DE602004011330D1 - Imidazo- und thiazolopyridine als jak3-kinase-inhibitoren - Google Patents
Imidazo- und thiazolopyridine als jak3-kinase-inhibitorenInfo
- Publication number
- DE602004011330D1 DE602004011330D1 DE602004011330T DE602004011330T DE602004011330D1 DE 602004011330 D1 DE602004011330 D1 DE 602004011330D1 DE 602004011330 T DE602004011330 T DE 602004011330T DE 602004011330 T DE602004011330 T DE 602004011330T DE 602004011330 D1 DE602004011330 D1 DE 602004011330D1
- Authority
- DE
- Germany
- Prior art keywords
- imidazo
- kinase inhibitors
- thiazolopyridines
- jak3 kinase
- jak3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Otolaryngology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301373A SE0301373D0 (sv) | 2003-05-09 | 2003-05-09 | Novel compounds |
SE0301373 | 2003-05-09 | ||
PCT/SE2004/000694 WO2004099204A1 (en) | 2003-05-09 | 2004-05-06 | Imidazo and thiazolopyridines as jak3 kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE602004011330D1 true DE602004011330D1 (de) | 2008-03-06 |
DE602004011330T2 DE602004011330T2 (de) | 2009-01-15 |
Family
ID=20291271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004011330T Expired - Fee Related DE602004011330T2 (de) | 2003-05-09 | 2004-05-06 | Imidazo- und thiazolopyridine als jak3-kinase-inhibitoren |
Country Status (17)
Country | Link |
---|---|
US (1) | US20060287355A1 (de) |
EP (2) | EP1625126B1 (de) |
JP (1) | JP2006525997A (de) |
CN (1) | CN1784402A (de) |
AT (1) | ATE384061T1 (de) |
AU (1) | AU2004236144B2 (de) |
BR (1) | BRPI0410081A (de) |
CA (1) | CA2524624A1 (de) |
CY (1) | CY1107301T1 (de) |
DE (1) | DE602004011330T2 (de) |
DK (1) | DK1625126T3 (de) |
ES (1) | ES2298754T3 (de) |
MX (1) | MXPA05012025A (de) |
PL (1) | PL1625126T3 (de) |
PT (1) | PT1625126E (de) |
SE (1) | SE0301373D0 (de) |
WO (1) | WO2004099204A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0301372D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
KR20080013886A (ko) * | 2005-04-05 | 2008-02-13 | 파마코페이아, 인코포레이티드 | 면역억제용 퓨린 및 이미다조피리딘 유도체 |
US7884109B2 (en) | 2005-04-05 | 2011-02-08 | Wyeth Llc | Purine and imidazopyridine derivatives for immunosuppression |
KR20080026654A (ko) | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
CN102127078A (zh) | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
JP5305905B2 (ja) * | 2005-08-08 | 2013-10-02 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | チアゾロピリミジンキナーゼ阻害剤 |
EP2270014A1 (de) | 2005-09-22 | 2011-01-05 | Incyte Corporation | Azepinhemmer von Janus-Kinasen |
LT2474545T (lt) | 2005-12-13 | 2017-02-27 | Incyte Holdings Corporation | Heteroarilu pakeisti pirolo[2,3-b]piridinai ir pirolo[2,3-b]pirimidinai kaip janus kinazės inhibitoriai |
US7989459B2 (en) | 2006-02-17 | 2011-08-02 | Pharmacopeia, Llc | Purinones and 1H-imidazopyridinones as PKC-theta inhibitors |
EP1900729A1 (de) * | 2006-09-15 | 2008-03-19 | Novartis AG | Benzoxazole und Oxazolopyridine und ihre Verwendung als Inhibitoren von Janus-Kinasen |
US7902187B2 (en) | 2006-10-04 | 2011-03-08 | Wyeth Llc | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
WO2008043019A1 (en) | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc | 8-substituted 2-(benzimidazolyl) purine derivatives for immunosuppression |
WO2008043031A1 (en) | 2006-10-04 | 2008-04-10 | Pharmacopeia, Inc. | 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression |
ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
ES2627221T3 (es) | 2006-12-28 | 2017-07-27 | Rigel Pharmaceuticals, Inc. | Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso |
KR20090106604A (ko) | 2007-01-12 | 2009-10-09 | 아스텔라스세이야쿠 가부시키가이샤 | 축합 피리딘 화합물 |
LT3070090T (lt) | 2007-06-13 | 2019-06-25 | Incyte Holdings Corporation | Janus kinazės inhibitoriaus (r)-3-(4-(7h-pirol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropannitrilo druskų panaudojimas |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
WO2009001021A1 (en) * | 2007-06-26 | 2008-12-31 | Chroma Therapeutics Ltd. | Imidazopyridine derivatives useful as enzyme inhibitors for the treatment of cell proliferative and autoimmune diseases |
US8309718B2 (en) | 2007-11-16 | 2012-11-13 | Incyte Corporation | 4-pyrazolyl-N-arylpyrimidin-2-amines and 4-pyrazolyl-N-heteroarylpyrimidin-2-amines as janus kinase inhibitors |
PE20091158A1 (es) * | 2007-12-19 | 2009-08-28 | Genentech Inc | 5-anilinoimidazopiridinas y metodos de uso |
KR20100101666A (ko) * | 2007-12-19 | 2010-09-17 | 제넨테크, 인크. | 8-아닐리노이미다조피리딘 및 항암제 및/또는 소염제로서의 이들의 용도 |
DK2288610T3 (en) | 2008-03-11 | 2016-11-28 | Incyte Holdings Corp | Azetidinesulfonic AND CYCLOBUTANDERIVATER AS JAK INHIBITORS |
NZ599853A (en) * | 2008-04-11 | 2012-08-31 | Janssen Pharmaceutica Nv | Process for the preparation of meso-N-[(3-endo)-8-benzyl-8-azabicyclo[3.2.1]oct-3-yl]acetamide and its derivatives |
EP2274288A2 (de) | 2008-04-24 | 2011-01-19 | Incyte Corporation | Makrocyclische verbindungen und ihre verwendung als kinaseinhibitoren |
WO2009151910A2 (en) * | 2008-05-25 | 2009-12-17 | Wyeth | Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer |
JPWO2010058846A1 (ja) * | 2008-11-21 | 2012-04-19 | アステラス製薬株式会社 | 4,6−ジアミノニコチンアミド化合物 |
WO2010085597A1 (en) | 2009-01-23 | 2010-07-29 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
MY161416A (en) | 2009-05-22 | 2017-04-14 | Incyte Holdings Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4yl)-1h-pyrazol-1-yl]octane-or heptane-nitrile as jak inhibitors |
JP5775070B2 (ja) | 2009-05-22 | 2015-09-09 | インサイト・コーポレイションIncyte Corporation | ヤヌスキナーゼ阻害剤としてのピラゾール−4−イル−ピロロ[2,3−d]ピリミジンおよびピロール−3−イル−ピロロ[2,3−d]ピリミジンのN−(ヘテロ)アリール−ピロリジン誘導体 |
US9249145B2 (en) | 2009-09-01 | 2016-02-02 | Incyte Holdings Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
WO2011044481A1 (en) | 2009-10-09 | 2011-04-14 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
AR081315A1 (es) | 2010-03-10 | 2012-08-08 | Incyte Corp | Derivados heterociclicos de piperidin y pirimidin -4-il-azetidina, una forma cristalina de la sal del acido acetonitriladipico de un derivado pirimidinico, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades relacionadas con la inhibicion de jak-1, t |
ME02445B (de) | 2010-05-21 | 2016-09-20 | Incyte Holdings Corp | Topische formulierung für einen jak-hemmer |
AR083933A1 (es) | 2010-11-19 | 2013-04-10 | Incyte Corp | Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
EP2675451B9 (de) | 2011-02-18 | 2017-07-26 | Novartis Pharma AG | Kombinationstherapie aus mtor/jak-hemmer |
AR085435A1 (es) | 2011-03-17 | 2013-10-02 | Bristol Myers Squibb Co | Inhibidores de pirrolopiridazina jak3 y su uso para el tratamiento de enfermedades inflamatorias y autoinmunes |
WO2012125886A1 (en) * | 2011-03-17 | 2012-09-20 | Bristol-Myers Squibb Company | Pyrrolopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
AR085436A1 (es) * | 2011-03-17 | 2013-10-02 | Bristol Myers Squibb Co | Derivados de pirrolopiridazina inhibidores de jak3, composiciones farmaceuticas que los contienen y su uso para tratar enfermedades inflamatorias y autoinmunes |
WO2012127506A1 (en) | 2011-03-22 | 2012-09-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
PE20140832A1 (es) | 2011-06-20 | 2014-07-14 | Incyte Corp | Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak |
JP2014521725A (ja) | 2011-08-10 | 2014-08-28 | ノバルティス・ファルマ・アクチェンゲゼルシャフト | JAKPI3K/mTOR併用療法 |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
WO2013116291A1 (en) * | 2012-01-30 | 2013-08-08 | Cephalon, Inc. | Imidazo [4, 5 - b] pyridine derivatives as alk and jak modulators for the treatment of proliferative disorders |
US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
WO2014039595A1 (en) * | 2012-09-06 | 2014-03-13 | Bristol-Myers Squibb Company | Imidazopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases |
WO2014045305A1 (en) | 2012-09-21 | 2014-03-27 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
CA3178452A1 (en) | 2012-11-15 | 2014-05-22 | Incyte Holdings Corporation | Sustained-release dosage forms of ruxolitinib |
LT3489239T (lt) | 2013-03-06 | 2022-03-10 | Incyte Holdings Corporation | Jak inhibitoriaus gamybos būdai ir tarpiniai junginiai |
MY195091A (en) | 2013-08-07 | 2023-01-10 | Incyte Corp | Sustained Release Dosage Forms for a JAK1 Inhibitor |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
WO2017009751A1 (en) | 2015-07-15 | 2017-01-19 | Pfizer Inc. | Pyrimidine derivatives |
CN107513067A (zh) | 2016-06-16 | 2017-12-26 | 北京赛林泰医药技术有限公司 | 含有取代环戊基的吡咯并嘧啶化合物 |
WO2018102552A1 (en) * | 2016-11-30 | 2018-06-07 | Case Western Reserve University | Combinations of 15-pgdh inhibitors with corcosteroids and/or tnf inhibitors and uses thereof |
AU2018215678A1 (en) | 2017-02-06 | 2019-08-22 | Board Of Regents Of The University Of Texas System | Compositions and methods of modulating short-chain dehydrogenase activity |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
WO2019116256A1 (en) * | 2017-12-13 | 2019-06-20 | Glaxosmithkline Intellectual Property Development Limited | Fused pyridines which act as inhibitors of h-pgds |
WO2019152374A1 (en) | 2018-01-30 | 2019-08-08 | Incyte Corporation | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
MX2020010322A (es) | 2018-03-30 | 2022-11-30 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
WO2021016289A1 (en) * | 2019-07-23 | 2021-01-28 | Bristol-Myers Squibb Company | Thienopyridinyl and thiazolopyridinyl compounds useful as irak4 inhibitors |
EP4061367A1 (de) | 2019-11-22 | 2022-09-28 | Incyte Corporation | Kombinationstherapie, die einen alk2-inhibitor und einen jak2-inhibitor umfasst |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996233A (en) * | 1975-02-10 | 1976-12-07 | E. R. Squibb & Sons, Inc. | Amino derivatives of imidazo[4,5-b]pyridines |
CA1077484A (en) * | 1975-03-05 | 1980-05-13 | E.R. Squibb And Sons | Amino derivatives of thiazolo (5,4-b) pyridine-6-carboxylic acids and esters |
US3953461A (en) * | 1975-03-05 | 1976-04-27 | E. R. Squibb & Sons, Inc. | Amino derivatives of thiazolo[5,4-b]pyridine-6-carboxylic acids and esters |
US6992188B1 (en) * | 1995-12-08 | 2006-01-31 | Pfizer, Inc. | Substituted heterocyclic derivatives |
US6107300A (en) * | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
SE0101675D0 (sv) | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
SE0301372D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Novel compounds |
-
2003
- 2003-05-09 SE SE0301373A patent/SE0301373D0/xx unknown
-
2004
- 2004-05-06 JP JP2006508045A patent/JP2006525997A/ja active Pending
- 2004-05-06 MX MXPA05012025A patent/MXPA05012025A/es active IP Right Grant
- 2004-05-06 EP EP04731525A patent/EP1625126B1/de not_active Expired - Lifetime
