DE60133014T2 - Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten - Google Patents
Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten Download PDFInfo
- Publication number
- DE60133014T2 DE60133014T2 DE60133014T DE60133014T DE60133014T2 DE 60133014 T2 DE60133014 T2 DE 60133014T2 DE 60133014 T DE60133014 T DE 60133014T DE 60133014 T DE60133014 T DE 60133014T DE 60133014 T2 DE60133014 T2 DE 60133014T2
- Authority
- DE
- Germany
- Prior art keywords
- compound
- compound according
- alkyl
- mmol
- allergy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 *c1ccc(C(c(cc2)ccc2I)OCCCc2c[n]cn2)cc1 Chemical compound *c1ccc(C(c(cc2)ccc2I)OCCCc2c[n]cn2)cc1 0.000 description 9
- PDAYVXKCKWVRHT-NYMZINODSA-N CC(/C(/CCc1cc(Cl)ccc11)=C\C=C/N)C1=C1CCNCC1 Chemical compound CC(/C(/CCc1cc(Cl)ccc11)=C\C=C/N)C1=C1CCNCC1 PDAYVXKCKWVRHT-NYMZINODSA-N 0.000 description 1
- ZOSHQVILRIOTCB-UHFFFAOYSA-N CC(CCc1cccnc1C1C2CCN(CC3=CNCN3)CC2)(C1C=C1)C=C1Cl Chemical compound CC(CCc1cccnc1C1C2CCN(CC3=CNCN3)CC2)(C1C=C1)C=C1Cl ZOSHQVILRIOTCB-UHFFFAOYSA-N 0.000 description 1
- VUQLWEZYDIEMAG-UHFFFAOYSA-N CN(CC1)CCN1C1c2ncccc2CCc2cc(Cl)ccc12 Chemical compound CN(CC1)CCN1C1c2ncccc2CCc2cc(Cl)ccc12 VUQLWEZYDIEMAG-UHFFFAOYSA-N 0.000 description 1
- OTVVRSAIPMVZBS-UHFFFAOYSA-N ClC(C1)C=CC2=C1CCc1cccnc1C2N1CCNCC1 Chemical compound ClC(C1)C=CC2=C1CCc1cccnc1C2N1CCNCC1 OTVVRSAIPMVZBS-UHFFFAOYSA-N 0.000 description 1
- JHDMBWUQBCALLF-UHFFFAOYSA-N Clc1ccc(C(C2CCN(Cc3c[nH]cn3)CC2)c2ncccc2CC2)c2c1 Chemical compound Clc1ccc(C(C2CCN(Cc3c[nH]cn3)CC2)c2ncccc2CC2)c2c1 JHDMBWUQBCALLF-UHFFFAOYSA-N 0.000 description 1
- NYXGBXBGXUSGSJ-UHFFFAOYSA-N Clc1ccc(C(C2CCNCC2)c2ncccc2CC2)c2c1 Chemical compound Clc1ccc(C(C2CCNCC2)c2ncccc2CC2)c2c1 NYXGBXBGXUSGSJ-UHFFFAOYSA-N 0.000 description 1
- IVJGFHQRSVPSCP-UHFFFAOYSA-N Clc1ccc(C(c2ncccc2CC2)N3CCN(CCCc4c[nH]cn4)CC3)c2c1 Chemical compound Clc1ccc(C(c2ncccc2CC2)N3CCN(CCCc4c[nH]cn4)CC3)c2c1 IVJGFHQRSVPSCP-UHFFFAOYSA-N 0.000 description 1
- QQDZZMYDBOIBNK-UHFFFAOYSA-N O=C(CCc1c[nH]cn1)N(CC1)CCN1C1c2ncccc2CCc2cc(Cl)ccc12 Chemical compound O=C(CCc1c[nH]cn1)N(CC1)CCN1C1c2ncccc2CCc2cc(Cl)ccc12 QQDZZMYDBOIBNK-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23405300P | 2000-09-20 | 2000-09-20 | |
| US234053P | 2000-09-20 | ||
| PCT/US2001/029095 WO2002024659A2 (en) | 2000-09-20 | 2001-09-18 | Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60133014D1 DE60133014D1 (de) | 2008-04-10 |
| DE60133014T2 true DE60133014T2 (de) | 2009-02-26 |
Family
ID=22879692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60133014T Expired - Lifetime DE60133014T2 (de) | 2000-09-20 | 2001-09-18 | Substituierte imidazole als duale histamin h1 und h3 agonisten oder antagonisten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6506756B2 (https=) |
| EP (1) | EP1318994B1 (https=) |
| JP (1) | JP2004509871A (https=) |
| CN (1) | CN1461303A (https=) |
| AR (1) | AR030946A1 (https=) |
| AT (1) | ATE387439T1 (https=) |
| AU (1) | AU2001292730A1 (https=) |
| CA (1) | CA2421826C (https=) |
| DE (1) | DE60133014T2 (https=) |
| ES (1) | ES2300364T3 (https=) |
| HK (1) | HK1052179A1 (https=) |
| MX (1) | MXPA03002448A (https=) |
| MY (1) | MY117975A (https=) |
| TW (1) | TW589303B (https=) |
| WO (1) | WO2002024659A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6607862B2 (en) | 2001-08-24 | 2003-08-19 | Intel Corporation | Damascene extreme ultraviolet lithography alternative phase shift photomask and method of making |
| US7105505B2 (en) | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
| PT1499316E (pt) * | 2002-04-18 | 2008-06-30 | Schering Corp | Derivados de (1-4-piperidinil)benzimidazole úteis como antagonistas de histamina h3 |
| NZ535764A (en) * | 2002-04-18 | 2007-10-26 | Schering Corp | 1-(4-piperidinyl) benzimidazolones as histamine H3 antagonists |
| NL1026634C2 (nl) * | 2004-07-12 | 2006-01-16 | Willem Jacob Van Der Burg | Psychofarmaceutisch preparaat en werkzame stof daarin. |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| US9224955B1 (en) * | 2014-10-31 | 2015-12-29 | Feng-wen Yen | Purifying method for organic optoelectronic material |
| CN113880808B (zh) * | 2020-07-03 | 2024-12-31 | 合肥医工医药股份有限公司 | 一类三唑类化合物、制备方法及其医药用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2586562B1 (fr) | 1985-09-02 | 1989-03-10 | Inst Nat Sante Rech Med | Composition pharmaceutique contenant de l'a-methylhistamine |
| EP0411048A1 (en) * | 1988-04-28 | 1991-02-06 | Schering Corporation | Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use |
| GB8916947D0 (en) | 1989-07-25 | 1989-09-13 | Smith Kline French Lab | Medicaments |
| ES2058651T3 (es) | 1990-03-30 | 1994-11-01 | Heumann Pharma Gmbh & Co | Uso derivados de guanidina para la fabricacion de un medicamento con actividad antagonista de npy. |
| GB9115740D0 (en) | 1991-07-20 | 1991-09-04 | Smithkline Beecham Plc | Medicaments |
| WO1993012093A1 (en) | 1991-12-18 | 1993-06-24 | Schering Corporation | Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists |
| US5352707A (en) | 1992-03-26 | 1994-10-04 | Harbor Branch Oceanographic Institution, Inc. | Method for treating airway congestion |
| ATE234290T1 (de) | 1993-11-15 | 2003-03-15 | Schering Corp | Phenylalkyl-imidazole als h3-rezeptor- antagonisten |
| FR2732017B1 (fr) * | 1995-03-21 | 2000-09-22 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques |
| WO1998058646A1 (en) | 1997-06-24 | 1998-12-30 | Novo Nordisk A/S | Use of somatostatin agonists and antagonists for treating diseases related to the eye |
| US5869479A (en) | 1997-08-14 | 1999-02-09 | Schering Corporation | Treatment of upper airway allergic responses |
| ATE274498T1 (de) * | 1998-07-24 | 2004-09-15 | Russinsky Ltd | Verfahren zur herstellung von benzocycloheptapyridin-11-one |
-
2001
- 2001-09-18 AR ARP010104399A patent/AR030946A1/es unknown
- 2001-09-18 ES ES01973119T patent/ES2300364T3/es not_active Expired - Lifetime
- 2001-09-18 AT AT01973119T patent/ATE387439T1/de not_active IP Right Cessation
- 2001-09-18 HK HK03104436.1A patent/HK1052179A1/zh unknown
- 2001-09-18 MX MXPA03002448A patent/MXPA03002448A/es active IP Right Grant
- 2001-09-18 CA CA002421826A patent/CA2421826C/en not_active Expired - Fee Related
- 2001-09-18 US US09/954,867 patent/US6506756B2/en not_active Expired - Fee Related
- 2001-09-18 CN CN01815978A patent/CN1461303A/zh active Pending
- 2001-09-18 EP EP01973119A patent/EP1318994B1/en not_active Expired - Lifetime
- 2001-09-18 DE DE60133014T patent/DE60133014T2/de not_active Expired - Lifetime
- 2001-09-18 AU AU2001292730A patent/AU2001292730A1/en not_active Abandoned
- 2001-09-18 JP JP2002529071A patent/JP2004509871A/ja not_active Withdrawn
- 2001-09-18 MY MYPI20014365A patent/MY117975A/en unknown
- 2001-09-18 WO PCT/US2001/029095 patent/WO2002024659A2/en not_active Ceased
- 2001-09-19 TW TW090123001A patent/TW589303B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK1052179A1 (zh) | 2003-09-05 |
| DE60133014D1 (de) | 2008-04-10 |
| AR030946A1 (es) | 2003-09-03 |
| WO2002024659A3 (en) | 2002-10-24 |
| MY117975A (en) | 2004-08-30 |
| TW589303B (en) | 2004-06-01 |
| CA2421826C (en) | 2009-10-27 |
| EP1318994A2 (en) | 2003-06-18 |
| ES2300364T3 (es) | 2008-06-16 |
| CN1461303A (zh) | 2003-12-10 |
| MXPA03002448A (es) | 2003-06-19 |
| AU2001292730A1 (en) | 2002-04-02 |
| EP1318994B1 (en) | 2008-02-27 |
| US6506756B2 (en) | 2003-01-14 |
| CA2421826A1 (en) | 2002-03-28 |
| ATE387439T1 (de) | 2008-03-15 |
| WO2002024659A2 (en) | 2002-03-28 |
| US20020086859A1 (en) | 2002-07-04 |
| JP2004509871A (ja) | 2004-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |