DE60310576T2 - 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer - Google Patents

2-hydroxy-6-phenylphenanthridine als pde-4-hemmer Download PDF

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Publication number
DE60310576T2
DE60310576T2 DE60310576T DE60310576T DE60310576T2 DE 60310576 T2 DE60310576 T2 DE 60310576T2 DE 60310576 T DE60310576 T DE 60310576T DE 60310576 T DE60310576 T DE 60310576T DE 60310576 T2 DE60310576 T2 DE 60310576T2
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DE
Germany
Prior art keywords
10brs
4ars
hexahydrophenanthridin
methoxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE60310576T
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German (de)
English (en)
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DE60310576D1 (en
Inventor
Ulrich Kautz
Beate Schmidt
Dieter Flockerzi
Gerhard Grundler
Rüdiger Nave
Rolf-Peter Hummel
Ernst Sturm
Armin Hatzelmann
Johannes Barsig
Degenhard Marx
Hans-Peter Kley
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Takeda GmbH
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Altana Pharma AG
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Publication of DE60310576T2 publication Critical patent/DE60310576T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Orthopedic Medicine & Surgery (AREA)
DE60310576T 2002-08-29 2003-08-28 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer Expired - Lifetime DE60310576T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02019335 2002-08-29
EP02019335 2002-08-29
PCT/EP2003/009547 WO2004019944A1 (en) 2002-08-29 2003-08-28 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors

Publications (2)

Publication Number Publication Date
DE60310576D1 DE60310576D1 (en) 2007-02-01
DE60310576T2 true DE60310576T2 (de) 2007-10-31

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DE60310576T Expired - Lifetime DE60310576T2 (de) 2002-08-29 2003-08-28 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer

Country Status (9)

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US (2) US7329676B2 (enExample)
EP (1) EP1539164B1 (enExample)
JP (1) JP4587294B2 (enExample)
AT (1) ATE348616T1 (enExample)
AU (1) AU2003255493B8 (enExample)
CA (1) CA2495827C (enExample)
DE (1) DE60310576T2 (enExample)
ES (1) ES2279215T3 (enExample)
WO (1) WO2004019944A1 (enExample)

Families Citing this family (70)

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GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
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GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
HRP20120494T1 (hr) 2006-04-21 2012-08-31 Novartis Ag Derivati purina za uporabu kao agonista adenozin a2a receptora
BRPI0718266A2 (pt) 2006-10-30 2014-01-07 Novartis Ag Compostos heterocíclicos como agentes anti-inflamatórios.
AU2007342223B2 (en) 2007-01-10 2011-02-24 Irm Llc Compounds and compositions as channel activating protease inhibitors
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JP5584138B2 (ja) 2008-01-11 2014-09-03 ノバルティス アーゲー キナーゼ阻害剤としてのピリミジン類
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ES2396023T3 (es) 2009-01-29 2013-02-18 Novartis Ag Bencimidazoles sustituidos para el tratamiento de astrocitomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
BR112012003262A8 (pt) 2009-08-12 2016-05-17 Novartis Ag compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação
UA111579C2 (uk) 2009-08-17 2016-05-25 Інтеллікіне Ллк ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
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US7632844B2 (en) 2009-12-15
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US20080319067A1 (en) 2008-12-25
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ATE348616T1 (de) 2007-01-15
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AU2003255493B8 (en) 2009-03-26
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