ATE110103T1 - Verfahren zur extraktion von docosahexaensäureethylester aus fischölen und docosahexaen- und eicosapentaensäureethylester enthaltende pharmazeutische und/oder diät- zusammensetzungen. - Google Patents
Verfahren zur extraktion von docosahexaensäureethylester aus fischölen und docosahexaen- und eicosapentaensäureethylester enthaltende pharmazeutische und/oder diät- zusammensetzungen.Info
- Publication number
- ATE110103T1 ATE110103T1 AT88107910T AT88107910T ATE110103T1 AT E110103 T1 ATE110103 T1 AT E110103T1 AT 88107910 T AT88107910 T AT 88107910T AT 88107910 T AT88107910 T AT 88107910T AT E110103 T1 ATE110103 T1 AT E110103T1
- Authority
- AT
- Austria
- Prior art keywords
- docosahexaenoic
- acid ethylester
- extraction
- pharmaceutical
- fish oils
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Fats And Perfumes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT20700/87A IT1205043B (it) | 1987-05-28 | 1987-05-28 | Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE110103T1 true ATE110103T1 (de) | 1994-09-15 |
Family
ID=11170757
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88107910T ATE110103T1 (de) | 1987-05-28 | 1988-05-18 | Verfahren zur extraktion von docosahexaensäureethylester aus fischölen und docosahexaen- und eicosapentaensäureethylester enthaltende pharmazeutische und/oder diät- zusammensetzungen. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5130061A (de) |
EP (1) | EP0292846B1 (de) |
JP (1) | JP2721890B2 (de) |
AT (1) | ATE110103T1 (de) |
DE (1) | DE3851092T2 (de) |
ES (1) | ES2056852T3 (de) |
IT (1) | IT1205043B (de) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
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US4874629A (en) * | 1988-05-02 | 1989-10-17 | Chang Stephen S | Purification of fish oil |
GB2218984B (en) * | 1988-05-27 | 1992-09-23 | Renafield Limited | Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses |
GB8819110D0 (en) * | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
WO1992022631A1 (en) * | 1991-06-11 | 1992-12-23 | Beku Environmental Products Ltd. | Degreaser composition comprising monounsaturated wax ester |
US5484611A (en) * | 1992-07-15 | 1996-01-16 | The Scottish Agricultural College | Method of producing a fatty acid |
JPH0717855A (ja) * | 1992-09-02 | 1995-01-20 | Maruha Corp | 脳機能改善組成物、学習能力増強剤、記憶力増強剤、痴呆予防剤、痴呆治療剤、または脳機能改善効果を有する機能性食品 |
WO1997019601A1 (en) * | 1995-11-24 | 1997-06-05 | Loders Croklaan B.V. | Composition based on fish oil |
US5917068A (en) * | 1995-12-29 | 1999-06-29 | Eastman Chemical Company | Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds |
US5883273A (en) * | 1996-01-26 | 1999-03-16 | Abbott Laboratories | Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds |
US6063946A (en) * | 1996-01-26 | 2000-05-16 | Eastman Chemical Company | Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds |
US6200624B1 (en) | 1996-01-26 | 2001-03-13 | Abbott Laboratories | Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids |
CN1055079C (zh) * | 1996-08-23 | 2000-08-02 | 中国科学院化学研究所 | 一种提取鱼油中不饱和脂肪酸酯的方法 |
US5955102A (en) | 1998-09-04 | 1999-09-21 | Amway Corporation | Softgel capsule containing DHA and antioxidants |
CA2260397A1 (en) | 1999-01-29 | 2000-07-29 | Atlantis Marine Inc. | Method of converting rendered triglyceride oil from marine sources into bland, stable food oil |
IT1308613B1 (it) | 1999-02-17 | 2002-01-09 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella prevenzione di eventi cardiovascolari. |
