DE60117295T2 - Synergistische kombinationen mit einem renin-inhibitor für kardiovaskuläre erkrankungen - Google Patents
Synergistische kombinationen mit einem renin-inhibitor für kardiovaskuläre erkrankungen Download PDFInfo
- Publication number
- DE60117295T2 DE60117295T2 DE2001617295 DE60117295T DE60117295T2 DE 60117295 T2 DE60117295 T2 DE 60117295T2 DE 2001617295 DE2001617295 DE 2001617295 DE 60117295 T DE60117295 T DE 60117295T DE 60117295 T2 DE60117295 T2 DE 60117295T2
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- hypertension
- group
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002461 renin inhibitor Substances 0.000 title claims abstract description 19
- 229940086526 renin-inhibitors Drugs 0.000 title claims abstract description 19
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 44
- 239000003814 drug Substances 0.000 claims abstract description 21
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- 206010020772 Hypertension Diseases 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 28
- 239000005541 ACE inhibitor Substances 0.000 claims description 22
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims description 22
- 201000006370 kidney failure Diseases 0.000 claims description 17
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 claims description 16
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 claims description 16
- 201000010099 disease Diseases 0.000 claims description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 15
- 208000010125 myocardial infarction Diseases 0.000 claims description 15
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims description 14
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims description 13
- 230000002265 prevention Effects 0.000 claims description 13
- 229960004699 valsartan Drugs 0.000 claims description 13
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims description 13
- 102100030988 Angiotensin-converting enzyme Human genes 0.000 claims description 10
- 201000001320 Atherosclerosis Diseases 0.000 claims description 10
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 10
- 102000008186 Collagen Human genes 0.000 claims description 9
- 108010035532 Collagen Proteins 0.000 claims description 9
- 108010061435 Enalapril Proteins 0.000 claims description 9
- 206010048554 Endothelial dysfunction Diseases 0.000 claims description 9
- 206010019280 Heart failures Diseases 0.000 claims description 9
- 208000001647 Renal Insufficiency Diseases 0.000 claims description 9
- 208000020832 chronic kidney disease Diseases 0.000 claims description 9
- 208000022831 chronic renal failure syndrome Diseases 0.000 claims description 9
- 229920001436 collagen Polymers 0.000 claims description 9
- 239000002552 dosage form Substances 0.000 claims description 9
- 229960000873 enalapril Drugs 0.000 claims description 9
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims description 9
- 230000008694 endothelial dysfunction Effects 0.000 claims description 9
- 206010016654 Fibrosis Diseases 0.000 claims description 8
- 208000031226 Hyperlipidaemia Diseases 0.000 claims description 8
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims description 8
- 206010007559 Cardiac failure congestive Diseases 0.000 claims description 7
- 208000010412 Glaucoma Diseases 0.000 claims description 7
- 239000003112 inhibitor Substances 0.000 claims description 7
- 230000004083 survival effect Effects 0.000 claims description 7
- 206010022489 Insulin Resistance Diseases 0.000 claims description 6
- 230000004761 fibrosis Effects 0.000 claims description 6
- 208000017169 kidney disease Diseases 0.000 claims description 6
- 208000037803 restenosis Diseases 0.000 claims description 6
- 208000011580 syndromic disease Diseases 0.000 claims description 6
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 4
- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 4
- 208000008589 Obesity Diseases 0.000 claims description 4
- 208000018262 Peripheral vascular disease Diseases 0.000 claims description 4
- 238000002399 angioplasty Methods 0.000 claims description 4
- 230000001028 anti-proliverative effect Effects 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 208000029078 coronary artery disease Diseases 0.000 claims description 4
- 210000004351 coronary vessel Anatomy 0.000 claims description 4
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims description 4
- 208000003532 hypothyroidism Diseases 0.000 claims description 4
- 230000002989 hypothyroidism Effects 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 238000007634 remodeling Methods 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 claims description 4
- 206010042957 Systolic hypertension Diseases 0.000 claims description 3
- 102000015427 Angiotensins Human genes 0.000 claims description 2
- 108010064733 Angiotensins Proteins 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims 1
- 229940072367 zymine Drugs 0.000 claims 1
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 1
- 229960004601 aliskiren Drugs 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 210000005240 left ventricle Anatomy 0.000 description 28
