1989-05-19 1997-08-15 Genentech Inc Her2 extrazellulare domäne
US5183884A (en) 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
US5578482A (en) * 1990-05-25 1996-11-26 Georgetown University Ligand growth factors that bind to the erbB-2 receptor protein and induce cellular responses
US6824777B1 (en) * 1992-10-09 2004-11-30 Licentia Ltd. Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
US5776755A (en) * 1992-10-09 1998-07-07 Helsinki University Licensing, Ltd. FLT4, a receptor tyrosine kinase
US6107046A (en) * 1992-10-09 2000-08-22 Orion Corporation Antibodies to Flt4, a receptor tyrosine kinase and uses thereof
US5811098A (en) * 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
EP0706573A1 (de) * 1993-07-09 1996-04-17 The Institute Of Cancer Research Protein - Tyrosinkinase und Ligande davon
DE69435103D1 (de) * 1993-10-27 2008-07-10 Univ Columbia Methode zur Bildung einer subtrahierten cDNA Bank und ihre Verwendung
US5518885A (en) * 1994-04-19 1996-05-21 The United States Of America As Represented By The Department Of Health & Human Services ERBB2 promoter binding protein in neoplastic disease
US5985598A (en) * 1994-10-27 1999-11-16 Thomas Jefferson University TCL-1 gene and protein and related methods and compositions
US7175995B1 (en) 1994-10-27 2007-02-13 Thomas Jefferson University TCL-1 protein and related methods
US5635351A (en) * 1995-03-14 1997-06-03 The Regents Of The University Of California Genetic gain and loss in gliomas
US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
PT896586E (pt) * 1996-03-27 2007-01-31 Genentech Inc Anticorpos de erbb3
US5968511A (en) 1996-03-27 1999-10-19 Genentech, Inc. ErbB3 antibodies
DE69740038D1 (de) 1996-07-12 2010-12-16 Genentech Inc
JP4382879B2 (ja) * 1996-07-12 2009-12-16 ジェネンテック・インコーポレーテッド ガンマ―ヘレグリン
US5710137A (en) * 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
US7371376B1 (en) 1996-10-18 2008-05-13 Genentech, Inc. Anti-ErbB2 antibodies
US6387638B1 (en) 1997-02-10 2002-05-14 Genentech, Inc. Heregulin variants
US6136558A (en) * 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
EP1690927A1 (de) * 1997-04-30 2006-08-16 Hans Klingemann Natürliche Killerzelllinien und Verfahren zu ihrer Verwendung
US7052692B1 (en) 1997-09-02 2006-05-30 Advanced Research & Technology Institute Role of tyrosine phosphorylation of a cellular protein in adeno-associated virus 2-mediated transgene expression
IL135607A0 (en) 1997-10-29 2001-05-20 Genentech Inc Wnt-1 inducible genes
US6387657B1 (en) 1997-10-29 2002-05-14 Genentech, Inc. WISP polypeptides and nucleic acids encoding same
ZA9811162B (en) * 1997-12-12 2000-06-07 Genentech Inc Treatment with anti-ERBB2 antibodies.
US20010023241A1 (en) * 1998-02-04 2001-09-20 Sliwkowski Mark X. Use of heregulin as a growth factor
EP1941905A1 (de) 1998-03-27 2008-07-09 Genentech, Inc. APO-2 Liganden-Anti-HER-2-Antikörper-Synergismus
ATE489108T1 (de) * 1998-10-09 2010-12-15 Vegenics Ltd Flt4 (vegfr-3) als ziel für tumornachweis (imaging) und antitumortherapie
ES2307505T3 (es) * 1999-04-06 2008-12-01 Genentech, Inc. Utilizacion de ligandos receptores de erbb en el tratamiento de la diabetes.
CA2370466C (en) 1999-06-25 2011-02-08 Sharon Erickson Methods of treatment using anti-erbb antibody-maytansinoid conjugates
AUPQ105799A0 (en) * 1999-06-18 1999-07-08 Victor Chang Cardiac Research Institute, The Cell growth inhibition
US7041292B1 (en) 1999-06-25 2006-05-09 Genentech, Inc. Treating prostate cancer with anti-ErbB2 antibodies
MXPA01013395A (es) * 1999-06-25 2003-09-04 Genentech Inc Tratamiento de cancer de prostata con anticuerpos anti-erbb2.
