AU2001270413A1 - Improved liposomal camptothecins and uses thereof - Google Patents
Improved liposomal camptothecins and uses thereofInfo
- Publication number
- AU2001270413A1 AU2001270413A1 AU2001270413A AU7041301A AU2001270413A1 AU 2001270413 A1 AU2001270413 A1 AU 2001270413A1 AU 2001270413 A AU2001270413 A AU 2001270413A AU 7041301 A AU7041301 A AU 7041301A AU 2001270413 A1 AU2001270413 A1 AU 2001270413A1
- Authority
- AU
- Australia
- Prior art keywords
- improved liposomal
- liposomal camptothecins
- camptothecins
- improved
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
This invention relates to improved liposomal camptothecin compositions and methods of manufacturing and using such compositions for treating neoplasia and for inhibiting angiogenesis.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21555600P | 2000-06-30 | 2000-06-30 | |
US60/215,556 | 2000-06-30 | ||
US26461601P | 2001-01-26 | 2001-01-26 | |
US60/264,616 | 2001-01-26 | ||
PCT/CA2001/000981 WO2002002078A2 (en) | 2000-06-30 | 2001-06-29 | Improved liposomal camptothecins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001270413A1 true AU2001270413A1 (en) | 2002-01-14 |
Family
ID=26910152
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU7038501A Pending AU7038501A (en) | 2000-06-30 | 2001-06-29 | Liposomal antineoplastic drugs and uses thereof |
AU2001270385A Expired AU2001270385B2 (en) | 2000-06-30 | 2001-06-29 | Liposomal antineoplastic drugs and uses thereof |
AU2001270413A Abandoned AU2001270413A1 (en) | 2000-06-30 | 2001-06-29 | Improved liposomal camptothecins and uses thereof |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU7038501A Pending AU7038501A (en) | 2000-06-30 | 2001-06-29 | Liposomal antineoplastic drugs and uses thereof |
AU2001270385A Expired AU2001270385B2 (en) | 2000-06-30 | 2001-06-29 | Liposomal antineoplastic drugs and uses thereof |
Country Status (12)
Country | Link |
---|---|
US (7) | US7244448B2 (en) |
EP (2) | EP1299084B1 (en) |
JP (3) | JP2004501955A (en) |
CN (1) | CN1245977C (en) |
AT (2) | ATE309787T1 (en) |
AU (3) | AU7038501A (en) |
CA (2) | CA2412795C (en) |
DE (2) | DE60115044T2 (en) |
ES (1) | ES2253398T3 (en) |
IL (2) | IL153676A0 (en) |
MX (1) | MXPA02012817A (en) |
WO (2) | WO2002002077A2 (en) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040247662A1 (en) * | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
US20030022854A1 (en) | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
IL153676A0 (en) * | 2000-06-30 | 2003-07-06 | Inex Pharmaceuticals Corp | Liposomal pharmaceutical compositions |
US7452550B2 (en) * | 2000-06-30 | 2008-11-18 | Hana Biosciences, Inc. | Liposomal antineoplastic drugs and uses thereof |
US20030059375A1 (en) * | 2001-08-20 | 2003-03-27 | Transave, Inc. | Method for treating lung cancers |
BRPI0313191A2 (en) * | 2002-08-02 | 2016-11-08 | Transave Inc | composition and process for producing a platinum aggregate and pharmaceutical formulation |
US9186322B2 (en) * | 2002-08-02 | 2015-11-17 | Insmed Incorporated | Platinum aggregates and process for producing the same |
US20060030578A1 (en) * | 2002-08-20 | 2006-02-09 | Neopharm, Inc. | Pharmaceutically active lipid based formulation of irinotecan |
EP1585504A4 (en) * | 2002-11-06 | 2009-07-15 | Azaya Therapeutics Inc | Protein-stabilized liposomal formulations of pharmaceutical agents |
