DE69009755D1 - Orale heilmittelform für dauerverabreichung. - Google Patents

Orale heilmittelform für dauerverabreichung.

Info

Publication number
DE69009755D1
DE69009755D1 DE69009755T DE69009755T DE69009755D1 DE 69009755 D1 DE69009755 D1 DE 69009755D1 DE 69009755 T DE69009755 T DE 69009755T DE 69009755 T DE69009755 T DE 69009755T DE 69009755 D1 DE69009755 D1 DE 69009755D1
Authority
DE
Germany
Prior art keywords
drug
particles
stomach
solution
solubility
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69009755T
Other languages
English (en)
Other versions
DE69009755T2 (de
Inventor
John Shell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Depomed Systems Inc
Original Assignee
Depomed Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Depomed Systems Inc filed Critical Depomed Systems Inc
Publication of DE69009755D1 publication Critical patent/DE69009755D1/de
Application granted granted Critical
Publication of DE69009755T2 publication Critical patent/DE69009755T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69009755T 1989-04-11 1990-04-10 Orale heilmittelform für dauerverabreichung. Expired - Fee Related DE69009755T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/336,440 US5007790A (en) 1989-04-11 1989-04-11 Sustained-release oral drug dosage form
PCT/US1990/001933 WO1990011757A1 (en) 1989-04-11 1990-04-10 Sustained-release oral drug dosage form

Publications (2)

Publication Number Publication Date
DE69009755D1 true DE69009755D1 (de) 1994-07-14
DE69009755T2 DE69009755T2 (de) 1994-10-20

Family

ID=23316106

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69009755T Expired - Fee Related DE69009755T2 (de) 1989-04-11 1990-04-10 Orale heilmittelform für dauerverabreichung.

Country Status (10)

Country Link
US (1) US5007790A (de)
EP (1) EP0467975B1 (de)
JP (1) JP2878837B2 (de)
KR (1) KR0167078B1 (de)
AT (1) ATE106717T1 (de)
AU (1) AU638012B2 (de)
CA (1) CA2014451C (de)
DE (1) DE69009755T2 (de)
FI (1) FI914765A0 (de)
WO (1) WO1990011757A1 (de)

Families Citing this family (244)

* Cited by examiner, † Cited by third party
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