- 239000004480 active ingredient Substances 0.000 description 20
- 230000000694 effects Effects 0.000 description 18
- 239000003826 tablet Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 16
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 12
- 241000700159 Rattus Species 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 11
- 230000036772 blood pressure Effects 0.000 description 11
- 206010011086 Coronary artery occlusion Diseases 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- 239000007941 film coated tablet Substances 0.000 description 9
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 description 8
- 229960002478 aldosterone Drugs 0.000 description 8
- 239000002775 capsule Substances 0.000 description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 108090000783 Renin Proteins 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 210000002700 urine Anatomy 0.000 description 6
- 101800000733 Angiotensin-2 Proteins 0.000 description 5
- 102400000345 Angiotensin-2 Human genes 0.000 description 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 5
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 description 5
- 229950006323 angiotensin ii Drugs 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 210000003734 kidney Anatomy 0.000 description 5
- 210000004165 myocardium Anatomy 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 description 4
- 206010003210 Arteriosclerosis Diseases 0.000 description 4
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 4
- 102000012422 Collagen Type I Human genes 0.000 description 4
- 108010022452 Collagen Type I Proteins 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 4
- 206010061216 Infarction Diseases 0.000 description 4
- 102100028255 Renin Human genes 0.000 description 4
- 229960004530 benazepril Drugs 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000008119 colloidal silica Substances 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 229940099112 cornstarch Drugs 0.000 description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 4
- 229960003765 fluvastatin Drugs 0.000 description 4
- 230000007574 infarction Effects 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 230000035488 systolic blood pressure Effects 0.000 description 4
- 101800000734 Angiotensin-1 Proteins 0.000 description 3
- 102400000344 Angiotensin-1 Human genes 0.000 description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- ORWYRWWVDCYOMK-HBZPZAIKSA-N angiotensin I Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C1=CC=C(O)C=C1 ORWYRWWVDCYOMK-HBZPZAIKSA-N 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000007903 gelatin capsule Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 238000010191 image analysis Methods 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 238000003127 radioimmunoassay Methods 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 238000009097 single-agent therapy Methods 0.000 description 3
- 230000002861 ventricular Effects 0.000 description 3
- 229910002016 Aerosil® 200 Inorganic materials 0.000 description 2
- 102000004881 Angiotensinogen Human genes 0.000 description 2
- 108090001067 Angiotensinogen Proteins 0.000 description 2
- 208000020446 Cardiac disease Diseases 0.000 description 2
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- KCWZGJVSDFYRIX-YFKPBYRVSA-N N(gamma)-nitro-L-arginine methyl ester Chemical compound COC(=O)[C@@H](N)CCCN=C(N)N[N+]([O-])=O KCWZGJVSDFYRIX-YFKPBYRVSA-N 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 206010038923 Retinopathy Diseases 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 102000002262 Thromboplastin Human genes 0.000 description 2
- 108010000499 Thromboplastin Proteins 0.000 description 2
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 2
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 2
- 206010047139 Vasoconstriction Diseases 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 229960000830 captopril Drugs 0.000 description 2
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 2
- 210000004413 cardiac myocyte Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 229940109239 creatinine Drugs 0.000 description 2
- 229960000913 crospovidone Drugs 0.000 description 2
- 230000001258 dyslipidemic effect Effects 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 210000003038 endothelium Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000020764 fibrinolysis Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 230000001631 hypertensive effect Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- -1 moveltopril Chemical compound 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 229960002582 perindopril Drugs 0.000 description 2
- IPVQLZZIHOAWMC-QXKUPLGCSA-N perindopril Chemical compound C1CCC[C@H]2C[C@@H](C(O)=O)N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@H]21 IPVQLZZIHOAWMC-QXKUPLGCSA-N 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 229960001455 quinapril Drugs 0.000 description 2
- JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 description 2
- 229960003401 ramipril Drugs 0.000 description 2
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229960000187 tissue plasminogen activator Drugs 0.000 description 2
