DE69031007T2 - Antivirale Nukleosid-Derivate - Google Patents

Antivirale Nukleosid-Derivate

Info

Publication number
DE69031007T2
DE69031007T2 DE69031007T DE69031007T DE69031007T2 DE 69031007 T2 DE69031007 T2 DE 69031007T2 DE 69031007 T DE69031007 T DE 69031007T DE 69031007 T DE69031007 T DE 69031007T DE 69031007 T2 DE69031007 T2 DE 69031007T2
Authority
DE
Germany
Prior art keywords
nucleoside derivatives
antiviral nucleoside
sugar
nucleoside
analogue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69031007T
Other languages
English (en)
Other versions
DE69031007D1 (de
Inventor
David Frederick Horrobin
John Charles Marshall Stewart
Michael David Winther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Protarga Inc
Original Assignee
Scotia Holdings PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898908646A external-priority patent/GB8908646D0/en
Priority claimed from GB898921266A external-priority patent/GB8921266D0/en
Application filed by Scotia Holdings PLC filed Critical Scotia Holdings PLC
Application granted granted Critical
Publication of DE69031007D1 publication Critical patent/DE69031007D1/de
Publication of DE69031007T2 publication Critical patent/DE69031007T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE69031007T 1989-04-17 1990-04-11 Antivirale Nukleosid-Derivate Expired - Lifetime DE69031007T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898908646A GB8908646D0 (en) 1989-04-17 1989-04-17 Anti-viral agents
GB898921266A GB8921266D0 (en) 1989-09-20 1989-09-20 Anti-viral agents

Publications (2)

Publication Number Publication Date
DE69031007D1 DE69031007D1 (de) 1997-08-14
DE69031007T2 true DE69031007T2 (de) 1997-12-04

Family

ID=26295232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69031007T Expired - Lifetime DE69031007T2 (de) 1989-04-17 1990-04-11 Antivirale Nukleosid-Derivate

Country Status (16)

Country Link
US (2) US5216142A (de)
EP (2) EP0693498A1 (de)
JP (1) JP2952505B2 (de)
KR (1) KR100188616B1 (de)
AT (1) ATE155142T1 (de)
AU (1) AU637362B2 (de)
CA (1) CA2014662C (de)
DE (1) DE69031007T2 (de)
DK (1) DK0393920T3 (de)
ES (1) ES2108686T3 (de)
FI (1) FI901903A0 (de)
GR (1) GR3024835T3 (de)
HK (1) HK1001003A1 (de)
IE (1) IE980216A1 (de)
NZ (1) NZ233297A (de)
TW (1) TW215417B (de)

Families Citing this family (41)

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US6107499A (en) * 1988-02-26 2000-08-22 Neuromedica, Inc. Dopamine analog amide
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
EP0604409B1 (de) * 1990-01-11 2004-07-14 Isis Pharmaceuticals, Inc. Oligonukleotidderivate zur detektieren und modulation von rna aktivität und genexpression
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US6262241B1 (en) * 1990-08-13 2001-07-17 Isis Pharmaceuticals, Inc. Compound for detecting and modulating RNA activity and gene expression
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
MY118354A (en) 1995-05-01 2004-10-30 Scarista Ltd 1,3-propane diol derivatives as bioactive compounds
USRE40546E1 (en) * 1996-05-01 2008-10-21 Scarista, Ltd. 1,3-Propane diol esters and ethers and methods for their use in drug delivery
WO1996034858A1 (en) * 1995-05-01 1996-11-07 Scotia Holdings Plc Nicotinic acid esters and pharmaceutical compositions containing them
US5639460A (en) * 1995-06-07 1997-06-17 Raymond; Hal C. Aqueous plant extract having antiviral activity
US5840711A (en) * 1995-06-21 1998-11-24 University Of Kentucky Research Foundation Compositions containing lithium inorganic salts and anti-viral drugs and method of treating viral infections such as acquired immunodeficiency syndrome
US6703394B2 (en) * 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6673784B1 (en) * 1996-03-19 2004-01-06 G. D. Searle & Co. Electrophilic ketones for the treatment of herpesvirus infections
US6054591A (en) * 1996-03-28 2000-04-25 Shionogi & Co., Ltd. Lymph-absorbable aryl substituted imidazole derivatives
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
US6440980B1 (en) 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US5952392A (en) * 1996-09-17 1999-09-14 Avanir Pharmaceuticals Long-chain alcohols, alkanes, fatty acids and amides in the treatment of burns and viral inhibition
JP2001524486A (ja) * 1997-11-25 2001-12-04 プロタルガ，インコーポレーテッド ヌクレオシド類似成分組成物およびその使用
US5955459A (en) * 1997-11-26 1999-09-21 Neuromedica, Inc. Fatty acid-antipsychotic compositions and uses thereof
US5977174A (en) * 1997-11-26 1999-11-02 Neuromedica, Inc. Cholinergic compositions and uses thereof
US6153653A (en) * 1997-11-26 2000-11-28 Protarga, Inc. Choline compositions and uses thereof
US6197764B1 (en) 1997-11-26 2001-03-06 Protarga, Inc. Clozapine compositions and uses thereof
US6225444B1 (en) 1998-02-10 2001-05-01 Protarga, Inc. Neuroprotective peptides and uses thereof
WO2000016625A1 (en) * 1998-09-23 2000-03-30 University Of Kentucky Research Foundation Antiviral drug compositions containing lithium inorganic salts
US7235583B1 (en) * 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
ES2387562T3 (es) * 2001-03-23 2012-09-26 Luitpold Pharmaceuticals, Inc. Conjugados alcohol graso-medicamento
AU2002303164A1 (en) * 2001-03-23 2002-10-08 Protarga, Inc. Fatty amine drug conjugates
US20060122174A1 (en) * 2001-09-21 2006-06-08 Henderson Morley Research & Development Limited Antiviral treatment
CA2421026C (en) * 2001-10-16 2005-02-15 Avanir Pharmaceuticals Viral inhibition by n-docosanol
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2004052905A2 (en) * 2002-12-10 2004-06-24 F. Hoffmann-La Roche Ag Antiviral nucleoside derivatives
US7417037B2 (en) * 2004-01-20 2008-08-26 The Board Of Regents Of The University Of Oklahoma Compositions and methods of treatment for inflammatory diseases
NO324263B1 (no) 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US20090111774A1 (en) * 2007-06-01 2009-04-30 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
CN101835374B (zh) 2007-07-09 2014-08-27 东弗吉尼亚医学院 具有抗病毒和抗微生物性质的取代的核苷衍生物
MX2010003002A (es) 2007-09-26 2010-07-05 Sinai School Medicine Analogos de azacitidina y sus usos.
US10463684B2 (en) 2014-01-29 2019-11-05 Board Of Regents, The Uneversety Of Texas System Nucleobase analogue derivatives and their applications

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2354288C2 (de) * 1973-10-30 1976-01-02 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Aminophenylalkyläthern
JPS5126883A (en) * 1974-08-22 1976-03-05 Asahi Chemical Ind N44 ashiru shichijinno seiho
JPS5132573A (en) * 1974-09-11 1976-03-19 Asahi Chemical Ind Nn ashiruarabinonukureoshido no seizohoho
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
JPS5813394A (ja) * 1981-07-17 1983-01-25 Ajinomoto Co Inc １−β−Ｄ−リボフラノシル−４，５−置換イミダゾ−ルの製造法
EP0082668A1 (de) * 1981-12-18 1983-06-29 Beecham Group Plc 5-(2-Halogenvinyl)-2'-Deoxyuridinderivate, Verfahren zu ihrer Herstellung, die sie enthaltende pharmazeutische Präparate und ihre Verwendung bei der Bekämpfung von viralen Infektionen
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4612314A (en) * 1982-12-22 1986-09-16 Syntex (U.S.A.) Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
IL72173A0 (en) * 1983-06-24 1984-10-31 Merck & Co Inc Guanine derivatives,their preparation and pharmaceutical compositions containing them
JPS6144897A (ja) * 1984-08-10 1986-03-04 Terumo Corp ５−フルオロウラシル誘導体およびこれを含有する医薬製剤
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
CA1285935C (en) * 1985-03-16 1991-07-09 Janet Lister Rideout Therapeutic nucleosides
FR2580283B1 (fr) * 1985-04-15 1989-11-24 Toyo Jozo Kk Nouveau conjugue nucleoside-phospholipide
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
EP0262876B1 (de) * 1986-09-27 1992-04-29 Toyo Jozo Kabushiki Kaisha Nukleosid-Phospholipid-Konjugat
DE3856557T2 (de) * 1987-10-28 2004-06-03 Wellstat Therapeutics Corp. Acyldeoxyribonukleosid-Derivate und Verwendungen davon
DE3883374T2 (de) * 1987-10-28 1993-12-09 Pro Neuron Inc Acylatiertes uridin und cytidin und deren verwendungen.
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals

Also Published As

Publication number Publication date
US5216142A (en) 1993-06-01
CA2014662C (en) 2002-09-17
JPH02304084A (ja) 1990-12-17
KR100188616B1 (ko) 1999-06-01
AU637362B2 (en) 1993-05-27
JP2952505B2 (ja) 1999-09-27
KR900015742A (ko) 1990-11-10
TW215417B (de) 1993-11-01
EP0393920A2 (de) 1990-10-24
US5276020A (en) 1994-01-04
EP0693498A1 (de) 1996-01-24
ES2108686T3 (es) 1998-01-01
EP0393920A3 (de) 1991-07-03
ATE155142T1 (de) 1997-07-15
EP0393920B1 (de) 1997-07-09
IE980216A1 (en) 2000-02-23
AU5329090A (en) 1990-10-18
CA2014662A1 (en) 1990-10-17
HK1001003A1 (en) 1998-05-15
NZ233297A (en) 1997-07-27
DK0393920T3 (da) 1997-09-22
DE69031007D1 (de) 1997-08-14
GR3024835T3 (en) 1998-01-30
FI901903A0 (fi) 1990-04-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PROTARGA, INC., KING OF PRUSSIA, PA., US