DE60238085D1 - Vorrichtung und Verfahren zum herstellen von Mikrokapseln - Google Patents

Vorrichtung und Verfahren zum herstellen von Mikrokapseln

Info

Publication number
DE60238085D1
DE60238085D1 DE60238085T DE60238085T DE60238085D1 DE 60238085 D1 DE60238085 D1 DE 60238085D1 DE 60238085 T DE60238085 T DE 60238085T DE 60238085 T DE60238085 T DE 60238085T DE 60238085 D1 DE60238085 D1 DE 60238085D1
Authority
DE
Germany
Prior art keywords
producing microcapsules
microcapsules
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60238085T
Other languages
English (en)
Inventor
Toshiro Higuchi
Toru Torii
Takashi Nishisako
Tomohiro Taniguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Japan Science and Technology Agency
Original Assignee
Japan Science and Technology Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26609974&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60238085(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Science and Technology Agency filed Critical Japan Science and Technology Agency
Application granted granted Critical
Publication of DE60238085D1 publication Critical patent/DE60238085D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3011—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions using a sheathing stream of a fluid surrounding a central stream of a different fluid, e.g. for reducing the cross-section of the central stream or to produce droplets from the central stream
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/4105—Methods of emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4144—Multiple emulsions, in particular double emulsions, e.g. water in oil in water; Three-phase emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/313—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced in the centre of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B01F25/3142—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction
    • B01F25/31422—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit the conduit having a plurality of openings in the axial direction or in the circumferential direction with a plurality of perforations in the axial direction only
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3031—Micromixers using electro-hydrodynamic [EHD] or electro-kinetic [EKI] phenomena to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7179—Feed mechanisms characterised by the means for feeding the components to the mixer using sprayers, nozzles or jets
    • B01F35/71791—Feed mechanisms characterised by the means for feeding the components to the mixer using sprayers, nozzles or jets using ink jet heads or cartridges, e.g. of the thermal bubble jet or piezoelectric type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2215/00—Auxiliary or complementary information in relation with mixing
    • B01F2215/04—Technical information in relation with mixing
    • B01F2215/0413—Numerical information
    • B01F2215/0418—Geometrical information
    • B01F2215/0431—Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B01F23/414—Emulsifying characterised by the internal structure of the emulsion
    • B01F23/4143—Microemulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00853—Employing electrode arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S366/00—Agitating
    • Y10S366/04—Micromixers: with application of energy to influence mixing/agitation, e.g. magnetic, electrical, e-m radiation, particulate radiation, or ultrasound
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
    • Y10S516/924—Significant dispersive or manipulative operation or step in making or stabilizing colloid system
    • Y10S516/927—Significant dispersive or manipulative operation or step in making or stabilizing colloid system in situ formation of a colloid system making or stabilizing agent which chemical reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0324—With control of flow by a condition or characteristic of a fluid
    • Y10T137/0329—Mixing of plural fluids of diverse characteristics or conditions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Colloid Chemistry (AREA)
DE60238085T 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum herstellen von Mikrokapseln Expired - Lifetime DE60238085D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001048097 2001-02-23
JP2001238624 2001-08-07

Publications (1)

Publication Number Publication Date
DE60238085D1 true DE60238085D1 (de) 2010-12-02

Family

ID=26609974

Family Applications (6)

Application Number Title Priority Date Filing Date
DE2002614604 Expired - Lifetime DE60214604T2 (de) 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
DE60238955T Expired - Lifetime DE60238955D1 (de) 2001-02-23 2002-02-13 Vorrichtung zum Erzeugen von Emulsionen
DE2002621036 Expired - Lifetime DE60221036T2 (de) 2001-02-23 2002-02-13 Vorrichtung zum Erzeugen von Emulsionen und Mikrokapseln
DE60229454T Expired - Lifetime DE60229454D1 (de) 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
DE2002611857 Expired - Lifetime DE60211857T2 (de) 2001-02-23 2002-02-13 Verfahren zur herstellung einer emulsion und vorrichtung dafür
DE60238085T Expired - Lifetime DE60238085D1 (de) 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum herstellen von Mikrokapseln

Family Applications Before (5)

Application Number Title Priority Date Filing Date
DE2002614604 Expired - Lifetime DE60214604T2 (de) 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
DE60238955T Expired - Lifetime DE60238955D1 (de) 2001-02-23 2002-02-13 Vorrichtung zum Erzeugen von Emulsionen
DE2002621036 Expired - Lifetime DE60221036T2 (de) 2001-02-23 2002-02-13 Vorrichtung zum Erzeugen von Emulsionen und Mikrokapseln
DE60229454T Expired - Lifetime DE60229454D1 (de) 2001-02-23 2002-02-13 Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
DE2002611857 Expired - Lifetime DE60211857T2 (de) 2001-02-23 2002-02-13 Verfahren zur herstellung einer emulsion und vorrichtung dafür

Country Status (6)

Country Link
US (6) US7268167B2 (de)
EP (5) EP1721658B2 (de)
JP (1) JP3746766B2 (de)
CA (1) CA2438856C (de)
DE (6) DE60214604T2 (de)
WO (1) WO2002068104A1 (de)

Families Citing this family (254)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60214604T2 (de) * 2001-02-23 2006-12-28 Japan Science And Technology Agency, Kawaguchi Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
US7718099B2 (en) 2002-04-25 2010-05-18 Tosoh Corporation Fine channel device, fine particle producing method and solvent extraction method
US6932502B2 (en) * 2002-05-01 2005-08-23 Hewlett-Packard Development Company, L.P. Mixing apparatus
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
JP2004154745A (ja) * 2002-09-10 2004-06-03 Tosoh Corp 液滴生成用微小流路構造体、これを用いた液滴生成方法及びその生成物
JP4186637B2 (ja) * 2002-11-06 2008-11-26 東ソー株式会社 粒子製造方法及びそのための微小流路構造体
JP4527384B2 (ja) * 2002-12-06 2010-08-18 綜研化学株式会社 マイクロチャンネルを用いた着色球状粒子の製造方法、およびその製造方法に用いるマイクロチャンネル式製造装置
JP4306243B2 (ja) * 2002-12-17 2009-07-29 東ソー株式会社 粒子製造方法
JP4356312B2 (ja) * 2002-12-17 2009-11-04 東ソー株式会社 微小流路構造体
JP4166590B2 (ja) * 2003-02-04 2008-10-15 独立行政法人科学技術振興機構 ダブルエマルション・マイクロカプセル生成装置
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) * 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
JP2006523142A (ja) * 2003-04-10 2006-10-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体種の形成および制御
US8580211B2 (en) 2003-05-16 2013-11-12 Velocys, Inc. Microchannel with internal fin support for catalyst or sorption medium
US7485671B2 (en) 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
DE602004009681T2 (de) * 2003-05-16 2008-08-14 Velocys, Inc., Plain City Verfahren zur erzeugung einer emulsion durch verwendung einer mikrokanalverfahrentechnologie
KR100932418B1 (ko) 2003-06-11 2009-12-17 아사히 가라스 가부시키가이샤 무기질 구상체의 제조 방법 및 제조 장치
KR20070029618A (ko) 2003-08-27 2007-03-14 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유체종의 전자적 제어
US7311476B2 (en) 2003-10-30 2007-12-25 Cytonome, Inc. Multilayer hydrodynamic sheath flow structure
ES2283158B1 (es) * 2003-11-10 2008-09-16 Universidad De Sevilla Procedimiento y dispositivo para la generacion de espumas y emulsiones mediante pares de tubos enfrentados.
JP4042683B2 (ja) * 2003-11-17 2008-02-06 東ソー株式会社 微小流路構造体及びこれを用いた微小粒子製造方法
EP1533605A3 (de) * 2003-11-19 2006-05-31 Aisin Seiki Kabushiki Kaisha Mikrokontrollsystem zum Flüssigkeitstransfer
JP4352890B2 (ja) * 2003-12-24 2009-10-28 東ソー株式会社 微粒子製造装置及びこれを利用した微粒子の製造方法
US7029647B2 (en) 2004-01-27 2006-04-18 Velocys, Inc. Process for producing hydrogen peroxide using microchannel technology
US7084180B2 (en) 2004-01-28 2006-08-01 Velocys, Inc. Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US9023900B2 (en) 2004-01-28 2015-05-05 Velocys, Inc. Fischer-Tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
US8747805B2 (en) 2004-02-11 2014-06-10 Velocys, Inc. Process for conducting an equilibrium limited chemical reaction using microchannel technology
JP2005238118A (ja) * 2004-02-26 2005-09-08 Tosoh Corp 微小流路構造体を用いた固化粒子の製造方法及び装置
JP2005254124A (ja) * 2004-03-11 2005-09-22 Yokohama Tlo Co Ltd 液滴分散液の製法
US8741192B2 (en) * 2004-03-23 2014-06-03 Japan Science And Technology Agency Method and device for producing micro-droplets
JP4639624B2 (ja) * 2004-03-30 2011-02-23 東ソー株式会社 微小流路構造体
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
GB0502398D0 (en) 2005-02-04 2005-03-16 Q Chip Ltd Device and method for producing spherical segmented flow
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
US7305850B2 (en) 2004-07-23 2007-12-11 Velocys, Inc. Distillation process using microchannel technology
JP5627837B2 (ja) 2004-07-23 2014-11-19 ヴェロシス，インク． マイクロチャネル技術を用いる蒸留プロセス
JP4470640B2 (ja) * 2004-08-12 2010-06-02 東ソー株式会社 微粒子製造方法及びそのための微小流路構造体
EP1786797B1 (de) 2004-08-12 2014-11-26 Velocys, Inc. Verfahren zur umwandlung von ethylen in ethylenoxid unter anwendung einer mikrokanalverfahrenstechnologie
JP5079977B2 (ja) * 2004-09-16 2012-11-21 大日本塗料株式会社 単分散粒子の製造方法
EP1804964A1 (de) 2004-10-01 2007-07-11 Velocys Inc. Mehrphasiges mischverfahren mit mikrokanalverarbeitungstechnologie
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2008517997A (ja) * 2004-10-29 2008-05-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超音波撮像における造影剤として使用するための粒子の分散調合
CA2586971C (en) 2004-11-12 2013-07-23 Velocys Inc. Process using microchannel technology for conducting alkylation or acylation reaction
JP5704786B2 (ja) 2004-11-16 2015-04-22 ヴェロシス，インク． マイクロチャネル技術を用いる多相反応プロセス
CN102580593A (zh) * 2004-11-17 2012-07-18 万罗赛斯公司 使用微通道处理技术的乳化方法
EP2248578B1 (de) * 2005-03-04 2012-06-06 President and Fellows of Harvard College Verfahren zur Bildung mehrerer Emulsionen
US20070054119A1 (en) * 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
JP4580801B2 (ja) * 2005-03-29 2010-11-17 株式会社東芝 複合型微粒子の製造方法及び複合型微粒子の製造装置
EP1890802A2 (de) 2005-05-25 2008-02-27 Velocys, Inc. Träger zur verwendung bei der mikrokanalverarbeitung
JP2008188477A (ja) * 2005-06-23 2008-08-21 Seiko Kagaku Kk 粒状化学物質の製造方法
ES2925730T3 (es) 2005-07-08 2022-10-19 Velocys Inc Proceso de reacción catalítica usando la tecnología de microcanales
US20080259720A1 (en) * 2005-07-21 2008-10-23 Yee Cheong Lam Methods and Apparatus for Microfluidic Mixing
DE102005037401B4 (de) * 2005-08-08 2007-09-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Bildung einer Emulsion in einem fluidischen Mikrosystem
WO2007039265A1 (en) * 2005-10-06 2007-04-12 Unilever Plc Microfluidic network and method
DE102005048259B4 (de) * 2005-10-07 2007-09-13 Landesstiftung Baden-Württemberg Vorrichtung und Verfahren zur Erzeugung eines Gemenges von zwei ineinander unlösbaren Phasen
US20070085227A1 (en) * 2005-10-13 2007-04-19 Tonkovich Anna L Multi-phase contacting process using microchannel technology
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
EP2263787A3 (de) * 2006-01-27 2012-02-22 President and Fellows of Harvard College Fluidtröpfchenkoaleszenz
JP4921829B2 (ja) * 2006-03-30 2012-04-25 株式会社東芝 微粒子の製造装置、乳化剤保持部、微粒子の製造方法および分子膜の製造方法
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
WO2007133710A2 (en) * 2006-05-11 2007-11-22 Raindance Technologies, Inc. Microfluidic devices and methods of use thereof
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008021123A1 (en) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Fluorocarbon emulsion stabilizing surfactants
US8524173B2 (en) 2006-09-01 2013-09-03 Tosoh Corporation Microchannel structure and fine-particle production method using the same
JP2007044692A (ja) * 2006-09-27 2007-02-22 Japan Science & Technology Agency ダブルエマルション・マイクロカプセル生成装置
JP4417361B2 (ja) * 2006-09-27 2010-02-17 独立行政法人科学技術振興機構 ダブルエマルション・マイクロカプセル生成装置
FR2907030B1 (fr) * 2006-10-13 2014-06-06 Rhodia Recherches & Tech Procede et dispositif de gestion de bouchons dans un ecoulement fluidique
WO2008053988A1 (fr) * 2006-11-02 2008-05-08 National University Corporation Nagoya University Procédé de production de microcapsules
US20080121733A1 (en) * 2006-11-29 2008-05-29 Donald Ackley Droplet generating device and method
US7985058B2 (en) * 2007-01-12 2011-07-26 Mark Gray Method and apparatus for making uniformly sized particles
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US9029085B2 (en) 2007-03-07 2015-05-12 President And Fellows Of Harvard College Assays and other reactions involving droplets
CN102014871A (zh) * 2007-03-28 2011-04-13 哈佛大学 乳液及其形成技术
WO2008120816A1 (ja) * 2007-03-30 2008-10-09 Tokyo Institute Of Technology 二分子膜の製造方法および二分子平面膜
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
GB2455143A (en) * 2007-11-30 2009-06-03 Ct Angewandte Nanotech Can Preparation of emulsions using inkjet technology
EP2235210B1 (de) 2007-12-21 2015-03-25 President and Fellows of Harvard College Verfahren zur nukleinsäuresequenzierung
KR100942184B1 (ko) 2008-04-25 2010-02-11 한국과학기술연구원 마이크로 캡슐 제조장치 및 방법
FR2931082B1 (fr) * 2008-05-13 2010-05-21 Commissariat Energie Atomique Dispositif, systeme et procede microfluidique pour l'encapsulation controlee de particules ou amas de particules
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
WO2010025988A1 (en) * 2008-09-04 2010-03-11 Unilever Plc Method and apparatus for producing microparticles
US8583380B2 (en) 2008-09-05 2013-11-12 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
WO2010033200A2 (en) 2008-09-19 2010-03-25 President And Fellows Of Harvard College Creation of libraries of droplets and related species
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
WO2011120024A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet generation for droplet-based assays
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8633015B2 (en) 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US9598725B2 (en) 2010-03-02 2017-03-21 Bio-Rad Laboratories, Inc. Emulsion chemistry for encapsulated droplets
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
WO2011120020A1 (en) 2010-03-25 2011-09-29 Quantalife, Inc. Droplet transport system for detection
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
EP3290531B1 (de) 2008-12-19 2019-07-24 President and Fellows of Harvard College Partikelunterstützte nukleinsäuresequenzierung
US9713802B2 (en) * 2009-01-13 2017-07-25 Kobe Steel, Ltd. Method and apparatus for manufacturing liquid microspheres
JP2009166039A (ja) * 2009-03-11 2009-07-30 Tosoh Corp 微粒子製造装置
US9056299B2 (en) 2009-03-13 2015-06-16 President And Fellows Of Harvard College Scale-up of flow-focusing microfluidic devices
EP2411148B1 (de) 2009-03-23 2018-02-21 Raindance Technologies, Inc. Manipulation von mikrofluidiktröpfchen
DE102009024048B3 (de) * 2009-05-08 2010-08-19 Institut für Bioprozess- und Analysenmesstechnik e.V. Montier- und demontierbares Mikrofluidiksystem und Verfahren zur Flutung des Systems
EP4019977A1 (de) 2009-06-26 2022-06-29 President and Fellows of Harvard College Flüssigkeitseinspritzung
GB2471522B (en) * 2009-07-03 2014-01-08 Cambridge Entpr Ltd Microfluidic devices
CA3021714C (en) 2009-09-02 2021-03-09 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
WO2011028760A2 (en) * 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using junctions
JP5869482B2 (ja) 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ ジェッティングおよび他の技術を使用して生成された多重エマルジョン
EP2486409A1 (de) 2009-10-09 2012-08-15 Universite De Strasbourg Markiertes nanomaterial auf siliziumbasis mit verbesserten eigenschaften und seine verwendung
EP3842150A1 (de) 2009-10-27 2021-06-30 President and Fellows of Harvard College Tröpfchenbildungsverfahren
WO2011056389A2 (en) * 2009-11-03 2011-05-12 Manuel Marquez Method of making an artificial micro-gland using taxis
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
AR080405A1 (es) * 2010-03-17 2012-04-04 Basf Se Emulsificacion para fundir
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
DE102010017523A1 (de) * 2010-06-22 2011-12-22 Technische Universität Berlin Verfahren und Mischvorrichtung zum Mischen von zwei Fluiden sowie deren Verwendung
EP2594332B1 (de) 2010-07-13 2020-03-04 Tokyo Institute of Technology Vorrichtung zur herstellung von mikroflüssigkeitstropfen
US8465707B2 (en) * 2010-07-22 2013-06-18 Gencell Biosystems Ltd. Composite liquid cells
JP2012024313A (ja) 2010-07-23 2012-02-09 Nitto Denko Corp 液滴生成器及び液滴生成方法
EP2619329B1 (de) 2010-09-24 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer
EP3447155A1 (de) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Sandwichassays in tröpfchen
WO2012061444A2 (en) 2010-11-01 2012-05-10 Hiddessen Amy L System for forming emulsions
US20120167410A1 (en) * 2010-12-21 2012-07-05 Basf Se Spray drying techniques
CN104772056A (zh) 2010-12-23 2015-07-15 赢创有限公司 用来制备乳化液的设备和方法
EP3859011A1 (de) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
JP2014509865A (ja) 2011-03-18 2014-04-24 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド シグナルの組合せ使用による多重化デジタルアッセイ
WO2012149042A2 (en) 2011-04-25 2012-11-01 Bio-Rad Laboratories, Inc. Methods and compositions for nucleic acid analysis
WO2012162296A2 (en) * 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (de) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzymquantifizierung
US8944083B2 (en) 2011-06-15 2015-02-03 Ut-Battelle, Llc Generation of monodisperse droplets by shape-induced shear and interfacial controlled fusion of individual droplets on-demand
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
EP2737089B1 (de) 2011-07-29 2017-09-06 Bio-rad Laboratories, Inc. Bibliothekscharakterisierung durch digitalen test
WO2014018562A1 (en) * 2012-07-23 2014-01-30 Bio-Rad Laboratories, Inc. Droplet generation system with features for sample positioning
GB201214122D0 (en) 2012-08-07 2012-09-19 Oxford Catalysts Ltd Treating of catalyst support
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9388465B2 (en) 2013-02-08 2016-07-12 10X Genomics, Inc. Polynucleotide barcode generation
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US20150376609A1 (en) 2014-06-26 2015-12-31 10X Genomics, Inc. Methods of Analyzing Nucleic Acids from Individual Cells or Cell Populations
WO2014028537A1 (en) 2012-08-14 2014-02-20 10X Technologies, Inc. Microcapsule compositions and methods
EP2703497B1 (de) * 2012-08-31 2016-06-22 Roche Diagniostics GmbH Mikrofluidischer chip, vorrichtung und system zur erzeugung wässriger tröpfchen in emulsionsöl zur nukleinsäureamplifikation
US9790546B2 (en) 2012-08-31 2017-10-17 Roche Molecular Systems, Inc. Microfluidic chip, device and system for the generation of aqueous droplets in emulsion oil for nucleic acid amplification
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2014093676A1 (en) 2012-12-14 2014-06-19 10X Technologies, Inc. Methods and systems for processing polynucleotides