- 230000025033 vasoconstriction Effects 0.000 description 2
- 238000001262 western blot Methods 0.000 description 2
- UXOWGYHJODZGMF-IYQSZBERSA-N (2s)-5-amino-n-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide Chemical compound COCCCOC1=CC(CC(CC(N)C(O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-IYQSZBERSA-N 0.000 description 1
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 1
- CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- FHHHOYXPRDYHEZ-COXVUDFISA-N Alacepril Chemical compound CC(=O)SC[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 FHHHOYXPRDYHEZ-COXVUDFISA-N 0.000 description 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
- 102000008873 Angiotensin II receptor Human genes 0.000 description 1
- 108050000824 Angiotensin II receptor Proteins 0.000 description 1
- 206010005746 Blood pressure fluctuation Diseases 0.000 description 1
- 239000002083 C09CA01 - Losartan Substances 0.000 description 1
- 239000002080 C09CA02 - Eprosartan Substances 0.000 description 1
- 239000002947 C09CA04 - Irbesartan Substances 0.000 description 1
- 239000002081 C09CA05 - Tasosartan Substances 0.000 description 1
- 239000002053 C09CA06 - Candesartan Substances 0.000 description 1
- 239000005537 C09CA07 - Telmisartan Substances 0.000 description 1
- VWWMGPCUZVOLLK-UHFFFAOYSA-N Cc1c2nc(C3CC3)[n](Cc(cc3)ccc3-c3ccccc3C(O)=O)c2ncc1 Chemical compound Cc1c2nc(C3CC3)[n](Cc(cc3)ccc3-c3ccccc3C(O)=O)c2ncc1 VWWMGPCUZVOLLK-UHFFFAOYSA-N 0.000 description 1
- IFYLTXNCFVRALQ-OALUTQOASA-N Ceronapril Chemical compound O([C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)P(O)(=O)CCCCC1=CC=CC=C1 IFYLTXNCFVRALQ-OALUTQOASA-N 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 108010007859 Lisinopril Proteins 0.000 description 1
- 101100033673 Mus musculus Ren1 gene Proteins 0.000 description 1
- 101100033674 Mus musculus Ren2 gene Proteins 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 239000005480 Olmesartan Substances 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010061481 Renal injury Diseases 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 238000003639 Student–Newman–Keuls (SNK) method Methods 0.000 description 1
- VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 description 1
- 238000010162 Tukey test Methods 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 206010000891 acute myocardial infarction Diseases 0.000 description 1
- 210000004100 adrenal gland Anatomy 0.000 description 1
- 229950007884 alacepril Drugs 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000003276 anti-hypertensive effect Effects 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 1
- 229960004067 benazeprilat Drugs 0.000 description 1
- MADRIHWFJGRSBP-ROUUACIJSA-N benazeprilat Chemical compound C([C@H](N[C@H]1CCC2=CC=CC=C2N(C1=O)CC(=O)O)C(O)=O)CC1=CC=CC=C1 MADRIHWFJGRSBP-ROUUACIJSA-N 0.000 description 1
- 230000002902 bimodal effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229960000932 candesartan Drugs 0.000 description 1
- SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 150000003943 catecholamines Chemical class 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 229950005749 ceronapril Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229960005025 cilazapril Drugs 0.000 description 1
- HHHKFGXWKKUNCY-FHWLQOOXSA-N cilazapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N2[C@@H](CCCN2CCC1)C(O)=O)=O)CC1=CC=CC=C1 HHHKFGXWKKUNCY-FHWLQOOXSA-N 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940096422 collagen type i Drugs 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229960005227 delapril Drugs 0.000 description 1
- WOUOLAUOZXOLJQ-MBSDFSHPSA-N delapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N(CC(O)=O)C1CC2=CC=CC=C2C1)CC1=CC=CC=C1 WOUOLAUOZXOLJQ-MBSDFSHPSA-N 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000003205 diastolic effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 229960004563 eprosartan Drugs 0.000 description 1
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 229950011548 fadrozole Drugs 0.000 description 1
- 238000005048 flame photometry Methods 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 229960002490 fosinopril Drugs 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 206010061989 glomerulosclerosis Diseases 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 229960001195 imidapril Drugs 0.000 description 1
- KLZWOWYOHUKJIG-BPUTZDHNSA-N imidapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1C(N(C)C[C@H]1C(O)=O)=O)CC1=CC=CC=C1 KLZWOWYOHUKJIG-BPUTZDHNSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000007914 intraventricular administration Methods 0.000 description 1
- 229960002198 irbesartan Drugs 0.000 description 1
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 description 1
- 230000005977 kidney dysfunction Effects 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229960002394 lisinopril Drugs 0.000 description 1
- CZRQXSDBMCMPNJ-ZUIPZQNBSA-N lisinopril dihydrate Chemical compound O.O.C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 CZRQXSDBMCMPNJ-ZUIPZQNBSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960004773 losartan Drugs 0.000 description 1
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical compound CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012792 lyophilization process Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 230000003562 morphometric effect Effects 0.000 description 1
- 238000013425 morphometry Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- JPXMTWWFLBLUCD-UHFFFAOYSA-N nitro blue tetrazolium(2+) Chemical compound COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 JPXMTWWFLBLUCD-UHFFFAOYSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- VTRAEEWXHOVJFV-UHFFFAOYSA-N olmesartan Chemical compound CCCC1=NC(C(C)(C)O)=C(C(O)=O)N1CC1=CC=C(C=2C(=CC=CC=2)C=2NN=NN=2)C=C1 VTRAEEWXHOVJFV-UHFFFAOYSA-N 0.000 description 1
- 229960005117 olmesartan Drugs 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 230000004526 pharmaceutical effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000013105 post hoc analysis Methods 0.000 description 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 201000001474 proteinuria Diseases 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000000275 quality assurance Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012439 solid excipient Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960002909 spirapril Drugs 0.000 description 1
- 108700035424 spirapril Proteins 0.000 description 1
- HRWCVUIFMSZDJS-SZMVWBNQSA-N spirapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2(C1)SCCS2)C(O)=O)CC1=CC=CC=C1 HRWCVUIFMSZDJS-SZMVWBNQSA-N 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229960000651 tasosartan Drugs 0.000 description 1
- ADXGNEYLLLSOAR-UHFFFAOYSA-N tasosartan Chemical compound C12=NC(C)=NC(C)=C2CCC(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1C=1N=NNN=1 ADXGNEYLLLSOAR-UHFFFAOYSA-N 0.000 description 1
- 229960005187 telmisartan Drugs 0.000 description 1
- 229960004084 temocapril Drugs 0.000 description 1
- FIQOFIRCTOWDOW-BJLQDIEVSA-N temocapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C[C@H](SC1)C=1SC=CC=1)=O)CC1=CC=CC=C1 FIQOFIRCTOWDOW-BJLQDIEVSA-N 0.000 description 1
- 229960002051 trandolapril Drugs 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0028151A GB0028151D0 (en) | 2000-11-17 | 2000-11-17 | Combination of organic compounds |
| GB0028151 | 2000-11-17 | ||
| PCT/EP2001/013241 WO2002040007A1 (en) | 2000-11-17 | 2001-11-15 | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60117295D1 DE60117295D1 (de) | 2006-04-20 |
| DE60117295T2 true DE60117295T2 (de) | 2006-08-17 |
Family
ID=9903412
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60134349T Expired - Lifetime DE60134349D1 (de) | 2000-11-17 | 2001-11-15 | Synergistische Kombinationen enthaltend einen Renininhibitor für Kardiovaskulären Erkrankungen |
| DE2001617295 Expired - Lifetime DE60117295T2 (de) | 2000-11-17 | 2001-11-15 | Synergistische kombinationen mit einem renin-inhibitor für kardiovaskuläre erkrankungen |
| DE200912000021 Pending DE122009000021I1 (de) | 2000-11-17 | 2001-11-15 | Synergistische Kombinationen enthaltend einen Renininhibitor für kardiovaskuläre Erkrankungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60134349T Expired - Lifetime DE60134349D1 (de) | 2000-11-17 | 2001-11-15 | Synergistische Kombinationen enthaltend einen Renininhibitor für Kardiovaskulären Erkrankungen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE200912000021 Pending DE122009000021I1 (de) | 2000-11-17 | 2001-11-15 | Synergistische Kombinationen enthaltend einen Renininhibitor für kardiovaskuläre Erkrankungen |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US8168616B1 (enExample) |
| EP (7) | EP1930000A1 (enExample) |
| JP (6) | JP2004513920A (enExample) |
| KR (6) | KR101008752B1 (enExample) |
| CN (4) | CN100404024C (enExample) |
| AT (2) | ATE317692T1 (enExample) |
| AU (2) | AU2002223680B2 (enExample) |
| BR (1) | BR0115411A (enExample) |
| CA (2) | CA2763223A1 (enExample) |
| CY (5) | CY1105603T1 (enExample) |
| CZ (2) | CZ305341B6 (enExample) |
| DE (3) | DE60134349D1 (enExample) |
| DK (3) | DK1341533T3 (enExample) |
| EC (1) | ECSP034603A (enExample) |
| ES (4) | ES2256335T3 (enExample) |
| GB (1) | GB0028151D0 (enExample) |
| HU (2) | HUP0301841A3 (enExample) |
| IL (3) | IL155707A (enExample) |
| LU (2) | LU91563I2 (enExample) |
| MX (1) | MXPA03004358A (enExample) |
| NL (2) | NL300385I1 (enExample) |
| NO (2) | NO334002B1 (enExample) |
| NZ (6) | NZ568764A (enExample) |
| PL (3) | PL400915A1 (enExample) |
| PT (3) | PT1341533E (enExample) |
| RU (2) | RU2310443C2 (enExample) |
| SG (1) | SG135969A1 (enExample) |
| SI (3) | SI1915993T1 (enExample) |
| SK (1) | SK287881B6 (enExample) |
| WO (1) | WO2002040007A1 (enExample) |
| ZA (1) | ZA200303497B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016015812A1 (de) | 2014-07-30 | 2016-02-04 | Merck Patent Gmbh | Direkt verpressbare polyvinylalkohole |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003035046A2 (en) * | 2001-10-18 | 2003-05-01 | Novartis Ag | Salts formed of an at1-receptor antagonist and a cardiovascular agent |
| ES2369216T3 (es) | 2002-05-17 | 2011-11-28 | Novartis Pharma Ag | Composición farmacéutica que comprende un inhibidor de renina, un bloqueador del canal de calcio y un diurético. |
| GB0212410D0 (en) | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
| AU2003255527A1 (en) * | 2002-06-28 | 2004-01-19 | Speedel Pharma Ag | Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant |
| JP2005537822A (ja) * | 2002-06-28 | 2005-12-15 | ノバルティス アクチエンゲゼルシャフト | 有機化合物の使用 |
| SE0300988D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | New use |
| TW200900399A (en) | 2003-10-01 | 2009-01-01 | Speedel Experimenta Ag | Organic compounds |
| GB0325605D0 (en) * | 2003-11-03 | 2003-12-10 | Novartis Ag | Combination of organic compounds |
| CN1882528A (zh) * | 2003-11-26 | 2006-12-20 | 诺瓦提斯公司 | 有机化合物 |
| GB0327839D0 (en) * | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| ATE472524T1 (de) * | 2004-01-23 | 2010-07-15 | Novartis Ag | Diaminoalkohole und deren verwendung als renininhibitoren |
| PT1756037E (pt) * | 2004-01-23 | 2011-02-25 | Novartis Ag | Derivados de aminoálcoois e a sua actividade como inibidores de renina |
| AR047445A1 (es) | 2004-01-23 | 2006-01-18 | Speedel Experimenta Ag | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. |
| MY148773A (en) * | 2004-03-17 | 2013-05-31 | Novartis Ag | Galenic formulations of organic compounds |
| WO2005089731A2 (en) * | 2004-03-17 | 2005-09-29 | Novartis Ag | Use of renin inhibitors in therapy |
| EP1725530A1 (en) * | 2004-03-19 | 2006-11-29 | Speedel Experimenta AG | Organic compounds |
| WO2005099695A1 (en) * | 2004-04-19 | 2005-10-27 | Novartis Ag | Drug delivery systems for the prevention and treatment of vascular diseases |
| WO2006041974A1 (en) * | 2004-10-08 | 2006-04-20 | Novartis Ag | Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
| EP1897879A3 (en) | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-substituted piperidines as renin inhibitors |
| AU2006241219A1 (en) * | 2005-04-27 | 2006-11-02 | Novartis Ag | Methods of treating atherosclerosis |
| GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| CN1732952B (zh) * | 2005-09-02 | 2010-04-07 | 姚俊华 | 一种治疗高血压的复方分散片 |
| ES2303198T3 (es) * | 2005-09-28 | 2008-08-01 | Teva Pharmaceutical Industries Ltd. | Combinaciones estables de besilato de amlodipina e hidrocloruro de benazeprilo. |
| US8158146B2 (en) | 2005-09-28 | 2012-04-17 | Teva Pharmaceutical Industries Ltd. | Stable combinations of amlodipine besylate and benazepril hydrochloride |
| WO2007056324A2 (en) * | 2005-11-08 | 2007-05-18 | Novartis Ag | Combination of an angiotensin ii receptor blocker, a calcium channel blocker and another active agent |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| KR20080104149A (ko) * | 2006-03-13 | 2008-12-01 | 엔싸이시브 파마슈티칼즈 인코퍼레이티드 | 확장기 심장 부전의 치료를 위한 방법 및 조성물 |
| US20070260203A1 (en) * | 2006-05-04 | 2007-11-08 | Allergan, Inc. | Vasoactive agent intraocular implant |
| GB0612540D0 (en) | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| TW200831463A (en) * | 2006-09-12 | 2008-08-01 | Speedel Experimenta Ag | Nitrate esters of aminoalcohols |
| KR100888131B1 (ko) * | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
| BRPI0721167A2 (pt) * | 2006-12-15 | 2014-03-18 | Novartis Ag | Inibidores de renina para prevenção e tratamento de hipertensão em pacientes obesos. |
| US20080194626A1 (en) * | 2007-02-14 | 2008-08-14 | Gorczynski Richard J | Antihypertensive drug combination |
| AU2008309058B2 (en) * | 2007-09-28 | 2012-08-09 | Novartis Ag | Galenical formulations of Aliskiren and Valsartan |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| CN102014881A (zh) | 2008-02-22 | 2011-04-13 | 韩兀生物制药株式会社 | 药物制剂 |
| WO2009125981A2 (ko) | 2008-04-10 | 2009-10-15 | 한올제약주식회사 | 약제학적 제제 |
| WO2009127251A1 (en) * | 2008-04-16 | 2009-10-22 | Novartis Ag | Combinations comprising a renin inhibitor |
| EP2281557A4 (en) | 2008-04-29 | 2011-08-31 | Hanall Biopharma Co Ltd | PHARMACEUTICAL FORMULATION CONTAINING AN ANGIOTENSIN II RECEPTOR BLOCKING AGENT |
| WO2010024772A1 (en) * | 2008-08-29 | 2010-03-04 | Medivir Ab | Aspartyl protease inhibitors |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| KR20110130491A (ko) | 2009-03-20 | 2011-12-05 | 노파르티스 아게 | 발사르탄 및 알리스키렌의 고정 용량 조합물의 생약 제형 |
| CN101926793B (zh) * | 2010-08-05 | 2012-08-15 | 成都自豪药业有限公司 | 一种含替米沙坦和阿利吉伦的联合用药物及其制备方法 |
| WO2012152718A1 (en) | 2011-05-06 | 2012-11-15 | Farmicom Pharmaceutical Company D.O.O. | Composition comprising angiotensin ii receptor antagonist and antioxidant for maintaining and/or improving skin properties |
| RU2483750C1 (ru) * | 2012-03-19 | 2013-06-10 | Общество с ограниченной ответственностью "СупраГен" | Способ лечения больных с острым инфарктом миокарда с подъемом сегмента st |
| NZ724002A (en) * | 2012-05-18 | 2017-07-28 | Luoda Pharma Pty Ltd | Liquid formulation comprising propylene glycol and an ace inhibitor |
| RU2554815C1 (ru) * | 2014-06-18 | 2015-06-27 | Общество с ограниченной ответственностью "Нанолек" | Гипотензивное средство |
| BR112019007954A2 (pt) * | 2016-10-27 | 2019-07-02 | Damian Pharma Ag | inibidor da aldosterona sintase |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889861A (en) | 1982-12-21 | 1989-12-26 | Ciba-Geigy Corp. | Substituted imidazo[1,5-a]pyridine derivatives and other substituted bicyclic derivatives and their use as aromatase inhibitors |
