DE60226353D1 - Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben - Google Patents

Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben

Info

Publication number
DE60226353D1
DE60226353D1 DE60226353T DE60226353T DE60226353D1 DE 60226353 D1 DE60226353 D1 DE 60226353D1 DE 60226353 T DE60226353 T DE 60226353T DE 60226353 T DE60226353 T DE 60226353T DE 60226353 D1 DE60226353 D1 DE 60226353D1
Authority
DE
Germany
Prior art keywords
labeling
substrate
cyclin
cell cycle
regulatory factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60226353T
Other languages
English (en)
Other versions
DE60226353T2 (de
Inventor
Hideki Ishihara
Tomokazu Yoshida
Masatoshi Yamasaki
Sachiyo Tada
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sysmex Corp
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Publication of DE60226353D1 publication Critical patent/DE60226353D1/de
Application granted granted Critical
Publication of DE60226353T2 publication Critical patent/DE60226353T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE60226353T 2001-02-14 2002-02-14 Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben Expired - Lifetime DE60226353T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001037115 2001-02-14
JP2001037115 2001-02-14

Publications (2)

Publication Number Publication Date
DE60226353D1 true DE60226353D1 (de) 2008-06-12
DE60226353T2 DE60226353T2 (de) 2009-06-10

Family

ID=18900293

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60223432T Expired - Lifetime DE60223432T2 (de) 2001-02-14 2002-02-14 Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben
DE60226353T Expired - Lifetime DE60226353T2 (de) 2001-02-14 2002-02-14 Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60223432T Expired - Lifetime DE60223432T2 (de) 2001-02-14 2002-02-14 Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben

Country Status (4)

Country Link
US (2) US7338774B2 (de)
EP (2) EP1609854B1 (de)
AT (2) ATE378400T1 (de)
DE (2) DE60223432T2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE458830T1 (de) 2003-02-26 2010-03-15 Sysmex Corp Verfahren zur untersuchung einer zelle
US8921057B2 (en) * 2004-05-31 2014-12-30 Sysmex Corporation Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same
WO2005118842A1 (ja) * 2004-06-01 2005-12-15 Sysmex Corporation 酵素活性測定方法および酵素活性測定用カラム
EP1634603A1 (de) 2004-08-26 2006-03-15 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von transformierten oder infizierten biologischen Zellen
US7348159B2 (en) 2005-04-20 2008-03-25 Boehringer Ingelheim International Gmbh Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
DE602006001701D1 (de) 2005-08-01 2008-08-21 Sysmex Corp Verfahren zur Beurteilung der Beschaffenheit maligner Tumore
JP4766969B2 (ja) 2005-09-14 2011-09-07 シスメックス株式会社 組織性質判定装置
JP4841266B2 (ja) * 2005-09-27 2011-12-21 シスメックス株式会社 被検出物質の検出方法
JP2007097448A (ja) * 2005-09-30 2007-04-19 Sysmex Corp 組織の性質判定用試薬キット
JP5111902B2 (ja) * 2007-03-14 2013-01-09 シスメックス株式会社 癌の診断支援装置
US8921114B2 (en) 2007-08-24 2014-12-30 Sysmex Corporation Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product
JP2010057486A (ja) 2008-09-02 2010-03-18 Sysmex Corp 化学療法に対するがん患者の応答の予測方法
JP5830249B2 (ja) 2010-03-31 2015-12-09 シスメックス株式会社 癌細胞のアンスラサイクリン系抗癌剤への感受性の判定方法及びコンピュータプログラム
JP6002379B2 (ja) 2011-11-29 2016-10-05 シスメックス株式会社 癌の再発リスクの判定方法及びその利用
JP6214449B2 (ja) * 2014-03-31 2017-10-18 シスメックス株式会社 キナーゼ活性の測定方法
CN106324255A (zh) * 2016-08-17 2017-01-11 山东博科生物产业有限公司 一种稳定性强的生化用特种蛋白液体复合质控品
CN106876715B (zh) * 2017-03-30 2020-03-17 湖北金泉新材料有限责任公司 一种含碳纳米管的正极浆料、其制备方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252783A (en) * 1979-06-18 1981-02-24 Syva Company Reducing fluorescent background in fluorescent immunoassays
DE3049033A1 (de) * 1980-12-24 1982-07-22 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt "ringinterferometer"
US5518911A (en) * 1995-01-06 1996-05-21 Onyx Pharmaceuticals, Inc. Human PAK65
AU3801997A (en) 1996-07-16 1998-02-09 Regents Of The University Of California, The Assays for protein kinases using fluorescent protein substrates
EP1003746A1 (de) * 1997-08-07 2000-05-31 The Regents Of The University Of California Purin inhibitoren der protein kinasen, g proteine und polymerasen
ES2192801T3 (es) 1997-12-05 2003-10-16 Upjohn Co Ensayos de criba de alta productividad de proteina quinasas y fosfatasas, basados en fluorescencia.
GB2334578A (en) 1998-02-18 1999-08-25 Univ Liverpool Diagnosis of cancer involving assay of levels of cyclin-dependent kinase (CDK) isoenzymes

