DE60321808D1 - Flavon derivate als inhibitoren von cyclin-abhängigen kinasen - Google Patents

Flavon derivate als inhibitoren von cyclin-abhängigen kinasen

Info

Publication number
DE60321808D1
DE60321808D1 DE60321808T DE60321808T DE60321808D1 DE 60321808 D1 DE60321808 D1 DE 60321808D1 DE 60321808 T DE60321808 T DE 60321808T DE 60321808 T DE60321808 T DE 60321808T DE 60321808 D1 DE60321808 D1 DE 60321808D1
Authority
DE
Germany
Prior art keywords
cyclin
inhibitors
dependent kinases
flavon
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60321808T
Other languages
German (de)
English (en)
Inventor
Bansi Lal
Kalpana Sanjay Joshi
Sanjeev Anant Kulkarni
Malcolm Mascarenhas
Shrikant Gangadhar Kamble
Maggie Joyce Rathos
Rajendrakumar Dinanath Joshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Piramal Enterprises Ltd
Original Assignee
Nicholas Piramal India Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicholas Piramal India Ltd filed Critical Nicholas Piramal India Ltd
Application granted granted Critical
Publication of DE60321808D1 publication Critical patent/DE60321808D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60321808T 2002-07-08 2003-07-07 Flavon derivate als inhibitoren von cyclin-abhängigen kinasen Expired - Lifetime DE60321808D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN616MU2002 2002-07-08
PCT/IN2003/000234 WO2004004632A2 (en) 2002-07-08 2003-07-07 Flavone derivatives as inhibitors of cyclin-dependent kinases

Publications (1)

Publication Number Publication Date
DE60321808D1 true DE60321808D1 (de) 2008-08-07

Family

ID=30012269

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60321808T Expired - Lifetime DE60321808D1 (de) 2002-07-08 2003-07-07 Flavon derivate als inhibitoren von cyclin-abhängigen kinasen

Country Status (20)

Country Link
EP (1) EP1556375B1 (zh)
JP (1) JP4860148B2 (zh)
KR (1) KR100991920B1 (zh)
CN (1) CN1668613B (zh)
AR (1) AR041184A1 (zh)
AT (1) ATE399162T1 (zh)
AU (1) AU2003272070B2 (zh)
BR (1) BR0312633A (zh)
CA (1) CA2492130C (zh)
DE (1) DE60321808D1 (zh)
DK (1) DK1556375T3 (zh)
ES (1) ES2309338T3 (zh)
IL (1) IL166153A (zh)
MX (1) MXPA05000388A (zh)
NZ (1) NZ537518A (zh)
PT (1) PT1556375E (zh)
RU (1) RU2334746C2 (zh)
TW (1) TWI331034B (zh)
WO (1) WO2004004632A2 (zh)
ZA (1) ZA200500138B (zh)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7915301B2 (en) 2002-07-08 2011-03-29 Piramal Life Science Limited Inhibitors of cyclin dependent kinases and their use
JP5498782B2 (ja) * 2006-06-21 2014-05-21 ピラマル エンタープライジーズ リミテッド 増殖性疾患治療用のエナンチオマー的に純粋なフラボン誘導体の調製方法
JP5006396B2 (ja) 2006-07-07 2012-08-22 ピラマル・ライフ・サイエンシーズ・リミテッド ピロリジン置換フラボンのエナンチオ選択的合成
CA2687204C (en) * 2007-05-15 2015-11-24 Piramal Life Sciences Limited A synergistic pharmaceutical combination for the treatment of cancer
CN101333205A (zh) * 2008-07-10 2008-12-31 大连理工大学 周期素依赖蛋白激酶抑制剂黄芩素哌嗪衍生物及其制法
TWI461194B (zh) 2009-05-05 2014-11-21 Piramal Entpr Ltd 吡咯啶取代黃酮作為輻射致敏劑
EP2429292B1 (en) * 2009-05-08 2019-04-03 Georgia State University Research Foundation Compounds and compositions comprising cdk inhibitors and their use in the treatment of cancer
US7928067B2 (en) 2009-05-14 2011-04-19 Ischemix Llc Compositions and methods for treating ischemia and ischemia-reperfusion injury
MX2012009830A (es) * 2010-02-26 2013-02-11 Piramal Entpr Ltd Flavonas sustituidas de pirrolidina para el tratamiento de desordenes inflamatorios.
SG190794A1 (en) 2010-11-18 2013-07-31 Ischemix Llc Lipoyl compounds and their use for treating ischemic injury
RU2013127655A (ru) * 2010-11-19 2014-12-27 Пирамал Энтерпрайзис Лимитед Фармацевтическая комбинация паклитаксела и ингибитора cdk
WO2012069972A1 (en) 2010-11-19 2012-05-31 Piramal Life Sciences Limited A pharmaceutical combination for the treatment of breast cancer
WO2012123889A1 (en) 2011-03-14 2012-09-20 Piramal Healthcare Limited A synergistic pharmaceutical combination for the treatment of pancreatic cancer
UY34013A (es) * 2011-04-13 2012-11-30 Astrazeneca Ab ?compuestos de cromenona con actividad anti-tumoral?.
TW201300105A (zh) 2011-05-31 2013-01-01 Piramal Life Sciences Ltd 治療頭頸鱗狀細胞癌之相乘藥物組合物
WO2012176163A2 (en) 2011-06-24 2012-12-27 Piramal Enterprises Limited Compounds for the treatment of cancers associated with human papillomavirus
US20140348950A1 (en) 2012-01-13 2014-11-27 Piramal Enterprises Limited Pyrrolidine- substituted flavone derivatives for prevention or treatment of oral mucositis
WO2014049515A1 (en) * 2012-09-25 2014-04-03 Piramal Enterprises Limited Pyrrolidine substituted flavones for treatment of renal cystic diseases
WO2015004636A1 (en) 2013-07-12 2015-01-15 Piramal Enterprises Limited A pharmaceutical combination for the treatment of melanoma
WO2015181737A1 (en) 2014-05-28 2015-12-03 Piramal Enterprises Limited Pharmaceutical combination for the treatment of cancer
US20180180994A1 (en) * 2015-06-23 2018-06-28 Covestro Deutschland Ag Substituted triazines
KR20230156443A (ko) 2016-03-28 2023-11-14 프레시지 바이오싸이언시스, 인크. 암 치료를 위한 제약학적 조합물
MX2019004602A (es) 2016-10-20 2019-06-17 Pfizer Agentes anti-proliferativos para tratar pah.
EP3615023B1 (en) 2017-04-25 2023-06-21 Ischemix LLC Lipoyl-glu-ala for the treatment of neurodegenerative damage caused by traumatic brain injury
CN107573270B (zh) * 2017-09-29 2019-11-29 河南师范大学 一种α-甲酰基吡咯烷类化合物的合成方法
JP2022512711A (ja) 2018-10-19 2022-02-07 エフ．ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス疾患の処置及び予防のための、クロメン－４－オン誘導体
CN110028475B (zh) * 2019-05-13 2022-07-01 中国药科大学 基于苯并吡喃结构的新型cdk9抑制剂、其制备方法及应用
JP2023504249A (ja) 2019-11-28 2023-02-02 バイエル・アクチエンゲゼルシヤフト 免疫活性化のためのｄｇｋアルファ阻害剤としての置換アミノキノロン類
AR121719A1 (es) 2020-04-03 2022-06-29 Petra Pharma Corp Inhibidores alostéricos de cromenona del fosfoinosítido 3-quinasa (pi3k) para el tratamiento de enfermedades
JP7308369B2 (ja) 2021-05-03 2023-07-13 ペトラ・ファーマ・コーポレイション 疾患の治療のためのホスホイノシチド３－キナーゼ（ｐｉ３ｋ）のアロステリッククロメノン阻害剤
US11878970B2 (en) 2021-05-27 2024-01-23 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease
CN113549044B (zh) * 2021-07-23 2024-01-23 中国药科大学 8-氮杂环取代色酮类衍生物及其制备方法与制药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3836676A1 (de) * 1988-10-28 1990-05-03 Hoechst Ag Die verwendung von 4h-1-benzopyran-4-on-derivaten, neue 4h-1-benzopyran-4-on-derivate und diese enthaltende arzneimittel
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
US5849733A (en) * 1996-05-10 1998-12-15 Bristol-Myers Squibb Co. 2-thio or 2-oxo flavopiridol analogs
AU2001255090A1 (en) * 2000-05-03 2001-11-12 Lg Live Sciences Ltd. Cdk inhibitors having 3-hydroxychromen-4-one structure

Also Published As

Publication number Publication date
ES2309338T3 (es) 2008-12-16
RU2334746C2 (ru) 2008-09-27
JP2006502109A (ja) 2006-01-19
EP1556375A2 (en) 2005-07-27
AU2003272070B2 (en) 2009-02-26
EP1556375B1 (en) 2008-06-25
AU2003272070A1 (en) 2004-01-23
DK1556375T3 (da) 2008-11-03
CN1668613A (zh) 2005-09-14
PT1556375E (pt) 2008-10-03
BR0312633A (pt) 2005-07-19
ZA200500138B (en) 2006-02-22
KR20050017110A (ko) 2005-02-21
JP4860148B2 (ja) 2012-01-25
IL166153A0 (en) 2006-01-15
WO2004004632A3 (en) 2004-09-16
IL166153A (en) 2009-11-18
CN1668613B (zh) 2012-07-04
KR100991920B1 (ko) 2010-11-04
NZ537518A (en) 2008-02-29
AR041184A1 (es) 2005-05-04
TW200406202A (en) 2004-05-01
ATE399162T1 (de) 2008-07-15
TWI331034B (en) 2010-10-01
WO2004004632A8 (en) 2005-03-24
CA2492130C (en) 2011-09-06
CA2492130A1 (en) 2004-01-15
RU2005102939A (ru) 2005-09-10
WO2004004632A2 (en) 2004-01-15
MXPA05000388A (es) 2005-09-30

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