| US4617307A (en) | 1984-06-20 | 1986-10-14 | Ciba-Geigy Corporation | Substituted imidazo[1,5-A]pyridine derivatives as aromatase inhibitors |
| US4559332A (en) | 1983-04-13 | 1985-12-17 | Ciba Geigy Corporation | 20-Spiroxanes and analogues having an open ring E, processes for their manufacture, and pharmaceutical preparations thereof |
| US4782043A (en) | 1983-06-15 | 1988-11-01 | Merck & Co., Inc. | Renin inhibitors containing a C-terminal amide cycle |
| US4898729A (en) | 1983-12-09 | 1990-02-06 | Euroceltique, S.A. | Treatment of hypertension, compounds and compositions for antihypertension and diuresis |
| US4812442A (en) | 1984-05-29 | 1989-03-14 | Merck & Co., Inc. | Tripeptide renin inhibitors |
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US4927807A (en) | 1987-10-06 | 1990-05-22 | Abbott Laboratories | Glaucoma treatment |
| SE8802428D0 (sv) * | 1988-06-28 | 1988-06-28 | Haessle Ab | New compounds |
| US5268374A (en) | 1988-10-04 | 1993-12-07 | Abbott Laboratories | Non-peptide renin inhibitors |
| US5164388A (en) | 1988-10-19 | 1992-11-17 | Abbott Laboratories | Heterocyclic peptide renin inhibitors |
| ATE190051T1 (de) | 1989-06-14 | 2000-03-15 | Smithkline Beecham Corp | Imidazoalkensäure |
| EP0438311A3 (en) * | 1990-01-19 | 1992-07-01 | Merck & Co. Inc. | Di- and tripeptide renin inhibitors |
| US5182266A (en) * | 1990-01-31 | 1993-01-26 | Abbott Laboratories | Method for treating renal disease |
| DE122010000024I1 (de) * | 1990-02-19 | 2010-07-08 | Novartis Ag | Acylverbindungen |
| PT97078B (pt) | 1990-03-20 | 1997-07-31 | Sanofi Sa | Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| IE68045B1 (en) | 1990-05-11 | 1996-05-15 | Abbott Lab | Renin inhibitors |
| US5821232A (en) | 1990-05-11 | 1998-10-13 | Pfizer Inc. | Synergistic therapeutic compositions and methods |
| KR970005839B1 (ko) * | 1990-05-11 | 1997-04-21 | 화이자 인코포레이티드 | 상승 치료효과를 얻기 위한 조성물 및 방법 |
| WO1992000972A1 (en) | 1990-07-11 | 1992-01-23 | Abbott Laboratories | Renin inhibiting compounds |
| WO1992003429A1 (en) * | 1990-08-15 | 1992-03-05 | Abbott Laboratories | Renin inhibitors |
| US5656650A (en) * | 1990-12-14 | 1997-08-12 | Smithkline Beecham Corp. | Angiotensin II receptor blocking compositions |
| JP3398379B2 (ja) | 1990-12-14 | 2003-04-21 | スミスクライン・ビーチャム・コーポレイション | アンジオテンシンｉｉ受容体遮断組成物 |
| EP0498361A3 (en) | 1991-02-06 | 1992-09-02 | Schering Corporation | Combination of an angiotensin ii antagonist or renin inhibitor with a neutral endopeptidase inhibitor |
| IE920540A1 (en) | 1991-02-21 | 1992-08-26 | Sankyo Co | 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use |
| RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| DE4121975A1 (de) | 1991-07-03 | 1993-01-07 | Basf Ag | Thermoplastische formmassen auf der basis von polycarbonaten, styrol/acrylnitril-polymerisaten und polyolefinen |
| US5256667A (en) * | 1991-09-25 | 1993-10-26 | Merck & Co., Inc. | Quinazolinones and pyridopyrimidinones |
| TW226375B (enExample) | 1991-10-24 | 1994-07-11 | American Home Prod | |
| US6057344A (en) | 1991-11-26 | 2000-05-02 | Sepracor, Inc. | Methods for treating hypertension, and angina using optically pure (-) amlodipine |
| KR100331667B1 (ko) | 1993-04-27 | 2002-11-08 | 스미스클라인 비참 코포레이션 | 엔도텔린수용체길항제 |
| US5508272A (en) | 1993-06-15 | 1996-04-16 | Bristol-Myers Squibb Company | Compounds containing a fused bicycle ring and processes therefor |
| ES2154277T3 (es) * | 1993-07-15 | 2001-04-01 | Hoffmann La Roche | Combinacion farmaceutica que contiene un inhibidor del sistema renina-angiotensina y un antagonista de endotelina. |
| ES2156157T3 (es) | 1993-08-18 | 2001-06-16 | Banyu Pharma Co Ltd | Derivado de ciclopenteno heteroaromatico fusionado con una actividad antagonista de la endotelina. |
| US5606078A (en) | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5659065A (en) | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| US5562921A (en) | 1994-07-15 | 1996-10-08 | Sherman; Bernard C. | Stable solid pharmaceutical compositions containing enalapril maleate |
| JP3741441B2 (ja) | 1994-08-19 | 2006-02-01 | アボツト・ラボラトリーズ | エンドセリン・アンタゴニスト |
| US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
| DE19533023B4 (de) | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
| TW313568B (enExample) | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
| CZ223697A3 (en) | 1995-01-27 | 1997-12-17 | Rhone Poulenc Rorer Ltd | Substituted phenyl derivatives as endothelin antagonists |
| US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| JPH0971586A (ja) * | 1995-09-07 | 1997-03-18 | Yamanouchi Pharmaceut Co Ltd | 新規な二環性縮合イミダゾール誘導体 |
| US5696166A (en) | 1995-10-31 | 1997-12-09 | Yanni; John M. | Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders |
| ATE201202T1 (de) | 1995-12-20 | 2001-06-15 | Yamanouchi Pharma Co Ltd | Arylethensulfonamid-derivate und diese enthaltende medikamente |
| IT1277737B1 (it) | 1995-12-28 | 1997-11-12 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
| WO1997027314A1 (fr) | 1996-01-23 | 1997-07-31 | Shionogi & Co., Ltd. | Processus de production d'analogues d'acide oleanolique par la culture de racine pileuse |
| JP3345891B2 (ja) | 1996-04-04 | 2002-11-18 | 萬有製薬株式会社 | エンドセリン拮抗薬を含有することを特徴とする心不全治療剤 |
| GB9613470D0 (en) | 1996-06-27 | 1996-08-28 | Ciba Geigy Ag | Small solid oral dosage form |
| GT199800126A (es) * | 1997-08-29 | 2000-01-29 | Terapia de combinacion. | |
| DE19806438A1 (de) * | 1998-02-17 | 1999-08-19 | Basf Ag | Neue Carbonsäurederivate mit 5-substituiertem Pyrimidinring, ihre Herstellung und Verwendung |
| CA2332608C (en) * | 1998-06-17 | 2010-03-23 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination |
| EP1098634A4 (en) | 1998-07-20 | 2006-10-25 | Smithkline Beecham Corp | EPROSARTAN CONTAINING MORE EFFECTIVE FORMULATIONS IN ORAL SOLID PHARMACEUTICAL FORM |
| UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
| EP1175246A4 (en) * | 1999-03-19 | 2004-12-15 | Brigham & Womens Hospital | POSITIVE REGULATION OF NITRIC OXIDE SYNTHASE OF TYPE III ENDOTHELIAL CELLS BY HMG-COA REDUCTASE INHIBITORS |
| ES2288487T3 (es) | 1999-11-09 | 2008-01-16 | Pharmacia Corporation | Uso de eplerenona para tratamiento de la restenosis. |
| US20030114389A1 (en) * | 2001-11-13 | 2003-06-19 | Webb Randy Lee | Combination of organic compounds |
| ES2369216T3 (es) * | 2002-05-17 | 2011-11-28 | Novartis Pharma Ag | Composición farmacéutica que comprende un inhibidor de renina, un bloqueador del canal de calcio y un diurético. |
| ATE397147T1 (de) | 2002-12-31 | 2008-06-15 | Volkswagen Ag | Verfahren zur steuerung einer verbrennungskraftmaschine sowie magerlauffahige verbrennungskraftmaschine |
-
2000
- 2000-11-15 US US10/416,039 patent/US8168616B1/en not_active Expired - Fee Related
- 2000-11-17 GB GB0028151A patent/GB0028151D0/en not_active Ceased
-
2001
- 2001-11-15 CZ CZ2011-614A patent/CZ305341B6/cs not_active IP Right Cessation
- 2001-11-15 AU AU2002223680A patent/AU2002223680B2/en not_active Expired
- 2001-11-15 NZ NZ568764A patent/NZ568764A/en not_active IP Right Cessation
- 2001-11-15 PT PT01996377T patent/PT1341533E/pt unknown
- 2001-11-15 DE DE60134349T patent/DE60134349D1/de not_active Expired - Lifetime
- 2001-11-15 SI SI200131026T patent/SI1915993T1/sl unknown
- 2001-11-15 ES ES01996377T patent/ES2256335T3/es not_active Expired - Lifetime
- 2001-11-15 AU AU2368002A patent/AU2368002A/xx active Pending
- 2001-11-15 ES ES10179109T patent/ES2734523T3/es not_active Expired - Lifetime
- 2001-11-15 EP EP20080002604 patent/EP1930000A1/en not_active Withdrawn
- 2001-11-15 CN CNB018190685A patent/CN100404024C/zh not_active Expired - Fee Related
- 2001-11-15 KR KR1020087024052A patent/KR101008752B1/ko not_active Expired - Fee Related
- 2001-11-15 NZ NZ550896A patent/NZ550896A/en not_active IP Right Cessation
- 2001-11-15 CA CA 2763223 patent/CA2763223A1/en not_active Withdrawn
- 2001-11-15 PT PT08002401T patent/PT1915993E/pt unknown
- 2001-11-15 HU HU0301841A patent/HUP0301841A3/hu not_active Application Discontinuation
- 2001-11-15 AT AT01996377T patent/ATE317692T1/de active
- 2001-11-15 EP EP20100179101 patent/EP2305231A1/en not_active Withdrawn
- 2001-11-15 NZ NZ525795A patent/NZ525795A/en not_active IP Right Cessation
- 2001-11-15 ES ES05015603T patent/ES2308347T3/es not_active Expired - Lifetime
- 2001-11-15 KR KR1020087001407A patent/KR20080011355A/ko not_active Ceased
- 2001-11-15 EP EP20080002401 patent/EP1915993B1/en not_active Revoked
- 2001-11-15 EP EP20100179116 patent/EP2305233A1/en not_active Withdrawn
- 2001-11-15 KR KR1020107018819A patent/KR20100114904A/ko not_active Ceased
- 2001-11-15 DK DK01996377T patent/DK1341533T3/da active
- 2001-11-15 CN CNA2008100985065A patent/CN101264073A/zh active Pending
- 2001-11-15 NZ NZ550898A patent/NZ550898A/en not_active IP Right Cessation
- 2001-11-15 EP EP20050015603 patent/EP1602370B1/en not_active Revoked
- 2001-11-15 DK DK08002401T patent/DK1915993T3/da active
- 2001-11-15 DE DE2001617295 patent/DE60117295T2/de not_active Expired - Lifetime
- 2001-11-15 ES ES08002401T patent/ES2429292T3/es not_active Expired - Lifetime
- 2001-11-15 CZ CZ20031341A patent/CZ299749B6/cs not_active IP Right Cessation
- 2001-11-15 CN CNA200710140212XA patent/CN101091703A/zh active Pending
- 2001-11-15 NZ NZ550897A patent/NZ550897A/en not_active IP Right Cessation
- 2001-11-15 EP EP20010996377 patent/EP1341533B1/en not_active Expired - Lifetime
- 2001-11-15 CA CA 2428647 patent/CA2428647A1/en not_active Withdrawn
- 2001-11-15 PL PL40091501A patent/PL400915A1/pl unknown
- 2001-11-15 SG SG200504685-9A patent/SG135969A1/en unknown
- 2001-11-15 EP EP10179109.3A patent/EP2305232B1/en not_active Expired - Lifetime
- 2001-11-15 DE DE200912000021 patent/DE122009000021I1/de active Pending
- 2001-11-15 AT AT05015603T patent/ATE397445T1/de active
- 2001-11-15 HU HUP1400409A patent/HU230882B1/hu not_active IP Right Cessation
- 2001-11-15 JP JP2002542381A patent/JP2004513920A/ja not_active Withdrawn
- 2001-11-15 MX MXPA03004358A patent/MXPA03004358A/es active IP Right Grant
- 2001-11-15 KR KR10-2003-7005901A patent/KR20030051753A/ko not_active Ceased
- 2001-11-15 SK SK584-2003A patent/SK287881B6/sk not_active IP Right Cessation
- 2001-11-15 SI SI200130850T patent/SI1602370T1/sl unknown
- 2001-11-15 PT PT05015603T patent/PT1602370E/pt unknown
- 2001-11-15 CN CNA2008100985050A patent/CN101264072A/zh active Pending