WO2005002546A1 (en) * | 2003-06-27 | 2005-01-13 | Smithkline Beecham Corporation | Stabilized topotecan liposomal composition and methods |
EP1686959B1 (en) * | 2003-11-14 | 2009-06-24 | HET NEDERLANDS KANKER INSTITUUT (The Netherlands Cancer Institute) | Pharmaceutical formulations employing short-chain sphingolipids and their use |
WO2005072776A2 (en) * | 2004-01-30 | 2005-08-11 | Instytut Farmaceutyczny | Liposomal formulations of the antineoplastic agents |
US20050181035A1 (en) * | 2004-02-17 | 2005-08-18 | Dow Steven W. | Systemic immune activation method using non CpG nucleic acids |
EP1729786A4 (en) * | 2004-03-18 | 2008-03-26 | Transave Inc | Administration of cisplatin by inhalation |
US20070065522A1 (en) * | 2004-03-18 | 2007-03-22 | Transave, Inc. | Administration of high potency platinum compound formulations by inhalation |
ES2967961T3 (en) | 2004-05-03 | 2024-05-06 | Ipsen Biopharm Ltd | Liposomes useful in drug administration |
AU2005251691A1 (en) * | 2004-05-17 | 2005-12-22 | Tekmira Pharmaceuticals Corporation | Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof |
CN101001633A (en) * | 2004-05-21 | 2007-07-18 | 特兰萨夫公司 | Treatment of lung diseases and pre-lung disease conditions |
GEP20094620B (en) * | 2004-06-01 | 2009-02-25 | Yakult Honsha Kk | Irinotecan preparation |
US20070082042A1 (en) * | 2004-08-06 | 2007-04-12 | Deok-Hoon Park | Multiple-layered liposome and preparation method thereof |
BRPI0516265A (en) * | 2004-10-06 | 2008-08-26 | Bc Cancer Agency | composition, use thereof, method of enhancing retention of a therapeutic agent within liposomes, liposomal formulation, and use of a liposomally encapsulated therapeutic agent |
WO2006052767A2 (en) * | 2004-11-05 | 2006-05-18 | Inex Pharmaceuticals Corporation | Compositions and methods for stabilizing liposomal camptothecin formulations |
KR20070089693A (en) * | 2004-11-08 | 2007-08-31 | 트랜세이브, 인코포레이티드 | Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally |
CN100348194C (en) * | 2005-07-26 | 2007-11-14 | 康辰医药发展有限公司 | Lipid formulation of nolatrexed dihydrochloride and its preparation method |
CN100375621C (en) * | 2005-11-04 | 2008-03-19 | 唐星 | Vinorelbine liposome micro ball injection and its prepn |
US9107824B2 (en) | 2005-11-08 | 2015-08-18 | Insmed Incorporated | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
WO2007056264A2 (en) * | 2005-11-08 | 2007-05-18 | Transave, Inc. | Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally |
FR2895258B1 (en) | 2005-12-22 | 2008-03-21 | Aventis Pharma Sa | COMBINATION COMPRISING COMBRETASTATIN AND ANTICANCER AGENTS |
WO2007127839A2 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
WO2008070009A2 (en) * | 2006-12-01 | 2008-06-12 | Alza Corporation | Treating solid tumors and monocytic leukemia using topoisomerase inhibitors in liposomes |
US8067432B2 (en) | 2008-03-31 | 2011-11-29 | University Of Kentucky Research Foundation | Liposomal, ring-opened camptothecins with prolonged, site-specific delivery of active drug to solid tumors |
US20100093873A1 (en) * | 2008-10-02 | 2010-04-15 | Goldfischer Sidney L | Methods of improving therapy of perfluorocarbons (PFC) |
JPWO2010058840A1 (en) * | 2008-11-20 | 2012-04-19 | テルモ株式会社 | Drug release means from liposome and evaluation method for release |
EP2524280A1 (en) | 2010-01-14 | 2012-11-21 | BrainLAB AG | Controlling a surgical navigation system |
WO2012058666A2 (en) * | 2010-10-29 | 2012-05-03 | Health Research, Inc. | Novel formulations of water-insoluble chemical compounds and methods of using a formulation of compound fl118 for cancer therapy |
PL226015B1 (en) | 2011-03-03 | 2017-06-30 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną | Liposome preparation containing anticancer active substance, process for the preparation thereof and pharmaceutical compositions containing thereof |
US10117881B2 (en) | 2011-06-03 | 2018-11-06 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies |
US10449193B2 (en) * | 2011-06-03 | 2019-10-22 | Signpath Pharma Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies |
US10532045B2 (en) | 2013-12-18 | 2020-01-14 | Signpath Pharma, Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
CA2836904C (en) * | 2011-06-03 | 2019-09-24 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced long qt syndrome and potassium delayed-rectifier current |
US10238602B2 (en) | 2011-06-03 | 2019-03-26 | Signpath Pharma, Inc. | Protective effect of DMPC, DMPG, DMPC/DMPG, LysoPG and LysoPC against drugs that cause channelopathies |
US10349884B2 (en) * | 2011-06-03 | 2019-07-16 | Sighpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac ikr channel |
US12004868B2 (en) * | 2011-06-03 | 2024-06-11 | Signpath Pharma Inc. | Liposomal mitigation of drug-induced inhibition of the cardiac IKr channel |
US9717724B2 (en) | 2012-06-13 | 2017-08-01 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies |
AU2013202947B2 (en) | 2012-06-13 | 2016-06-02 | Ipsen Biopharm Ltd. | Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan |
EP2892524B1 (en) | 2012-09-04 | 2020-11-25 | Eleison Pharmaceuticals, LLC | Preventing pulmonary recurrence of cancer with lipid-complexed cisplatin |
US9801874B2 (en) | 2012-11-20 | 2017-10-31 | Spectrum Pharmaceuticals | Method for the preparation of liposome encapsulated vincristine for therapeutic use |
CN105407878A (en) * | 2013-05-30 | 2016-03-16 | 纳米生物技术公司 | Pharmaceutical composition, preparation and uses thereof |
JP2017516813A (en) | 2014-06-03 | 2017-06-22 | サインパス ファルマ, インク.Signpath Pharma, Inc. | Protective effects of DMPC, DMPG, DMPC / DMPG, EGPG, LYSOPG and LYSOPC against drugs that cause channel disease |
EP3229776B1 (en) * | 2014-11-25 | 2023-06-28 | Curadigm Sas | Pharmaceutical composition combining at least two distinct nanoparticles and a pharmaceutical compound, preparation and uses thereof |
US11318131B2 (en) * | 2015-05-18 | 2022-05-03 | Ipsen Biopharm Ltd. | Nanoliposomal irinotecan for use in treating small cell lung cancer |
TWI678213B (en) | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | A ready-to-use formulation for vincristine sulfate liposome injection |
PT3337467T (en) | 2015-08-20 | 2021-01-25 | Ipsen Biopharm Ltd | Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment |
SG10201913077QA (en) | 2015-08-21 | 2020-02-27 | Ipsen Biopharm Ltd | Methods for treating metastatic pancreatic cancer using combination therapies comprising liposomal irinotecan and oxaliplatin |
CA2940470C (en) * | 2015-09-18 | 2019-08-20 | Signpath Pharma Inc. | Treatment for glioblastoma |
BR122021024957B1 (en) | 2015-10-16 | 2023-12-12 | Ipsen Biopharm Ltd | Processes for producing a storage-stabilized liposomal irinotecan composition |
WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
US11806401B2 (en) | 2016-04-27 | 2023-11-07 | Signpath Pharma, Inc. | Prevention of drug-induced atrio-ventricular block |
EP4101859A1 (en) | 2016-09-02 | 2022-12-14 | Dicerna Pharmaceuticals, Inc. | 4'-oxymethylphosphonate nucleotide analogs and oligonucleotides comprising the same |
AU2017354903B2 (en) | 2016-11-02 | 2023-04-13 | Ipsen Biopharm Ltd. | Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin) |
WO2018181963A1 (en) | 2017-03-31 | 2018-10-04 | 富士フイルム株式会社 | Liposome composition and pharmaceutical composition |
WO2019160732A1 (en) * | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
TWI737974B (en) * | 2018-04-09 | 2021-09-01 | 美商標徑製藥公司 | Dosing regimens for treatment of proliferative disorders |
CN112437674A (en) * | 2018-04-11 | 2021-03-02 | 新墨西哥科技大学研究园公司 | Lipid prodrugs for drug delivery |
EP3811931B1 (en) | 2018-06-20 | 2024-07-03 | FUJIFILM Corporation | Combination medication containing liposome composition encapsulating drug and immune checkpoint inhibitor |
TWI837189B (en) | 2018-10-01 | 2024-04-01 | 日商富士軟片股份有限公司 | Combination medicine comprising a liposome composition containing a drug and a platinum preparation |
BR112021018739A2 (en) | 2019-03-29 | 2022-05-03 | Dicerna Pharmaceuticals Inc | Compositions and methods for treating kras-associated diseases or disorders |
MX2021013418A (en) | 2019-05-03 | 2021-12-10 | Dicerna Pharmaceuticals Inc | Double-stranded nucleic acid inhibitor molecules with shortened sense strands. |
CA3165388A1 (en) * | 2019-12-20 | 2021-06-24 | Translate Bio, Inc. | Improved process of preparing mrna-loaded lipid nanoparticles |
TW202140043A (en) | 2020-01-15 | 2021-11-01 | 美商戴瑟納製藥股份有限公司 | 4’-o-methylene phosphonate nucleic acids and analogues thereof |
WO2022031433A1 (en) | 2020-08-04 | 2022-02-10 | Dicerna Pharmaceuticals, Inc. | Systemic delivery of oligonucleotides |
TW202313031A (en) | 2021-05-24 | 2023-04-01 | 日商富士軟片股份有限公司 | Anti-tumor agent |
EP4349338A4 (en) | 2021-05-24 | 2024-09-04 | Fujifilm Corp | Treatment agent |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5023087A (en) | 1986-02-10 | 1991-06-11 | Liposome Technology, Inc. | Efficient method for preparation of prolonged release liposome-based drug delivery system |
AU7128887A (en) * | 1986-02-10 | 1987-08-25 | Liposome Technology, Inc. | Controlled-release liposome delivery system |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
US5552156A (en) | 1992-10-23 | 1996-09-03 | Ohio State University | Liposomal and micellular stabilization of camptothecin drugs |
WO1995008986A1 (en) | 1993-09-27 | 1995-04-06 | Smithkline Beecham Corporation | Camptothecin formulations |
US6855331B2 (en) * | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
US5741516A (en) | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
US5543152A (en) * | 1994-06-20 | 1996-08-06 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
AU702519B2 (en) * | 1994-10-05 | 1999-02-25 | Glaxo Wellcome Inc. | Parenteral pharmaceutical compositions containing GF120918A |
US5972379A (en) * | 1995-02-14 | 1999-10-26 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering a quinolone |
IL122290A0 (en) * | 1995-06-07 | 1998-04-05 | Inex Pharmaceuticals Corp | Lipid-nucleic acid complex its preparation and use |
US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
AU4990397A (en) * | 1996-10-22 | 1998-05-15 | Dmitri Kirpotin | Compound-loaded liposomes and methods for their preparation |
US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
WO1999013816A2 (en) * | 1997-09-16 | 1999-03-25 | Nexstar Pharmaceuticals, Inc. | Liposomal camptothecin formulations |
US6355268B1 (en) | 1998-09-16 | 2002-03-12 | Alza Corporation | Liposome-entrapped topoisomerase inhibitors |
US6723338B1 (en) * | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
US6352996B1 (en) * | 1999-08-03 | 2002-03-05 | The Stehlin Foundation For Cancer Research | Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs |
US6191119B1 (en) * | 1999-10-15 | 2001-02-20 | Supergen, Inc. | Combination therapy including 9-nitro-20(S)-camptothecin |
IL153676A0 (en) * | 2000-06-30 | 2003-07-06 | Inex Pharmaceuticals Corp | Liposomal pharmaceutical compositions |
JP2004511510A (en) * | 2000-10-16 | 2004-04-15 | ネオファーム、インコーポレイティッド | Liposomal formulation of mitoxantrone |
US6825206B1 (en) * | 2000-11-16 | 2004-11-30 | Research Triangle Institute | Camptothecin compounds with a thioether group |
US6627614B1 (en) * | 2002-06-05 | 2003-09-30 | Super Gen, Inc. | Sequential therapy comprising a 20(S)-camptothecin and an anthracycline |
-
2001
- 2001-06-29 IL IL15367601A patent/IL153676A0/en active IP Right Grant
- 2001-06-29 CA CA2412795A patent/CA2412795C/en not_active Expired - Lifetime
- 2001-06-29 DE DE60115044T patent/DE60115044T2/en not_active Expired - Lifetime
- 2001-06-29 EP EP01949141A patent/EP1299084B1/en not_active Expired - Lifetime
- 2001-06-29 ES ES01949169T patent/ES2253398T3/en not_active Expired - Lifetime
- 2001-06-29 AU AU7038501A patent/AU7038501A/en active Pending
- 2001-06-29 US US09/896,812 patent/US7244448B2/en not_active Expired - Lifetime
- 2001-06-29 JP JP2002506699A patent/JP2004501955A/en not_active Withdrawn
- 2001-06-29 US US09/896,811 patent/US7060828B2/en not_active Expired - Lifetime
- 2001-06-29 WO PCT/CA2001/000925 patent/WO2002002077A2/en active IP Right Grant
- 2001-06-29 DE DE60115045T patent/DE60115045T2/en not_active Expired - Lifetime
- 2001-06-29 WO PCT/CA2001/000981 patent/WO2002002078A2/en active IP Right Grant
- 2001-06-29 MX MXPA02012817A patent/MXPA02012817A/en active IP Right Grant
- 2001-06-29 EP EP01949169A patent/EP1299085B1/en not_active Expired - Lifetime
- 2001-06-29 AT AT01949169T patent/ATE309787T1/en not_active IP Right Cessation
- 2001-06-29 CN CNB018138187A patent/CN1245977C/en not_active Expired - Lifetime
- 2001-06-29 CA CA2412790A patent/CA2412790C/en not_active Expired - Lifetime
- 2001-06-29 AT AT01949141T patent/ATE309786T1/en not_active IP Right Cessation
- 2001-06-29 AU AU2001270385A patent/AU2001270385B2/en not_active Expired
- 2001-06-29 AU AU2001270413A patent/AU2001270413A1/en not_active Abandoned
-
2002
- 2002-12-26 IL IL153676A patent/IL153676A/en unknown
-
2004
- 2004-02-27 US US10/788,649 patent/US20040170678A1/en not_active Abandoned
-
2005
- 2005-12-06 US US11/294,826 patent/US20060093662A1/en not_active Abandoned
-
2006
- 2006-05-08 US US11/429,911 patent/US20060269594A1/en not_active Abandoned
-
2010
- 2010-12-09 US US12/963,888 patent/US20110086826A1/en not_active Abandoned
-
2012
- 2012-02-09 JP JP2012025785A patent/JP2012092148A/en active Pending
- 2012-06-28 US US13/536,325 patent/US20130136787A1/en not_active Abandoned
-
2014
- 2014-02-17 JP JP2014027576A patent/JP2014088444A/en active Pending
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