DE69031951D1 - Transformation von tierischen Hautzellen mit hilfe von Partikeln - Google Patents
Transformation von tierischen Hautzellen mit hilfe von PartikelnInfo
- Publication number
- DE69031951D1 DE69031951D1 DE69031951T DE69031951T DE69031951D1 DE 69031951 D1 DE69031951 D1 DE 69031951D1 DE 69031951 T DE69031951 T DE 69031951T DE 69031951 T DE69031951 T DE 69031951T DE 69031951 D1 DE69031951 D1 DE 69031951D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- microprojectiles
- transformation
- help
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241001465754 Metazoa Species 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title 1
- 210000004927 skin cell Anatomy 0.000 title 1
- 230000009466 transformation Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 230000001105 regulatory effect Effects 0.000 abstract 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 1
- 210000004207 dermis Anatomy 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 230000006461 physiological response Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000022532 regulation of transcription, DNA-dependent Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
- C12N15/895—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection using biolistic methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- Sustainable Development (AREA)
- Mechanical Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43784889A | 1989-11-16 | 1989-11-16 | |
PCT/US1990/006597 WO1991007487A1 (en) | 1989-11-16 | 1990-11-13 | Particle-mediated transformation of animal tissue cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69031951D1 true DE69031951D1 (de) | 1998-02-19 |
DE69031951T2 DE69031951T2 (de) | 1998-08-13 |
Family
ID=23738164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69031951T Expired - Lifetime DE69031951T2 (de) | 1989-11-16 | 1990-11-13 | Transformation von tierischen Hautzellen mit hilfe von Partikeln |
Country Status (11)
Country | Link |
---|---|
US (6) | US6194389B1 (de) |
EP (1) | EP0500799B1 (de) |
JP (2) | JPH05503841A (de) |
AT (1) | ATE162219T1 (de) |
AU (1) | AU6964191A (de) |
CA (1) | CA2068863C (de) |
DE (1) | DE69031951T2 (de) |
DK (1) | DK0500799T3 (de) |
ES (1) | ES2113371T3 (de) |
GR (1) | GR3026594T3 (de) |
WO (1) | WO1991007487A1 (de) |
Families Citing this family (98)
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US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US6867195B1 (en) | 1989-03-21 | 2005-03-15 | Vical Incorporated | Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected |
US6214804B1 (en) | 1989-03-21 | 2001-04-10 | Vical Incorporated | Induction of a protective immune response in a mammal by injecting a DNA sequence |
ES2113371T3 (es) | 1989-11-16 | 1998-05-01 | Univ Duke | Transformacion de celulas epidermicas de tejidos animales con la ayuda de particulas. |
US6228844B1 (en) | 1991-11-12 | 2001-05-08 | Vical Incorporated | Stimulating vascular growth by administration of DNA sequences encoding VEGF |
US6706694B1 (en) | 1990-03-21 | 2004-03-16 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate |
JP3881689B2 (ja) * | 1992-03-11 | 2007-02-14 | パウダージェクト ヴァクシンズ,インコーポレイテッド | 免疫不全ウイルス用の遺伝子ワクチン |
AU2146092A (en) * | 1992-05-28 | 1993-12-30 | Scientific Dimensions Usa, Inc. | Transgenic animal production with biolistically transformed spermatozoa |
GB2282139A (en) * | 1993-09-24 | 1995-03-29 | Univ Reading | Introducing DNA into the germ line of birds |
US6995008B1 (en) | 1994-03-07 | 2006-02-07 | Merck & Co., Inc. | Coordinate in vivo gene expression |
DE4416784A1 (de) * | 1994-05-09 | 1995-11-30 | Soft Gene Gmbh | Methode zur Anreicherung von Zellen, die durch ballistischen Transfer modifiziert wurden |
US7223739B1 (en) | 1995-06-07 | 2007-05-29 | Powderject Vaccines, Inc. | Adjuvanted genetic vaccines |
AU2814897A (en) * | 1996-04-25 | 1997-11-12 | T Cell Sciences, Inc. | Method of isolating regulators of t cell activation |