FR2798667B1 (fr) * | 1999-09-22 | 2001-12-21 | Pharmascience Lab | Procede d'extraction des composes furaniques et alcools gras polyhydroxyles de l'avocat, composition a base de et utilisation de ces composes en therapeutique, cosmetique et alimentaire |
ITMI20010129A1 (it) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco |
ITMI20012384A1 (it) * | 2001-11-12 | 2003-05-12 | Quatex Nv | Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori |
US6974592B2 (en) * | 2002-04-11 | 2005-12-13 | Ocean Nutrition Canada Limited | Encapsulated agglomeration of microcapsules and method for the preparation thereof |
EP2295529B2 (de) | 2002-07-11 | 2022-05-18 | Basf As | Verfahren zur Verminderung von Umweltschadstoffen in einem Öl oder einem Fett und Fischfutterprodukt |
SE0202188D0 (sv) | 2002-07-11 | 2002-07-11 | Pronova Biocare As | A process for decreasing environmental pollutants in an oil or a fat, a volatile fat or oil environmental pollutants decreasing working fluid, a health supplement, and an animal feed product |
ES2347045T3 (es) * | 2002-11-04 | 2010-10-25 | Ocean Nutrition Canada Limited | Microcapsulas que tienen multiples cortezas, y metodo para su preparacion. |
US6846942B2 (en) * | 2003-05-20 | 2005-01-25 | David Rubin | Method for preparing pure EPA and pure DHA |
DK1673423T3 (da) * | 2003-10-21 | 2009-03-30 | Dsm Ip Assets Bv | Stabilisering af polyumættede fedtsyre(PUFA)-esterkoncentrater |
ITMI20040069A1 (it) * | 2004-01-21 | 2004-04-21 | Tiberio Bruzzese | Uso di composizioni di acidi grassi n-3 ad elevata concentrazione per il trattamento di disturbi del sistema nervoso centrale |
US8034450B2 (en) * | 2005-01-21 | 2011-10-11 | Ocean Nutrition Canada Limited | Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof |
ATE452120T1 (de) * | 2005-01-27 | 2010-01-15 | Ocean Nutrition Canada Ltd | Fettsäure-benzenediol-derivate sowie herstellungs-und verwendungsverfahren dafür |
EP1848729A2 (de) * | 2005-01-27 | 2007-10-31 | Ocean Nutrition Canada Limited | Chrom-fettsäureverbindungen und verfahren zu ihrer herstellung und verwendung |
US9968120B2 (en) * | 2006-05-17 | 2018-05-15 | Dsm Nutritional Products Ag | Homogenized formulations containing microcapsules and methods of making and using thereof |
JP2009533490A (ja) * | 2006-04-07 | 2009-09-17 | オーシャン ニュートリッション カナダ リミテッド | 低い界面張力を有する物質を含む乳濁液およびマイクロカプセル、ならびにそれらを作製および使用する方法 |
ES2391305T3 (es) * | 2006-04-12 | 2012-11-23 | Unilever N.V. | Composición oral que comprende un ácido graso poliinsaturado y ácido salicílico para obtener un efecto antiinflamatorio en la piel |
PL2189155T3 (pl) * | 2006-04-12 | 2016-07-29 | Unilever Nv | Doustna kompozycja o przeciwstarzeniowym działaniu na skórę |
NZ573327A (en) * | 2006-06-05 | 2012-07-27 | Ocean Nutrition Canada Ltd | Microcapsules with improved shells |
ES2604081T3 (es) | 2007-01-10 | 2017-03-02 | Dsm Nutritional Products Ag | Microcápsulas que incluyen proteína de guisante |
US20080268117A1 (en) * | 2007-04-30 | 2008-10-30 | David Rubin | Method of purifying oils containing epa and dha |
CA2692355C (en) * | 2007-06-29 | 2018-09-11 | Martek Biosciences Corporation | Production and purification of esters of polyunsaturated fatty acids |
WO2009102558A2 (en) * | 2008-02-11 | 2009-08-20 | Monsanto Technology Llc | Aquaculture feed, products, and methods comprising beneficial fatty acids |
JP2010132631A (ja) * | 2008-11-04 | 2010-06-17 | Bizen Chemical Co Ltd | カンナビノイド受容体のインバースアゴニストおよびアンタゴニスト活性を有する組成物 |
PL2429317T5 (pl) | 2009-04-17 | 2019-09-30 | Natac Pharma, S.L. | Kompozycje bogate w kwasy tłuszczowe omega 3 z niską zawartością kwasu fitanowego |
CL2009001343A1 (es) | 2009-06-02 | 2009-07-10 | Golden Omega S A | Proceso de obtencion concentrado de esteres de epa y dha a partir de aceite marino, que comprende agregar al aceite alcali y agua a menos de 100 grados celsius, agregar solvente, separar fase de refinado, agregar acido, separar la fase no acuosa y agregar alcohol y un catalizador a menos de 150 grados celsius, desolventilizar y destilar. |
CN101766238B (zh) * | 2009-12-31 | 2012-04-25 | 山东三星玉米产业科技有限公司 | 含dha的儿童专用玉米油及其制备方法 |
CN105997973A (zh) * | 2010-11-19 | 2016-10-12 | 日本水产株式会社 | 用于角膜上皮病变和/或结膜上皮病变的治疗剂或预防剂 |
CL2010001587A1 (es) | 2010-12-27 | 2013-01-11 | Golden Omega S A | Proceso de preparacion de un concentrado de etil esteres de acidos grasos omega-3 que comprende sobre el 80% en peso de dichos esteres en configuracion cis y sus dobles enlaces separados por una unidad metilenica. |
CA2825039C (en) | 2011-02-11 | 2020-04-28 | E.I. Du Pont De Nemours And Company | Method for obtaining a lipid-containing composition from microbial biomass |
US8952000B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
US8715648B2 (en) | 2011-02-16 | 2014-05-06 | Pivotal Therapeutics Inc. | Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics |
US8951514B2 (en) | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
ES2661234T3 (es) | 2011-03-08 | 2018-03-28 | Cognis Ip Management Gmbh | Un procedimiento para la destilación de ésteres de ácidos grasos |
ES2685703T3 (es) | 2012-01-06 | 2018-10-10 | Omthera Pharmaceuticals Inc. | Composiciones enriquecidas en DPA de ácidos grasos omega-3 poliinsaturados en forma de ácido libre |
CN102994236B (zh) * | 2012-12-11 | 2015-03-25 | 成都圆大生物科技有限公司 | 一种制备Omega-3大于90%的脂肪酸乙酯的方法 |
EP2978307B1 (de) | 2013-03-28 | 2018-12-26 | The Trustees of Columbia University in the City of New York | Reperfusion mit omega-3-glyceriden zur förderung eines spenderorganschutzes für transplantationen |
US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
RU2537252C1 (ru) * | 2013-06-29 | 2014-12-27 | Федеральное государственное бюджетное учреждение науки Институт биологии моря им. А.В. Жирмунского Дальневосточного отделения Российской академии наук | Способ получения докозагексаеновой кислоты |
US9328054B1 (en) | 2013-09-27 | 2016-05-03 | Travis Danner | Method of alcoholisis of fatty acids and fatty acid gyicerides |
EP2883860B1 (de) * | 2013-12-11 | 2016-08-24 | Novasep Process | Chromatografisches Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren |
WO2015104464A1 (fr) | 2014-01-07 | 2015-07-16 | Novasep Process | Procédé de purification d'acides aminés aromatiques |
CN105272844B (zh) * | 2014-06-09 | 2017-05-17 | 河北海德生物科技有限公司 | 一种提纯高纯鱼油epa乙酯和dha乙酯的方法 |
US9416091B1 (en) * | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
CN105384635B (zh) * | 2014-09-09 | 2018-03-09 | 浙江医药股份有限公司新昌制药厂 | 一种从鱼油中分离纯化Omega‑3脂肪酸乙酯的方法 |
EP3358960A4 (de) | 2015-10-05 | 2019-07-03 | DSM IP Assets B.V. | Ölzusammensetzungen und verfahren zur herstellung |
EP3858843A1 (de) | 2015-11-23 | 2021-08-04 | Retrotope, Inc. | Ortsspezifische isotopische markierung von 1,4-dien-systemen |
CN106753817A (zh) * | 2016-12-30 | 2017-05-31 | 山东禹王制药有限公司 | 一种高度不饱和脂肪酸鱼油的工业化生产方法 |
CN107162910B (zh) * | 2017-05-19 | 2019-12-31 | 陕西源邦生物技术有限公司 | 从鱼油中制备高纯度epa-ee的方法 |
EP3710591A4 (de) * | 2017-11-17 | 2021-07-14 | Guangxi Xiaozao Agricultural Technology Co., Ltd. | Herstellung von aus algen gewonnenen, mehrfach ungesättigten fettsäuren |
