DE68901382D1 - Verfahren zur herstellung von polyungesaettigten fettsaeuren. - Google Patents

Verfahren zur herstellung von polyungesaettigten fettsaeuren.

Info

Publication number
DE68901382D1
DE68901382D1 DE8989906102T DE68901382T DE68901382D1 DE 68901382 D1 DE68901382 D1 DE 68901382D1 DE 8989906102 T DE8989906102 T DE 8989906102T DE 68901382 T DE68901382 T DE 68901382T DE 68901382 D1 DE68901382 D1 DE 68901382D1
Authority
DE
Germany
Prior art keywords
dha
fatty acids
epa
total concentration
polyungesatured
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8989906102T
Other languages
English (en)
Inventor
Tenna Giovanni Mosca
Max Zigerlig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Staroil Ltd
Original Assignee
Staroil Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Staroil Ltd filed Critical Staroil Ltd
Application granted granted Critical
Publication of DE68901382D1 publication Critical patent/DE68901382D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/08—Refining
    • C11C1/10—Refining by distillation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
    • B01D3/12—Molecular distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C1/00—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids
    • C11C1/02—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils
    • C11C1/025—Preparation of fatty acids from fats, fatty oils, or waxes; Refining the fatty acids from fats or fatty oils by saponification and release of fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE8989906102T 1988-05-27 1989-05-24 Verfahren zur herstellung von polyungesaettigten fettsaeuren. Expired - Lifetime DE68901382D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8812655A GB2218984B (en) 1988-05-27 1988-05-27 Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
PCT/EP1989/000577 WO1989011521A1 (en) 1988-05-27 1989-05-24 Process for preparing polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
DE68901382D1 true DE68901382D1 (de) 1992-06-04

Family

ID=10637694

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989906102T Expired - Lifetime DE68901382D1 (de) 1988-05-27 1989-05-24 Verfahren zur herstellung von polyungesaettigten fettsaeuren.

Country Status (11)

Country Link
EP (1) EP0409903B1 (de)
KR (1) KR900701981A (de)
CN (1) CN1031285C (de)
AT (1) ATE75502T1 (de)
CA (1) CA1334207C (de)
DE (1) DE68901382D1 (de)
ES (1) ES2017268A6 (de)
GB (1) GB2218984B (de)
GR (1) GR890100345A (de)
PT (1) PT90668B (de)
WO (1) WO1989011521A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
CA2043615C (en) * 1990-06-04 2001-08-14 Kazuhiko Hata Method of producing eicosapentaenoic acid or the ester derivative thereof
US5917068A (en) * 1995-12-29 1999-06-29 Eastman Chemical Company Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds
US6063946A (en) * 1996-01-26 2000-05-16 Eastman Chemical Company Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds
US6200624B1 (en) 1996-01-26 2001-03-13 Abbott Laboratories Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids
US5883273A (en) * 1996-01-26 1999-03-16 Abbott Laboratories Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds
CN1072711C (zh) * 1998-01-05 2001-10-10 山东禹王制药有限公司 一种高度不饱和脂肪酸的工业化生产方法
US7413759B2 (en) 1998-05-21 2008-08-19 Beech-Nut Nutrition Corporation Method of enhancing cognitive ability in infant fed DHA containing baby-food compositions
US6579551B1 (en) 1998-05-21 2003-06-17 Beech-Nut Nutrition Corporation Baby-food compositions containing egg yolk and methods therefor
IT1308613B1 (it) * 1999-02-17 2002-01-09 Pharmacia & Upjohn Spa Acidi grassi essenziali nella prevenzione di eventi cardiovascolari.
ITMI20010129A1 (it) 2001-01-25 2002-07-25 Pharmacia & Upjohn Spa Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco
ITMI20012384A1 (it) 2001-11-12 2003-05-12 Quatex Nv Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori
SE0202188D0 (sv) 2002-07-11 2002-07-11 Pronova Biocare As A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product
EP2295529B2 (de) 2002-07-11 2022-05-18 Basf As Verfahren zur Verminderung von Umweltschadstoffen in einem Öl oder einem Fett und Fischfutterprodukt
WO2004091603A1 (fr) * 2003-04-07 2004-10-28 Clinigenetics Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires
ITMI20032247A1 (it) * 2003-11-19 2005-05-20 Tiberio Bruzzese Interazione di derivati polari di composti insaturi con substrati inorganici
TWI365716B (en) * 2003-12-02 2012-06-11 Suntory Holdings Ltd Oil or fat and oil compositions containing phospholipids and a long-chain polyunsaturated fatty acid supply compound, and food using same
DE602004029090D1 (de) 2003-12-30 2010-10-21 Dsm Ip Assets Bv Entlüftungsverfahren
ITMI20040069A1 (it) * 2004-01-21 2004-04-21 Tiberio Bruzzese Uso di composizioni di acidi grassi n-3 ad elevata concentrazione per il trattamento di disturbi del sistema nervoso centrale
DE102005003625A1 (de) * 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Verfahren zur Herstellung einer DHA-haltigen Fettsäure-Zusammensetzung
ES2277557B1 (es) * 2005-12-21 2008-07-01 Proyecto Empresarial Brudy, S.L. Utilizacion de acido docosahexaenoico para el tratamiento del daño celular oxidativo.
EP2510927A3 (de) * 2005-12-21 2013-05-01 Brudy Technology, S.L. Verwendung von DHA, EPA oder DHA-angeleitetes EPA zur Behandlung einer Krankheitserscheinung im Zusammenhang mit Zelloxidationsschädigung
CN101049297B (zh) * 2006-04-06 2010-11-24 北京百慧生化制药有限责任公司 一种高dha型-乙酯和epa-乙酯的脂肪酸乙酯及其制造方法和制剂
JP2010532418A (ja) 2007-06-29 2010-10-07 マーテック バイオサイエンシーズ コーポレーション 多価不飽和脂肪酸のエステルの製造方法および精製方法
US8592439B2 (en) 2008-08-07 2013-11-26 Spa Societa Prodotti Antibiotici S.P.A. Long-term treatment of symptomatic heart failure
ES2345241B1 (es) * 2009-03-16 2011-09-08 Lipopharma Therapeutics Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos.
CL2009001343A1 (es) 2009-06-02 2009-07-10 Golden Omega S A Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar.
WO2012109545A2 (en) 2011-02-11 2012-08-16 E. I. Du Pont De Nemours And Company Method for obtaining a lipid-containing composition from microbial biomass
CN102211986A (zh) * 2011-04-19 2011-10-12 中南林业科技大学 从山苍子油中提取柠檬醛的工艺及装置
CN102417447B (zh) * 2011-10-31 2014-04-30 广西亿康药业股份有限公司 十一烯酸的生产方法
CN102964249B (zh) * 2012-11-16 2015-03-11 成都圆大生物科技有限公司 一种同时生产并分离高纯度epa乙酯和dha乙酯的工艺
CN103937617B (zh) * 2014-03-31 2016-04-20 中海海洋无锡海洋工程装备有限公司 一种以脱酸副产物为原料制备富含epa和/或dha的鱼油乙酯产品的方法
WO2016182452A1 (en) 2015-05-13 2016-11-17 Epax Norway As Very long chain polyunsaturated fatty acids from natural oils
RU2698720C1 (ru) * 2019-06-18 2019-08-29 Федеральное государственное бюджетное учреждение науки "Национальный научный центр морской биологии им. А.В. Жирмунского" Дальневосточного отделения Российской академии наук (ННЦМБ ДВО РАН) Способ получения докозагексаеновой кислоты
CN110818554B (zh) * 2019-11-29 2022-04-08 宁夏农林科学院动物科学研究所 两阶段短程分子蒸馏提取滩羊尾脂中共轭亚油酸的方法
JPWO2021172151A1 (de) * 2020-02-28 2021-09-02

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3082228A (en) * 1959-12-18 1963-03-19 Escambia Chem Corp Method for producing monoesters of polyunsaturated fatty acids
GB1364126A (en) * 1971-12-10 1974-08-21 Croda Int Ltd Oleic acid
JPS5735512A (en) * 1980-06-27 1982-02-26 Nippon Oil & Fats Co Ltd Preventive and remedy for thrombosis
JPS59113099A (ja) * 1982-12-20 1984-06-29 高尾　正保 高度不飽和油組成物
JPS6023493A (ja) * 1983-07-18 1985-02-06 高尾　正保 精製魚油の製法
JPS60133094A (ja) * 1983-12-21 1985-07-16 日清製油株式会社 高純度エイコサペンタエン酸の製造法
JPS6388159A (ja) * 1986-09-30 1988-04-19 Nippon Oil & Fats Co Ltd ドコサヘキサエン酸エステルの製造法
HU203660B (en) * 1987-04-23 1991-09-30 Biogal Gyogyszergyar Improved process for producing food-additive composition rich in omega-3-unsaturated fatty acids
IT1205043B (it) * 1987-05-28 1989-03-10 Innova Di Ridolfi Flora & C S Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri

Also Published As

Publication number Publication date
KR900701981A (ko) 1990-12-05
CN1031285C (zh) 1996-03-13
EP0409903B1 (de) 1992-04-29
GB2218984A (en) 1989-11-29
CA1334207C (en) 1995-01-31
ES2017268A6 (es) 1991-01-16
EP0409903A1 (de) 1991-01-30
ATE75502T1 (de) 1992-05-15
GR890100345A (el) 1991-10-10
PT90668A (pt) 1989-11-30
GB2218984B (en) 1992-09-23
GB8812655D0 (en) 1988-06-29
CN1040050A (zh) 1990-02-28
PT90668B (pt) 1994-10-31
WO1989011521A1 (en) 1989-11-30

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Legal Events

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