DE60112325D1 - Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen - Google Patents

Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen

Info

Publication number
DE60112325D1
DE60112325D1 DE60112325T DE60112325T DE60112325D1 DE 60112325 D1 DE60112325 D1 DE 60112325D1 DE 60112325 T DE60112325 T DE 60112325T DE 60112325 T DE60112325 T DE 60112325T DE 60112325 D1 DE60112325 D1 DE 60112325D1
Authority
DE
Germany
Prior art keywords
chinolones
naphthyridines
preparation
process step
cyclisation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60112325T
Other languages
English (en)
Other versions
DE60112325T2 (de
Inventor
Reddy Mundla
Lynn Randall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Co LLC
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of DE60112325D1 publication Critical patent/DE60112325D1/de
Application granted granted Critical
Publication of DE60112325T2 publication Critical patent/DE60112325T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
DE60112325T 2000-12-14 2001-12-07 Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen Expired - Lifetime DE60112325T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25563300P 2000-12-14 2000-12-14
US255633P 2000-12-14
PCT/US2001/048536 WO2002048113A1 (en) 2000-12-14 2001-12-07 Cyclization process step in the making of quinolones and naphthyridines

Publications (2)

Publication Number Publication Date
DE60112325D1 true DE60112325D1 (de) 2005-09-01
DE60112325T2 DE60112325T2 (de) 2006-05-24

Family

ID=22969207

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112325T Expired - Lifetime DE60112325T2 (de) 2000-12-14 2001-12-07 Cyclisierungsverfahrensschritt bei der herstellung von chinolonen und naphthyridinen

Country Status (19)

Country Link
EP (1) EP1343766B1 (de)
JP (2) JP4417007B2 (de)
KR (1) KR100603163B1 (de)
CN (1) CN1232508C (de)
AT (1) ATE300522T1 (de)
AU (2) AU2905702A (de)
BR (1) BR0116229A (de)
CA (1) CA2427831C (de)
CZ (1) CZ20031379A3 (de)
DE (1) DE60112325T2 (de)
DK (1) DK1343766T3 (de)
ES (1) ES2247190T3 (de)
HU (1) HUP0303991A3 (de)
IL (2) IL155677A0 (de)
MX (1) MXPA03005338A (de)
NO (1) NO325236B1 (de)
NZ (1) NZ525569A (de)
PL (1) PL207394B1 (de)
WO (1) WO2002048113A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803469B2 (en) * 2002-08-05 2004-10-12 The Procter & Gamble Company Process for preparing quinolone antibiotic intermediates
KR100735587B1 (ko) * 2002-08-05 2007-07-04 더 프록터 앤드 갬블 캄파니 퀴놀론계 항생제 중간체의 제조 방법
KR100665919B1 (ko) 2002-11-20 2007-03-08 니뽄 다바코 산교 가부시키가이샤 4-옥소퀴놀린 화합물 및 ｈｉｖ 인테그라제 저해제로서의그의 용도
US7402674B2 (en) 2004-01-31 2008-07-22 Sanofi-Aventis Deutschland Gmbh, 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
WO2007102512A1 (ja) 2006-03-06 2007-09-13 Japan Tobacco Inc. ４－オキソキノリン化合物の製造方法
WO2007102499A1 (ja) 2006-03-06 2007-09-13 Japan Tobacco Inc. ４－オキソキノリン化合物の製造方法
ES2536923T3 (es) 2006-09-12 2015-05-29 Gilead Sciences, Inc. Proceso e intermedios para preparar inhibidores de la integrasa del VIH
US8658183B2 (en) 2007-08-09 2014-02-25 Taigen Biotechnology Company, Ltd. Antimicrobial parenteral formulation
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
EP2303271B1 (de) 2008-07-01 2018-11-07 Taigen Biotechnology Co., Ltd. Behandlung von antibiotika-resistenter bakterieller infektion
CN104520275B (zh) 2012-08-03 2016-11-02 吉利德科学公司 用于制备整合酶抑制剂的方法和中间产物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT775114E (pt) * 1994-08-02 2000-09-29 Procter & Gamble Processo para produzir compostos antimicrobianos
KR100239200B1 (ko) * 1994-08-02 2000-03-02 데이비드 엠 모이어 퀴놀로닐 락탐 항생제의 제조 방법 및 신규 중간체 화합물

Also Published As

Publication number Publication date
ATE300522T1 (de) 2005-08-15
ES2247190T3 (es) 2006-03-01
BR0116229A (pt) 2003-11-04
JP2010001315A (ja) 2010-01-07
CZ20031379A3 (cs) 2003-11-12
CN1481365A (zh) 2004-03-10
NZ525569A (en) 2004-09-24
NO20032667D0 (no) 2003-06-12
PL207394B1 (pl) 2010-12-31
AU2905702A (en) 2002-06-24
PL363355A1 (en) 2004-11-15
WO2002048113A1 (en) 2002-06-20
HUP0303991A3 (en) 2012-09-28
CA2427831C (en) 2009-08-18
IL155677A (en) 2009-02-11
NO325236B1 (no) 2008-03-03
HUP0303991A2 (hu) 2004-04-28
MXPA03005338A (es) 2003-10-06
NO20032667L (no) 2003-08-14
KR100603163B1 (ko) 2006-07-24
DK1343766T3 (da) 2005-10-31
JP4417007B2 (ja) 2010-02-17
EP1343766B1 (de) 2005-07-27
EP1343766A1 (de) 2003-09-17
IL155677A0 (en) 2003-11-23
DE60112325T2 (de) 2006-05-24
JP2004515542A (ja) 2004-05-27
CA2427831A1 (en) 2002-06-20
AU2002229057B2 (en) 2005-04-21
KR20030063420A (ko) 2003-07-28
CN1232508C (zh) 2005-12-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WARNER CHILCOTT COMPANY, LLC, FAJARDO, P.R., US