- 2004-05-06 DK DK04731525T patent/DK1625126T3/da active
- 2004-05-06 CA CA002524624A patent/CA2524624A1/en not_active Abandoned
- 2004-05-06 PT PT04731525T patent/PT1625126E/pt unknown
- 2004-05-06 AU AU2004236144A patent/AU2004236144B2/en not_active Ceased
- 2004-05-06 EP EP07119970A patent/EP1887007A3/de not_active Withdrawn
- 2004-05-06 WO PCT/SE2004/000694 patent/WO2004099204A1/en active IP Right Grant
- 2004-05-06 DE DE602004011330T patent/DE602004011330T2/de not_active Expired - Fee Related
- 2004-05-06 US US10/556,228 patent/US20060287355A1/en not_active Abandoned
- 2004-05-06 PL PL04731525T patent/PL1625126T3/pl unknown
- 2004-05-06 CN CNA200480012617XA patent/CN1784402A/zh active Pending
- 2004-05-06 AT AT04731525T patent/ATE384061T1/de not_active IP Right Cessation
- 2004-05-06 BR BRPI0410081-6A patent/BRPI0410081A/pt not_active IP Right Cessation
- 2004-05-06 ES ES04731525T patent/ES2298754T3/es not_active Expired - Lifetime
-
2008
- 2008-03-12 CY CY20081100279T patent/CY1107301T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2298754T3 (es) | 2008-05-16 |
DE602004011330T2 (de) | 2009-01-15 |
EP1887007A2 (de) | 2008-02-13 |
CN1784402A (zh) | 2006-06-07 |
SE0301373D0 (sv) | 2003-05-09 |
EP1887007A3 (de) | 2008-03-26 |
CA2524624A1 (en) | 2004-11-18 |
AU2004236144A1 (en) | 2004-11-18 |
CY1107301T1 (el) | 2012-11-21 |
EP1625126B1 (de) | 2008-01-16 |
PT1625126E (pt) | 2008-03-10 |
DK1625126T3 (da) | 2008-03-31 |
PL1625126T3 (pl) | 2008-07-31 |
EP1625126A1 (de) | 2006-02-15 |
JP2006525997A (ja) | 2006-11-16 |
WO2004099204A1 (en) | 2004-11-18 |
MXPA05012025A (es) | 2006-02-03 |
ATE384061T1 (de) | 2008-02-15 |
US20060287355A1 (en) | 2006-12-21 |
BRPI0410081A (pt) | 2006-05-16 |
AU2004236144B2 (en) | 2008-02-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE384061T1 (de) | Imidazo- und thiazolopyridine als jak3-kinase- inhibitoren | |
ATE362932T1 (de) | Azaindolverbindungen als kinaseinhibitoren | |
SE0101675D0 (sv) | Novel composition | |
ATE433447T1 (de) | Pyrimiidinverbindungen | |
EA200700188A1 (ru) | Производные замещенного 2-алкилхиназолинона как ингибиторы parp | |
NO20056192L (no) | Kapaseinhibitorer og anvendelse derav | |
EA200970156A1 (ru) | Пиридизиноновые производные | |
ATE420879T1 (de) | Indolizine als kinaseproteinhemmer | |
CY1109998T1 (el) | Ενδυναμωτες υποδοχεων γλουταμινικου | |
ATE540948T1 (de) | Pyrrolopyridine als proteinkinasehemmer | |
EA200700185A1 (ru) | Производные хиназолиндиона в качестве ингибиторов parp | |
SE0303180D0 (sv) | Novel compounds | |
SE0302232D0 (sv) | Novel Compounds | |
HRP20110566T8 (en) | Azaindoles useful as inhibitors of jak and other protein kinases | |
EA200801608A1 (ru) | Производные бензимидазолонкарбоновой кислоты | |
ATE365740T1 (de) | Substituierte pyrazolopyrimidine | |
CY1107747T1 (el) | Υποκατεστημενα τετρακυκλικα παραγωγα πυρρολοκινολονης χρησιμα ως αναστολεις της φωσφοδιεστερασης | |
WO2004106293A3 (en) | Oxazolyl - and thiazolyl - purine based tricyclic compounds. | |
SE0400284D0 (sv) | Novel compounds | |
NO20064344L (no) | Caspaseinhibitorer og anvendelser derav | |
EA200700166A1 (ru) | 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции | |
BR0318521A (pt) | arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados | |
WO2005011609A3 (en) | Triazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same | |
EA200600100A1 (ru) | Производные никотинамида, полезные в качестве ингибиторов pde4 | |
WO2004075846A3 (en) | Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |