DE60127237T2 - Therapeutischer monoklonaler rekombinanter anti-ige antikörper gegen hunde-allergie - Google Patents
Therapeutischer monoklonaler rekombinanter anti-ige antikörper gegen hunde-allergie Download PDFInfo
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- DE60127237T2 DE60127237T2 DE60127237T DE60127237T DE60127237T2 DE 60127237 T2 DE60127237 T2 DE 60127237T2 DE 60127237 T DE60127237 T DE 60127237T DE 60127237 T DE60127237 T DE 60127237T DE 60127237 T2 DE60127237 T2 DE 60127237T2
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- 238000010561 standard procedure Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17962900P | 2000-02-01 | 2000-02-01 | |
| US179629P | 2000-02-01 | ||
| US592998 | 2000-06-12 | ||
| US09/592,998 US6504013B1 (en) | 2000-02-01 | 2000-06-12 | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
| PCT/US2001/002924 WO2001057090A1 (en) | 2000-02-01 | 2001-01-30 | Canine allergy therapeutic recombinant chimeric anti-ige monoclonal antibody |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60127237D1 DE60127237D1 (de) | 2007-04-26 |
| DE60127237T2 true DE60127237T2 (de) | 2007-12-20 |
Family
ID=26875491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60127237T Expired - Lifetime DE60127237T2 (de) | 2000-02-01 | 2001-01-30 | Therapeutischer monoklonaler rekombinanter anti-ige antikörper gegen hunde-allergie |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6504013B1 (enExample) |
| EP (1) | EP1254180B1 (enExample) |
| JP (1) | JP4605973B2 (enExample) |
| AU (1) | AU2001233102A1 (enExample) |
| DE (1) | DE60127237T2 (enExample) |
| WO (1) | WO2001057090A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7393529B2 (en) | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
| JP2004521336A (ja) * | 2001-01-03 | 2004-07-15 | ヘスカ コーポレイション | アレルゲン特異的ＩｇＥの検出 |
| WO2003060080A2 (en) * | 2001-12-21 | 2003-07-24 | Idexx Laboratories, Inc. | Canine immunoglobulin variable domains, caninized antibodies, and methods for making and using them |
| ES2551682T3 (es) * | 2002-11-08 | 2015-11-23 | Ablynx N.V. | Anticuerpos de dominio simple dirigidos contra factor de necrosis tumoral-alfa y usos para los mismos |
| US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| US20060034845A1 (en) * | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
| NZ540196A (en) * | 2002-11-08 | 2008-09-26 | Ablynx Nv | Camelidae antibodies against imminoglobulin E and use thereof for the treatment of allergic disorders |
| US20100003253A1 (en) * | 2002-11-08 | 2010-01-07 | Ablynx N.V. | Single domain antibodies directed against epidermal growth factor receptor and uses therefor |
| GB0304576D0 (en) | 2003-02-28 | 2003-04-02 | Lonza Biologics Plc | Protein a chromatography |
| WO2005095967A1 (en) * | 2004-03-23 | 2005-10-13 | Quidel Corporation | Hybrid phase lateral flow assay |
| ATE524561T1 (de) | 2004-04-06 | 2011-09-15 | Sinai School Medicine | Verfahren zur bestimmung einer allergenreaktion unter verwendung von mikroarray-immunoassay- techniken |
| JP2006151880A (ja) * | 2004-11-30 | 2006-06-15 | Asahi Breweries Ltd | 抗イヌＩｇＥモノクローナル抗体、その製造法および用途 |
| RU2457214C2 (ru) | 2005-03-11 | 2012-07-27 | Вайет | Способ хроматографии в режиме слабого распределения |
| JP2007172129A (ja) * | 2005-12-20 | 2007-07-05 | Sony Corp | 不揮発性メモリアクセス制御装置および不揮発性メモリ制御システム |
| DK2162133T3 (en) * | 2007-07-09 | 2016-10-24 | Nestec Sa | Approaches to reduce allergies caused by environmental allergens |
| US9388236B2 (en) | 2007-07-09 | 2016-07-12 | Nestec Sa | Methods for reducing allergies caused by environmental allergens |
| JP6121903B2 (ja) | 2010-08-19 | 2017-04-26 | ゾエティス・ベルジャム・エス・アー | 抗ｎｇｆ抗体およびその使用 |