CN103071550A (zh) * 2012-12-17 2013-05-01 西安交通大学 一种基于不同入射角微通道的多组分液滴产生装置及方法
NZ711384A (en) 2013-03-14 2018-06-29 Cytonome St Llc Hydrodynamic focusing apparatus and methods
KR101424610B1 (ko) 2013-06-14 2014-08-04 (주) 라미나 코어-쉘 입자 제조장치 및 이를 이용한 코어-쉘 입자 제조방법
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US9233859B2 (en) 2013-09-30 2016-01-12 Uchicago Argonne, Llc. Microfluidic process monitor for industrial solvent extraction system
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US20160279068A1 (en) 2013-11-08 2016-09-29 President And Fellows Of Harvard College Microparticles, methods for their preparation and use
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
CA2935122C (en) 2013-12-30 2023-09-19 Atreca, Inc. Analysis of nucleic acids associated with single cells using nucleic acid barcodes
WO2015103367A1 (en) 2013-12-31 2015-07-09 Raindance Technologies, Inc. System and method for detection of rna species
AU2015243445B2 (en) 2014-04-10 2020-05-28 10X Genomics, Inc. Fluidic devices, systems, and methods for encapsulating and partitioning reagents, and applications of same
AU2015279546B2 (en) 2014-06-26 2021-04-08 10X Genomics, Inc. Processes and systems for nucleic acid sequence assembly
TWI523684B (zh) * 2014-07-15 2016-03-01 Metal Ind Res & Dev Ct Combined microsphere manufacturing device
CN114807307A (zh) 2014-10-29 2022-07-29 10X 基因组学有限公司 用于靶核酸测序的方法和组合物
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
EP3017868A1 (de) 2014-11-10 2016-05-11 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie - Hans-Knöll-Institut - Vorrichtung und verfahren zur extraktion einzelner picolitertröpfchen aus mikrofluidischen emulsionen zur weiteren analyse und aufskalierung
CN112126675B (zh) 2015-01-12 2022-09-09 10X基因组学有限公司 用于制备核酸测序文库的方法和系统以及用其制备的文库
WO2016115273A1 (en) 2015-01-13 2016-07-21 10X Genomics, Inc. Systems and methods for visualizing structural variation and phasing information
EP3256606B1 (de) 2015-02-09 2019-05-22 10X Genomics, Inc. Systeme und verfahren zur bestimmung struktureller varianten
EP3262188B1 (de) 2015-02-24 2021-05-05 10X Genomics, Inc. Verfahren zur sequenzierung von nukleinsäuren in gesteuertem ausmass
EP4286516A3 (de) 2015-02-24 2024-03-06 10X Genomics, Inc. Partitionsverarbeitungsverfahren und -systeme
CN104741158B (zh) * 2015-04-03 2019-04-12 北京天天极因科技有限公司 一种利用惯性力产生微液滴的方法和装置
GB2554618B (en) 2015-06-12 2021-11-10 Velocys Inc Synthesis gas conversion process
US11123740B2 (en) 2015-06-29 2021-09-21 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for continuous flow digital droplet polymerase chain reaction bioanalysis
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11123297B2 (en) 2015-10-13 2021-09-21 President And Fellows Of Harvard College Systems and methods for making and using gel microspheres
KR20180097536A (ko) 2015-11-04 2018-08-31 아트레카, 인크. 단일 세포와 연관된 핵산의 분석을 위한 핵산 바코드의 조합 세트
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
WO2017096158A1 (en) 2015-12-04 2017-06-08 10X Genomics, Inc. Methods and compositions for nucleic acid analysis
SG11201806757XA (en) 2016-02-11 2018-09-27 10X Genomics Inc Systems, methods, and media for de novo assembly of whole genome sequence data
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US10654040B2 (en) 2016-08-18 2020-05-19 Northeastern University Platform for liquid droplet formation and isolation
EP3471865A4 (de) * 2016-10-21 2019-08-14 Hewlett-Packard Development Company, L.P. Tröpfchenerzeuger
US20190316180A1 (en) 2016-11-23 2019-10-17 Universite De Strasbourg Tandem barcoding of target molecules for their absolute quantification at single-entity resolution
JP2020500517A (ja) 2016-11-28 2020-01-16 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 連続流小滴反応に関連するシステムおよび方法
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
EP3343223A1 (de) 2016-12-30 2018-07-04 Blink AG Vorgefertigtes mikropartikel zur durchführung einer digitalen detektion eines analyten
EP3545089B1 (de) 2017-01-30 2022-03-09 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
KR102371209B1 (ko) 2017-03-24 2022-03-07 (주)아모레퍼시픽 순간 유화 화장품 제조 장치 및 제조 방법
EP3625353B1 (de) 2017-05-18 2022-11-30 10X Genomics, Inc. Verfahren und systeme zum sortieren von tröpfchen und perlen
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
EP3625715A4 (de) 2017-05-19 2021-03-17 10X Genomics, Inc. Systeme und verfahren zur analyse von datensätzen
US10400235B2 (en) 2017-05-26 2019-09-03 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
SG11201901822QA (en) 2017-05-26 2019-03-28 10X Genomics Inc Single cell analysis of transposase accessible chromatin
US10639607B2 (en) 2017-06-16 2020-05-05 Matralix Pte Ltd Systems and methods for preparing wax and lipid particles
WO2019006190A1 (en) * 2017-06-28 2019-01-03 Bio-Rad Laboratories, Inc. SYSTEM AND METHOD FOR DROPLELET DETECTION
US10821442B2 (en) 2017-08-22 2020-11-03 10X Genomics, Inc. Devices, systems, and kits for forming droplets
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019078311A1 (ja) * 2017-10-19 2019-04-25 国立大学法人北陸先端科学技術大学院大学 略１ｆＬカプセル化体の製造方法及びそれに用いる装置
US11745179B2 (en) * 2017-10-20 2023-09-05 The Regents Of The University Of California Microfluidic systems and methods for lipoplex-mediated cell transfection
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
EP4241882A3 (de) 2017-10-27 2023-12-06 10X Genomics, Inc. Verfahren zur probenvorbereitung und -analyse
US11045805B2 (en) 2017-11-01 2021-06-29 Bio-Rad Laboratories, Inc. Microfluidic system and method for arranging objects
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
WO2019110591A1 (en) 2017-12-06 2019-06-13 Samplix Aps A microfluidic device and a method for provision of emulsion droplets
US11779923B2 (en) 2017-12-06 2023-10-10 Samplix Aps Microfluidic device and a method for provision of double emulsion droplets
EP3752832A1 (de) 2018-02-12 2020-12-23 10X Genomics, Inc. Verfahren zur charakterisierung mehrerer analyten aus einzelnen zellen oder zellpopulationen
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
EP3543351B1 (de) 2018-03-19 2022-08-10 Ricoh Company, Ltd. Nukleinsäureprobenhaltiger behälter, verfahren zur herstellung eines nukleinsäureprobenhaltigen behälters und nukleinsäureprobe
CN114713056A (zh) 2018-04-02 2022-07-08 滴管公司 用于连续流乳液处理的系统和方法
WO2019195166A1 (en) 2018-04-06 2019-10-10 10X Genomics, Inc. Systems and methods for quality control in single cell processing
US20190321791A1 (en) * 2018-04-19 2019-10-24 President And Fellows Of Harvard College Apparatus and method for forming emulsions
WO2019224219A1 (en) 2018-05-22 2019-11-28 Universite De Strasbourg Absolute quantification of target molecules at single-entity resolution using tandem barcoding
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
CN109046482A (zh) * 2018-08-16 2018-12-21 复旦大学 一种单泵微液滴控制系统及其用途
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
FR3092011B1 (fr) * 2019-01-25 2021-11-05 Fluigent Dispositif et procédé pour créer une émulsion
WO2020157262A1 (en) 2019-01-31 2020-08-06 Samplix Aps A microfluidic device and a method for provision of double emulsion droplets
JP7335343B2 (ja) 2019-01-31 2023-08-29 サンプリックス エーピーエス マイクロ流体デバイスおよびエマルション液滴の提供のための方法
WO2020168013A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
CN113767178A (zh) 2019-03-11 2021-12-07 10X基因组学有限公司 用于处理光学标签化珠粒的系统和方法
CA3204372A1 (en) 2019-07-01 2021-01-07 Oakwood Laboratories, Llc System and method for making microspheres and emulsions
WO2021016605A1 (en) 2019-07-23 2021-01-28 Orange Maker LLC Improvements to security features and anti-counterfeiting and part tracking system for 3d printed parts
JP7236679B2 (ja) * 2019-09-26 2023-03-10 パナソニックＩｐマネジメント株式会社 ミスト発生装置
JP2021139793A (ja) 2020-03-06 2021-09-16 株式会社エンプラス 流体取扱装置、分散液製造セット、および分散液の製造方法
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
JP7440905B2 (ja) 2020-08-25 2024-02-29 株式会社オンチップ・バイオテクノロジーズ 粒子の純化方法、単一粒子分注方法、及び細胞クラスター解析方法、並びそれに用いる装置
JP2022049382A (ja) 2020-09-16 2022-03-29 株式会社エンプラス 流体取扱装置および流体取扱装置の製造方法
EP4249109A1 (de) * 2020-11-20 2023-09-27 Japan Science and Technology Agency Mikrovorrichtung zur erzeugung eines zweiphasigen flüssigkeitströpfchen
EP4298244A1 (de) 2021-02-23 2024-01-03 10X Genomics, Inc. Sonden-basierte analyse von nukleinsäuren und proteinen
US11819850B2 (en) 2021-05-12 2023-11-21 Enplas Corporation Fluid handling device
WO2023210755A1 (ja) * 2022-04-28 2023-11-02 国立研究開発法人理化学研究所 有用微生物のスクリーニング方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US535267A (en) * 1895-03-05 Electrolytic conduit for beer or other liquids
US3054553A (en) * 1959-08-11 1962-09-18 Cottrell Res Inc Electrostatic blower apparatus
US3885180A (en) * 1973-07-10 1975-05-20 Us Army Microchannel imaging display device
US4360376A (en) * 1978-03-17 1982-11-23 Pennwalt Corporation Microencapsulated trifluralin
