ATE179602T1 - Stabilisierte, feste pharmazeutische zubereitung, die dextromethorphan phenylpropanolamine und coffein enthält - Google Patents
Stabilisierte, feste pharmazeutische zubereitung, die dextromethorphan phenylpropanolamine und coffein enthältInfo
- Publication number
- ATE179602T1 ATE179602T1 AT94304756T AT94304756T ATE179602T1 AT E179602 T1 ATE179602 T1 AT E179602T1 AT 94304756 T AT94304756 T AT 94304756T AT 94304756 T AT94304756 T AT 94304756T AT E179602 T1 ATE179602 T1 AT E179602T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutical preparation
- caffeine
- solid pharmaceutical
- phenylpropanolamine
- active ingredients
- Prior art date
Links
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 title abstract 6
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 4
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001948 caffeine Drugs 0.000 title abstract 3
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 title abstract 2
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 title abstract 2
- 229960000395 phenylpropanolamine Drugs 0.000 title abstract 2
- MKXZASYAUGDDCJ-NJAFHUGGSA-N dextromethorphan Chemical compound C([C@@H]12)CCC[C@]11CCN(C)[C@H]2CC2=CC=C(OC)C=C21 MKXZASYAUGDDCJ-NJAFHUGGSA-N 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 5
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 229960001985 dextromethorphan Drugs 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 238000010348 incorporation Methods 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16115893 | 1993-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE179602T1 true ATE179602T1 (de) | 1999-05-15 |
Family
ID=15729701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94304756T ATE179602T1 (de) | 1993-06-30 | 1994-06-29 | Stabilisierte, feste pharmazeutische zubereitung, die dextromethorphan phenylpropanolamine und coffein enthält |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5629316A (de) |
| EP (1) | EP0631782B1 (de) |
| AT (1) | ATE179602T1 (de) |
| AU (1) | AU676315B2 (de) |
| CA (1) | CA2127085A1 (de) |
| DE (1) | DE69418252T2 (de) |
| ZA (1) | ZA944732B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
| US6274592B1 (en) | 1997-02-04 | 2001-08-14 | Senju Pharmaceutical Co., Ltd. | Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid |
| US6110502A (en) * | 1998-02-19 | 2000-08-29 | Mcneil-Ppc, Inc. | Method for producing water dispersible sterol formulations |
| CZ300931B6 (cs) * | 1998-07-08 | 2009-09-16 | Kirin-Amgen Inc. | Prípravek v práškové forme pro podání na sliznici |
| US6027728A (en) * | 1998-08-05 | 2000-02-22 | Yuen; Liu | Herbal skin regeneration composition and method |
| US6242001B1 (en) | 1998-11-30 | 2001-06-05 | Mcneil-Ppc, Inc. | Method for producing dispersible sterol and stanol compounds |
| US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
| US6841544B2 (en) * | 2000-02-23 | 2005-01-11 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6793942B2 (en) | 2000-02-23 | 2004-09-21 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6787164B2 (en) | 2000-02-23 | 2004-09-07 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US6759062B2 (en) | 2000-02-23 | 2004-07-06 | Bioselect Innovations, Inc. | Composition and method for treating the effects of diseases and maladies |
| US20070087048A1 (en) * | 2001-05-31 | 2007-04-19 | Abrams Andrew L | Oral dosage combination pharmaceutical packaging |
| JP2003252749A (ja) * | 2002-03-04 | 2003-09-10 | Shin Etsu Chem Co Ltd | 外用基剤 |
| US20050267222A1 (en) * | 2002-10-22 | 2005-12-01 | Dainippon Pharmaceutical Co. Ltd. | Stabilized composition |
