DE69418252T2 - Stabilisierte, feste pharmazeutische Zubereitung, die Dextromethorphan Phenylpropanolamine und Coffein enthält - Google Patents

Stabilisierte, feste pharmazeutische Zubereitung, die Dextromethorphan Phenylpropanolamine und Coffein enthält

Info

Publication number
DE69418252T2
DE69418252T2 DE69418252T DE69418252T DE69418252T2 DE 69418252 T2 DE69418252 T2 DE 69418252T2 DE 69418252 T DE69418252 T DE 69418252T DE 69418252 T DE69418252 T DE 69418252T DE 69418252 T2 DE69418252 T2 DE 69418252T2
Authority
DE
Germany
Prior art keywords
pharmaceutical preparation
caffeine
stabilized
solid pharmaceutical
active ingredients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69418252T
Other languages
English (en)
Other versions
DE69418252D1 (de
Inventor
Masahiko Kurihara
Shunichi Itoh
Kou Moriyama
Mitsutaka Isobe
Kenichiro Kiyoshima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69418252D1 publication Critical patent/DE69418252D1/de
Application granted granted Critical
Publication of DE69418252T2 publication Critical patent/DE69418252T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69418252T 1993-06-30 1994-06-29 Stabilisierte, feste pharmazeutische Zubereitung, die Dextromethorphan Phenylpropanolamine und Coffein enthält Expired - Fee Related DE69418252T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16115893 1993-06-30

Publications (2)

Publication Number Publication Date
DE69418252D1 DE69418252D1 (de) 1999-06-10
DE69418252T2 true DE69418252T2 (de) 1999-11-04

Family

ID=15729701

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69418252T Expired - Fee Related DE69418252T2 (de) 1993-06-30 1994-06-29 Stabilisierte, feste pharmazeutische Zubereitung, die Dextromethorphan Phenylpropanolamine und Coffein enthält

Country Status (7)

Country Link
US (2) US5629316A (de)
EP (1) EP0631782B1 (de)
AT (1) ATE179602T1 (de)
AU (1) AU676315B2 (de)
CA (1) CA2127085A1 (de)
DE (1) DE69418252T2 (de)
ZA (1) ZA944732B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641512A (en) * 1995-03-29 1997-06-24 The Procter & Gamble Company Soft gelatin capsule compositions
US6274592B1 (en) * 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
US6110502A (en) * 1998-02-19 2000-08-29 Mcneil-Ppc, Inc. Method for producing water dispersible sterol formulations
PT1093818E (pt) * 1998-07-08 2006-07-31 Kirin Amgen Inc Preparacao em po para administracao nas mucosas contendo um medicamento polimerico
US6027728A (en) * 1998-08-05 2000-02-22 Yuen; Liu Herbal skin regeneration composition and method
US6242001B1 (en) 1998-11-30 2001-06-05 Mcneil-Ppc, Inc. Method for producing dispersible sterol and stanol compounds
US6428809B1 (en) * 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6787164B2 (en) 2000-02-23 2004-09-07 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US6841544B2 (en) * 2000-02-23 2005-01-11 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US6793942B2 (en) 2000-02-23 2004-09-21 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US6759062B2 (en) 2000-02-23 2004-07-06 Bioselect Innovations, Inc. Composition and method for treating the effects of diseases and maladies
US20070087048A1 (en) * 2001-05-31 2007-04-19 Abrams Andrew L Oral dosage combination pharmaceutical packaging
JP2003252749A (ja) * 2002-03-04 2003-09-10 Shin Etsu Chem Co Ltd 外用基剤
EP1559433A4 (de) * 2002-10-22 2009-11-04 Dainippon Sumitomo Pharma Co Stabilisierte zusammensetzung
US20060052370A1 (en) * 2004-08-24 2006-03-09 Meyerson Laurence R Methods and compositions for treating nociceptive pain
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
DE602006016934D1 (de) * 2005-04-06 2010-10-28 Adamas Pharmaceuticals Inc Verfahren und zusammensetzungen zur behandlung von zns-erkrankungen
JPWO2007018190A1 (ja) * 2005-08-10 2009-02-19 塩野義製薬株式会社 苦味抑制製剤
US8637078B2 (en) * 2005-11-24 2014-01-28 Boehringer Ingelheim International Gmbh Bilayer tablet comprising telmisartan and diuretic
ES2370062T3 (es) * 2006-09-15 2011-12-12 Echo Pharmaceuticals B.V. Granulado que contiene una sustancia farmacéuticamente activa y un emulsionante y método para su producción.
CN101541299B (zh) 2006-09-15 2013-04-17 艾可制药有限公司 供舌下、口含或口服施用的不溶于水的药物活性物质的剂量单位
GB2447898B (en) * 2007-03-24 2011-08-17 Reckitt Benckiser Healthcare A tablet having improved stability with at least two actives
US20090087483A1 (en) * 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
TWI589313B (zh) 2010-01-05 2017-07-01 麥可朵斯斯若波特公司 醫藥遞送封裝及吸入器
US20130115253A1 (en) * 2011-11-07 2013-05-09 Mahendra R. Patel Sustained Release Suspension Preparation For Dextromethorphan

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4049803A (en) * 1976-04-26 1977-09-20 Bristol-Myers Company Augmentation of blood levels of aspirin
JPS5423132A (en) * 1977-07-19 1979-02-21 Dai Ichi Seiyaku Co Ltd Analgesic composition
JPS56154416A (en) * 1980-04-30 1981-11-30 Kaken Pharmaceut Co Ltd Antipyretic analgesic composition
US4420483A (en) * 1982-07-22 1983-12-13 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising ibuprofen and methods of using same
FR2544315B1 (fr) * 1983-04-12 1985-07-05 Adir Polymethylene imines disubstituees, leurs procedes de preparation, et les compositions pharmaceutiques les renfermant
US4552899A (en) * 1984-04-09 1985-11-12 Analgesic Associates Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs
JPH05509300A (ja) * 1990-05-21 1993-12-22 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 上部気道における粘液分泌促進剤としてフェニルプロパノールアミンの使用
JPH069382A (ja) * 1992-04-17 1994-01-18 Takeda Chem Ind Ltd 安定化された固型製剤およびその製造方法

Also Published As

Publication number Publication date
EP0631782A1 (de) 1995-01-04
US5629316A (en) 1997-05-13
US5726180A (en) 1998-03-10
AU676315B2 (en) 1997-03-06
ATE179602T1 (de) 1999-05-15
DE69418252D1 (de) 1999-06-10
CA2127085A1 (en) 1994-12-31
ZA944732B (en) 1995-07-13
EP0631782B1 (de) 1999-05-06
AU6597494A (en) 1995-01-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

8339 Ceased/non-payment of the annual fee