AU2001292730A1 - Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists - Google Patents

Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists

Info

Publication number
AU2001292730A1
AU2001292730A1 AU2001292730A AU9273001A AU2001292730A1 AU 2001292730 A1 AU2001292730 A1 AU 2001292730A1 AU 2001292730 A AU2001292730 A AU 2001292730A AU 9273001 A AU9273001 A AU 9273001A AU 2001292730 A1 AU2001292730 A1 AU 2001292730A1
Authority
AU
Australia
Prior art keywords
antgonists
agonists
substituted imidazoles
dual histamine
histamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001292730A
Inventor
Michael J. Green
Andrew T. Lupo Jr.
John J. Piwinski
Neng-Yang Shih
Daniel M. Solomon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of AU2001292730A1 publication Critical patent/AU2001292730A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2001292730A 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists Abandoned AU2001292730A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23405300P 2000-09-20 2000-09-20
US60/234,053 2000-09-20
PCT/US2001/029095 WO2002024659A2 (en) 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists

Publications (1)

Publication Number Publication Date
AU2001292730A1 true AU2001292730A1 (en) 2002-04-02

Family

ID=22879692

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001292730A Abandoned AU2001292730A1 (en) 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists

Country Status (15)

Country Link
US (1) US6506756B2 (en)
EP (1) EP1318994B1 (en)
JP (1) JP2004509871A (en)
CN (1) CN1461303A (en)
AR (1) AR030946A1 (en)
AT (1) ATE387439T1 (en)
AU (1) AU2001292730A1 (en)
CA (1) CA2421826C (en)
DE (1) DE60133014T2 (en)
ES (1) ES2300364T3 (en)
HK (1) HK1052179A1 (en)
MX (1) MXPA03002448A (en)
MY (1) MY117975A (en)
TW (1) TW589303B (en)
WO (1) WO2002024659A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607862B2 (en) 2001-08-24 2003-08-19 Intel Corporation Damascene extreme ultraviolet lithography alternative phase shift photomask and method of making
JP4384918B2 (en) * 2002-04-18 2009-12-16 シェーリング コーポレイション (1-4-piperidinyl) benzimidazole derivatives useful as histamine H3 antagonists
EP1494671B1 (en) 2002-04-18 2011-10-19 Schering Corporation 1-(4-piperidinyl)benzimidazolones as histamine h3 antagonists
US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
NL1026634C2 (en) * 2004-07-12 2006-01-16 Willem Jacob Van Der Burg Psychopharmaceutical preparation and active ingredient.
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
US9224955B1 (en) * 2014-10-31 2015-12-29 Feng-wen Yen Purifying method for organic optoelectronic material
CN113880808A (en) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 Triazole compounds, preparation method and medical application thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586562B1 (en) 1985-09-02 1989-03-10 Inst Nat Sante Rech Med PHARMACEUTICAL COMPOSITION CONTAINING A-METHYLHISTAMINE
EP0411048A1 (en) 1988-04-28 1991-02-06 Schering Corporation Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
GB8916947D0 (en) 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
ES2058651T3 (en) 1990-03-30 1994-11-01 Heumann Pharma Gmbh & Co USE OF GUANIDINE DERIVATIVES FOR THE MANUFACTURE OF A MEDICINE WITH ANTAGONIST ACTIVITY OF NPY.
GB9115740D0 (en) 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
JP2540015B2 (en) 1991-12-18 1996-10-02 シェリング・コーポレーション Histamine H 2) Imidazolyl-alkyl-piperazine and -diazepine derivatives as agonists / antagonists
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
ATE234290T1 (en) 1993-11-15 2003-03-15 Schering Corp PHENYLALKYL-IMIDAZOLE AS H3 RECEPTOR ANTAGONISTS
FR2732017B1 (en) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med NOVEL IMIDAZOLE DERIVATIVES AND / OR HISTAMINE H3 RECEPTOR AGONISTS AND / OR AGONISTS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS
JP2002515912A (en) 1997-06-24 2002-05-28 ノボ ノルディスク アクティーゼルスカブ Use of somatostatin agonists and antagonists for the treatment of eye-related diseases
US5869479A (en) 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
AU4387699A (en) 1998-07-24 2000-02-14 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones

Also Published As

Publication number Publication date
MXPA03002448A (en) 2003-06-19
DE60133014T2 (en) 2009-02-26
CA2421826C (en) 2009-10-27
MY117975A (en) 2004-08-30
US20020086859A1 (en) 2002-07-04
CN1461303A (en) 2003-12-10
CA2421826A1 (en) 2002-03-28
EP1318994A2 (en) 2003-06-18
HK1052179A1 (en) 2003-09-05
WO2002024659A2 (en) 2002-03-28
AR030946A1 (en) 2003-09-03
ES2300364T3 (en) 2008-06-16
EP1318994B1 (en) 2008-02-27
JP2004509871A (en) 2004-04-02
ATE387439T1 (en) 2008-03-15
WO2002024659A3 (en) 2002-10-24
TW589303B (en) 2004-06-01
DE60133014D1 (en) 2008-04-10
US6506756B2 (en) 2003-01-14

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