Also Published As

Publication number Publication date
EP1233060B1 (de) 2007-11-14
EP1609854B1 (de) 2008-04-30
EP1609854A1 (de) 2005-12-28
US7338774B2 (en) 2008-03-04
EP1233060A2 (de) 2002-08-21
DE60223432T2 (de) 2008-09-18
US20070264624A1 (en) 2007-11-15
DE60226353T2 (de) 2009-06-10
US20020164673A1 (en) 2002-11-07
EP1233060A3 (de) 2003-10-15
ATE378400T1 (de) 2007-11-15
DE60223432D1 (de) 2007-12-27
ATE393821T1 (de) 2008-05-15

Similar Documents

Publication Publication Date Title
DE60223432D1 (de) Verfahren zur Bestimmung der Aktivität des Zellzyklus-Regulationsfaktors und Verfahren zur Diagnose von Krebs unter Verwendung desselben
AU671928B2 (en) Infra-red dye-labelled nucleotides and their use in nucleic acid detection
CN103403533B (zh) 用于分辨光信号检测器中不同调制频率的光信号的系统和方法
JP3098545B2 (ja) ビス−ジカチオンアリールフラン類を用いる核酸および細胞骨格成分の蛍光検出方法
CN101213439A (zh) 测定非挥发性分析物浓度的方法
CN105823768B (zh) 一种基于表面增强拉曼散射技术的检测芯片、制备方法以及试剂盒
ATE416385T1 (de) Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen
DE69841388D1 (de) Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln
CN104892541A (zh) 一种用于γ-谷氨酰转肽酶检测的荧光探针及其制备方法与应用
CN109438326B (zh) 一种用于检测羧酸酯酶的荧光探针及其制备方法与专用检测试剂盒
CN102507689A (zh) 一种检测凝血酶的电化学发光传感器的制备方法及应用
CN101416054A (zh) 荧光测定法
WO2003062791A2 (en) Detection of single nucleotide polymorphisms using planar waveguides
CN110849863B (zh) 一种检测适配体与配体小分子结合过程中构象改变的方法
DE3876108D1 (de) Diagnostischer test unter verwendung von nucleinsaeure-sonden.
CN104007152A (zh) 基于铂纳米粒子催化电化学循环信号放大技术测定dna的电化学传感器和测定dna的方法
CN103940808B (zh) 一种双信号放大电化学发光生物传感器的制备方法及应用
JP2009186350A (ja) リン酸イオンの検出方法および検出用キット
Zanchetta et al. Design of a rapid, multiplex, one-pot miRNA assay optimized by label-free analysis
CN109988816A (zh) 一种腺苷脱氨酶测定试剂盒
WO2015024948A1 (en) Detection of nucleic acid amplification in a porous substrate
Zuber et al. A descriptive model for the kinetics of a homogeneous fluorometric immunoassay
ATE439451T1 (de) Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon
ATE412775T1 (de) Verfahren zur quantifizierung von nukleinsäuren mittels bestimmung der zellzahl
CN101868554B (zh) 用于校正传感器元件的方法和装置

Legal Events

Date Code Title Description
8364 No opposition during term of opposition