US6893664B1 (en) * | 1996-06-17 | 2005-05-17 | Powderject Research Limited | Particle delivery techniques |
US6294378B1 (en) * | 1996-07-26 | 2001-09-25 | Sloan-Kettering Institute For Cancer Research | Method and reagents for genetic immunization |
US6433154B1 (en) | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
DE69930294T2 (de) * | 1998-10-19 | 2006-11-02 | Powderject Vaccines, Inc., Madison | Minimale promotoren und ihre verwendung |
US6881723B1 (en) | 1998-11-05 | 2005-04-19 | Powderject Vaccines, Inc. | Nucleic acid constructs |
WO2000045792A1 (en) | 1999-02-03 | 2000-08-10 | Powderject Research Limited | Hydrogel particle formulations |
US7022320B1 (en) | 1999-02-09 | 2006-04-04 | Powderject Vaccines, Inc. | Mycobacterium tuberculosis immunization |
US20040234539A1 (en) * | 1999-11-03 | 2004-11-25 | Powderject Research Limited | Nucleic acid vaccine compositions having a mammalian cd80/cd86 gene promoter driving antigen expression |
US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
US20040109874A1 (en) * | 1999-11-10 | 2004-06-10 | Powderject Vaccines, Inc. | Induction of mucosal immunity by vaccination via the skin route |
IL151097A0 (en) | 2000-02-23 | 2003-04-10 | Smithkline Beecham Biolog | Tumour-specific animal proteins |
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DE60135455D1 (de) | 2000-05-16 | 2008-10-02 | Univ Minnesota | It einer mehrfachdüsenanordnung |
JP2004513615A (ja) | 2000-06-28 | 2004-05-13 | コリクサ コーポレイション | 肺癌の治療および診断のための組成物および方法 |
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FR7781E (fr) | 1907-04-16 | 1907-10-11 | Jacques Delpech | Procédé ayant pour but de supprimer le tremblement apparent des projections cinématographiques |
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-
1990
- 1990-11-13 ES ES91901057T patent/ES2113371T3/es not_active Expired - Lifetime
- 1990-11-13 DK DK91901057T patent/DK0500799T3/da active
- 1990-11-13 JP JP3501470A patent/JPH05503841A/ja active Pending
- 1990-11-13 AU AU69641/91A patent/AU6964191A/en not_active Abandoned
- 1990-11-13 AT AT91901057T patent/ATE162219T1/de not_active IP Right Cessation
- 1990-11-13 DE DE69031951T patent/DE69031951T2/de not_active Expired - Lifetime
- 1990-11-13 EP EP91901057A patent/EP0500799B1/de not_active Expired - Lifetime
- 1990-11-13 WO PCT/US1990/006597 patent/WO1991007487A1/en active IP Right Grant
- 1990-11-13 CA CA002068863A patent/CA2068863C/en not_active Expired - Lifetime
-
1997
- 1997-04-11 US US08/840,224 patent/US6194389B1/en not_active Expired - Fee Related
-
1998
- 1998-04-10 GR GR980400787T patent/GR3026594T3/el unknown
-
2000
- 2000-08-21 JP JP2000250310A patent/JP2001103968A/ja not_active Withdrawn
-
2001
- 2001-01-08 US US09/755,199 patent/US20020006637A1/en not_active Abandoned
-
2003
- 2003-07-02 US US10/610,651 patent/US7449449B2/en not_active Expired - Fee Related
- 2003-07-02 US US10/610,601 patent/US7358234B2/en not_active Expired - Fee Related
-
2004
- 2004-03-05 US US10/792,934 patent/US20040170616A1/en not_active Abandoned
-
2007
- 2007-11-19 US US11/984,545 patent/US20080138325A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE162219T1 (de) | 1998-01-15 |
AU6964191A (en) | 1991-06-13 |
US20020006637A1 (en) | 2002-01-17 |
US20040170616A1 (en) | 2004-09-02 |
CA2068863A1 (en) | 1991-05-17 |
US20040097458A1 (en) | 2004-05-20 |
JPH05503841A (ja) | 1993-06-24 |
DE69031951T2 (de) | 1998-08-13 |
US7358234B2 (en) | 2008-04-15 |
EP0500799A4 (en) | 1993-05-05 |
US20080138325A1 (en) | 2008-06-12 |
EP0500799A1 (de) | 1992-09-02 |
DK0500799T3 (da) | 1998-09-14 |
US7449449B2 (en) | 2008-11-11 |
US20040092019A1 (en) | 2004-05-13 |
CA2068863C (en) | 2009-06-02 |
EP0500799B1 (de) | 1998-01-14 |
ES2113371T3 (es) | 1998-05-01 |
JP2001103968A (ja) | 2001-04-17 |
US6194389B1 (en) | 2001-02-27 |
GR3026594T3 (en) | 1998-07-31 |
WO1991007487A1 (en) | 1991-05-30 |
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