| WO2013119419A1 (en) | 2012-02-08 | 2013-08-15 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| JP6199054B2 (ja) * | 2013-03-19 | 2017-09-20 | 公益財団法人かずさＤｎａ研究所 | 抗イヌＩｇＥモノクローナル抗体並びに抗イヌＩｇＥモノクローナル抗体の重鎖可変領域及び軽鎖可変領域 |
| EP3538558A4 (en) * | 2016-11-09 | 2020-07-15 | North Carolina State University | TREATMENT OF ALLERGIC DISEASES USING CHIMERIC PROTEIN |
| US12060437B2 (en) | 2018-03-23 | 2024-08-13 | North Carolina State University | Methods and compositions for antibody to high affinity receptor for IgE |
| CN109143137B (zh) * | 2018-06-14 | 2020-09-29 | 国电南瑞科技股份有限公司 | 一种发电机pmu装置测量精度提升方法 |
| US20230148946A1 (en) * | 2020-03-27 | 2023-05-18 | Aquavit Pharmaceuticals, Inc. | Methods of detecting allergic reactions in subjects using microchannel delivery devices |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449760A (en) | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
| DE122006000007I1 (de) | 1987-12-31 | 2006-04-27 | Tanox Biosystems Inc | Antigene epitope, die sich ausschlisslich auf ige-tragenden B-Lymphocyten befinden. |
| US5422258A (en) | 1987-12-31 | 1995-06-06 | Tanox Biosystems, Inc. | Methods for producing high affinity anti-human IgE-monoclonal antibodies which binds to IgE on IgEabearing B cells but not basophils |
| JP2811089B2 (ja) * | 1989-08-25 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ×マウスヘテロハイブリドーマおよびイヌ免疫グロブリンλ鎖の定常領域をコードする遺伝子断片 |
| JP2837240B2 (ja) * | 1990-06-07 | 1998-12-14 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンγ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| JP2811096B2 (ja) * | 1989-09-30 | 1998-10-15 | 財団法人化学及血清療法研究所 | イヌ免疫グロブリンκ鎖の定常領域をコードする遺伝子断片およびマウス×イヌキメラ抗体 |
| AU2498192A (en) * | 1991-08-14 | 1993-03-16 | Genentech Inc. | Immunoglobulin variants for specific fc epsilon receptors |
| US5965709A (en) | 1991-08-14 | 1999-10-12 | Genentech, Inc. | IgE antagonists |
| SE9102808L (sv) | 1991-09-26 | 1993-03-27 | Lars T Hellman Inst F Immunolo | Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner |
| DE69332521T2 (de) | 1993-03-11 | 2003-10-02 | Tanox Biosystems, Inc. | ANTIGENE EPITOPE VON IgE REPRÄSENTIERENDEN PEPTIDEN AUF DER B-ZELL-OBERFLÄCHE ABER NICHT AUF OBERFLÄCHEN VON BASOPHILEN |
| US5629415A (en) | 1994-11-09 | 1997-05-13 | Merck & Co., Inc. | DNA encoding canine immunoglobulin E |
| WO1997020859A1 (en) | 1995-12-08 | 1997-06-12 | Idexx Laboratories, Inc. | Methods and compositions concerning allergy in dogs |
| US5945294A (en) | 1996-11-26 | 1999-08-31 | Heska Corporation | Method to detect IgE |
| US6060326A (en) | 1997-04-07 | 2000-05-09 | Heska Corporation | Method to detect canine IgE and kit therefor |
| US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| DE69922873T2 (de) | 1998-04-09 | 2005-12-29 | Idexx Laboratories, Inc. | Spezifische Bindungsproteine zur Behandlung von Allergien beim Hund |
| TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
-
2000
- 2000-06-12 US US09/592,998 patent/US6504013B1/en not_active Expired - Fee Related
-
2001
- 2001-01-30 DE DE60127237T patent/DE60127237T2/de not_active Expired - Lifetime
- 2001-01-30 AU AU2001233102A patent/AU2001233102A1/en not_active Abandoned
- 2001-01-30 JP JP2001557921A patent/JP4605973B2/ja not_active Expired - Fee Related
- 2001-01-30 EP EP01905198A patent/EP1254180B1/en not_active Expired - Lifetime
- 2001-01-30 WO PCT/US2001/002924 patent/WO2001057090A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001233102A1 (en) | 2001-08-14 |
| US6504013B1 (en) | 2003-01-07 |
| JP2003521916A (ja) | 2003-07-22 |
| EP1254180B1 (en) | 2007-03-14 |
| JP4605973B2 (ja) | 2011-01-05 |
| DE60127237D1 (de) | 2007-04-26 |
| EP1254180A1 (en) | 2002-11-06 |
| WO2001057090A1 (en) | 2001-08-09 |
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| 8364 | No opposition during term of opposition |