HK1052179A1 - 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑 - Google Patents

作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑

Info

Publication number
HK1052179A1
HK1052179A1 HK03104436.1A HK03104436A HK1052179A1 HK 1052179 A1 HK1052179 A1 HK 1052179A1 HK 03104436 A HK03104436 A HK 03104436A HK 1052179 A1 HK1052179 A1 HK 1052179A1
Authority
HK
Hong Kong
Prior art keywords
agonists
antagonists
substituted imidazoles
dual histamine
histamine
Prior art date
Application number
HK03104436.1A
Other languages
English (en)
Inventor
Shih Neng-Yang
M Solomon Daniel
J Piwinski John
T Lupo Andrew Jr
J Green Michael
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1052179A1 publication Critical patent/HK1052179A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK03104436.1A 2000-09-20 2003-06-20 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑 HK1052179A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23405300P 2000-09-20 2000-09-20
PCT/US2001/029095 WO2002024659A2 (en) 2000-09-20 2001-09-18 Substituted imidazoles as dual histamine h1 and h3 agonists or antgonists

Publications (1)

Publication Number Publication Date
HK1052179A1 true HK1052179A1 (zh) 2003-09-05

Family

ID=22879692

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03104436.1A HK1052179A1 (zh) 2000-09-20 2003-06-20 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑

Country Status (15)

Country Link
US (1) US6506756B2 (zh)
EP (1) EP1318994B1 (zh)
JP (1) JP2004509871A (zh)
CN (1) CN1461303A (zh)
AR (1) AR030946A1 (zh)
AT (1) ATE387439T1 (zh)
AU (1) AU2001292730A1 (zh)
CA (1) CA2421826C (zh)
DE (1) DE60133014T2 (zh)
ES (1) ES2300364T3 (zh)
HK (1) HK1052179A1 (zh)
MX (1) MXPA03002448A (zh)
MY (1) MY117975A (zh)
TW (1) TW589303B (zh)
WO (1) WO2002024659A2 (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607862B2 (en) 2001-08-24 2003-08-19 Intel Corporation Damascene extreme ultraviolet lithography alternative phase shift photomask and method of making
PE20040684A1 (es) * 2002-04-18 2004-10-05 Schering Corp Derivados de bencimidazol como antagonistas de histamina h3
US7105505B2 (en) 2002-04-18 2006-09-12 Schering Corporation Benzimidazole derivatives useful as histamine H3 antagonists
MXPA04010172A (es) * 2002-04-18 2005-02-03 Schering Corp 1-(4-piperidinil)benzimidazolonas como antagonistas de histamina h3).
NL1026634C2 (nl) * 2004-07-12 2006-01-16 Willem Jacob Van Der Burg Psychofarmaceutisch preparaat en werkzame stof daarin.
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
US9224955B1 (en) * 2014-10-31 2015-12-29 Feng-wen Yen Purifying method for organic optoelectronic material
CN113880808A (zh) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 一类三唑类化合物、制备方法及其医药用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2586562B1 (fr) 1985-09-02 1989-03-10 Inst Nat Sante Rech Med Composition pharmaceutique contenant de l'a-methylhistamine
JPH0678315B2 (ja) 1988-04-28 1994-10-05 シェリング・コーポレーション 新規なベンゾピリド‐ピペリジン、ピペリジリデンおよびピペラジン化合物、組成物、製造法および利用法
GB8916947D0 (en) 1989-07-25 1989-09-13 Smith Kline French Lab Medicaments
DE59006842D1 (de) 1990-03-30 1994-09-22 Heumann Pharma Gmbh & Co Verwendung von Guanidinderivaten zur Herstellung eines Arzneimittels mit NPY-antagonistischer Wirkung.
GB9115740D0 (en) 1991-07-20 1991-09-04 Smithkline Beecham Plc Medicaments
CA2125964C (en) 1991-12-18 2001-06-19 Neng-Yang Shih Imidazolyl-alkyl-piperazine and -diazepine derivatives as histamine h3 agonists/antagonists
US5352707A (en) 1992-03-26 1994-10-04 Harbor Branch Oceanographic Institution, Inc. Method for treating airway congestion
NZ276883A (en) 1993-11-15 1998-08-26 Schering Corp 1h-imidazol-4-yl)alkyl]benzene derivatives
FR2732017B1 (fr) 1995-03-21 2000-09-22 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole antagonistes et/ou agonistes du recepteur h3 de l'histamine, leur preparation et leurs applications therapeutiques
WO1998058646A1 (en) 1997-06-24 1998-12-30 Novo Nordisk A/S Use of somatostatin agonists and antagonists for treating diseases related to the eye
US5869479A (en) 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
WO2000005215A1 (en) 1998-07-24 2000-02-03 Russinsky Limited A process for preparing benzocycloheptapyridin-11-ones

Also Published As

Publication number Publication date
TW589303B (en) 2004-06-01
CA2421826C (en) 2009-10-27
DE60133014T2 (de) 2009-02-26
ES2300364T3 (es) 2008-06-16
EP1318994A2 (en) 2003-06-18
MY117975A (en) 2004-08-30
EP1318994B1 (en) 2008-02-27
AU2001292730A1 (en) 2002-04-02
ATE387439T1 (de) 2008-03-15
DE60133014D1 (de) 2008-04-10
CA2421826A1 (en) 2002-03-28
WO2002024659A3 (en) 2002-10-24
WO2002024659A2 (en) 2002-03-28
AR030946A1 (es) 2003-09-03
US20020086859A1 (en) 2002-07-04
JP2004509871A (ja) 2004-04-02
US6506756B2 (en) 2003-01-14
MXPA03002448A (es) 2003-06-19
CN1461303A (zh) 2003-12-10

Similar Documents

Publication Publication Date Title
EP1206262A4 (en) Y NEUROPEPTID ANTAGONISTS: SPIROISOQUINOLINONE DERIVATIVES
PL366233A1 (en) Substituted pyridoindoles as serotonin agonists and antagonists
HK1041266A1 (en) Bicyclic heteroaromatic compounds useful as lh agonists.
IL150632A0 (en) Corticotropin releasing factor antagonists
PL376477A1 (en) Substituted piperazines, (1,4) diaszepines, and 2,5-diazabicyclo (2.2.1) heptanes as histamine h1 and/or h3 antagonists or histamine h3 reverse antagonists
IL154604A0 (en) Guanidinobenzamides as mc4-r agonists
IL153181A0 (en) Glucagon antagonists/inverse agonists
PL372295A1 (en) Quinoline derivatives as npy antagonists
MXPA03006484A (es) Derivados de imidazolilo como inhibidores del factor de liberacion de corticotropina.
AU2002223501A1 (en) Glucagon antagonists/inverse agonists
AU2002223500A1 (en) Glucagon antagonists/inverse agonists
HUP0401756A3 (en) Substituted benzimidazole compounds and their use
HK1052182B (zh) 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑
GB0015562D0 (en) Heterocycles
HK1052179A1 (zh) 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑
EP0986553A4 (en) DIHYDROPYRIMIDONE DERIVATIVES AS NPY ANTAGONISTS
HK1052181A1 (zh) 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑
HK1052180A1 (zh) 作為雙重組胺h1和h3激動劑或拮抗劑的取代咪唑
AU7635401A (en) Hetaryl-substituted heterocycles
SI1261588T1 (en) IMIDAZOLE COMPOUNDS AS Alpha2-ADRENOCEPTORS ANTAGONISTS
IL156087A0 (en) Histamine receptor antagonists
EP1202738A4 (en) DIHYDROPYRAZINE DERIVATIVES AS NPY ANTAGONISTS
AU6043500A (en) New npy antagonists
GB9927761D0 (en) Anti-microbial compounds and feed additives incorporating the same
GB0009125D0 (en) Antagonists