ATE393821T1 - Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben - Google Patents

Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

Info

Publication number
ATE393821T1
ATE393821T1 AT05019765T AT05019765T ATE393821T1 AT E393821 T1 ATE393821 T1 AT E393821T1 AT 05019765 T AT05019765 T AT 05019765T AT 05019765 T AT05019765 T AT 05019765T AT E393821 T1 ATE393821 T1 AT E393821T1
Authority
AT
Austria
Prior art keywords
labeling
substrate
cyclin
cell cycle
regulatory factor
Prior art date
Application number
AT05019765T
Other languages
English (en)
Inventor
Hideki Ishihara
Tomokazu Yoshida
Masatoshi Yamasaki
Sachiyo Tada
Original Assignee
Sysmex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sysmex Corp filed Critical Sysmex Corp
Application granted granted Critical
Publication of ATE393821T1 publication Critical patent/ATE393821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
AT05019765T 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben ATE393821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2001037115 2001-02-14

Publications (1)

Publication Number Publication Date
ATE393821T1 true ATE393821T1 (de) 2008-05-15

Family

ID=18900293

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05019765T ATE393821T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben
AT02003139T ATE378400T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02003139T ATE378400T1 (de) 2001-02-14 2002-02-14 Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben

Country Status (4)

Country Link
US (2) US7338774B2 (de)
EP (2) EP1233060B1 (de)
AT (2) ATE393821T1 (de)
DE (2) DE60223432T2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501257B2 (en) 2003-02-26 2009-03-10 Sysmex Corporation Molecular diagnostic method of a cancer tissue or a cancer cell
DE602005024964D1 (de) * 2004-05-31 2011-01-05 Sysmex Corp Verfahren zur beurteilung der malignität einer säuger-krebszelle
US20110136131A1 (en) * 2004-06-01 2011-06-09 Sysmex Corporation Method for measuring enzyme activity and column for use in measuring enzyme activity
EP1634603A1 (de) * 2004-08-26 2006-03-15 Eberhard-Karls-Universität Tübingen Universitätsklinikum Behandlung von transformierten oder infizierten biologischen Zellen
US7348159B2 (en) 2005-04-20 2008-03-25 Boehringer Ingelheim International Gmbh Methods for determining phosphoryltransferase activity using adenosine 5'-triphosphate (ATP)-gamma-S
DE602006001701D1 (de) 2005-08-01 2008-08-21 Sysmex Corp Verfahren zur Beurteilung der Beschaffenheit maligner Tumore
JP4766969B2 (ja) 2005-09-14 2011-09-07 シスメックス株式会社 組織性質判定装置
JP4841266B2 (ja) 2005-09-27 2011-12-21 シスメックス株式会社 被検出物質の検出方法
JP2007097448A (ja) * 2005-09-30 2007-04-19 Sysmex Corp 組織の性質判定用試薬キット
JP5111902B2 (ja) * 2007-03-14 2013-01-09 シスメックス株式会社 癌の診断支援装置
EP2028600B1 (de) 2007-08-24 2016-10-26 Sysmex Corporation Diagnose-Hilfssystem für Krebs, Diagnosehilfe für Informationen über das Krebsverfahren und Computerprogrammprodukt
JP2010057486A (ja) 2008-09-02 2010-03-18 Sysmex Corp 化学療法に対するがん患者の応答の予測方法
JP5830249B2 (ja) 2010-03-31 2015-12-09 シスメックス株式会社 癌細胞のアンスラサイクリン系抗癌剤への感受性の判定方法及びコンピュータプログラム
JP6002379B2 (ja) 2011-11-29 2016-10-05 シスメックス株式会社 癌の再発リスクの判定方法及びその利用
JP6214449B2 (ja) * 2014-03-31 2017-10-18 シスメックス株式会社 キナーゼ活性の測定方法
CN106324255A (zh) * 2016-08-17 2017-01-11 山东博科生物产业有限公司 一种稳定性强的生化用特种蛋白液体复合质控品
CN106876715B (zh) * 2017-03-30 2020-03-17 湖北金泉新材料有限责任公司 一种含碳纳米管的正极浆料、其制备方法及用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4252783A (en) * 1979-06-18 1981-02-24 Syva Company Reducing fluorescent background in fluorescent immunoassays
DE3049033A1 (de) * 1980-12-24 1982-07-22 Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt "ringinterferometer"
US5518911A (en) * 1995-01-06 1996-05-21 Onyx Pharmaceuticals, Inc. Human PAK65
EP0915989B1 (de) * 1996-07-16 2010-06-02 The Regents Of The University Of California Tests auf proteinkinasen mit fluoreszierenden proteinsubstraten
WO1999007705A1 (en) * 1997-08-07 1999-02-18 The Regents Of The University Of California Purine inhibitor of protein kinases, g proteins and polymerases
DK1036192T3 (da) * 1997-12-05 2003-06-10 Upjohn Co Fluorescensbaserede screeningsanalyser med høj hastighedforproteinkinaser og phosphataser
GB2334578A (en) * 1998-02-18 1999-08-25 Univ Liverpool Diagnosis of cancer involving assay of levels of cyclin-dependent kinase (CDK) isoenzymes