PL3560342T3 (pl) | 2018-04-25 | 2021-02-22 | Nuseed Nutritional Us Inc. | Kompozycje wielonienasyconych kwasów tłuszczowych wzbogacone w dha |
MX2020011185A (es) | 2018-04-25 | 2021-02-09 | Nuseed Nutritional Us Inc | Composiciones de acidos grasos poliinsaturados enriquecidos con dha. |
CN108753451B (zh) * | 2018-05-25 | 2022-03-25 | 江南大学 | 一种注射级中/长链结构甘油三酯的纯化方法及其产品 |
EP3586642A1 (de) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala-angereicherte mehrfach ungesättigte fettsäurezusammensetzungen |
EP3586640A1 (de) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha-angereicherte mehrfach ungesättigte fettsäurezusammensetzungen |
EP3586643A1 (de) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha-angereicherte mehrfach ungesättigte fettsäurezusammensetzungen |
EP3586641A1 (de) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha-angereicherte mehrfach ungesättigte fettsäurezusammensetzungen |
CN109369389A (zh) * | 2018-12-20 | 2019-02-22 | 燕园泽龙(涿鹿)生物科技有限公司 | 高纯度α-亚麻酸乙酯的制备工艺 |
WO2021168311A1 (en) | 2020-02-21 | 2021-08-26 | Retrotope, Inc. | Processes for isotopic modification of polyunsaturated fatty acids and derivatives thereof |
CN113004977A (zh) * | 2021-02-25 | 2021-06-22 | 华侨大学 | 高纯度多不饱和鱼油的制备方法以及鱿鱼油加工方法 |
CN115350493A (zh) * | 2022-09-15 | 2022-11-18 | 江苏海莱康生物科技有限公司 | 一种分离提纯鱼油中的二十碳五烯酸乙酯的方法及精馏装置 |
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US3082228A (en) * | 1959-12-18 | 1963-03-19 | Escambia Chem Corp | Method for producing monoesters of polyunsaturated fatty acids |
US3082223A (en) | 1961-05-19 | 1963-03-19 | Syntex Corp | 2-methylene-androstanes |
JPS6025478B2 (ja) * | 1977-03-17 | 1985-06-18 | 花王株式会社 | 脂肪酸低級アルコ−ルエステルの製造法 |
US4179454A (en) * | 1978-07-24 | 1979-12-18 | Scm Corporation | Production of hydrogenated fatty acids from crude glyceride oils |
JPS5947018B2 (ja) * | 1981-03-11 | 1984-11-16 | 財団法人電気磁気材料研究所 | 磁気録音および再生ヘツド用磁性合金ならびにその製造法 |
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JPS5813541A (ja) * | 1981-07-16 | 1983-01-26 | Kureha Chem Ind Co Ltd | エイコサペンタエン酸又はドコサヘキサエン酸のシクロデキストリン包接化合物 |
JPS59118740A (ja) * | 1982-12-27 | 1984-07-09 | Tama Seikagaku Kk | エイコサペンタエン酸またはその低級アルコ−ルエステルの製造方法 |
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US4675132A (en) * | 1985-03-28 | 1987-06-23 | The United States Of America As Represented By The Secretary Of Commerce | Polyunsaturated fatty acids from fish oils |
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JPS6293234A (ja) * | 1985-10-21 | 1987-04-28 | Terumo Corp | 精製された魚油およびその製造方法 |
-
1987
- 1987-05-28 IT IT20700/87A patent/IT1205043B/it active
-
1988
- 1988-05-18 EP EP88107910A patent/EP0292846B1/de not_active Expired - Lifetime
- 1988-05-18 ES ES88107910T patent/ES2056852T3/es not_active Expired - Lifetime
- 1988-05-18 AT AT88107910T patent/ATE110103T1/de not_active IP Right Cessation
- 1988-05-18 DE DE3851092T patent/DE3851092T2/de not_active Expired - Lifetime
- 1988-05-26 JP JP63129423A patent/JP2721890B2/ja not_active Expired - Lifetime
-
1989
- 1989-05-24 US US07/357,650 patent/US5130061A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IT1205043B (it) | 1989-03-10 |
US5130061A (en) | 1992-07-14 |
EP0292846A3 (en) | 1990-03-21 |
DE3851092T2 (de) | 1994-12-01 |
JP2721890B2 (ja) | 1998-03-04 |
IT8720700A0 (it) | 1987-05-28 |
EP0292846A2 (de) | 1988-11-30 |
EP0292846B1 (de) | 1994-08-17 |
JPS6470439A (en) | 1989-03-15 |
DE3851092D1 (de) | 1994-09-22 |
ES2056852T3 (es) | 1994-10-16 |
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