DE60215461D1 - Serpin von bifidobakterien - Google Patents

Serpin von bifidobakterien

Info

Publication number
DE60215461D1
DE60215461D1 DE60215461T DE60215461T DE60215461D1 DE 60215461 D1 DE60215461 D1 DE 60215461D1 DE 60215461 T DE60215461 T DE 60215461T DE 60215461 T DE60215461 T DE 60215461T DE 60215461 D1 DE60215461 D1 DE 60215461D1
Authority
DE
Germany
Prior art keywords
sequences
polypeptides
ncc2705
pertains
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60215461T
Other languages
English (en)
Other versions
DE60215461T2 (de
Inventor
Fabrizio Arigoni
Stephanie Blum
Michele Delley
Alan Schell
Eduardo Schiffrin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Societe des Produits Nestle SA
Nestle SA
Original Assignee
Societe des Produits Nestle SA
Nestle SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe des Produits Nestle SA, Nestle SA filed Critical Societe des Produits Nestle SA
Application granted granted Critical
Publication of DE60215461D1 publication Critical patent/DE60215461D1/de
Publication of DE60215461T2 publication Critical patent/DE60215461T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/12Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/123Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt
    • A23C9/1234Fermented milk preparations; Treatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceae; Yoghurt characterised by using a Lactobacillus sp. other than Lactobacillus Bulgaricus, including Bificlobacterium sp.
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C2220/00Biochemical treatment
    • A23C2220/20Treatment with microorganisms
    • A23C2220/202Genetic engineering of microorganisms used in dairy technology
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/51Bifidobacterium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81Protease inhibitors
    • G01N2333/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121Serpins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Polymers & Plastics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
DE60215461T 2001-01-30 2002-01-30 Serpin von bifidobakterien Expired - Lifetime DE60215461T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01102050 2001-01-30
EP01102050A EP1227152A1 (de) 2001-01-30 2001-01-30 Bakterienstamm und Genom des Bifidobacteriums
PCT/EP2002/000956 WO2002060932A2 (en) 2001-01-30 2002-01-30 A serpin in bifidobacteria

Publications (2)

Publication Number Publication Date
DE60215461D1 true DE60215461D1 (de) 2006-11-30
DE60215461T2 DE60215461T2 (de) 2007-05-03

Family

ID=8176339

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215461T Expired - Lifetime DE60215461T2 (de) 2001-01-30 2002-01-30 Serpin von bifidobakterien

Country Status (12)

Country Link
US (2) US7183101B2 (de)
EP (3) EP1227152A1 (de)
JP (2) JP4570329B2 (de)
CN (3) CN100558896C (de)
AT (1) ATE342986T1 (de)
AU (3) AU2002302360A1 (de)
CA (2) CA2435664C (de)
DE (1) DE60215461T2 (de)
DK (1) DK1358332T3 (de)
ES (2) ES2274019T3 (de)
PT (2) PT1360299E (de)
WO (3) WO2002074798A2 (de)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001241934A1 (en) 2000-03-03 2001-09-17 Beckman Coulter Inc. Multiplex hybridization system for identification of pathogenic mycobacterium and method of use
EP1227152A1 (de) * 2001-01-30 2002-07-31 Société des Produits Nestlé S.A. Bakterienstamm und Genom des Bifidobacteriums
EP1264893A1 (de) * 2001-06-08 2002-12-11 Teagasc Dairy Products Research Centre Biosynthese von CLA durch Bifidobakterien
EP1462516B2 (de) * 2001-12-03 2013-04-17 Kyowa Hakko Bio Co., Ltd. Mutierte 6-phosphogluconat-dehydrogenase
US7268221B2 (en) 2002-08-23 2007-09-11 E.I. Du Pont De Nemours And Company Alpha(1,6)-linked glucose oligosaccharide hydrolyzing enzyme polynucleotides and polypeptides and methods of use thereof
EP2228379A1 (de) 2003-04-25 2010-09-15 North Carolina State University Für Zelloberflächenproteinhomologe codierende Nukleinsäuresequenzen aus Lactobacillus acidophilus
JP4866725B2 (ja) 2003-06-23 2012-02-01 ノース キャロライナ ステイト ユニヴァーシティー フラクトオリゴ糖利用化合物をコードするアシドフィルス菌核酸及びその使用
WO2005000882A2 (en) * 2003-06-27 2005-01-06 University College Cork - National University Of Ireland, Cork Dna fragments and proteins encoded by said dna isolated from bifidobacteria
JP4384656B2 (ja) 2003-06-30 2009-12-16 クラサド インコーポレイテッド 新規のガラクトシダーゼ酵素活性を生じさせるビフィドバクテリウムビフィダムの新規株
KR100492455B1 (ko) * 2003-09-26 2005-05-30 주식회사 비피도 로바타바이러스 억제활성을 갖는 신균주 비피도 박테리움 롱검 에이알81 및 이로부터 분리된 활성단백질
WO2005034971A2 (en) * 2003-10-08 2005-04-21 Masami Moriyama Antiviral agent
US8877178B2 (en) 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
US20050158294A1 (en) 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
US7455992B2 (en) 2004-02-23 2008-11-25 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding protease homologues and uses therefore
WO2005085478A2 (en) * 2004-02-27 2005-09-15 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Detection and identification of mycobacterium and nocardia using primers and probes directed to the seca1 gene
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
US7459289B2 (en) 2004-03-08 2008-12-02 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
US7550576B2 (en) 2004-08-09 2009-06-23 North Carolina State University Nucleic acid sequences encoding two-component sensing and regulatory proteins, antimicrobial proteins and uses therefor
JP4784224B2 (ja) * 2004-09-24 2011-10-05 味の素株式会社 糖鎖転移方法および糖鎖転移酵素
EP1814995A2 (de) 2004-10-27 2007-08-08 North Carolina State University Nukleinsäuren aus lactobacillus acidophilus und deren verwendung
US7495092B2 (en) 2005-01-14 2009-02-24 North Carolina State University Compositions comprising promoter sequences and methods of use
DK1856148T3 (da) 2005-03-07 2013-05-21 Barbara Kofler Neuropeptider
ES2325887T3 (es) * 2005-05-16 2009-09-23 Universite De Liege Especie bifidobacteriana probiotica.
AR052472A1 (es) 2005-05-31 2007-03-21 Iams Company Lactobacilos probioticos para felinos
EP1885383B1 (de) 2005-05-31 2016-09-21 IAMS Europe B.V. Katzen probiotisches bifidobacterium
GB0525857D0 (en) * 2005-12-20 2006-02-01 Product and process
GB0601901D0 (en) 2006-01-31 2006-03-08 Product and Process
GB0606112D0 (en) 2006-03-28 2006-05-03 Product and process
CN100389125C (zh) * 2006-05-30 2008-05-21 中国科学院昆明动物研究所 无指盘臭蛙丙精肽、基因和变异体
WO2008093303A2 (en) 2007-02-01 2008-08-07 The Iams Company Method for decreasing inflammation and stress in a mammal using glucose antimetaboltes, avocado or avocado extracts
CN101273738B (zh) * 2007-03-28 2011-06-01 哈尔滨正方科技有限公司 在常温下保持高活菌数的调配型酸性乳饮料的制备方法
EP2522358B1 (de) * 2007-06-27 2016-11-09 Laboratorios Ordesa, S.l. Peptide gegen Infektionen mit Rotaviren
EP2053122A1 (de) * 2007-10-23 2009-04-29 Nestec S.A. Stresstolerante Bifidobakterien
US9730968B2 (en) 2008-04-17 2017-08-15 Anaeropharma Science, Inc. Therapeutic agent for ischemic diseases
CN101570755B (zh) * 2008-04-29 2011-09-28 中国农业科学院植物保护研究所 一种细菌源蛋白酶抑制剂新基因及其表达与应用
US9771199B2 (en) * 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
US9232813B2 (en) * 2008-07-07 2016-01-12 The Iams Company Probiotic supplement, process for making, and packaging
MX349705B (es) 2008-11-11 2017-08-09 Alimentary Health Ltd Bifidobacterium longum.
PT2429539T (pt) * 2009-05-11 2017-01-12 Nestec Sa Lactobacilos johnsonii la1 ncc533 não replicativo (cncm i-1225) e distúrbios imunitários
BRPI0925002A2 (pt) 2009-05-27 2016-06-21 Clasado Inc uso de uma composição para a prevenção de diarréia
EP2270134A1 (de) * 2009-07-03 2011-01-05 Nestec S.A. Gegen oxidativen Stress resistente Bifido-Bakterien
US10104903B2 (en) 2009-07-31 2018-10-23 Mars, Incorporated Animal food and its appearance
EP2467032B1 (de) * 2009-08-18 2018-02-21 Nestec S.A. Ernährungszusammensetzung mit bifidobacterium longum-ketten zur reduktion von lebensmittelallergiesymptomen, insbesondere bei kleinkindern und kindern
JPWO2011027875A1 (ja) * 2009-09-03 2013-02-04 独立行政法人理化学研究所 腸管バリア機能改善剤
EP2823822B1 (de) * 2009-11-11 2016-10-12 Alimentary Health Limited Bifidobakteriumstamm
AU2011206532B8 (en) 2010-01-14 2015-08-06 Inserm (Institut National De La Sante Et De La Recherche Medicale) Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)
JP5836129B2 (ja) 2010-01-29 2015-12-24 株式会社アネロファーマ・サイエンス 形質転換用プラスミド
US8755425B2 (en) * 2010-06-30 2014-06-17 Comtech Ef Data Corp. Method and system for transmission of identification via metadata for repeating relays using spread-spectrum technology
CN101880668B (zh) * 2010-05-07 2012-05-23 广西大学 一种编码丝氨酸蛋白酶抑制剂的基因及其应用
EP2397145A1 (de) * 2010-06-18 2011-12-21 Nestec S.A. L. johnsonii La1, B. longum NCC2705 und Immunerkrankungen
CN101884782B (zh) * 2010-06-29 2015-09-16 南昌大学 长双歧杆菌粘附抑制蛋白Aip在防治腹泻中的应用
CN105647715B (zh) 2010-07-02 2019-10-25 宝洁公司 洗涤剂产品
BR112013000101A2 (pt) 2010-07-02 2016-05-17 Procter & Gamble filamentos compreendendo mantas de não tecido com agente ativo e métodos de fabricação dos mesmos
BR112013000044B1 (pt) 2010-07-02 2022-01-04 The Procter & Gamble Company Método para a distribuição de agentes ativos a artigos de tecido ou superfícies duras
EP2449891A1 (de) * 2010-11-05 2012-05-09 Nestec S.A. Trinkjoghurtzubereitungen mit nicht-replizierenden probiotischen Mikroorganismen
GB201021399D0 (en) * 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
TWI487530B (zh) * 2011-01-10 2015-06-11 可產生高免疫激活反應之比菲德氏龍根菌分離株
CN103649321B (zh) * 2011-04-05 2019-07-16 拉勒曼德匈牙利流动性管理有限责任公司 用于通过添加交替电子受体改善微生物中的产品收率和产量的方法
CA2841451A1 (en) * 2011-07-13 2013-01-17 Anaeropharma Science, Inc. Ischemic disease therapeutic agent
GB201112091D0 (en) 2011-07-14 2011-08-31 Gt Biolog Ltd Bacterial strains isolated from pigs
GB201117313D0 (en) 2011-10-07 2011-11-16 Gt Biolog Ltd Bacterium for use in medicine
RU2527069C2 (ru) * 2011-11-08 2014-08-27 Автономная Некоммерческая Организация "Научно-исследовательский центр биотехнологи антибиотиков и других биологически активных веществ "БИОАН" СПОСОБ ВИДОВОЙ И ШТАММОВОЙ ИДЕНТИФИКАЦИИ БИФИДОБАКТЕРИЙ ФИЛОТИПА Bifidobacterium longum
BR112014021388A2 (pt) 2012-02-29 2017-07-18 Ethicon Endo Surgery Inc composições de microbiota e métodos rela-cionados às mesmas
US8686114B2 (en) 2012-03-05 2014-04-01 E I Du Pont De Nemours And Company Variant sucrose transporter polypeptides
US9161957B2 (en) 2012-08-03 2015-10-20 Life Well Lived, Llc Compositions and methods for reducing blood alcohol content
ES2821383T3 (es) * 2012-10-17 2021-04-26 Enterome Firmas genéticas de trastornos inflamatorios relacionados con el hígado y la enfermedad de Crohn
FR2999933B1 (fr) * 2012-12-21 2020-01-31 Société des Produits Nestlé S.A. Utilisation de microorganismes probiotiques comme agent favorisant la synthese de melanine
GB201306536D0 (en) 2013-04-10 2013-05-22 Gt Biolog Ltd Polypeptide and immune modulation
WO2015021530A1 (en) * 2013-08-12 2015-02-19 Mansel Griffiths Antiviral methods and compositions comprising probiotic bacterial molecules
KR20170002403A (ko) * 2014-05-01 2017-01-06 가부시키가이샤 아네로파마·사이엔스 이종 폴리펩티드 발현 카세트
WO2015166641A1 (ja) 2014-05-02 2015-11-05 国立大学法人信州大学 抗体遺伝子の発現・分泌システム
GB2551642B (en) 2014-10-31 2020-09-23 Pendulum Therapeutics Inc Methods and compositions relating to microbial treatment and diagnosis of disorders
CA2969100C (en) * 2014-12-03 2023-03-21 Anaeropharma Science, Inc. Coexpression plasmid
US20180267037A1 (en) * 2014-12-23 2018-09-20 Evolve Biosystems Inc. Method for the noninvasive detection of activated bifidobacteria
EP3395351A1 (de) 2014-12-23 2018-10-31 4D Pharma Research Limited Immunmodulation
JP6427278B2 (ja) 2014-12-23 2018-11-21 フォーディー ファーマ リサーチ リミテッド4D Pharma Research Limited pirinポリペプチド及び免疫モジュレーション
GB201508860D0 (en) 2015-05-22 2015-07-01 Nat Univ Ireland Diagnostic method
CN107847529B (zh) 2015-06-15 2022-05-03 4D制药研究有限公司 包含细菌菌株的组合物
PT3650033T (pt) 2015-06-15 2022-05-25 4D Pharma Res Ltd Composições compreendendo estirpes bacterianas
MA41060B1 (fr) 2015-06-15 2019-11-29 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
BR112017025005A2 (pt) 2015-06-15 2018-08-07 4D Pharma Research Limited composições compreendendo cepas baterianas
MA41010B1 (fr) 2015-06-15 2020-01-31 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
MA41013A (fr) 2015-11-20 2017-08-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
GB201520497D0 (en) 2015-11-20 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520638D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
GB201520631D0 (en) 2015-11-23 2016-01-06 4D Pharma Res Ltd Compositions comprising bacterial strains
EA035949B1 (ru) 2016-03-04 2020-09-04 4Д ФАРМА ПиЭлСи Применение композиции, содержащей бактериальный штамм вида blautia hydrogenotrophica, и способ лечения или предотвращения висцеральной гиперчувствительности
GB201612191D0 (en) 2016-07-13 2016-08-24 4D Pharma Plc Compositions comprising bacterial strains
CN105694892A (zh) * 2016-03-16 2016-06-22 山东大学 一种表面带正电荷的CdSe量子点的制备方法
TW201821093A (zh) 2016-07-13 2018-06-16 英商4D製藥有限公司 包含細菌菌株之組合物
US10738338B2 (en) 2016-10-18 2020-08-11 The Research Foundation for the State University Method and composition for biocatalytic protein-oligonucleotide conjugation and protein-oligonucleotide conjugate
CN106478812B (zh) * 2016-10-21 2020-11-20 沈阳药科大学 丝氨酸蛋白酶抑制剂-3及其功能、制备方法和应用
GB201621123D0 (en) 2016-12-12 2017-01-25 4D Pharma Plc Compositions comprising bacterial strains
JP6882519B2 (ja) 2017-01-27 2021-06-02 ザ プロクター アンド ギャンブル カンパニーThe Procter & Gamble Company 発泡性凝集粒子を含む溶解性固形構造体形態の組成物
CA3059275A1 (en) 2017-04-11 2018-10-18 Chr. Hansen A/S Lactase enzymes with improved properties
MX2019013048A (es) 2017-05-16 2019-12-11 Procter & Gamble Composiciones acondicionadoras para el cuidado del cabello en la forma de estructuras solidas solubles.
MA48939B1 (fr) 2017-05-22 2021-06-30 4D Pharma Res Ltd Compositions comprenant des souches bactériennes
WO2018215782A1 (en) 2017-05-24 2018-11-29 4D Pharma Research Limited Compositions comprising bacterial strain
HUE053488T2 (hu) 2017-06-14 2021-06-28 4D Pharma Res Ltd Baktériumtörzseket tartalmazó készítmények
LT3638271T (lt) 2017-06-14 2021-01-11 4D Pharma Research Limited Kompozicijos, apimančios bakterines padermes
MD3600364T2 (ro) 2017-06-14 2020-12-31 4D Pharma Res Ltd Compoziții care conţin tulpină bacteriană din genul Megasphaera și utilizări ale acestora
AU2018326705A1 (en) 2017-08-30 2020-03-05 Pendulum Therapeutics, Inc. Methods and compositions for treatment of microbiome-associated disorders
US20200216787A1 (en) * 2017-09-18 2020-07-09 Dupont Nutrition Biosciences Aps Riboflavinase enzymes and their use to prevent off flavor in brewing
US11666514B2 (en) 2018-09-21 2023-06-06 The Procter & Gamble Company Fibrous structures containing polymer matrix particles with perfume ingredients
WO2020079116A1 (en) * 2018-10-17 2020-04-23 Chr. Hansen A/S Lactase enzymes with improved properties at acidic ph
CN110343672B (zh) * 2018-12-27 2021-07-06 华东理工大学 一种抗尿苷酸反馈抑制的氨甲酰磷酸合成酶突变体及其应用
JP2021083433A (ja) * 2019-11-29 2021-06-03 地方独立行政法人神奈川県立産業技術総合研究所 抗原結合分子、核酸組成物、ベクター組成物、細胞およびBifidobacterium longumの精製方法
EP4188554A1 (de) 2020-07-31 2023-06-07 The Procter & Gamble Company Wasserlöslicher faserbeutel mit perlen zur haarpflege
CN112458015B (zh) * 2020-11-27 2021-11-19 石家庄君乐宝乳业有限公司 长双歧杆菌长亚种i772、其分离纯化方法及应用
KR102271333B1 (ko) * 2021-01-29 2021-06-30 씨제이제일제당 (주) 신규한 미코티온 리덕타제 변이체 및 이를 이용한 l-라이신 생산 방법
CN113957073B (zh) * 2021-10-19 2023-09-01 山东寿光巨能金玉米开发有限公司 一种tkt基因启动子突变体及其在生产L-赖氨酸中的应用
CN114774335B (zh) * 2022-06-22 2022-09-02 广东省科学院微生物研究所(广东省微生物分析检测中心) 具有靶向葡萄糖激酶显著降血糖和降血脂功效的长双歧杆菌070103及其应用
CN116334263A (zh) * 2023-04-21 2023-06-27 四川农业大学 一种用于检测鱼类鳃结节病病原菌的双重pcr引物、试剂盒及检测方法
CN116814822B (zh) * 2023-08-25 2023-11-24 中国食品发酵工业研究院有限公司 一种长双歧杆菌婴儿亚种cicc 6069菌株的鉴定方法和应用
CN117551799B (zh) * 2024-01-11 2024-03-19 广东海洋大学 用于鰤鱼诺卡氏菌菌株分型的引物组合、多重pcr鉴定方法及应用
CN118086539A (zh) * 2024-03-05 2024-05-28 中国食品发酵工业研究院有限公司 长双歧杆菌婴儿亚种的PMA-qPCR活菌定量检测方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0687732B2 (ja) * 1987-02-25 1994-11-09 カルピス食品工業株式会社 ビフイズス菌入り発酵乳の製造法
DE69219768T2 (de) * 1992-07-06 1997-08-28 Societe Des Produits Nestle S.A., Vevey Milchbakterien
US6737248B2 (en) * 1996-01-05 2004-05-18 Human Genome Sciences, Inc. Staphylococcus aureus polynucleotides and sequences
DE69737125T3 (de) * 1996-10-31 2015-02-26 Human Genome Sciences, Inc. Streptococcus pneumoniae-Antigene und Impfstoffe
JP2002529046A (ja) * 1997-05-06 2002-09-03 ヒューマン ジノーム サイエンシーズ,インコーポレイテッド Enterococcus faecalisのポリヌクレオチドおよびポリペプチド
JP4046389B2 (ja) * 1997-09-04 2008-02-13 株式会社ヤクルト本社 ビフィドバクテリウム・ブレーベ及びこれを用いた発酵豆乳
EP1227152A1 (de) * 2001-01-30 2002-07-31 Société des Produits Nestlé S.A. Bakterienstamm und Genom des Bifidobacteriums

Also Published As

Publication number Publication date
CN1500146A (zh) 2004-05-26
CN101671640A (zh) 2010-03-17
JP4570329B2 (ja) 2010-10-27
US7700315B2 (en) 2010-04-20
WO2002060931A2 (en) 2002-08-08
US20040126870A1 (en) 2004-07-01
DE60215461T2 (de) 2007-05-03
WO2002074798A2 (en) 2002-09-26
AU2002249151A1 (en) 2002-08-12
ES2420907T3 (es) 2013-08-27
EP1360299A2 (de) 2003-11-12
PT1358332E (pt) 2007-01-31
JP4249483B2 (ja) 2009-04-02
WO2002060932A2 (en) 2002-08-08
WO2002060931A3 (en) 2002-10-24
US7183101B2 (en) 2007-02-27
AU2002302360A1 (en) 2002-10-03
CA2436049A1 (en) 2002-08-08
CN100516220C (zh) 2009-07-22
WO2002074798A3 (en) 2002-12-12
EP1227152A1 (de) 2002-07-31
JP2004531229A (ja) 2004-10-14
EP1358332A2 (de) 2003-11-05
AU2002247668A1 (en) 2002-08-12
PT1360299E (pt) 2013-07-16
CN101671640B (zh) 2012-08-22
CA2436049C (en) 2012-01-03
CN1518598A (zh) 2004-08-04
DK1358332T3 (da) 2007-01-08
EP1360299B1 (de) 2013-04-10
ES2274019T3 (es) 2007-05-16
WO2002060932A3 (en) 2003-06-05
CN100558896C (zh) 2009-11-11
CA2435664C (en) 2013-04-30
US20040115773A1 (en) 2004-06-17
CA2435664A1 (en) 2002-09-26
ATE342986T1 (de) 2006-11-15
EP1358332B1 (de) 2006-10-18
JP2004531245A (ja) 2004-10-14

Similar Documents

Publication Publication Date Title
DE60215461D1 (de) Serpin von bifidobakterien
DK1032674T3 (da) Chlamydia pneumoniae genomisk sekvens og polypeptider, fragmenter deraf og anvendelser deraf, især til diagnosen, forebyggelsen og behandlingen af infektion
WO1999028475A3 (en) Chlamydia trachomatis genomic sequence and polypeptides, fragments thereof and uses thereof, in particular for the diagnosis, prevention and treatment of infection
AU2002345084A1 (en) Process for the preparation of l-amino acids using strains of the enterobacteriaceae family which contain an enhanced succ or sucd gene
DE69841894D1 (de) Äusseres Membranpolypeptid von Chlamydia pneumoniae sowie Fragmente davon und deren Verwendung, insbesondere zur Diagnose, Prävention und Behandlung einer Infektion
GR3031152T3 (en) 5' to 3' exonuclease mutations of thermostable dna polymerases
WO2003004675A3 (en) Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
ATE256196T1 (de) Chimäre vektoren, die die verpackungsregion eines phagengenoms und einen teil des genoms eines eukaryontischen virus enthalten
AU2003223971A8 (en) La1 - the genome of a lactobacillus strain
WO2003056021A3 (en) Modified tetracycline repressor protein compositions and methods of use
Sul et al. Rapid identification of Lactobacillus and Bifidobacterium in probiotic products using multiplex PCR
RU94046362A (ru) Последовательности днк, плазмиды, применение плазмиды, растения, бактерии, применение последовательности днк, дрожжевые штаммы
Meyer et al. Taxonomic heterogeneity, as shown by siderotyping, of strains primarily identified as Pseudomonas putida
EP1788075A4 (de) Grosstechnisch geeigneter mikroorganismus
WO2002068662A8 (en) Plasmid originated from bifidobacterium, recombinant expression vector using the plasmid and transformation method
Esikova et al. Key role of the dca genes in ε-caprolactam catabolism in Pseudomonas strains
WO2001060975A3 (en) Gene disruption methodologies in fungi for drug target discovery
AU2002346803A1 (en) Genes encoding for carbon metabolism and energy-producing proteins
Juárez et al. Biosensor libraries harness large classes of binding domains for allosteric transcription regulators
AU2002342763A1 (en) Process for the preparation of non-aromatic l-amino acids using strains of the enterobacteriaceae family
WO2003076636A3 (en) Process for the preparation of l-amino acids using strains of the enterobacteriaceae family
Gharbia et al. Unique expression mechanisms among oral anaerobes: implications of genome size and regulatory components
ES2208033B1 (es) Metodo de identificacion de microorganismos basado en la amplificacion de dna.
Schuster et al. Plenarvorträge
Clancy et al. Correction for Clancy

Legal Events

Date Code Title Description
8364 No opposition during term of opposition