- 2001-11-15 IL IL155707A patent/IL155707A/en not_active IP Right Cessation
- 2001-11-15 WO PCT/EP2001/013241 patent/WO2002040007A1/en not_active Ceased
- 2001-11-15 PL PL361404A patent/PL227576B1/pl unknown
- 2001-11-15 DK DK05015603T patent/DK1602370T3/da active
- 2001-11-15 BR BR0115411A patent/BR0115411A/pt not_active Application Discontinuation
- 2001-11-15 PL PL40091401A patent/PL400914A1/pl unknown
- 2001-11-15 SI SI200130530T patent/SI1341533T1/sl unknown
- 2001-11-15 RU RU2003116896A patent/RU2310443C2/ru not_active IP Right Cessation
- 2001-11-15 NZ NZ537691A patent/NZ537691A/en not_active IP Right Cessation
- 2001-11-15 KR KR1020087024051A patent/KR20080096715A/ko not_active Withdrawn
- 2001-11-15 KR KR1020117012347A patent/KR101258365B1/ko not_active Expired - Fee Related
-
2003
- 2003-05-07 ZA ZA200303497A patent/ZA200303497B/en unknown
- 2003-05-13 EC ECSP034603 patent/ECSP034603A/es unknown
- 2003-05-16 NO NO20032233A patent/NO334002B1/no not_active IP Right Cessation
-
2006
- 2006-04-13 CY CY20061100519T patent/CY1105603T1/el unknown
- 2006-09-12 RU RU2006132668A patent/RU2346703C2/ru not_active IP Right Cessation
-
2008
- 2008-09-02 CY CY20081100932T patent/CY1108305T1/el unknown
-
2009
- 2009-04-24 NL NL300385C patent/NL300385I1/nl unknown
- 2009-05-06 LU LU91563C patent/LU91563I2/fr unknown
- 2009-05-11 CY CY2009005C patent/CY2009005I1/el unknown
- 2009-07-22 JP JP2009171142A patent/JP2009235107A/ja not_active Withdrawn
-
2011
- 2011-03-31 IL IL212075A patent/IL212075A/en not_active IP Right Cessation
- 2011-09-19 US US13/235,758 patent/US9023894B2/en not_active Expired - Fee Related
- 2011-09-19 US US13/235,659 patent/US9023893B2/en not_active Expired - Fee Related
- 2011-09-19 US US13/235,787 patent/US8618174B2/en not_active Expired - Fee Related
-
2012
- 2012-01-30 IL IL217847A patent/IL217847A0/en unknown
-
2013
- 2013-07-17 JP JP2013148269A patent/JP6089278B2/ja not_active Expired - Lifetime
- 2013-10-10 CY CY20131100889T patent/CY1114829T1/el unknown
- 2013-11-27 LU LU92315C patent/LU92315I2/fr unknown
- 2013-12-13 CY CY2013045C patent/CY2013045I2/el unknown
- 2013-12-17 NO NO2013019C patent/NO2013019I1/no unknown
-
2016
- 2016-11-01 JP JP2016214552A patent/JP6373931B2/ja not_active Expired - Lifetime
-
2017
- 2017-12-04 JP JP2017232474A patent/JP6577994B2/ja not_active Expired - Lifetime
-
2018
- 2018-05-30 JP JP2018103151A patent/JP6603757B2/ja not_active Expired - Lifetime
-
2019
- 2019-09-06 NL NL301005C patent/NL301005I2/nl unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016015812A1 (de) | 2014-07-30 | 2016-02-04 | Merck Patent Gmbh | Direkt verpressbare polyvinylalkohole |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60117295T2 (de) | Synergistische kombinationen mit einem renin-inhibitor für kardiovaskuläre erkrankungen | |
| AU2001273938B2 (en) | Novel medical use of aldosterone synthase inhibitors alone or in combination with ati-receptor antagonists | |
| DE60122928T2 (de) | Therapeutische zusammensetzung von amlodipin und benazepril / benazeprilat | |
| AU2001273938A1 (en) | Novel medical use of aldosterone synthase inhibitors alone or in combination with ati-receptor antagonists | |
| DE69929703T2 (de) | Neue orale formulierungen für 5-ht4 agonisten oder antagonisten | |
| EP1276476B1 (de) | Verwendung von bradycardica bei der behandlung von mit hypertrophie einhergehenden myocarderkrankungen und neue arzneimittelkombinationen | |
| DE602004012763T2 (de) | Pharmazeutische zusammensetzung mit einem selektiven i1 imidazolin-rezeptor-agonisten und einem angiotensin-ii-rezeptorblocker | |
| US20090036432A1 (en) | Combinations of AT1-antagonists, amiloride or triamterine, and a diuretic | |
| DE69813083T2 (de) | Kombination in feste Dosiermenge von Angiotensin-Converting-Enzyme-Hemmern mit Calcium-Kanal Antagonisten zur Behandlung von Herz-Kreislauferkrankungen | |
| DE60203192T2 (de) | Zubereitungen mit lisinopril und ungemahlenem dcpd | |
| DE69923982T2 (de) | Verwendung einer zusammensetzung enthaltend eine assoziation eines angiotensin ii at1 rezeptor antagonists und indomethacin zur herstellung eines arzneimittels zur behandlung von kronischen glomerulonephriten | |
| US20040204444A1 (en) | Combination of organic compounds | |
| Brunner et al. | Treatment of hypertension with ACE inhibitors as first step: pharmacologic and clinical considerations | |
| EP0334164A2 (de) | Antihypertensives Kombinationspräparat | |
| NZ534086A (en) | Use of an aldosterone synthase inhibitor in combination with an angiotensin I receptor antagonist or an angiotensin I receptor antagonist plus a diuretic to treat various conditions | |
| MXPA06004933A (en) | Combinations of at1-antagonists, amiloride or triamterine, and a diuretic | |
| HK1059212B (en) | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases | |
| HK1089356B (en) | Synergistic combinations comprising a renin inhibitor for cardiovascular diseases | |
| DE10230272A1 (de) | AT1-Rezeptorantagonisten zur Prävention von Folgeschlaganfällen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NOVARTIS PHARMA AG, BASEL, CH |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |