ATE378400T1 - Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben - Google Patents

Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

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Publication number
ATE378400T1
ATE378400T1 AT02003139T AT02003139T ATE378400T1 AT E378400 T1 ATE378400 T1 AT E378400T1 AT 02003139 T AT02003139 T AT 02003139T AT 02003139 T AT02003139 T AT 02003139T AT E378400 T1 ATE378400 T1 AT E378400T1
Authority
AT
Austria
Prior art keywords
labeling
substrate
cyclin
cell cycle
regulatory factor
Prior art date
Application number
AT02003139T
Other languages
English (en)
Inventor
Hideki Ishihara
Tomokazu Yoshida
Masatoshi Yamasaki
Sachiyo Tada
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Application granted granted Critical
Publication of ATE378400T1 publication Critical patent/ATE378400T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02003139T 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben ATE378400T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001037115 2001-02-14

Publications (1)

Publication Number Publication Date
ATE378400T1 true ATE378400T1 (de) 2007-11-15

Family

ID=18900293

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02003139T ATE378400T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben
AT05019765T ATE393821T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT05019765T ATE393821T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

Country Status (4)

Country Link
US (2) US7338774B2 (de)
EP (2) EP1609854B1 (de)
AT (2) ATE378400T1 (de)
DE (2) DE60223432T2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501257B2 (en) 2003-02-26 2009-03-10 Sysmex Corporation Molecular diagnostic method of a cancer tissue or a cancer cell
US8921057B2 (en) * 2004-05-31 2014-12-30 Sysmex Corporation Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same
US20110136131A1 (en) * 2004-06-01 2011-06-09 Sysmex Corporation Method for measuring enzyme activity and column for use in measuring enzyme activity
EP1634603A1 (de) * 2004-08-26 2006-03-15 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von transformierten oder infizierten biologischen Zellen
US7348159B2 (en) 2005-04-20 2008-03-25 Boehringer Ingelheim International Gmbh Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
DE602006001701D1 (de) * 2005-08-01 2008-08-21 Sysmex Corp Verfahren zur Beurteilung der Beschaffenheit maligner Tumore
JP4766969B2 (ja) * 2005-09-14 2011-09-07 シスメックス株式会社 組織性質判定装置
JP4841266B2 (ja) * 2005-09-27 2011-12-21 シスメックス株式会社 被検出物質の検出方法
JP2007097448A (ja) * 2005-09-30 2007-04-19 Sysmex Corp 組織の性質判定用試薬キット
JP5111902B2 (ja) * 2007-03-14 2013-01-09 シスメックス株式会社 癌の診断支援装置
US8921114B2 (en) 2007-08-24 2014-12-30 Sysmex Corporation Diagnosis support system for cancer, diagnosis support information providing method for cancer, and computer program product
JP2010057486A (ja) 2008-09-02 2010-03-18 Sysmex Corp 化学療法に対するがん患者の応答の予測方法
JP5830249B2 (ja) 2010-03-31 2015-12-09 シスメックス株式会社 癌細胞のアンスラサイクリン系抗癌剤への感受性の判定方法及びコンピュータプログラム
JP6002379B2 (ja) 2011-11-29 2016-10-05 シスメックス株式会社 癌の再発リスクの判定方法及びその利用
JP6214449B2 (ja) * 2014-03-31 2017-10-18 シスメックス株式会社 キナーゼ活性の測定方法
CN106324255A (zh) * 2016-08-17 2017-01-11 山东博科生物产业有限公司 一种稳定性强的生化用特种蛋白液体复合质控品
CN106876715B (zh) * 2017-03-30 2020-03-17 湖北金泉新材料有限责任公司 一种含碳纳米管的正极浆料、其制备方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252783A (en) * 1979-06-18 1981-02-24 Syva Company Reducing fluorescent background in fluorescent immunoassays
DE3049033A1 (de) * 1980-12-24 1982-07-22 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt "ringinterferometer"
US5518911A (en) * 1995-01-06 1996-05-21 Onyx Pharmaceuticals, Inc. Human PAK65
DE69739898D1 (de) * 1996-07-16 2010-07-15 Univ California Tests auf proteinkinasen mit fluoreszierenden proteinsubstraten
US6255485B1 (en) * 1997-08-07 2001-07-03 The Regents Of The University Of California Purine inhibitors of protein kinases, G proteins and polymerases
ATE233325T1 (de) * 1997-12-05 2003-03-15 Upjohn Co Fluoreszenz-basierte hts-(high throughput screening)assayverfahren für proteinkinase und phosphatase
GB2334578A (en) 1998-02-18 1999-08-25 Univ Liverpool Diagnosis of cancer involving assay of levels of cyclin-dependent kinase (CDK) isoenzymes

Also Published As

Publication number Publication date
EP1233060A2 (de) 2002-08-21
DE60226353D1 (de) 2008-06-12
EP1233060B1 (de) 2007-11-14
US20070264624A1 (en) 2007-11-15
EP1233060A3 (de) 2003-10-15
DE60223432T2 (de) 2008-09-18
DE60226353T2 (de) 2009-06-10
EP1609854B1 (de) 2008-04-30
EP1609854A1 (de) 2005-12-28
US20020164673A1 (en) 2002-11-07
ATE393821T1 (de) 2008-05-15
US7338774B2 (en) 2008-03-04
DE60223432D1 (de) 2007-12-27

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