DE60313657T2 - Antivirale zusammensetzungen - Google Patents

Antivirale zusammensetzungen Download PDF

Info

Publication number
DE60313657T2
DE60313657T2 DE60313657T DE60313657T DE60313657T2 DE 60313657 T2 DE60313657 T2 DE 60313657T2 DE 60313657 T DE60313657 T DE 60313657T DE 60313657 T DE60313657 T DE 60313657T DE 60313657 T2 DE60313657 T2 DE 60313657T2
Authority
DE
Germany
Prior art keywords
ester
pharmaceutical composition
composition according
pharmaceutically acceptable
oxathiolan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313657T
Other languages
German (de)
English (en)
Other versions
DE60313657D1 (de
Inventor
Gary Wayne Research Triangle Park GOODSON
Alison Green Research Triangle Park FLOYD
Cecilia Carpenter Research Triangle Park NAVY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
SmithKline Beecham Corp
Original Assignee
Glaxo Group Ltd
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, SmithKline Beecham Corp filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60313657D1 publication Critical patent/DE60313657D1/de
Publication of DE60313657T2 publication Critical patent/DE60313657T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE60313657T 2002-11-08 2003-11-07 Antivirale zusammensetzungen Expired - Lifetime DE60313657T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42518202P 2002-11-08 2002-11-08
US425182P 2002-11-08
PCT/US2003/035830 WO2004043433A2 (en) 2002-11-08 2003-11-07 Pharmaceutical antiviral compositions

Publications (2)

Publication Number Publication Date
DE60313657D1 DE60313657D1 (de) 2007-06-14
DE60313657T2 true DE60313657T2 (de) 2008-01-03

Family

ID=32312939

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60313657T Expired - Lifetime DE60313657T2 (de) 2002-11-08 2003-11-07 Antivirale zusammensetzungen

Country Status (9)

Country Link
US (1) US20050287177A1 (https=)
EP (1) EP1567133B1 (https=)
JP (1) JP2006508134A (https=)
AT (1) ATE361059T1 (https=)
AU (1) AU2003291457A1 (https=)
CA (1) CA2505130C (https=)
DE (1) DE60313657T2 (https=)
ES (1) ES2286471T3 (https=)
WO (1) WO2004043433A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY169670A (en) 2003-09-03 2019-05-08 Tibotec Pharm Ltd Combinations of a pyrimidine containing nnrti with rt inhibitors
ES2320663T3 (es) 2003-08-26 2009-05-27 Smithkline Beecham Corporation Nuevos indoles cicloalquil(b) condensados.
TW201414495A (zh) 2005-04-04 2014-04-16 Tibotec Pharm Ltd Ｈｉｖ-感染之預防
RU2008128424A (ru) * 2005-12-14 2010-01-20 Сипла Лимитед (In) Фармацевтическая комбинация, включающая нуклеотидный и нуклеозидный ингибиторы обратной транскриптазы (такие как тенофовир и ламивудин) в различных частях дозы
PT1981506E (pt) 2006-01-20 2013-06-25 Janssen R & D Ireland Tratamento a longo prazo da infeção pelo vih com tmc278
AR065720A1 (es) 2007-03-14 2009-06-24 Tibotec Pharm Ltd Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso.
JP2010529073A (ja) * 2007-06-06 2010-08-26 ビーエーエスエフ ソシエタス・ヨーロピア チュアブル錠及びトローチ剤製造のための医薬製剤
MX2009013063A (es) * 2007-06-06 2010-01-15 Basf Se Formulacion farmaceutica para la produccion de tabletas de desintegracion rapida.
MX2009013499A (es) * 2007-06-22 2010-01-18 Bristol Myers Squibb Co Composiciones comprimidas que contienen atazanavir.
KR101057640B1 (ko) * 2009-05-27 2011-08-18 (주)다산메디켐 발포성 층을 포함하는 다층 정제

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
GB8707421D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties
US5009895A (en) * 1990-02-02 1991-04-23 Merck & Co., Inc. Sustained release with high and low viscosity HPMC
GB9009861D0 (en) * 1990-05-02 1990-06-27 Glaxo Group Ltd Chemical compounds
WO1992020344A1 (en) * 1991-05-16 1992-11-26 Glaxo Group Limited Antiviral combinations containing nucleoside analogs
GB9111902D0 (en) * 1991-06-03 1991-07-24 Glaxo Group Ltd Chemical compounds
US6177435B1 (en) * 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
ATE186544T1 (de) * 1992-08-04 1999-11-15 James M Dunn Pharmazeutische formulierungen mit kontrollierter freigabe von 3'-azido-3'-deoxythymidin und verfahren zur verwendung
US6113920A (en) * 1996-10-31 2000-09-05 Glaxo Wellcome Inc. Pharmaceutical compositions
GB9622681D0 (en) * 1996-10-31 1997-01-08 Glaxo Group Ltd Pharmaceutical compositions
US6541014B2 (en) * 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof

Also Published As

Publication number Publication date
EP1567133B1 (en) 2007-05-02
CA2505130A1 (en) 2004-05-27
ES2286471T3 (es) 2007-12-01
AU2003291457A8 (en) 2004-06-03
EP1567133A2 (en) 2005-08-31
AU2003291457A1 (en) 2004-06-03
ATE361059T1 (de) 2007-05-15
US20050287177A1 (en) 2005-12-29
DE60313657D1 (de) 2007-06-14
CA2505130C (en) 2009-10-06
WO2004043433A3 (en) 2004-12-29
JP2006508134A (ja) 2006-03-09
WO2004043433A2 (en) 2004-05-27

Similar Documents

Publication Publication Date Title
DE60115870T2 (de) Niedrig dosierte entecavir-formulierung und deren verwendung
DE69911240T2 (de) Zusammensetzungen, enthaltend mikronisiertes eplerenon
DE69920344T2 (de) Verwendung eines Acrylsäure-Typ Polymeres als Desintegrationsmittel, Vefahren zur Herstellung von Tabletten und hergestellte Tabletten
DE69518820T2 (de) Rotogranulat und Beschichtung von Acetaminophen, Pseudoephedrin, Chlorpheniramin und, gegebenenfalls, Dextromethorphan
DE69022876T2 (de) Arzneimittelformulierungen mit verzögerter Wirkstoffabgabe.
DE69315257T2 (de) Simethicon enthaltende Arzneimittel zur Behandlung gastrointestinaler Störungen
DE3879080T2 (de) Pharmazeutische matrix mit verzoegerter freisetzung und verfahren.
DE60207383T2 (de) Ibuprofen und diphenhydramin enthaltende zusammensetzungen und deren verwendung zur behandlung von schlafstörungen
JP3010562B2 (ja) 徐放性調剤単位
DE69836424T2 (de) Laktose-freie, nicht-hygroskopische und wasserfreie pharmazeutische zusammensetzungen von descarboethoxyloratadin
DE3872739T2 (de) Arzneimittel mit langsamer freisetzung.
DE69630603T3 (de) Mittel zur gesteuerten freisetzung von paroxetin
DE69418252T2 (de) Stabilisierte, feste pharmazeutische Zubereitung, die Dextromethorphan Phenylpropanolamine und Coffein enthält
DE60224194T3 (de) Arzneizusammensetzungen enthaltend terbinafin und deren verwendung
DE69530759T2 (de) Filmbeschichtete tablette, die paracetamol und domperidone enthält
DE20219293U1 (de) Pharmazeutische Pellets enthaltend Tamsulosin
DE112011101605T5 (de) Pharmazeutische Zusammensetzung umfassend Hydromorphon und Naloxon
DE69327004T2 (de) Pharmazeutische formulierungen mit kontrollierter freigabe von 3'-azido-3'-deoxythymidin und verfahren zur verwendung
EP1509207B1 (de) Pharmazeutische zusammensetzung, enthaltend oxcarbazepin mit kontrollierter wirkstofffreisetzung
DE60313657T2 (de) Antivirale zusammensetzungen
DE60317993T2 (de) Pharmazeutische Zubereitung mit verzögerter Freisetzung zur oralen Wirkstoffverabreichung
DE60307819T2 (de) Venlafaxine Hydrochloridformulierungen mit verzögerter Freisetzung
JPH01308232A (ja) 固型医薬およびその製造法
DE69906982T2 (de) Ibuprofen und domperidone enthaltende pharmazeutische zusammensetzungen
DE69722433T2 (de) Pharmazeutische zubereitungen, welche zidovudin und lamivudine enthalten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition