DE60239612D1 - Monodisperse mischungen und verfahren zur behandlung von diabetes - Google Patents
Monodisperse mischungen und verfahren zur behandlung von diabetesInfo
- Publication number
- DE60239612D1 DE60239612D1 DE60239612T DE60239612T DE60239612D1 DE 60239612 D1 DE60239612 D1 DE 60239612D1 DE 60239612 T DE60239612 T DE 60239612T DE 60239612 T DE60239612 T DE 60239612T DE 60239612 D1 DE60239612 D1 DE 60239612D1
- Authority
- DE
- Germany
- Prior art keywords
- patient
- diabetes mellitus
- treatment
- diabetes
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26919801P | 2001-02-15 | 2001-02-15 | |
US34771302P | 2002-01-11 | 2002-01-11 | |
PCT/US2002/004440 WO2002065985A2 (en) | 2001-02-15 | 2002-02-14 | Methods of treating diabetes mellitus |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60239612D1 true DE60239612D1 (de) | 2011-05-12 |
Family
ID=26953561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60239612T Expired - Lifetime DE60239612D1 (de) | 2001-02-15 | 2002-02-14 | Monodisperse mischungen und verfahren zur behandlung von diabetes |
Country Status (17)
Country | Link |
---|---|
US (3) | US7060675B2 (de) |
EP (1) | EP1409006B1 (de) |
JP (1) | JP4113778B2 (de) |
KR (1) | KR100896945B1 (de) |
AT (1) | ATE503490T1 (de) |
AU (1) | AU2002244020B2 (de) |
BR (1) | BRPI0207700B8 (de) |
CA (1) | CA2437940C (de) |
CY (1) | CY1112034T1 (de) |
DE (1) | DE60239612D1 (de) |
DK (1) | DK1409006T3 (de) |
MX (1) | MXPA03007374A (de) |
NO (1) | NO327586B1 (de) |
NZ (1) | NZ527392A (de) |
PT (1) | PT1409006E (de) |
WO (1) | WO2002065985A2 (de) |
ZA (1) | ZA200306332B (de) |
Families Citing this family (71)
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US6191105B1 (en) * | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
US6867183B2 (en) * | 2001-02-15 | 2005-03-15 | Nobex Corporation | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US6713452B2 (en) | 2001-06-04 | 2004-03-30 | Nobex Corporation | Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828297B2 (en) * | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6828305B2 (en) | 2001-06-04 | 2004-12-07 | Nobex Corporation | Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6858580B2 (en) * | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
US6835802B2 (en) | 2001-06-04 | 2004-12-28 | Nobex Corporation | Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties |
US7713932B2 (en) * | 2001-06-04 | 2010-05-11 | Biocon Limited | Calcitonin drug-oligomer conjugates, and uses thereof |
NZ519403A (en) * | 2001-06-21 | 2005-03-24 | Pfizer Prod Inc | Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels |
US7312192B2 (en) * | 2001-09-07 | 2007-12-25 | Biocon Limited | Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same |
US6770625B2 (en) * | 2001-09-07 | 2004-08-03 | Nobex Corporation | Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith |
US7030082B2 (en) * | 2001-09-07 | 2006-04-18 | Nobex Corporation | Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith |
US7196059B2 (en) * | 2001-09-07 | 2007-03-27 | Biocon Limited | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith |
US20030198666A1 (en) * | 2002-01-07 | 2003-10-23 | Richat Abbas | Oral insulin therapy |
AU2003236521A1 (en) * | 2002-06-13 | 2003-12-31 | Nobex Corporation | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus |
US20040091544A1 (en) * | 2002-11-08 | 2004-05-13 | Ruff Michael D. | Coated dibasic calcium phosphate |
CA2504287A1 (en) * | 2002-11-26 | 2004-06-10 | Nobex Corporation | Natriuretic compounds, conjugates, and uses thereof |
ES2465496T3 (es) * | 2003-01-06 | 2014-06-05 | Emisphere Technologies, Inc. | Terapia de insulina oral nocturna |
JP2006519881A (ja) * | 2003-03-06 | 2006-08-31 | エミスフィアー テクノロジーズ インコーポレイテッド | 経口インスリン治療及びプロトコール |
AU2004220544B2 (en) * | 2003-03-06 | 2010-06-17 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
ES2328579T3 (es) * | 2003-07-25 | 2009-11-16 | Conjuchem Biotechnologies Inc. | Derivados de insulina de larga duracion y procedimientos asociados. |
EP1660047B1 (de) * | 2003-08-13 | 2013-11-27 | Biocon Limited | Mikroteilchenförmige fettsäure-salz-festdosis-formulierungen für therapeutische mittel |
US20050203001A1 (en) | 2004-03-05 | 2005-09-15 | Emisphere Technologies, Inc. | Oral insulin therapies and protocol |
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UA91512C2 (ru) | 2004-07-19 | 2010-08-10 | Биокон Лимитед | Коньюгати олигомеров инсулина, их композиция (варианты) и применение |
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KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
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AU2010226243A1 (en) | 2009-03-20 | 2011-09-22 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
US20110058558A1 (en) * | 2009-09-08 | 2011-03-10 | Electronics And Telecommunications Research Institute | Network control device and network control method |
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TWI608847B (zh) | 2011-08-29 | 2017-12-21 | 賽諾菲阿凡提斯德意志有限公司 | 用於控制糖尿病二型病患血糖的醫藥組合物 |
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CN105792852B (zh) | 2013-10-04 | 2019-12-10 | 默沙东公司 | 葡萄糖响应性的胰岛素缀合物 |
PE20171622A1 (es) | 2014-12-12 | 2017-11-02 | Sanofi Aventis Deutschland | Formulacion de relacion fija de insulina glargina/lixisenatida |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
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-
2002
- 2002-02-13 US US10/075,097 patent/US7060675B2/en not_active Expired - Lifetime
- 2002-02-14 AU AU2002244020A patent/AU2002244020B2/en not_active Expired
- 2002-02-14 MX MXPA03007374A patent/MXPA03007374A/es active IP Right Grant
- 2002-02-14 WO PCT/US2002/004440 patent/WO2002065985A2/en active Search and Examination
- 2002-02-14 AT AT02709541T patent/ATE503490T1/de active
- 2002-02-14 JP JP2002565546A patent/JP4113778B2/ja not_active Expired - Lifetime
- 2002-02-14 CA CA2437940A patent/CA2437940C/en not_active Expired - Lifetime
- 2002-02-14 KR KR1020037010645A patent/KR100896945B1/ko active IP Right Grant
- 2002-02-14 DE DE60239612T patent/DE60239612D1/de not_active Expired - Lifetime
- 2002-02-14 NZ NZ527392A patent/NZ527392A/en not_active IP Right Cessation
- 2002-02-14 BR BRPI0207700A patent/BRPI0207700B8/pt not_active IP Right Cessation
- 2002-02-14 PT PT02709541T patent/PT1409006E/pt unknown
- 2002-02-14 EP EP02709541A patent/EP1409006B1/de not_active Expired - Lifetime
- 2002-02-14 DK DK02709541.3T patent/DK1409006T3/da active
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2003
- 2003-08-14 ZA ZA2003/06332A patent/ZA200306332B/en unknown
- 2003-08-14 NO NO20033617A patent/NO327586B1/no not_active IP Right Cessation
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- 2005-12-21 US US11/314,309 patent/US7423014B2/en not_active Expired - Fee Related
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WO2002065985A2 (en) | 2002-08-29 |
CA2437940A1 (en) | 2002-08-29 |
EP1409006A2 (de) | 2004-04-21 |
US7381702B2 (en) | 2008-06-03 |
NO20033617D0 (no) | 2003-08-14 |
MXPA03007374A (es) | 2003-12-04 |
US20060293219A1 (en) | 2006-12-28 |
NZ527392A (en) | 2008-01-31 |
ZA200306332B (en) | 2005-07-27 |
BRPI0207700B8 (pt) | 2021-05-25 |
KR20040043113A (ko) | 2004-05-22 |
US20030050228A1 (en) | 2003-03-13 |
CY1112034T1 (el) | 2015-11-04 |
US20060100137A1 (en) | 2006-05-11 |
JP4113778B2 (ja) | 2008-07-09 |
EP1409006B1 (de) | 2011-03-30 |
ATE503490T1 (de) | 2011-04-15 |
NO20033617L (no) | 2003-10-15 |
KR100896945B1 (ko) | 2009-05-14 |
BR0207700A (pt) | 2005-07-19 |
AU2002244020B2 (en) | 2007-08-16 |
BRPI0207700B1 (pt) | 2016-06-07 |
NO327586B1 (no) | 2009-08-24 |
CA2437940C (en) | 2012-07-10 |
PT1409006E (pt) | 2011-07-01 |
US7060675B2 (en) | 2006-06-13 |
DK1409006T3 (da) | 2011-06-14 |
EP1409006A4 (de) | 2005-01-19 |
JP2004527487A (ja) | 2004-09-09 |
US7423014B2 (en) | 2008-09-09 |
WO2002065985A3 (en) | 2004-02-19 |
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