Also Published As

Publication number Publication date
ATE378400T1 (de) 2007-11-15
EP1233060A3 (de) 2003-10-15
EP1233060B1 (de) 2007-11-14
DE60223432T2 (de) 2008-09-18
DE60226353D1 (de) 2008-06-12
DE60223432D1 (de) 2007-12-27
DE60226353T2 (de) 2009-06-10
US20070264624A1 (en) 2007-11-15
EP1609854B1 (de) 2008-04-30
EP1233060A2 (de) 2002-08-21
US7338774B2 (en) 2008-03-04
US20020164673A1 (en) 2002-11-07
EP1609854A1 (de) 2005-12-28

Similar Documents

Publication Publication Date Title
ATE378400T1 (de) Verfahren zur bestimmung der aktivität des zellzyklus-regulationsfaktors und verfahren zur diagnose von krebs unter verwendung desselben
AU671928B2 (en) Infra-red dye-labelled nucleotides and their use in nucleic acid detection
CN103403533B (zh) 用于分辨光信号检测器中不同调制频率的光信号的系统和方法
CN101213439B (zh) 测定非挥发性分析物浓度的方法
JP3098545B2 (ja) ビス−ジカチオンアリールフラン類を用いる核酸および細胞骨格成分の蛍光検出方法
CN105823768B (zh) 一种基于表面增强拉曼散射技术的检测芯片、制备方法以及试剂盒
CN104892541A (zh) 一种用于γ-谷氨酰转肽酶检测的荧光探针及其制备方法与应用
DE69841388D1 (de) Verfahren für verbesserte lumineszenztests unter verwendung von mikropartikeln
ATE416385T1 (de) Verfahren zur quantifizierung der phosphokinaseaktivität auf proteinen
CN101416054A (zh) 荧光测定法
DE3686888T2 (de) Verfahren zum nachweis und zur quantitativbestimmung von immunologischen stoffen.
EP1476575A2 (de) Nachweis von einzelnukleotidpolymorphismen mittels planarer wellenleiter
CN104237193B (zh) 一种检测焦磷酸酶的荧光传感器及其制备方法
CN106279124A (zh) 一种用于检测酪氨酸酶的荧光探针及其制备方法与应用
CN103940808B (zh) 一种双信号放大电化学发光生物传感器的制备方法及应用
JP2009186350A (ja) リン酸イオンの検出方法および検出用キット
JP6374967B2 (ja) 多孔質基材における核酸増幅の検出
CN102168146B (zh) 高特异性高灵敏度的基因芯片及其制备方法与应用
CN109988816A (zh) 一种腺苷脱氨酶测定试剂盒
CN102171367A (zh) 在载体上测试核酸并对其质量控制的方法
Zuber et al. A descriptive model for the kinetics of a homogeneous fluorometric immunoassay
ATE439451T1 (de) Verfahren und kit zur bestimmung von thymidinkinase-aktivität und verwendung davon
CN108139393A (zh) 执行生化学检查与免疫反应检查的多功能装置及其检查方法
CN201993315U (zh) 葡萄糖氧化酶化学发光测定法试剂盒
CN103866023A (zh) 一种检测cyp2c19基因多态性的测序引物、试剂盒及检测方法

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties