DE60115044T2 - Liposomale antineoplastische arzneimittel und deren verwendungen - Google Patents
Liposomale antineoplastische arzneimittel und deren verwendungen Download PDFInfo
- Publication number
- DE60115044T2 DE60115044T2 DE60115044T DE60115044T DE60115044T2 DE 60115044 T2 DE60115044 T2 DE 60115044T2 DE 60115044 T DE60115044 T DE 60115044T DE 60115044 T DE60115044 T DE 60115044T DE 60115044 T2 DE60115044 T2 DE 60115044T2
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- Germany
- Prior art keywords
- drug
- topotecan
- liposomal formulation
- liposomes
- lipid
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21555600P | 2000-06-30 | 2000-06-30 | |
| US215556P | 2000-06-30 | ||
| US26461601P | 2001-01-26 | 2001-01-26 | |
| US264616P | 2001-01-26 | ||
| PCT/CA2001/000925 WO2002002077A2 (en) | 2000-06-30 | 2001-06-29 | Liposomal antineoplastic drugs and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60115044D1 DE60115044D1 (de) | 2005-12-22 |
| DE60115044T2 true DE60115044T2 (de) | 2006-08-03 |
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| DE60115045T Expired - Lifetime DE60115045T2 (de) | 2000-06-30 | 2001-06-29 | Verbesserte liposomale camptothecine und deren verwendungen |
| DE60115044T Expired - Lifetime DE60115044T2 (de) | 2000-06-30 | 2001-06-29 | Liposomale antineoplastische arzneimittel und deren verwendungen |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60115045T Expired - Lifetime DE60115045T2 (de) | 2000-06-30 | 2001-06-29 | Verbesserte liposomale camptothecine und deren verwendungen |
Country Status (12)
| Country | Link |
|---|---|
| US (7) | US7060828B2 (OSRAM) |
| EP (2) | EP1299085B1 (OSRAM) |
| JP (3) | JP2004501955A (OSRAM) |
| CN (1) | CN1245977C (OSRAM) |
| AT (2) | ATE309786T1 (OSRAM) |
| AU (3) | AU2001270413A1 (OSRAM) |
| CA (2) | CA2412790C (OSRAM) |
| DE (2) | DE60115045T2 (OSRAM) |
| ES (1) | ES2253398T3 (OSRAM) |
| IL (2) | IL153676A0 (OSRAM) |
| MX (1) | MXPA02012817A (OSRAM) |
| WO (2) | WO2002002077A2 (OSRAM) |
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| US20040247662A1 (en) * | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
| US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
| US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| US7452550B2 (en) * | 2000-06-30 | 2008-11-18 | Hana Biosciences, Inc. | Liposomal antineoplastic drugs and uses thereof |
| AU2001270413A1 (en) * | 2000-06-30 | 2002-01-14 | Inex Pharmaceuticals Corporation | Improved liposomal camptothecins and uses thereof |
| CZ20031515A3 (cs) | 2000-11-09 | 2003-09-17 | Neopharm, Inc. | Komplexy SN-38 s lipidem a způsob jejich použití |
| WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
| US20030059375A1 (en) * | 2001-08-20 | 2003-03-27 | Transave, Inc. | Method for treating lung cancers |
| JP2006502233A (ja) * | 2002-08-02 | 2006-01-19 | トランセーブ，インク． | 白金凝集物およびその製造方法 |
| US9186322B2 (en) * | 2002-08-02 | 2015-11-17 | Insmed Incorporated | Platinum aggregates and process for producing the same |
| US20060030578A1 (en) * | 2002-08-20 | 2006-02-09 | Neopharm, Inc. | Pharmaceutically active lipid based formulation of irinotecan |
| EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein stabilized liposomal formulations of pharmaceutical active ingredients |
| JP2007522085A (ja) * | 2003-06-27 | 2007-08-09 | スミスクライン・ビーチャム・コーポレイション | 安定化されたトポテカンリポソーム組成物および方法 |
| WO2005046637A2 (en) * | 2003-11-14 | 2005-05-26 | Het Nederlands Kanker Instituut | Pharmaceutical formulations employing short-chain sphingolipids and their use |
| WO2005072776A2 (en) * | 2004-01-30 | 2005-08-11 | Instytut Farmaceutyczny | Liposomal formulations of the antineoplastic agents |
| US20050181035A1 (en) * | 2004-02-17 | 2005-08-18 | Dow Steven W. | Systemic immune activation method using non CpG nucleic acids |
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