DE602004014525D1 - 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs - Google Patents

6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Info

Publication number
DE602004014525D1
DE602004014525D1 DE602004014525T DE602004014525T DE602004014525D1 DE 602004014525 D1 DE602004014525 D1 DE 602004014525D1 DE 602004014525 T DE602004014525 T DE 602004014525T DE 602004014525 T DE602004014525 T DE 602004014525T DE 602004014525 D1 DE602004014525 D1 DE 602004014525D1
Authority
DE
Germany
Prior art keywords
halo
aryl
imidazoä1
aüpyrimidine
against cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE602004014525T
Other languages
German (de)
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC, Wyeth LLC filed Critical Wyeth Holdings LLC
Publication of DE602004014525D1 publication Critical patent/DE602004014525D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE602004014525T 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs Expired - Lifetime DE602004014525D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
DE602004014525D1 true DE602004014525D1 (de) 2008-07-31

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004014525T Expired - Lifetime DE602004014525D1 (de) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazoä1,2-aüpyrimidine als mittel gegen krebs

Country Status (14)

Country Link
US (2) US7285555B2 (https=)
EP (1) EP1684763B1 (https=)
JP (1) JP4695595B2 (https=)
CN (1) CN100486580C (https=)
AT (1) ATE398452T1 (https=)
AU (1) AU2004275728A1 (https=)
BR (1) BRPI0414778A (https=)
CA (1) CA2537520A1 (https=)
DE (1) DE602004014525D1 (https=)
DK (1) DK1684763T3 (https=)
ES (1) ES2308256T3 (https=)
MX (1) MXPA06002939A (https=)
PL (1) PL1684763T3 (https=)
WO (1) WO2005030218A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2353593A1 (en) * 1998-12-18 2000-06-22 Hadasit Medical Research Services & Development Ltd. Method of administering a compound to multi-drug resistant cells
SI2495016T1 (sl) 2005-12-23 2020-04-30 Ariad Pharmaceuticals, Inc. Biciklične heteroarilne spojine
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW224044B (https=) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
JP2794510B2 (ja) * 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) * 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) * 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) * 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) * 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
DK0984919T3 (da) 1997-03-18 2003-05-12 Basf Ag Fremgangsmåde til fremstilling af arylmalonater
US5750766A (en) * 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US6255309B1 (en) * 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) * 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5948783A (en) * 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) * 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) * 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
HUP0100885A3 (en) 1998-02-11 2002-12-28 American Cyanamid Company Madi Fungicidal 7-alkyl-triazolopyrimidines
US6124301A (en) * 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
AU752669B2 (en) 1998-03-23 2002-09-26 Basf Aktiengesellschaft Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) * 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) * 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) * 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) * 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
ES2203021T3 (es) 1998-09-25 2004-04-01 Basf Aktiengesellschaft Mezclas fungicidas.
US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US5986135A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
JP2002525291A (ja) 1998-09-25 2002-08-13 アメリカン サイアナミツド コンパニー 非水性懸濁液濃縮物
US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) * 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
AU2001273062B2 (en) * 2000-06-30 2005-11-24 Wyeth Substituted-triazolopyrimidines as anticancer agents
ES2223932T3 (es) * 2000-08-25 2005-03-01 Basf Aktiengesellschaft Formulacion fungicida.
DE60013188T2 (de) 2000-12-06 2004-12-30 Basf Ag Fungiizide 6-(trifluormethyl-phenyl)-triazolpyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
CZ295558B6 (cs) 2001-04-11 2005-08-17 Basf Aktiengesellschaft 5-Halogen-6-fenyl-7-fluoralkylamino-triazolopyrimidiny, způsob jejich přípravy a prostředek pro potírání fytopatogenních hub
ES2287312T3 (es) 2001-09-04 2007-12-16 Sumitomo Chemical Company, Limited Imidazo(1,2-a)pirimidinas y composiciones fungicidas que las contienen.
WO2003089433A1 (en) * 2002-04-19 2003-10-30 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO[1,2-a]PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
ES2308256T3 (es) 2008-12-01
EP1684763A1 (en) 2006-08-02
BRPI0414778A (pt) 2006-11-21
US20050065167A1 (en) 2005-03-24
ATE398452T1 (de) 2008-07-15
CA2537520A1 (en) 2005-04-07
DK1684763T3 (da) 2008-09-01
US7285555B2 (en) 2007-10-23
CN100486580C (zh) 2009-05-13
US20080255157A1 (en) 2008-10-16
JP4695595B2 (ja) 2011-06-08
AU2004275728A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
MXPA06002939A (es) 2006-05-31
JP2007506745A (ja) 2007-03-22
WO2005030218A1 (en) 2005-04-07
EP1684763B1 (en) 2008-06-18
PL1684763T3 (pl) 2008-11-28
CN1856311A (zh) 2006-11-01

Similar Documents

Publication Publication Date Title
TR201900306T4 (tr) Mek inhibitörlerini kullanma yöntemleri.
IL260127B (en) mek inhibitors and methods of using them
BRPI0510177B8 (pt) composto, composição farmacêutica e uso do mesmo
EA200801998A1 (ru) ПИРИДИН[3,4-b]ПИРАЗИНОНЫ
UA93351C2 (uk) Похідні фталазіну як інгібітори parp
ATE440603T1 (de) 8-hydroxychinolinderivate
PT2420234E (pt) 1h-benzimidazole-4-carboxamidas substituídas com um carbono quaternário na posição 2 como inibidores de parp para uso no tratamento do cancro
MA29857B1 (fr) Derives de triazolopyridine en tant qu'inhibiteurs de lipases et phospholipases
ATE543819T1 (de) Heteroarylverbindungen, zusammensetzungen daraus und behandlungsverfahren damit
DE602004025698D1 (de) PYRIDINOi1,2-A PYRIMIDIN-4-ONVERBINDUNGEN ALS MITTEL GEGEN KREBS
EA200801428A1 (ru) Производные пиридиазинона для лечения опухолей
WO2006020722A3 (en) Polymer conjugates of beta-lapachone and beta-lapachone analogs for tumor targeting
EA201001196A1 (ru) Соединения 4-пиридинона и их применение для лечения рака
WO2005004808A3 (en) TETRACYCLIC COMPOUNDS AS c-MET INHIBITORS
EA200970936A1 (ru) СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА
EA201170344A1 (ru) Азаиндольные ингибиторы iap
MX2007013624A (es) Inhibidores de proteina cinasa.
GEP20125603B (en) Novel 4-(tetrazol-5-yl)-quinazoline derivatives as anti cancer agents
DK1313740T3 (da) Prodrugs af imidazopyridinderivater
WO2006125555A3 (de) Chinazolinone
ATE516031T1 (de) Verbindungen gegen krebs
DE602006020295D1 (de) Azabenzimidalzolderivate, ihre herstellung und ihre verwendung als antikrebsmittel
MX2007002525A (es) Compuestos de difeniletileno y usos de los mismos.
EA200901180A1 (ru) Производные тетрагидрохинолина и их применение для лечения злокачественного новообразования
EA200600601A1 (ru) Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы

Legal Events

Date Code Title Description
8364 No opposition during term of opposition