US6949245B1 (en) * 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
EP1189641B1 (de) 1999-06-25 2009-07-29 Genentech, Inc. Humanisierte anti-erbb2 antikörper und behandlung mit anti-erbb2 antikörper
US20040013667A1 (en) * 1999-06-25 2004-01-22 Genentech, Inc. Treatment with anti-ErbB2 antibodies
US20030086924A1 (en) * 1999-06-25 2003-05-08 Genentech, Inc. Treatment with anti-ErbB2 antibodies
SI1210115T1 (sl) 1999-08-27 2009-12-31 Genentech Inc Doziranja za zdravljenje s protitelesi proti ErbB2
US7390632B2 (en) * 1999-09-30 2008-06-24 Tumor Biology Investment Group, Inc. Soluble ErbB3 receptor isoforms
US7892541B1 (en) 1999-09-30 2011-02-22 Tumor Biology Investment Group, Inc. Soluble epidermal growth factor receptor isoforms
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
JP2003531588A (ja) 2000-04-11 2003-10-28 ジェネンテック・インコーポレーテッド 多価抗体とその用途
WO2001083781A2 (en) * 2000-04-28 2001-11-08 Millennium Pharmaceuticals, Inc. 14094, a novel human trypsin family member and uses thereof
DE60139768D1 (de) * 2000-05-19 2009-10-15 Genentech Inc Gennachweisverfahren zur verbesserung der wahrscheinlichkeit einer wirkungsvollen antwort auf eine k
CN1204142C (zh) * 2000-06-01 2005-06-01 冯宝章 反基因V-erbB寡核苷酸及其应用
US6277640B1 (en) 2000-07-31 2001-08-21 Isis Pharmaceuticals, Inc. Antisense modulation of Her-3 expression
US20020119148A1 (en) * 2000-09-01 2002-08-29 Gerritsen Mary E. ErbB4 antagonists
US7344829B2 (en) * 2000-11-03 2008-03-18 Board Of Regents, The University Of Texas System Methods for detecting the efficacy of anticancer treatments
DE60219419T2 (de) * 2001-01-19 2007-08-16 Ludwig Institute For Cancer Research Flt4 (vegfr-3) als ein ziel für krebsdarstellung und anti-krebs-behandlung
EP1228766A1 (de) * 2001-01-31 2002-08-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PYK2 Phosphorylierung durch HER3 induziert Tumorinvasion
WO2002081649A2 (en) * 2001-04-06 2002-10-17 The Trustees Of The University Of Pennsylvania ErbB INTERFACE PEPTIDOMIMETICS AND METHODS OF USE THEREOF
EP1385962A2 (de) * 2001-05-02 2004-02-04 Bayer HealthCare AG Menschliche prolyl 4-hydroxylasen
US7612042B2 (en) * 2001-05-31 2009-11-03 Tumor Biology Investment Group, Inc. Methods for inhibiting heregulin and treating cancer
US7744882B2 (en) 2001-05-31 2010-06-29 Tumor Biology Investment Group, Inc. Soluble ErbB3 methods of detection and antibodies
US7745398B2 (en) * 2001-05-31 2010-06-29 Tumor Biology Investment Group, Inc. Soluble ErbB3 and treatment of cancer
DE10131187C2 (de) * 2001-06-28 2003-06-18 Infineon Technologies Ag Belichtungsmaske mit reparierter Blindstruktur
US7125680B2 (en) 2001-07-27 2006-10-24 The Regents Of The University Of California Methods and materials for characterizing and modulating interaction between heregulin and HER3
EP1283053A1 (de) 2001-08-09 2003-02-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Inhibitore der HER3 Aktivität
AU2002326910A1 (en) * 2001-09-14 2003-04-01 Incyte Genomics, Inc. Receptors and membrane-associated proteins
JP2003110360A (ja) * 2001-09-28 2003-04-11 Seiko Epson Corp 電圧制御型発振器、受信装置および通信装置
JP4660094B2 (ja) * 2002-03-26 2011-03-30 ゼンサン (シャンハイ) サイ−テク. リミテッド 新生物を治療するためのErbB3に基づく方法および組成物
WO2005117986A2 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody drug conjugates and methods
US7402397B2 (en) 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
JP4405916B2 (ja) 2002-05-23 2010-01-27 トラスティース・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア Fasペプチド模倣体およびその使用
CA2490758C (en) 2002-07-15 2014-09-23 Genentech, Inc. Dosage form of recombinant humanized monoclonal antibody 2c4
TWI229650B (en) * 2002-11-19 2005-03-21 Sharp Kk Substrate accommodating tray
US20040258685A1 (en) * 2002-11-21 2004-12-23 Genentech, Inc. Therapy of non-malignant diseases or disorders with anti-ErbB2 antibodies
CA2521077A1 (en) 2003-04-01 2004-10-28 Monogram Biosciences, Inc. Erbb surface receptor complexes as biomarkers
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US20050239088A1 (en) * 2003-05-16 2005-10-27 Shepard H M Intron fusion proteins, and methods of identifying and using same
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
AU2004267420A1 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
WO2005037071A2 (en) * 2003-10-14 2005-04-28 Monogram Biosciences, Inc. Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
PT2489364E (pt) 2003-11-06 2015-04-16 Seattle Genetics Inc Compostos de monometilvalina conjugados com anticorpos
WO2005099756A2 (en) * 2004-04-08 2005-10-27 Agus David B ErbB ANTAGONISTS FOR PAIN THERAPY
WO2005113596A2 (en) * 2004-05-14 2005-12-01 Receptor Biologix, Inc. Cell surface receptor isoforms and methods of identifying and using the same
SV2006002143A (es) * 2004-06-16 2006-01-26 Genentech Inc Uso de un anticuerpo para el tratamiento del cancer resistente al platino
KR20180091967A (ko) 2004-07-22 2018-08-16 제넨테크, 인크. Her2 항체 조성물
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
DK1791565T3 (en) 2004-09-23 2016-08-01 Genentech Inc Cysteingensplejsede antibodies and conjugates
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
EP1825001A2 (de) * 2004-12-07 2007-08-29 Genentech, Inc. Auswahl von patienten zur therapie mit einem her-inhibitor
CN101141981A (zh) * 2005-01-21 2008-03-12 健泰科生物技术公司 Her抗体的固定剂量给药
KR20070100968A (ko) * 2005-02-09 2007-10-15 제넨테크, 인크. 매트릭스 메탈로프로테아제 길항제를 사용한, her2박리의 억제
DK1850874T3 (da) 2005-02-23 2013-11-11 Genentech Inc Forlængelse af tid til sygdomsprogression eller overlevelse for ovariecancer ved anvendelse af pertuzumab
WO2006096861A2 (en) * 2005-03-08 2006-09-14 Genentech, Inc. METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs)
US20090170769A1 (en) * 2005-05-13 2009-07-02 Pei Jin Cell surface receptor isoforms and methods of identifying and using the same
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Herceptin(登録商標)補助療法
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
MX2009001291A (es) 2006-08-04 2009-03-10 Astrazeneca Ab Anticuerpos para erbb2.
EP2518508A1 (de) 2006-11-28 2012-10-31 U3 Pharma GmbH Aktiviertes HER3 als Marker zur Vorhersage der Therapieeffizienz
JP5564266B2 (ja) * 2007-02-16 2014-07-30 メリマック ファーマシューティカルズ インコーポレーティッド Erbb3に対する抗体およびその使用
KR20090115980A (ko) 2007-03-02 2009-11-10 제넨테크, 인크. 낮은 her3 발현을 기초로 한 her 이량체화 억제제에 대한 반응 예측
CA2680237C (en) 2007-03-27 2018-11-06 Sea Lane Biotechnologies, Llc Constructs and libraries comprising antibody surrogate light chain sequences
ES2417148T3 (es) 2007-06-08 2013-08-06 Genentech, Inc. Marcadores de expresión génica de la resistencia tumoral al tratamiento con inhibidor de HER2
CA2706763C (en) * 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
US10416162B2 (en) * 2007-12-20 2019-09-17 Monogram Biosciences, Inc. Her2 diagnostic methods
SI2229369T1 (sl) * 2008-01-18 2016-11-30 Natco Pharma Limited Derivati 6,7-dialkoksi kinazolina, uporabni za zdravljenje motenj, povezanih z rakom
TWI472339B (zh) 2008-01-30 2015-02-11 Genentech Inc 包含結合至her2結構域ii之抗體及其酸性變異體的組合物
KR20210131473A (ko) 2008-03-18 2021-11-02 제넨테크, 인크. 항-her2 항체-약물 접합체와 화학요법제의 병용물, 및 사용 방법
BRPI0812682A2 (pt) 2008-06-16 2010-06-22 Genentech Inc tratamento de cáncer de mama metastático
WO2009157919A1 (en) * 2008-06-23 2009-12-30 Tumor Biology Investment Group, Inc. SOLUBLE ErbB3 DETECTION, REGULATION AND TREATMENT OF CANCER
BRPI0917871A2 (pt) * 2008-08-15 2017-06-20 Merrimack Pharmaceuticals Inc agente terapêutico anti-erbb3 para uso em terapia de um tumor, métodos para predizer responsividade de um tumor de um agente terapêutco anti-erbb3, para selecionar terapia anti-erbb3 para um paciente, para predizer a resposta de células ao tratamento com um agente terapêutico, para identificar um biomarcador, e para evitar administração de uma droga para câncer anti-erbb3, e, kit para predizer a resposta das células ao tratamento com um agente terapêutico
CA2764386C (en) 2008-12-01 2018-05-01 Laboratory Corporation Of America Holdings P95-her2 antibodies and uses thereof
US8349574B2 (en) * 2009-01-15 2013-01-08 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of Her-3
AU2010226453B2 (en) 2009-03-20 2013-11-21 Genentech, Inc. Bispecific anti-HER antibodies
EP2425009A4 (de) * 2009-04-29 2013-01-23 Trellis Bioscience Llc Verbesserte antikörper für immunreaktionen mit heregulin-gekoppeltem her3
JP2012526839A (ja) 2009-05-13 2012-11-01 シー レーン バイオテクノロジーズ, エルエルシー インフルエンザウイルスに対する中和分子
SG176073A1 (en) 2009-05-29 2011-12-29 Hoffmann La Roche Modulators for her2 signaling in her2 expressing patients with gastric cancer
US9050341B2 (en) 2009-07-14 2015-06-09 Natco Pharma Limited Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
AU2010306774A1 (en) 2009-10-14 2012-05-03 Merrimack Pharmaceuticals, Inc. Bispecific binding agents targeting IGF-1R and ErbB3 signalling and uses thereof
CN102812045B (zh) 2009-11-13 2018-04-13 第一三共欧洲有限公司 用于治疗或预防人表皮生长因子受体‑3(her‑3)相关疾病的材料和方法
JP6184695B2 (ja) 2009-12-04 2017-08-23 ジェネンテック, インコーポレイテッド 多重特異性抗体、抗体アナログ、組成物、及び方法
JP5680671B2 (ja) 2009-12-22 2015-03-04 ロシュ グリクアート アーゲー 抗her3抗体及びその使用
MX344355B (es) 2010-03-11 2016-12-14 Merrimack Pharmaceuticals Inc * Uso de inhibidores de erbb3 en el tratamiento de canceres de mama triple negativos y de tipo basal.
ES2566602T3 (es) 2010-04-09 2016-04-14 Aveo Pharmaceuticals, Inc. Anticuerpos anti-ErbB3
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
US8741288B2 (en) * 2010-07-07 2014-06-03 Chang Gung Medical Foundation, Linkou Branch Protein markers for detecting liver cancer and method for identifying the markers thereof
BR112013004012B1 (pt) 2010-08-20 2021-03-23 Novartis Ag Anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo ao receptor her3, seu uso e composição farmacêutica
TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
KR20140044796A (ko) 2011-03-11 2014-04-15 메리맥 파마슈티컬즈, 인크. 호르몬 무반응 유방암의 치료에서 egfr-패밀리 수용체의 저해제의 용도
SI2699602T1 (sl) 2011-04-19 2017-06-30 Merrimack Pharmaceuticals, Inc. Bispecifična protitelesa anti-igf-1r in anti-erbb3
WO2012156309A1 (en) 2011-05-13 2012-11-22 Millegen Antibodies against her3
JP6468838B2 (ja) 2011-05-19 2019-02-13 ラボラトリー コーポレイション オブ アメリカ ホールディングス 癌患者の生存可能性を決定するためおよび癌患者における転移可能性を予測するための方法
JPWO2012176779A1 (ja) 2011-06-20 2015-02-23 協和発酵キリン株式会社 抗erbB3抗体
WO2013016714A1 (en) 2011-07-28 2013-01-31 Sea Lane Biotechnologies Sur-binding proteins against erbb3
CN104024432B (zh) 2011-08-31 2017-02-22 基因泰克公司 诊断性标志物
US9273143B2 (en) 2011-09-30 2016-03-01 Regeneron Pharmaceuticals, Inc. Methods and compositions comprising a combination of an anti-ErbB3 antibody and an anti-EGFR antibody
EA028879B1 (ru) 2011-09-30 2018-01-31 Ридженерон Фармасьютикалз, Инк. АНТИТЕЛА К ErbB3 И ИХ ПРИМЕНЕНИЕ
AU2012318541B2 (en) 2011-10-06 2018-04-12 Aveo Pharmaceuticals, Inc. Predicting tumor response to anti-ERBB3 antibodies
KR20230028585A (ko) 2011-10-14 2023-02-28 제넨테크, 인크. Her2 이량체화 억제제인 페르투주맙의 용도 및 이를 포함하는 제조품
RU2620068C2 (ru) 2011-11-23 2017-05-22 МЕДИММЬЮН, ЭлЭлСи Связывающие молекулы, специфичные по отношению к her3, и их применения
US20130195870A1 (en) 2011-11-30 2013-08-01 Genentech, Inc. ERBB3 Mutations In Cancer
SG11201402783YA (en) 2011-12-05 2014-06-27 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
EP2788382A2 (de) 2011-12-05 2014-10-15 Novartis AG Antikörper für epidermalen wachstumsfaktor-rezeptor 3 (her3) gegen domäne ii von her3
WO2013083810A1 (en) 2011-12-09 2013-06-13 F. Hoffmann-La Roche Ag Identification of non-responders to her2 inhibitors
EP2793940B1 (de) 2011-12-22 2018-11-14 i2 Pharmaceuticals, Inc. Surrogatbindungsproteine
ES2842201T3 (es) 2012-02-23 2021-07-13 Daiichi Sankyo Europe Gmbh Inhibidor de HER3 para modulación de radiosensibilidad
JP2015514710A (ja) 2012-03-27 2015-05-21 ジェネンテック, インコーポレイテッド Her3阻害剤に関する診断及び治療
CA2868516A1 (en) 2012-04-02 2013-10-10 Merrimack Pharmaceuticals, Inc. Dosage and administration of monospecific and bispecific anti-igf-1r and anti-erbb3 antibodies
WO2014083178A1 (en) 2012-11-30 2014-06-05 F. Hoffmann-La Roche Ag Identification of patients in need of pd-l1 inhibitor cotherapy
US9180185B2 (en) 2013-01-11 2015-11-10 Hoffman-La Roche Inc. Combination therapy of anti-HER3 antibodies
EP2954068B8 (de) 2013-02-05 2018-10-31 Pierian Holdings, Inc. Wirkstoffauswahl für eine therapie gegen nicht-kleinzelligen lungenkrebs
WO2014124487A1 (en) 2013-02-18 2014-08-21 Vegenics Pty Limited Ligand binding molecules and uses thereof
JP6402173B2 (ja) 2013-04-05 2018-10-10 ラボラトリー コーポレイション オブ アメリカ ホールディングス Her3の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法
US10239951B2 (en) 2013-05-08 2019-03-26 Zymeworks Inc. Bispecific HER2 and HER3 antigen binding constructs
US11305012B2 (en) 2013-09-24 2022-04-19 Medimmune, Llc Binding molecules specific for HER3 and uses thereof
EP3087394A2 (de) 2013-12-27 2016-11-02 Merrimack Pharmaceuticals, Inc. Biomarkerprofile zur vorhersage der ergebnisse einer krebstherapie mit erbb3-inhibitoren und/oder chemotherapien
CN107002119A (zh) 2014-03-24 2017-08-01 豪夫迈·罗氏有限公司 使用c‑met拮抗剂的癌症治疗及前者与hgf表达的关联
TWI745021B (zh) 2014-04-10 2021-11-01 日商第一三共股份有限公司 抗her3抗體-藥物結合物之製造方法
US10745490B2 (en) 2014-04-11 2020-08-18 Celldex Therapeutics, Inc. Anti-ErbB antibodies and methods of use thereof
EP3169708B1 (de) 2014-07-16 2019-03-20 Dana-Farber Cancer Institute Inc. et Al. Her3-inhibition bei serösem low-grade-ovarialkarzinom
EP3169354A4 (de) 2014-07-17 2018-06-13 Brian J. Czerniecki Identifikation von immunogenen mhc-klasse-ii-peptiden für immunbasierte therapie
EP3229803B1 (de) 2014-12-12 2020-01-29 Massachusetts General Hospital Behandlung von brustkrebsgehirnmetastasen
EP3303398A1 (de) 2015-05-29 2018-04-11 Merrimack Pharmaceuticals, Inc. Kombinationskrebstherapien
US10184006B2 (en) 2015-06-04 2019-01-22 Merrimack Pharmaceuticals, Inc. Biomarkers for predicting outcomes of cancer therapy with ErbB3 inhibitors
US11173213B2 (en) 2015-06-29 2021-11-16 Daiichi Sankyo Company, Limited Method for selectively manufacturing antibody-drug conjugate
EP3325005A4 (de) * 2015-07-17 2019-03-27 Brian J. Czerniecki Identifikation von immunogenen mhc-klasse-ii-peptiden für immunbasierte therapie
US20170233491A1 (en) 2016-01-19 2017-08-17 Merrimack Pharmaceuticals, Inc. Dosage and administration of combination therapies comprising istiratumab, uses and methods of treatment
MX2018011054A (es) 2016-03-15 2019-01-21 Merrimack Pharmaceuticals Inc Metodos para tratar cancer de mama er+, her2-, hrg+ usando terapias de combinacion que comprenden un anticuerpo anti-erbb3.
US20190151346A1 (en) 2016-05-10 2019-05-23 INSERM (Institute National de la Santé et de la Recherche Médicale) Combinations therapies for the treatment of cancer
EP3552626A4 (de) 2016-12-12 2020-06-10 Daiichi Sankyo Company, Limited Kombination aus antikörper-wirkstoff-konjugat und immun-checkpoint-inhibitor
KR102313262B1 (ko) 2016-12-28 2021-10-14 제넨테크, 인크. 진행성 her2 발현 암의 치료
CN110382535A (zh) 2017-01-17 2019-10-25 第一三共株式会社 抗-gpr20抗体以及抗-gpr20抗体-药物缀合物
JP6741875B2 (ja) 2017-01-17 2020-08-19 ジェネンテック, インコーポレイテッド 皮下her2抗体製剤
KR102417583B1 (ko) 2017-03-02 2022-07-07 제넨테크, 인크. Her2-양성 유방암 어쥬번트 치료
KR20190140952A (ko) 2017-04-24 2019-12-20 제넨테크, 인크. 막관통 및 인접막 도메인에서의 erbb2/her2 돌연변이
TWI794230B (zh) 2017-05-15 2023-03-01 日商第一三共股份有限公司 抗cdh6抗體及抗cdh6抗體-藥物結合物、以及其製造方法
CN110831624B (zh) * 2017-06-02 2024-04-16 埃特彼塞斯公司 涉及her抗原的用于肿瘤疫苗接种和免疫疗法的组合物及方法
SG11202001514XA (en) 2017-08-31 2020-03-30 Daiichi Sankyo Co Ltd Novel method for producing antibody-drug conjugate
BR112020003646A2 (pt) 2017-08-31 2020-09-01 Daiichi Sankyo Company, Limited cristais, métodos para produção de cristais e de um conjugado anticorpo-fármaco, e, sal.
EP4249002A3 (de) 2018-05-18 2023-11-22 Daiichi Sankyo Co., Ltd. Conjugue agent cytotoxique et anticorps anti-muc1-exatecan
KR20230030621A (ko) 2020-06-29 2023-03-06 제넨테크, 인크. 퍼투주맙 + 트라스투주맙 고정 용량 조합
EP4180061A1 (de) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Linker-reagenzien für anthracyclinderivate, antikörper-arznemittelkonjugate und verfahren

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US4480968A (en) * 1984-04-05 1984-11-06 General Motors Corporation Two-cycle engine compressor
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
GB8910977D0 (en) 1989-05-12 1989-06-28 Rolls Royce Plc Metal matrix composite material
US5183884A (en) * 1989-12-01 1993-02-02 United States Of America Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
EP0444961A1 (de) * 1990-03-02 1991-09-04 Bristol-Myers Squibb Company Her3: Ein neues EGF-Rezeptor Homologes

Also Published As

Publication number Publication date
JP3196079B2 (ja) 2001-08-06
CA2069900C (en) 2004-07-27
EP0502927A1 (de) 1992-09-16
DK0502927T3 (da) 1998-06-02
EP0502927A4 (en) 1993-05-26
US5820859A (en) 1998-10-13
JP2001299373A (ja) 2001-10-30
CA2069900A1 (en) 1991-06-02
US5183884A (en) 1993-02-02
US6639060B1 (en) 2003-10-28
JPH06503467A (ja) 1994-04-21
EP0502927B1 (de) 1998-03-11
WO1991008214A1 (en) 1991-06-13
US20040063140A1 (en) 2004-04-01
AU654805B2 (en) 1994-11-24
ES2113877T3 (es) 1998-05-16
DE69032133D1 (de) 1998-04-16
AU6889991A (en) 1991-06-26
US5480968A (en) 1996-01-02
ATE163970T1 (de) 1998-03-15
US5916755A (en) 1999-06-29
JP3632171B2 (ja) 2005-03-23

Similar Documents

Publication Publication Date Title
DE69032133D1 (de) Dna-abschnitt, der für ein gen für den mit dem epidermalen wachstumsfaktorrezeptor verwandten rezeptor kodiert
Rubin et al. The basic biology of HER2
Scott et al. A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells
Petch et al. A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue
Kraus et al. Demonstration of ligand-dependent signaling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells.
Di Marco et al. Transformation of NIH 3T3 cells by overexpression of the normal coding sequence of the rat neu gene
Yarden Biology of HER2 and its importance in breast cancer
Yayon et al. Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases
Khan et al. Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation
Nanni et al. p185neu protein is required for tumor and anchorage‐independent growth, not for cell proliferation of transgenic mammary carcinoma
JP2010233572A (ja) 血管接着分子およびその機能の調節
Masuko et al. Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells
Okazaki et al. Development of an ErbB4 monoclonal antibody that blocks neuregulin-1-induced ErbB4 activation in cancer cells
US20030096373A1 (en) Antibodies to a novel EGF-receptor related protein (ERRP)
US10024844B2 (en) Identification of an inhibitor of iRhom1 or an inhibitor of iRhom2
EP0444961A1 (de) Her3: Ein neues EGF-Rezeptor Homologes
CN103212077B (zh) Erbin抑制剂在制备抗肿瘤药物中的应用
Taylor et al. Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain
Li et al. Suppression of MUC1 synthesis downregulates expression of the epidermal growth factor receptor
Tsuda et al. Coexpression of platelet‐derived growth factor (PDGF) A‐chain and PDGF receptor genes in human gastric carcinomas
US9198966B2 (en) B-type plexin antagonists and uses thereof
Tanaka et al. A Modified Adenovirus Vector–Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target
Kraus et al. Isolated polypeptide ERBB-3, related to the epidermal growth factor receptor and antibody thereto
Elenius et al. ErbB4 and its isoforms: patentable drug targets?
Lehtola et al. A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein

Legal Events

Date Code Title Description
8364 No opposition during term of opposition