DE69031007T2 - Antivirale Nukleosid-Derivate - Google Patents

Antivirale Nukleosid-Derivate

Info

Publication number
DE69031007T2
DE69031007T2 DE69031007T DE69031007T DE69031007T2 DE 69031007 T2 DE69031007 T2 DE 69031007T2 DE 69031007 T DE69031007 T DE 69031007T DE 69031007 T DE69031007 T DE 69031007T DE 69031007 T2 DE69031007 T2 DE 69031007T2
Authority
DE
Germany
Prior art keywords
derivatives
fatty acids
chain
unsaturated fatty
fatty acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69031007T
Other languages
German (de)
English (en)
Other versions
DE69031007D1 (de
Inventor
David Frederick Horrobin
John Charles Marshall Stewart
Michael David Winther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protarga Inc
Original Assignee
Scotia Holdings PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898908646A external-priority patent/GB8908646D0/en
Priority claimed from GB898921266A external-priority patent/GB8921266D0/en
Application filed by Scotia Holdings PLC filed Critical Scotia Holdings PLC
Application granted granted Critical
Publication of DE69031007D1 publication Critical patent/DE69031007D1/de
Publication of DE69031007T2 publication Critical patent/DE69031007T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69031007T 1989-04-17 1990-04-11 Antivirale Nukleosid-Derivate Expired - Lifetime DE69031007T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898908646A GB8908646D0 (en) 1989-04-17 1989-04-17 Anti-viral agents
GB898921266A GB8921266D0 (en) 1989-09-20 1989-09-20 Anti-viral agents

Publications (2)

Publication Number Publication Date
DE69031007D1 DE69031007D1 (de) 1997-08-14
DE69031007T2 true DE69031007T2 (de) 1997-12-04

Family

ID=26295232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69031007T Expired - Lifetime DE69031007T2 (de) 1989-04-17 1990-04-11 Antivirale Nukleosid-Derivate

Country Status (15)

Country Link
US (2) US5216142A (https=)
EP (2) EP0693498A1 (https=)
JP (1) JP2952505B2 (https=)
KR (1) KR100188616B1 (https=)
AT (1) ATE155142T1 (https=)
AU (1) AU637362B2 (https=)
CA (1) CA2014662C (https=)
DE (1) DE69031007T2 (https=)
DK (1) DK0393920T3 (https=)
ES (1) ES2108686T3 (https=)
FI (1) FI901903A7 (https=)
GR (1) GR3024835T3 (https=)
IE (1) IE980216A1 (https=)
NZ (1) NZ233297A (https=)
TW (1) TW215417B (https=)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
KR927003044A (ko) * 1990-01-11 1992-12-17 크리스토퍼 케이. 미라벨리 Rna 활성과 유전자 발현을 검출하고 조절하는 조성물 및 그 방법
US6262241B1 (en) * 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
MY118354A (en) * 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
DK0823897T3 (da) * 1995-05-01 2004-12-06 Scarista Ltd Nicotinsyreestere og farmaceutiske præparater indeholdende disse
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
US5639460A (en) * 1995-06-07 1997-06-17 Raymond; Hal C. Aqueous plant extract having antiviral activity
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
US6703394B2 (en) * 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6673784B1 (en) * 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
ATE286884T1 (de) * 1996-03-28 2005-01-15 Shionogi & Co Durch lymphe absorbierbare imidazolderivate
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
EP1042341A1 (en) * 1997-11-25 2000-10-11 Protarga Inc. Nucleoside analog compositions and uses thereof
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
EP1427407A4 (en) * 2001-03-23 2005-05-11 Luitpold Pharm Inc FAT AMIN DRUG CONJUGATES
ES2387562T3 (es) * 2001-03-23 2012-09-26 Luitpold Pharmaceuticals, Inc. Conjugados alcohol graso-medicamento
US20060122174A1 (en) * 2001-09-21 2006-06-08 Henderson Morley Research & Development Limited Antiviral treatment
HRP20040421B1 (hr) * 2001-10-16 2013-05-31 Avanir Pharmaceuticals INHIBICIJA VIRUSA n-DOKOZANOLOM
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
CN1742018A (zh) * 2002-12-10 2006-03-01 弗·哈夫曼-拉罗切有限公司 抗病毒的核苷衍生物
AU2004314731B2 (en) * 2004-01-20 2011-07-07 The Board Of Regents Of The University Of Oklahoma Compositions and methods of treatment for inflammatory diseases
NO324263B1 (no) 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
WO2008150438A1 (en) * 2007-06-01 2008-12-11 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
WO2009042767A1 (en) 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
WO2015116782A1 (en) * 2014-01-29 2015-08-06 Board Of Regents, The University Of Texas System Nucleobase analogue derivatives and their applications

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2354288C2 (de) * 1973-10-30 1976-01-02 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Aminophenylalkyläthern
JPS5132573A (en) * 1974-09-11 1976-03-19 Asahi Chemical Ind Nn ashiruarabinonukureoshido no seizohoho
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
JPS5813394A (ja) * 1981-07-17 1983-01-25 Ajinomoto Co Inc １−β−Ｄ−リボフラノシル−４，５−置換イミダゾ−ルの製造法
EP0082668A1 (en) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenovinyl)-2'-deoxyuridine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in treating viral infections
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
JPS6144897A (ja) * 1984-08-10 1986-03-04 Terumo Corp ５−フルオロウラシル誘導体およびこれを含有する医薬製剤
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
IE73219B1 (en) * 1985-03-16 1997-05-07 Wellcome Found Therapeutic nucleosides
GB2175588B (en) * 1985-04-15 1988-08-10 Toyo Jozo Kk Nucleoside-phospholipid conjugates
DE3650741T2 (de) * 1985-09-17 2000-10-12 The Wellcome Foundation Ltd., Greenford Kombination therapeutische Nukleoside mit weiteren therapeutisch wirksamen Komponenten.
DE3778626D1 (de) * 1986-09-27 1992-06-04 Toyo Jozo Kk Nukleosid-phospholipid-konjugat.
CA1321994C (en) * 1987-10-28 1993-09-07 Reid Von Borstel Acylated uridine and cytidine and uses thereof
EP0712629B1 (en) * 1987-10-28 2003-06-18 Wellstat Therapeutics Corporation Acyl deoxyribonucleoside derivatives and uses thereof
IE980216A1 (en) * 1989-04-17 2000-02-23 Scotia Holdings Plc Anti-virals

Also Published As

Publication number Publication date
AU5329090A (en) 1990-10-18
HK1001003A1 (en) 1998-05-15
AU637362B2 (en) 1993-05-27
US5216142A (en) 1993-06-01
DK0393920T3 (da) 1997-09-22
EP0393920B1 (en) 1997-07-09
FI901903A7 (fi) 1990-10-18
ATE155142T1 (de) 1997-07-15
EP0393920A2 (en) 1990-10-24
IE980216A1 (en) 2000-02-23
EP0393920A3 (en) 1991-07-03
KR100188616B1 (ko) 1999-06-01
DE69031007D1 (de) 1997-08-14
JP2952505B2 (ja) 1999-09-27
GR3024835T3 (en) 1998-01-30
ES2108686T3 (es) 1998-01-01
FI901903A0 (fi) 1990-04-12
TW215417B (https=) 1993-11-01
CA2014662A1 (en) 1990-10-17
KR900015742A (ko) 1990-11-10
JPH02304084A (ja) 1990-12-17
US5276020A (en) 1994-01-04
CA2014662C (en) 2002-09-17
EP0693498A1 (en) 1996-01-24
NZ233297A (en) 1997-07-27

Similar Documents

Publication Publication Date Title
DE69031007T2 (de) Antivirale Nukleosid-Derivate
DE69531749T2 (de) Nukleosid-Monophosphatderivate, Verfahren zu deren Herstellung sowie deren Verwendung als Immunsuppressive Arzneimittel
EP0248047B1 (de) Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung
DE69225719T2 (de) Glykosylierte steroid derivate für den transport durch biologische membranen und verfahren zu deren herstellung
EP0056265B1 (de) 5'-Ester von Pyrimidinnucleosiden mit antiviraler Wirksamkeit, Verfahren zur Herstellung und daraus hergestellte Arzneimittel
CH684310A5 (de) Substituierte Adeninderivate.
DE3612636A1 (de) Nucleosid-phospholipid-komplexe
EP0355031A2 (de) Substituierte Pyrimidinnucleoside, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
EP1071433A2 (de) 2',2'-difluornucleoside zur immunosuppressiven therapie und kombinationspräparate
EP0409227A2 (de) Pyrimidinnucleoside, ihre Herstellung und pharmazeutische Mittel
DE60032470T2 (de) Heilmittel die sulfopyranosylacylglycerolderivate enthalten
DE60316389T2 (de) Verwendung von Hederagenin-3-O-a-L-rhamnopyranosyl((1->2)-(ß-D-glucopyranosyl (1->4))-a-L-arabinopyranosid oder eines dieses enthaltenden Extrakts aus Pulsatillae radix als ein therapeutisches Mittel für solide Tumore
DE3873207T2 (de) Antivirale therapie gegen hepatitis b mit 2',3'-didesoxynucleosiden.
EP0817790B1 (de) Spezifische lipidkonjugate von nucleosid-diphosphaten und deren verwendung als arzneimittel
DE68927055T2 (de) 2',5'-oligoadenylat-derivate zur verwendung als heilmittel
DE2926463C2 (https=)
DE69813231T2 (de) Natürliche antitumor- oder antivirale substanzen und ihre anwendung
DE2538573A1 (de) Uridine und diese enthaltende pharmazeutische praeparate
DE3425466A1 (de) Synergistisches arzneimittelpraeparat zur behandlung von leberkrankheiten
DE3820270A1 (de) Verwendung von 5-(isopropyl)-2'-(ss-desoxy)-uridin
WO1996032111A9 (de) Trapidil zur verwendung in der therapie von immunmodulatorisch beeinflussbaren krankheitsbildern
DE2629133C2 (de) 5"-Amino-3',5"-didesoxyribostamycin, Verfahren zu dessen Herstellung sowie antimikrobielle Zubereitungen
EP0432309B1 (de) Neue Zuckerderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3940551C2 (de) Mittel zur Behandlung von durch Aids-Viren verursachter infektiöser Dementia
DE2052819C3 (de) Cytosininosinat, Verfahren zu dessen Herstellung und es enthaltende Arzneimittel

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PROTARGA, INC., KING OF PRUSSIA, PA., US