US4280909A (en) * 1978-05-30 1981-07-28 Deutsch Daniel Harold Microporous member with interconnected, oriented tapered voids
JPS5915005B2 (ja) * 1979-10-17 1984-04-07 コニカ株式会社 分散方法
GB2097692B (en) * 1981-01-10 1985-05-22 Shaw Stewart P D Combining chemical reagents
ATE85903T1 (de) * 1985-12-05 1993-03-15 Abs Int Sa Vorrichtung zur begasung von fluessigkeiten oder zur mischung von fluessigkeiten.
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5078504A (en) * 1989-02-06 1992-01-07 Spectrum Sciences B.V. Dispersion apparatus
DE3930866C1 (de) * 1989-09-15 1991-02-28 Didier-Werke Ag, 6200 Wiesbaden, De
GB9107628D0 (en) * 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
FR2703927B1 (fr) 1993-04-13 1995-07-13 Coletica Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées.
US5632876A (en) * 1995-06-06 1997-05-27 David Sarnoff Research Center, Inc. Apparatus and methods for controlling fluid flow in microchannels
US5718922A (en) * 1995-05-31 1998-02-17 Schepens Eye Research Institute, Inc. Intravitreal microsphere drug delivery and method of preparation
US5827707A (en) * 1995-06-07 1998-10-27 Neocrin Company Method for manufacturing minimal volume capsules containing biological materials
US5990183A (en) * 1996-02-26 1999-11-23 Reika Kogyo Kabushiki Kaisha Porous particles, porous hollow particles and method of preparing such particles
US6033544A (en) * 1996-10-11 2000-03-07 Sarnoff Corporation Liquid distribution system
US5858187A (en) * 1996-09-26 1999-01-12 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing electrodynamic focusing on a microchip
US6120666A (en) * 1996-09-26 2000-09-19 Ut-Battelle, Llc Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
US5915925A (en) * 1997-01-07 1999-06-29 North, Jr.; Howard L. Pulseless liquid supply system for flow cytometry
US6042209A (en) * 1997-07-28 2000-03-28 Eastman Kodak Company Microfluidic printing with optical density control
US6334676B1 (en) * 1997-09-29 2002-01-01 Eastman Kodak Company Using colorant precursors and reactants in microfluidic printing
US6103537A (en) * 1997-10-02 2000-08-15 Aclara Biosciences, Inc. Capillary assays involving separation of free and bound species
JP3081880B2 (ja) * 1998-03-30 2000-08-28 農林水産省食品総合研究所長 マイクロスフィアの連続製造装置
US6170981B1 (en) * 1998-05-07 2001-01-09 Purdue Research Foundation In situ micromachined mixer for microfluidic analytical systems
EP0964001A1 (de) * 1998-06-12 1999-12-15 Bayer Aktiengesellschaft Verfahren zur Herstellung mikroverkapselter Polymerisate
JP2981547B1 (ja) * 1998-07-02 1999-11-22 農林水産省食品総合研究所長 クロスフロー型マイクロチャネル装置及び同装置を用いたエマルションの生成または分離方法
JP3012608B1 (ja) * 1998-09-17 2000-02-28 農林水産省食品総合研究所長 マイクロチャネル装置及び同装置を用いたエマルションの製造方法
US6136171A (en) * 1998-09-18 2000-10-24 The University Of Utah Research Foundation Micromachined electrical field-flow fractionation system
US6146103A (en) * 1998-10-09 2000-11-14 The Regents Of The University Of California Micromachined magnetohydrodynamic actuators and sensors
US6032689A (en) * 1998-10-30 2000-03-07 Industrial Technology Research Institute Integrated flow controller module
JP4009035B2 (ja) * 1999-03-05 2007-11-14 株式会社フジキン 静止型混合攪拌装置
JP3030364B1 (ja) * 1999-03-24 2000-04-10 農林水産省食品総合研究所長 単分散固体脂質マイクロスフィアの製造方法
US6846399B2 (en) * 1999-05-12 2005-01-25 Sandia National Laboratories Castable three-dimensional stationary phase for electric field-driven applications
US6408884B1 (en) * 1999-12-15 2002-06-25 University Of Washington Magnetically actuated fluid handling devices for microfluidic applications
DE10000621A1 (de) * 2000-01-10 2001-07-12 Basf Ag Niedrigviskose, formaldehydreduzierte Dispersionen von Mikrokapseln aus Melamin-Formaldehyd-Harzen
GB2359765B (en) * 2000-03-02 2003-03-05 Univ Newcastle Capillary reactor distribution device and method
US20040134854A1 (en) * 2001-02-23 2004-07-15 Toshiro Higuchi Small liquid particle handling method, and device therefor
DE60214604T2 (de) * 2001-02-23 2006-12-28 Japan Science And Technology Agency, Kawaguchi Vorrichtung und Verfahren zum Herstellen von Mikrokapseln
US7485671B2 (en) * 2003-05-16 2009-02-03 Velocys, Inc. Process for forming an emulsion using microchannel process technology
DE602004009681T2 (de) * 2003-05-16 2008-08-14 Velocys, Inc., Plain City Verfahren zur erzeugung einer emulsion durch verwendung einer mikrokanalverfahrentechnologie
US8741192B2 (en) * 2004-03-23 2014-06-03 Japan Science And Technology Agency Method and device for producing micro-droplets
CN102580593A (zh) * 2004-11-17 2012-07-18 万罗赛斯公司 使用微通道处理技术的乳化方法

Also Published As

Publication number Publication date
EP1362634A1 (de) 2003-11-19
US7717615B2 (en) 2010-05-18
EP1510251B1 (de) 2006-09-06
JPWO2002068104A1 (ja) 2004-06-24
DE60221036D1 (de) 2007-08-16
EP1362634A4 (de) 2004-08-11
US20060077755A1 (en) 2006-04-13
WO2002068104A1 (en) 2002-09-06
DE60229454D1 (de) 2008-11-27
US7268167B2 (en) 2007-09-11
EP1362634B1 (de) 2006-05-31
DE60214604D1 (de) 2006-10-19
EP1721658B2 (de) 2020-08-05
DE60221036T2 (de) 2007-10-11
DE60211857T2 (de) 2006-12-21
US8883864B2 (en) 2014-11-11
EP1721658B1 (de) 2010-10-20
EP1721658A2 (de) 2006-11-15
EP1721658A3 (de) 2007-04-18
DE60211857D1 (de) 2006-07-06
EP1447127A1 (de) 2004-08-18
US20060079583A1 (en) 2006-04-13
US7375140B2 (en) 2008-05-20
US7772287B2 (en) 2010-08-10
US20040068019A1 (en) 2004-04-08
EP1510251A1 (de) 2005-03-02
US20060079585A1 (en) 2006-04-13
CA2438856A1 (en) 2002-09-06
JP3746766B2 (ja) 2006-02-15
EP1745839A1 (de) 2007-01-24
EP1447127B1 (de) 2007-07-04
DE60238955D1 (de) 2011-02-24
DE60214604T2 (de) 2006-12-28
US20060079584A1 (en) 2006-04-13
EP1745839B1 (de) 2011-01-12
US20100327471A1 (en) 2010-12-30
CA2438856C (en) 2007-08-07

Similar Documents

Publication Publication Date Title
DE60238085D1 (de) Vorrichtung und Verfahren zum herstellen von Mikrokapseln
DE69730109D1 (de) Verfahren und Vorrichtung zum Herstellen von Wasserzeichen
DE60222730D1 (de) Verfahren und Vorrichtung zum Ausführen von Aufgaben
DE50211121D1 (de) Verfahren und vorrichtung zum herstellen von beutelpackungen
DE60304002D1 (de) Automatisiertes System und Verfahren zum Herstellen von hochviskosen Flüssigkeitsrezepturen
DE50011329D1 (de) Verfahren und Vorrichtung zum Herstellen von (Zigaretten-)Packungen
DE60130217D1 (de) Verfahren und vorrichtung zum herstellen von fluorwasserstoff
DE69904374D1 (de) Vorrichtung und Verfahren zum Herstellen von zweifarbigen Mikrokugeln
ATE312661T1 (de) Vorrichtung und verfahren zum herstellen von kristallinen teilchen
DE50209553D1 (de) Verfahren und vorrichtung zum herstellen von filterzigaretten
DE60311286D1 (de) Vorrichtung und verfahren zum herstellen von hüllenlosen würsten
DE60206447D1 (de) Verfahren und Vorrichtung zum Ausbalancieren von Superkapazitäten
DE60115819D1 (de) Verfahren und Vorrichtung zum Steuern von Wiederübertragung
DE60223954D1 (de) Verfahren und Vorrichtung zum Herstellen laminierten Materials
DE50009851D1 (de) Verfahren und Vorrichtung zum Drückwalzen
DE50105557D1 (de) Verfahren und vorrichtung zum herstellen von dickwandingen formteilen
DE60329292D1 (de) Verfahren und Vorrichtung zum Herstellen von Metall-Schichten
DE60125070D1 (de) Vorrichtung und Verfahren zum Herstellen von metallischen Faltenbälgen
DE50104357D1 (de) Vorrichtung und Verfahren zum Herstellen von Dichtungslagen
DE60204394D1 (de) Vorrichtung und Verfahren zum Aufschäumen
AT4855U3 (de) Verfahren und vorrichtung zum behandeln von maische
DE50107027D1 (de) Verfahren und Vorrichtung zum kontinuierlichen Herstellen von Blockschaum
DE60127319D1 (de) Verfahren und vorrichtung zum integrieren mehrerer prozesssteuerungen
DE60232487D1 (de) Verfahren und vorrichtung zum herstellen von geflanschten gegenständen
DE60102932D1 (de) Mechanisches verfahren und vorrichtung zum erzeugen von nanostrukturen