DE68918657D1 - Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen. - Google Patents

Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen.

Info

Publication number
DE68918657D1
DE68918657D1 DE68918657T DE68918657T DE68918657D1 DE 68918657 D1 DE68918657 D1 DE 68918657D1 DE 68918657 T DE68918657 T DE 68918657T DE 68918657 T DE68918657 T DE 68918657T DE 68918657 D1 DE68918657 D1 DE 68918657D1
Authority
DE
Germany
Prior art keywords
detection
nucleic acid
acid sequences
specific nucleic
specific
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68918657T
Other languages
English (en)
Other versions
DE68918657T2 (de
Inventor
Edwin F Ullman
Thomas C Goodman
Paul D Stull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of DE68918657D1 publication Critical patent/DE68918657D1/de
Application granted granted Critical
Publication of DE68918657T2 publication Critical patent/DE68918657T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/975Kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
DE68918657T 1988-08-25 1989-08-24 Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen. Expired - Lifetime DE68918657T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/236,967 US5185243A (en) 1988-08-25 1988-08-25 Method for detection of specific nucleic acid sequences

Publications (2)

Publication Number Publication Date
DE68918657D1 true DE68918657D1 (de) 1994-11-10
DE68918657T2 DE68918657T2 (de) 1995-05-18

Family

ID=22891769

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918657T Expired - Lifetime DE68918657T2 (de) 1988-08-25 1989-08-24 Verfahren zum Nachweis spezifischer Nukleinsäuresequenzen.

Country Status (5)

Country Link
US (2) US5185243A (de)
EP (1) EP0357336B1 (de)
JP (1) JPH02135100A (de)
CA (1) CA1340775C (de)
DE (1) DE68918657T2 (de)

Families Citing this family (250)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242794A (en) * 1984-12-13 1993-09-07 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
ATE142272T1 (de) * 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
KR950013953B1 (ko) * 1990-01-26 1995-11-18 애보트 래보라토리즈 리가제 연쇄 반응에 적용가능한 표적 핵산의 증폭 방법
US5427930A (en) * 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
JPH04222599A (ja) * 1990-04-20 1992-08-12 Syntex Usa Inc 二重受容体ポリヌクレオチド検定方法
DE4123540A1 (de) * 1991-07-16 1993-01-21 Boehringer Mannheim Gmbh Immobilisierung von nukleinsaeuren
WO1993021311A1 (en) * 1992-04-15 1993-10-28 Commonwealth Scientific And Industrial Research Organisation Immortalisation of human cells by gene silencing
EP1262560A2 (de) * 1992-05-29 2002-12-04 Abbott Laboratories Methode zur Herstellung von cDNA ausgehend von einer RNA Zielsequenz in einer Probe
US6180338B1 (en) 1992-08-04 2001-01-30 Beckman Coulter, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
US6207368B1 (en) 1992-08-04 2001-03-27 Beckman Coulter, Inc. Methods and reagents for controlling chain extension and ligation chain reactions
US5312527A (en) * 1992-10-06 1994-05-17 Concordia University Voltammetric sequence-selective sensor for target polynucleotide sequences
US6436635B1 (en) * 1992-11-06 2002-08-20 Boston University Solid phase sequencing of double-stranded nucleic acids
US5795714A (en) * 1992-11-06 1998-08-18 Trustees Of Boston University Method for replicating an array of nucleic acid probes
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
US5658757A (en) * 1993-03-31 1997-08-19 The Regents Of The University Of California Cloned leptospira outer membrane protein
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5846709A (en) * 1993-06-15 1998-12-08 Imclone Systems Incorporated Chemical process for amplifying and detecting nucleic acid sequences
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
AU1911395A (en) * 1994-02-04 1995-08-21 Beckman Instruments, Inc. Method, reagent and kit for the detection and amplification of nucleic acid sequences
JP3175110B2 (ja) * 1994-02-07 2001-06-11 オーキッド・バイオサイエンシーズ・インコーポレイテッド リガーゼ/ポリメラーゼ媒体された単一ヌクレオチド多型のジェネティックビットアナリシスおよび遺伝子解析におけるその使用
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6593086B2 (en) 1996-05-20 2003-07-15 Mount Sinai School Of Medicine Of New York University Nucleic acid amplification methods
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US5876924A (en) * 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
WO1995035390A1 (en) * 1994-06-22 1995-12-28 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
USRE38442E1 (en) * 1994-06-22 2004-02-24 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5942391A (en) 1994-06-22 1999-08-24 Mount Sinai School Of Medicine Nucleic acid amplification method: ramification-extension amplification method (RAM)
US5843666A (en) * 1994-09-02 1998-12-01 Lumigen, Inc. Chemiluminescent detection methods using dual enzyer-labeled binding partners
US5705366A (en) 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US5871902A (en) * 1994-12-09 1999-02-16 The Gene Pool, Inc. Sequence-specific detection of nucleic acid hybrids using a DNA-binding molecule or assembly capable of discriminating perfect hybrids from non-perfect hybrids
US7803529B1 (en) * 1995-04-11 2010-09-28 Sequenom, Inc. Solid phase sequencing of biopolymers
US20060063193A1 (en) * 1995-04-11 2006-03-23 Dong-Jing Fu Solid phase sequencing of double-stranded nucleic acids
US5843650A (en) * 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5686310A (en) * 1995-06-06 1997-11-11 University Of Virginia Patent Foundation Method for determination of the amount of either phosphotyrosine or phosphoserine in a protein
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
JP4468488B2 (ja) 1996-05-29 2010-05-26 コーネル・リサーチ・ファンデーション・インコーポレイテッド 組み合せたリガーゼ検出およびポリメラーゼ連鎖反応を用いる核酸配列相違の検出
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
WO1998003877A1 (en) 1996-07-18 1998-01-29 Behringwerke Aktiengesellschaft Reagents for assays for ligands
DE69725118T2 (de) * 1996-07-18 2004-07-08 Dade Behring Marburg Gmbh Reagentien für tests für mycophenolsäure
US20030165971A1 (en) * 1996-10-31 2003-09-04 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050153373A1 (en) * 1996-10-31 2005-07-14 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
US20050202499A1 (en) 1996-10-31 2005-09-15 Billing-Medel Patricia A. Reagents and methods useful for detecting diseases of the breast
DE19782095T1 (de) 1996-11-06 2000-03-23 Sequenom Inc DNA-Diagnose auf der Basis von Massenspektrometrie
US20020137904A1 (en) * 1998-03-27 2002-09-26 Patricia A. Billing-Medel Reagents and methods useful for detecting diseases of the gastrointestinal tract
US20050208567A1 (en) * 1997-04-25 2005-09-22 Billing-Medel Patricia A Reagents and methods useful for detecting diseases of the prostate
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
US6103537A (en) * 1997-10-02 2000-08-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
US6233565B1 (en) 1998-02-13 2001-05-15 Saranac Software, Inc. Methods and apparatus for internet based financial transactions with evidence of payment
US6127121A (en) * 1998-04-03 2000-10-03 Epoch Pharmaceuticals, Inc. Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
US6153442A (en) * 1998-05-20 2000-11-28 Dade Behring Inc. Reagents and methods for specific binding assays
US6303325B1 (en) 1998-05-29 2001-10-16 Dade Behring Inc. Method for detecting analytes
EP2360271A1 (de) 1998-06-24 2011-08-24 Illumina, Inc. Dekodierung von Arraysensoren mit Mikrosphären