| EP1789028A2 (de) * | 2004-08-24 | 2007-05-30 | Neuromolecular Pharmaceuticals Inc | Zusammensetzungen zur behandlung von nociceptiven schmerzen |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| US8058291B2 (en) * | 2005-04-06 | 2011-11-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of CNS-related conditions |
| CA2618966C (en) * | 2005-08-10 | 2014-05-13 | Shionogi & Co., Ltd. | Bitterness-reducing agent |
| US8637078B2 (en) * | 2005-11-24 | 2014-01-28 | Boehringer Ingelheim International Gmbh | Bilayer tablet comprising telmisartan and diuretic |
| PL2061427T3 (pl) * | 2006-09-15 | 2011-12-30 | Echo Pharmaceuticals Bv | Granulat zawierający substancję farmaceutycznie aktywną i emulgator oraz sposób jego wytwarzania |
| PL2063861T3 (pl) | 2006-09-15 | 2015-07-31 | Echo Pharmaceuticals Bv | Jednostka dawkowania do podawania podjęzykowego, podpoliczkowego lub doustnego nierozpuszczalnych w wodzie substancji aktywnych farmaceutycznie |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| US20090087483A1 (en) * | 2007-09-27 | 2009-04-02 | Sison Raymundo A | Oral dosage combination pharmaceutical packaging |
| US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
| EP2521584B1 (de) | 2010-01-05 | 2018-10-17 | MicroDose Therapeutx, Inc. | Inhalationsvorrichtung |
| WO2013070656A1 (en) * | 2011-11-07 | 2013-05-16 | Navinta Llc | Sustained release suspension preparation for dextromethorphan |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4049803A (en) * | 1976-04-26 | 1977-09-20 | Bristol-Myers Company | Augmentation of blood levels of aspirin |
| JPS5423132A (en) * | 1977-07-19 | 1979-02-21 | Dai Ichi Seiyaku Co Ltd | Analgesic composition |
| JPS56154416A (en) * | 1980-04-30 | 1981-11-30 | Kaken Pharmaceut Co Ltd | Antipyretic analgesic composition |
| US4420483A (en) * | 1982-07-22 | 1983-12-13 | Richardson-Vicks, Inc. | Analgesic and anti-inflammatory compositions comprising ibuprofen and methods of using same |
| FR2544315B1 (fr) * | 1983-04-12 | 1985-07-05 | Adir | Polymethylene imines disubstituees, leurs procedes de preparation, et les compositions pharmaceutiques les renfermant |
| US4552899A (en) * | 1984-04-09 | 1985-11-12 | Analgesic Associates | Cough/cold mixtures comprising non-steroidal anti-inflammatory drugs |
| CA2083403A1 (en) * | 1990-05-21 | 1991-11-22 | Roger John Phipps | Use of phenylpropanolamine as a mucus secretogogue in the upper airways |
| JPH069382A (ja) * | 1992-04-17 | 1994-01-18 | Takeda Chem Ind Ltd | 安定化された固型製剤およびその製造方法 |
-
1994
- 1994-06-24 AU AU65974/94A patent/AU676315B2/en not_active Ceased
- 1994-06-28 US US08/266,641 patent/US5629316A/en not_active Expired - Fee Related
- 1994-06-29 DE DE69418252T patent/DE69418252T2/de not_active Expired - Fee Related
- 1994-06-29 CA CA002127085A patent/CA2127085A1/en not_active Abandoned
- 1994-06-29 EP EP94304756A patent/EP0631782B1/de not_active Expired - Lifetime
- 1994-06-29 AT AT94304756T patent/ATE179602T1/de not_active IP Right Cessation
- 1994-06-30 ZA ZA944732A patent/ZA944732B/xx unknown
-
1996
- 1996-10-30 US US08/742,179 patent/US5726180A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ZA944732B (en) | 1995-07-13 |
| DE69418252T2 (de) | 1999-11-04 |
| EP0631782B1 (de) | 1999-05-06 |
| AU6597494A (en) | 1995-01-12 |
| US5629316A (en) | 1997-05-13 |
| DE69418252D1 (de) | 1999-06-10 |
| EP0631782A1 (de) | 1995-01-04 |
| US5726180A (en) | 1998-03-10 |
| AU676315B2 (en) | 1997-03-06 |
| CA2127085A1 (en) | 1994-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |