CN100486580C - 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 - Google Patents

作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Download PDF

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Publication number
CN100486580C
CN100486580C CNB2004800273126A CN200480027312A CN100486580C CN 100486580 C CN100486580 C CN 100486580C CN B2004800273126 A CNB2004800273126 A CN B2004800273126A CN 200480027312 A CN200480027312 A CN 200480027312A CN 100486580 C CN100486580 C CN 100486580C
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CN
China
Prior art keywords
alkyl
pharmaceutically acceptable
formula
chemical compound
acceptable salt
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Expired - Fee Related
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CNB2004800273126A
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English (en)
Chinese (zh)
Other versions
CN1856311A (zh
Inventor
张楠
塞米拉米斯·艾拉尔-卡劳斯蒂安
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Publication of CN1856311A publication Critical patent/CN1856311A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB2004800273126A 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Expired - Fee Related CN100486580C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
US60/505,486 2003-09-24

Publications (2)

Publication Number Publication Date
CN1856311A CN1856311A (zh) 2006-11-01
CN100486580C true CN100486580C (zh) 2009-05-13

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800273126A Expired - Fee Related CN100486580C (zh) 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶

Country Status (14)

Country Link
US (2) US7285555B2 (https=)
EP (1) EP1684763B1 (https=)
JP (1) JP4695595B2 (https=)
CN (1) CN100486580C (https=)
AT (1) ATE398452T1 (https=)
AU (1) AU2004275728A1 (https=)
BR (1) BRPI0414778A (https=)
CA (1) CA2537520A1 (https=)
DE (1) DE602004014525D1 (https=)
DK (1) DK1684763T3 (https=)
ES (1) ES2308256T3 (https=)
MX (1) MXPA06002939A (https=)
PL (1) PL1684763T3 (https=)
WO (1) WO2005030218A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

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SI2495016T1 (sl) 2005-12-23 2020-04-30 Ariad Pharmaceuticals, Inc. Biciklične heteroarilne spojine
BRPI0807458A2 (pt) * 2007-01-08 2014-06-03 Basf Se Uso de compostos, agente, semente, método para combater fungos nocivos fitopatogênicos, e, composto

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US6242451B1 (en) * 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
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JP2002525291A (ja) 1998-09-25 2002-08-13 アメリカン サイアナミツド コンパニー 非水性懸濁液濃縮物
US6277856B1 (en) * 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US5985883A (en) * 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
US6156925A (en) * 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
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AU2001273062B2 (en) * 2000-06-30 2005-11-24 Wyeth Substituted-triazolopyrimidines as anticancer agents
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WO2003089433A1 (en) * 2002-04-19 2003-10-30 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO[1,2-a]PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Also Published As

Publication number Publication date
ES2308256T3 (es) 2008-12-01
EP1684763A1 (en) 2006-08-02
BRPI0414778A (pt) 2006-11-21
US20050065167A1 (en) 2005-03-24
ATE398452T1 (de) 2008-07-15
CA2537520A1 (en) 2005-04-07
DK1684763T3 (da) 2008-09-01
US7285555B2 (en) 2007-10-23
DE602004014525D1 (de) 2008-07-31
US20080255157A1 (en) 2008-10-16
JP4695595B2 (ja) 2011-06-08
AU2004275728A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
MXPA06002939A (es) 2006-05-31
JP2007506745A (ja) 2007-03-22
WO2005030218A1 (en) 2005-04-07
EP1684763B1 (en) 2008-06-18
PL1684763T3 (pl) 2008-11-28
CN1856311A (zh) 2006-11-01

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