US6140083A (en) 1998-07-23 2000-10-31 The Regents Of The University Of California Leptospiral outer membrane protein, LipL46
DE69911641T2 (de) * 1998-11-27 2004-08-05 Synaptics (Uk) Ltd., Harston Positionssensor
CA2372909A1 (en) * 1999-03-30 2000-10-05 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
DE60020143T2 (de) 1999-03-31 2006-02-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Centers for Disease Control and Prevention, Office of Technology Transfer, Atlanta Typisierung von humanen enteroviren
US20030207295A1 (en) * 1999-04-20 2003-11-06 Kevin Gunderson Detection of nucleic acid reactions on bead arrays
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
EP1923472B1 (de) 1999-04-20 2012-04-11 Illumina, Inc. Erkennung von Nukleinsäurereaktionen auf Bead-Arrays
US8080380B2 (en) * 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
WO2001007665A2 (en) * 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
US6692918B2 (en) * 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
DE60143723D1 (de) * 2000-02-07 2011-02-03 Illumina Inc Nukleinsäuredetektionsverfahren mit universellem Priming
US7611869B2 (en) * 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US8076063B2 (en) * 2000-02-07 2011-12-13 Illumina, Inc. Multiplexed methylation detection methods
US20050214825A1 (en) * 2000-02-07 2005-09-29 John Stuelpnagel Multiplex sample analysis on universal arrays
CA2400457A1 (en) 2000-02-16 2001-08-23 Illumina, Inc. Parallel genotyping of multiple patient samples
WO2001073122A1 (en) * 2000-03-28 2001-10-04 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
JP2004507226A (ja) * 2000-05-30 2004-03-11 ピーイー コーポレイション (エヌワイ) ライゲーションおよび増幅の組み合わせを用いて標的核酸を検出するための方法
JP2004513617A (ja) * 2000-06-26 2004-05-13 ニューゲン テクノロジーズ, インコーポレイテッド 転写に基づく核酸増幅のための方法および組成物
US7846733B2 (en) * 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
WO2002057491A2 (en) * 2000-10-24 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Direct multiplex characterization of genomic dna
EP1409721A2 (de) * 2000-11-13 2004-04-21 Gnothis Holding SA Nachweis von nukleinsäure-polymorphismen
DE60142709D1 (de) * 2000-12-13 2010-09-09 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
BR0205268A (pt) * 2001-03-09 2004-11-30 Nugen Technologies Inc Processos e composições para a mplificação de sequências de rna
EP1390537B1 (de) 2001-03-09 2013-11-13 Nugen Technologies, Inc. Verfahren und zusammensetzungen zur amplifikation von rna-sequenzen
US20030092157A1 (en) * 2001-03-16 2003-05-15 Hayden Michael R. Compositions, screening systems and methods for modulating HDL cholesterol and triglyceride levels
JP2004526453A (ja) * 2001-04-16 2004-09-02 アプレラ コーポレイション ヌクレオチド分析のための方法および組成物
US7838270B2 (en) * 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
WO2002097123A2 (en) * 2001-05-25 2002-12-05 Xenon Genetics, Inc. Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels
EP2246438B1 (de) 2001-07-12 2019-11-27 Illumina, Inc. Multiplex-nukleinsäurereaktionen
WO2003062783A2 (en) * 2001-07-20 2003-07-31 North Carolina State University Light addressable electrochemical detection of duplex structures
AU2002367750A1 (en) * 2001-08-14 2003-11-03 Discovery, Inc. Isothermal amplification in nucleic acid analysis
US7179658B2 (en) * 2001-09-06 2007-02-20 Beckman Coulter, Inc. Particle based homogeneous assays using capillary electrophoresis with laser-induced fluorescence detection
EP1453979B1 (de) 2001-11-19 2012-01-04 Affymetrix, Inc. Multiplex pcr
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
US20030165935A1 (en) 2001-11-21 2003-09-04 Vann Charles S. Digital assay
EP1860200A1 (de) * 2001-12-03 2007-11-28 Illumina, Inc. Multiplexverfahren zur Methylierungsdetektion
US9575070B2 (en) * 2001-12-04 2017-02-21 Wayne State University Neoepitope detection of disease using protein arrays
US20040171047A1 (en) * 2002-05-22 2004-09-02 Dahl Gary A. Target-dependent transcription
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
AU2003275065A1 (en) * 2002-09-20 2004-04-08 Wayne State University Molecular targets of cancer and aging
EP1403379A1 (de) * 2002-09-24 2004-03-31 QIAGEN GmbH Verbesserte Koamplifikation von Nukleinsäuren
US20040259105A1 (en) * 2002-10-03 2004-12-23 Jian-Bing Fan Multiplex nucleic acid analysis using archived or fixed samples
EP1558756A4 (de) * 2002-10-23 2006-09-27 Applera Corp Verfahren und zusammensetzung zumnachweis von targets
US20050003371A1 (en) * 2002-10-23 2005-01-06 Stratagene Modified nucleotides and methods of labeling nucleic acids
US20050053957A1 (en) * 2002-11-19 2005-03-10 Applera Corporation Polynucleotide sequence detection assays
WO2004046343A2 (en) * 2002-11-19 2004-06-03 Applera Corporation Polynucleotide sequence detection assays and analysis
EP1608952B1 (de) * 2002-12-20 2016-08-10 Life Technologies Corporation Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20040180369A1 (en) * 2003-01-16 2004-09-16 North Carolina State University Photothermal detection of nucleic acid hybridization
US7887752B2 (en) * 2003-01-21 2011-02-15 Illumina, Inc. Chemical reaction monitor
US6943768B2 (en) 2003-02-21 2005-09-13 Xtellus Inc. Thermal control system for liquid crystal cell
EP1460425A1 (de) * 2003-03-17 2004-09-22 Boehringer Mannheim Gmbh Entglykosilierte Enzymen für Konjugaten
US7402386B2 (en) * 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
US20050239089A1 (en) * 2003-06-06 2005-10-27 Johnson Martin D Mobility cassettes
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
WO2005021841A2 (en) * 2003-09-03 2005-03-10 Bioforms Methods and apparatus for rapid crystallization of biomolecules
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
US7354706B2 (en) * 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
WO2005042785A1 (en) * 2003-10-30 2005-05-12 North Carolina State University Electrochemical detection of nucleic acid hybridization
US20050130213A1 (en) * 2003-12-10 2005-06-16 Tom Morrison Selective ligation and amplification assay
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
SE0400441D0 (sv) * 2004-02-25 2004-02-25 Active Biotech Ab Novel Benzofurans and Indols
EP1574583A1 (de) * 2004-03-10 2005-09-14 Roche Diagnostics GmbH Verfahren zur Isolierung von Bakterien aus biologischen Proben
WO2005092038A2 (en) * 2004-03-22 2005-10-06 The Johns Hopkins University Methods for the detection of nucleic acid differences
CN100468683C (zh) * 2004-05-17 2009-03-11 株式会社日立国际电气 衬底处理装置
US7622281B2 (en) * 2004-05-20 2009-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for clonal amplification of nucleic acid
US7473551B2 (en) 2004-05-21 2009-01-06 Atonomics A/S Nano-mechanic microsensors and methods for detecting target analytes
US7785843B2 (en) * 2004-06-23 2010-08-31 Sequenom, Inc. Target-specific compomers and methods of use
US7776530B2 (en) * 2004-06-29 2010-08-17 Wallac Oy Integrated nucleic acid analysis
US20090269737A1 (en) * 2004-06-29 2009-10-29 Wallac Oy Integrated non-homogeneous nucleic acid amplification and detection
EP1666150B1 (de) 2004-11-20 2015-01-07 Roche Diagnostics GmbH Präparieren von Nucleinsäuren
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
KR20070118703A (ko) 2005-04-08 2007-12-17 나스텍 파마수티컬 컴퍼니 인코포레이티드 호흡기 바이러스 감염을 치료하는 알엔에이 아이
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US7939258B2 (en) 2005-09-07 2011-05-10 Nugen Technologies, Inc. Nucleic acid amplification procedure using RNA and DNA composite primers
US7981606B2 (en) * 2005-12-21 2011-07-19 Roche Molecular Systems, Inc. Control for nucleic acid testing
EP2677039B8 (de) 2006-05-10 2022-10-05 DxTerity Diagnostics Incorporated Erkennung von Nukleinsäuretargets mithilfe chemisch reaktiver Oligonnucleotidsonden
TW200831528A (en) 2006-11-30 2008-08-01 Astrazeneca Ab Compounds
WO2008085024A1 (en) * 2007-01-12 2008-07-17 Erasmus University Medical Center Rotterdam Identification and detection of peptides relating to specific disorders
US7862999B2 (en) 2007-01-17 2011-01-04 Affymetrix, Inc. Multiplex targeted amplification using flap nuclease
AR065368A1 (es) 2007-02-15 2009-06-03 Astrazeneca Ab Anticuerpos para moleculas de ige
US20080293589A1 (en) * 2007-05-24 2008-11-27 Affymetrix, Inc. Multiplex locus specific amplification
US8008010B1 (en) 2007-06-27 2011-08-30 Applied Biosystems, Llc Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor
US7790401B2 (en) 2007-08-06 2010-09-07 Siemens Healthcare Diagnostics Methods for detection of immunosuppressant drugs
WO2009052179A2 (en) * 2007-10-15 2009-04-23 Idexx Laboratories, Inc. Feline pancreatic lipase
US20090137405A1 (en) * 2007-11-16 2009-05-28 Christopher Bowman Detection of nucleic acid biomarkers using polymerization-based amplification
US20100121198A1 (en) * 2008-11-07 2010-05-13 Den-Mat Holdings Llc Multi-Purpose Illumination System And Method For Tissue Examination
US7910378B2 (en) 2007-12-14 2011-03-22 Siemens Healthcare Diagnostics Inc. Methods for detection of hydrophobic drugs
AU2008339576B2 (en) 2007-12-21 2014-05-22 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Ralpha)
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
AU2009205523A1 (en) 2008-01-14 2009-07-23 Applied Biosystems, Llc Compositions, methods, and kits for detecting ribonucleic acid
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
CN102449169B (zh) * 2009-04-01 2016-03-16 德克斯特里蒂诊断公司 化学连接依赖性的探针扩增(clpa)
US9714937B2 (en) * 2009-10-13 2017-07-25 Nanostring Technologies, Inc. Protein detection via nanoreporters
WO2011059686A2 (en) 2009-10-29 2011-05-19 Wisconsin Alumni Research Foundation Detection of b-cell activating factor as a biomaker for antibody mediated rejection in transplant recipients
CA2785587A1 (en) 2009-12-23 2011-06-30 4-Antibody Ag Binding members for human cytomegalovirus
US8420801B2 (en) * 2010-01-08 2013-04-16 Roche Molecular Systems, Inc. Recovery of nucleic acids from magnetic glass particles
US8828688B2 (en) 2010-05-27 2014-09-09 Affymetrix, Inc. Multiplex amplification methods
US8329424B2 (en) 2010-06-25 2012-12-11 Siemens Healthcare Diagnostics Reduction in false results in assay measurements
EP2601531A1 (de) 2010-08-04 2013-06-12 IDEXX Laboratories, Inc. Nachweis von zersetzungsprodukten von hundespezifischem nt-probnp
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
WO2013082164A1 (en) 2011-11-28 2013-06-06 Life Technologies Corporation Enhanced ligation reactions
KR20140003467A (ko) 2010-12-20 2014-01-09 메디뮨 리미티드 항il-18 항체 및 그의 용도
WO2012106385A2 (en) 2011-01-31 2012-08-09 Apprise Bio, Inc. Methods of identifying multiple epitopes in cells
AU2012212148B8 (en) 2011-02-02 2017-07-06 University Of Washington Through Its Center For Commercialization Massively parallel contiguity mapping
EP2710145B1 (de) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Verfahren und zusammensetzungen zum nachweis von zielnukleinsäuren
AU2012262154B2 (en) 2011-05-31 2016-08-04 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP
EP2980226A1 (de) 2011-07-08 2016-02-03 Keygene N.V. Sequenzbasierte genotypisierung auf grundlage von oligonukleotid-verknüpfungsassays
US8586322B2 (en) 2012-03-07 2013-11-19 Siemens Healthcare Diagnostics, Inc Sandwich assay for immunosuppressant drugs
US9658218B2 (en) 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
JP6525872B2 (ja) 2012-08-08 2019-06-05 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 細胞中の複数のエピトープを同定するためのダイナミックレンジを高めること
WO2014060444A1 (en) 2012-10-15 2014-04-24 Medimmune Limited Antibodies to amyloid beta
US9181583B2 (en) 2012-10-23 2015-11-10 Illumina, Inc. HLA typing using selective amplification and sequencing
US9121859B2 (en) 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
EP2971183A4 (de) 2013-03-13 2016-10-26 Meso Scale Technologies Llc Verbesserte testverfahren
DK3553175T3 (da) 2013-03-13 2021-08-23 Illumina Inc Fremgangsmåde til fremstilling af et nukleinsyresekvenseringsbibliotek
EP2971069B1 (de) 2013-03-13 2018-10-17 Illumina, Inc. Verfahren und systeme zum ausrichten wiederholter dna elemente
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
JP6472789B2 (ja) 2013-05-14 2019-02-20 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 受容体含有安定化液剤
WO2015088913A1 (en) 2013-12-09 2015-06-18 Illumina, Inc. Methods and compositions for targeted nucleic acid sequencing
JP6559135B2 (ja) 2013-12-13 2019-08-14 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 非凝集検定における前処理剤
US8980273B1 (en) 2014-07-15 2015-03-17 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
US8986691B1 (en) 2014-07-15 2015-03-24 Kymab Limited Method of treating atopic dermatitis or asthma using antibody to IL4RA
ES2670991T3 (es) 2013-12-18 2018-06-04 Siemens Healthcare Diagnostics Inc. Detección de enfermedad endotelial
EP3083994B1 (de) 2013-12-20 2021-08-18 Illumina, Inc. Konservierung von genom-verbindungsinformationen in fragmentierten genomischen dna-proben
US9926598B2 (en) 2014-01-16 2018-03-27 Illumina, Inc. Amplicon preparation and sequencing on solid supports
US9677132B2 (en) 2014-01-16 2017-06-13 Illumina, Inc. Polynucleotide modification on solid support
KR102497054B1 (ko) 2014-05-15 2023-02-06 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
US20150353989A1 (en) 2014-06-09 2015-12-10 Illumina Cambridge Limited Sample preparation for nucleic acid amplification
WO2015191777A2 (en) 2014-06-10 2015-12-17 Dxterity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
GB201410420D0 (en) 2014-06-11 2014-07-23 Illumina Cambridge Ltd Methods for estimating cluster numbers
CN117867071A (zh) 2014-06-13 2024-04-12 伊卢米纳剑桥有限公司 用于制备序列文库的方法和组合物
EP3161152B1 (de) 2014-06-30 2018-12-26 Illumina, Inc. Verfahren und zusammensetzungen mit verwendung von einseitiger transposition
WO2016040602A1 (en) 2014-09-11 2016-03-17 Epicentre Technologies Corporation Reduced representation bisulfite sequencing using uracil n-glycosylase (ung) and endonuclease iv
EP3194627B1 (de) 2014-09-18 2023-08-16 Illumina, Inc. Verfahren und systeme zur analyse von nukleinsäuresequenzierungsdaten
WO2016061517A2 (en) 2014-10-17 2016-04-21 Illumina Cambridge Limited Contiguity preserving transposition
GB201419731D0 (en) 2014-11-05 2014-12-17 Illumina Cambridge Ltd Sequencing from multiple primers to increase data rate and density
MX2017007381A (es) 2014-12-11 2017-11-06 Inbiomotion Sl Miembros de union para homologo del oncogen de fibrosarcoma musculoadoneurotico (c-maf) humano.
EP3234607B1 (de) 2014-12-17 2021-04-28 Siemens Healthcare Diagnostics Inc. Sandwichtestdesign für kleine moleküle
EP3783109A1 (de) 2015-03-31 2021-02-24 Illumina Cambridge Limited Oberfläche für conkatemerization von matrizen
WO2016164407A2 (en) 2015-04-07 2016-10-13 Polyskope Labs Detection of one or more pathogens
EP3878974A1 (de) 2015-07-06 2021-09-15 Illumina Cambridge Limited Probenvorbereitung zur nukleinsäureamplifikation
JP6879496B2 (ja) 2015-10-29 2021-06-02 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッドSiemens Healthcare Diagnostics Inc. 小分子のためのサンドイッチアッセイ
SG11201805665UA (en) 2016-03-28 2018-10-30 Illumina Inc Multi-plane microarrays
WO2018018008A1 (en) 2016-07-22 2018-01-25 Oregon Health & Science University Single cell whole genome libraries and combinatorial indexing methods of making thereof
WO2018197945A1 (en) 2017-04-23 2018-11-01 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
CA3059952C (en) 2017-04-23 2023-04-18 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
ES2893528T3 (es) 2017-04-23 2022-02-09 Illumina Cambridge Ltd Composiciones y métodos para mejorar la identificación de muestras en colecciones de ácidos nucleicos indexadas
AU2018261007A1 (en) 2017-05-05 2019-11-07 Quantum-Si Incorporated Substrates having modified surface reactivity and antifouling properties in biological reactions
US10995104B2 (en) 2017-05-30 2021-05-04 Roche Molecular System, Inc. Catalysts for reversing formaldehyde adducts and crosslinks
KR20240013852A (ko) 2017-06-07 2024-01-30 오레곤 헬스 앤드 사이언스 유니버시티 메틸화 서열결정을 위한 단일 세포 전체 게놈 라이브러리
CN110785813A (zh) 2017-07-31 2020-02-11 伊鲁米那股份有限公司 具有多路生物样本聚合的测序系统
CN111094585A (zh) 2017-08-01 2020-05-01 伊鲁米纳公司 用于核苷酸测序的水凝胶珠
CA3067140C (en) 2018-02-13 2023-03-21 Illumina, Inc. Dna sequencing using hydrogel beads
JP7134186B2 (ja) 2018-03-22 2022-09-09 イルミナ インコーポレイテッド Rnaおよびdnaからの核酸ライブラリーの作製
CN110832086A (zh) 2018-04-02 2020-02-21 伊鲁米那股份有限公司 用于制造用于基于序列的遗传检验的对照的组合物和方法
RU2750567C2 (ru) 2018-04-20 2021-06-29 Иллумина, Инк. Способы инкапсулирования одиночных клеток, инкапсулированные клетки и способы их применения
MX2019015262A (es) 2018-06-04 2023-01-25 Illumina Inc Bibliotecas de transcriptomas de celulas individuales de alto rendimiento y metodos de fabricacion y uso.
AU2019364545A1 (en) 2018-10-26 2021-04-29 Illumina, Inc. Modulating polymer beads for DNA processing
CN112867801A (zh) 2018-11-30 2021-05-28 Illumina公司 使用单一测定分析多种分析物
JP2022522917A (ja) 2019-03-01 2022-04-21 イルミナ インコーポレイテッド ハイスループット単一核及び単一細胞ライブラリー、並びに製造及び使用方法
JP2022539630A (ja) 2019-07-12 2022-09-13 イルミナ ケンブリッジ リミテッド 電気泳動を用いた核酸ライブラリの調製
US20220154173A1 (en) 2019-07-12 2022-05-19 Iiiumina Cambridge Limited Compositions and Methods for Preparing Nucleic Acid Sequencing Libraries Using CRISPR/CAS9 Immobilized on a Solid Support
BR112022006682A2 (pt) 2019-10-11 2022-07-12 Quantum Si Inc Modificação de superfície na fase de vapor
BR112021019640A2 (pt) 2019-12-19 2022-06-21 Illumina Inc Bibliotecas de células únicas de alto rendimento e métodos de preparo e uso
EP4127220A1 (de) 2020-03-30 2023-02-08 Illumina, Inc. Verfahren und zusammensetzungen zur herstellung von nukleinsäurebibliotheken
KR20230035237A (ko) 2020-05-12 2023-03-13 일루미나, 인코포레이티드 재조합 말단 데옥시뉴클레오티딜 트랜스퍼라제를 사용하여 변형된 염기를 갖는 핵산의 생성
WO2021252617A1 (en) 2020-06-09 2021-12-16 Illumina, Inc. Methods for increasing yield of sequencing libraries
US20210403993A1 (en) 2020-06-30 2021-12-30 Illumina, Inc. Catalytically controlled sequencing by synthesis to produce scarless dna
BR112023002051A2 (pt) 2020-08-06 2023-04-18 Illumina Inc Preparação de bibliotecas de sequenciamento de rna e dna usando transpossomos ligados a microesferas
CN116323971A (zh) 2020-08-18 2023-06-23 Illumina公司 核酸的序列特异性靶向转座和选择以及分选
JP2023540177A (ja) 2020-09-11 2023-09-22 イルミナ ケンブリッジ リミテッド ヘアピンアダプターを使用して配列決定ライブラリーから標的配列を濃縮する方法
EP4288562A1 (de) 2021-02-04 2023-12-13 Illumina, Inc. Erzeugung von langem indexiertem verknüpftem lesen auf transposomgebundenen kügelchen
KR20230163434A (ko) 2021-03-29 2023-11-30 일루미나, 인코포레이티드 라이브러리에서 dna 손상을 평가하고 앰플리콘 크기 바이어스를 정규화하기 위한 조성물 및 방법
AU2022252197A1 (en) 2021-03-29 2023-09-21 Illumina, Inc. Improved methods of library preparation
AU2022246579A1 (en) 2021-03-30 2023-09-21 Illumina, Inc. Improved methods of isothermal complementary dna and library preparation
EP4314283A1 (de) 2021-03-31 2024-02-07 Illumina, Inc. Verfahren zur herstellung von direktionalen tagmentationssequenzierungsbibliotheken mit transposonbasierter technologie mit eindeutigen molekularen identifikatoren zur fehlerkorrektur
WO2023196572A1 (en) 2022-04-07 2023-10-12 Illumina Singapore Pte. Ltd. Altered cytidine deaminases and methods of use
WO2024069581A1 (en) 2022-09-30 2024-04-04 Illumina Singapore Pte. Ltd. Helicase-cytidine deaminase complexes and methods of use
WO2024073047A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Cytidine deaminases and methods of use in mapping modified cytosine nucleotides
WO2024073043A1 (en) 2022-09-30 2024-04-04 Illumina, Inc. Methods of using cpg binding proteins in mapping modified cytosine nucleotides

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI63596C (fi) * 1981-10-16 1983-07-11 Orion Yhtymae Oy Mikrobdiagnostiskt foerfarande som grundar sig pao skiktshybridisering av nukleinsyror och vid foerfarandet anvaenda kombinationer av reagenser
US4423153A (en) * 1981-12-03 1983-12-27 Board Of Regents, The University Of Texas System Methods and compositions for the detection and determination of cellular DNA
US4480040A (en) * 1981-12-03 1984-10-30 The United States Of America As Represented By The Secretary Of Agriculture Sensitive and rapid diagnosis of viroid diseases and viruses
US4490472A (en) * 1982-06-17 1984-12-25 Imreg, Inc. Sensitive tests for malignancies based on DNA detection
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4677054A (en) * 1983-08-08 1987-06-30 Sloan-Kettering Institute For Cancer Research Method for simple analysis of relative nucleic acid levels in multiple small samples by cytoplasmic dot hybridization
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
FI71768C (fi) * 1984-02-17 1987-02-09 Orion Yhtymae Oy Foerbaettrade nykleinsyrareagenser och foerfarande foer deras framstaellning.
GB8405437D0 (en) * 1984-03-01 1984-04-04 Amersham Int Plc Detecting polynucleotide sequences
US4683194A (en) * 1984-05-29 1987-07-28 Cetus Corporation Method for detection of polymorphic restriction sites and nucleic acid sequences
US4647529A (en) * 1984-06-01 1987-03-03 Rodland Karin D Hybridization method of detecting nucleic acid sequences with probe containing thionucleotide
US4675283A (en) * 1984-07-19 1987-06-23 Massachusetts Institute Of Technology Detection and isolation of homologous, repeated and amplified nucleic acid sequences
US4775619A (en) * 1984-10-16 1988-10-04 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
FI72146C (fi) * 1985-01-02 1987-04-13 Orion Yhtymae Oy Foerfarande foer identifiering av nukleinsyror.
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GB8509367D0 (en) * 1985-04-12 1985-05-15 Amersham Int Plc Nucleic acid hybridisation
US4868104A (en) * 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4851331A (en) * 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
GB8612087D0 (en) * 1986-05-19 1986-06-25 Ici Plc Hybridisation probes
US4994368A (en) * 1987-07-23 1991-02-19 Syntex (U.S.A.) Inc. Amplification method for polynucleotide assays
GB2225112A (en) * 1988-11-22 1990-05-23 Ici Plc Hybridisation probes

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US5516641A (en) 1996-05-14
EP0357336B1 (de) 1994-10-05
EP0357336A3 (de) 1991-02-27
CA1340775C (en) 1999-09-28
US5185243A (en) 1993-02-09

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