DE60106482D1 - Verfahren zur Herstellung von 3-Oxo-4-azasteroiden - Google Patents

Verfahren zur Herstellung von 3-Oxo-4-azasteroiden

Info

Publication number
DE60106482D1
DE60106482D1 DE60106482T DE60106482T DE60106482D1 DE 60106482 D1 DE60106482 D1 DE 60106482D1 DE 60106482 T DE60106482 T DE 60106482T DE 60106482 T DE60106482 T DE 60106482T DE 60106482 D1 DE60106482 D1 DE 60106482D1
Authority
DE
Germany
Prior art keywords
azasteroids
oxo
preparation
compounds
ammonium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106482T
Other languages
English (en)
Other versions
DE60106482T2 (de
Inventor
Roman Davis
Alan Millar
Jeffrey Thomas Sterbenz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE60106482D1 publication Critical patent/DE60106482D1/de
Publication of DE60106482T2 publication Critical patent/DE60106482T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Valve Device For Special Equipments (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60106482T 2000-11-03 2001-11-02 Verfahren zur Herstellung von 3-Oxo-4-azasteroiden Expired - Lifetime DE60106482T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0026876.3A GB0026876D0 (en) 2000-11-03 2000-11-03 Process
GB0026876 2000-11-03
PCT/US2001/048173 WO2002046207A2 (en) 2000-11-03 2001-11-02 Process

Publications (2)

Publication Number Publication Date
DE60106482D1 true DE60106482D1 (de) 2004-11-18
DE60106482T2 DE60106482T2 (de) 2005-10-13

Family

ID=9902484

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106482T Expired - Lifetime DE60106482T2 (de) 2000-11-03 2001-11-02 Verfahren zur Herstellung von 3-Oxo-4-azasteroiden

Country Status (24)

Country Link
US (1) US6794508B2 (de)
EP (1) EP1335930B1 (de)
JP (1) JP4257117B2 (de)
KR (1) KR100821018B1 (de)
CN (1) CN1313480C (de)
AT (1) ATE279429T1 (de)
AU (2) AU2002241624B2 (de)
BR (1) BR0115089A (de)
CA (1) CA2427709A1 (de)
DE (1) DE60106482T2 (de)
DK (1) DK1335930T3 (de)
ES (1) ES2230383T3 (de)
GB (1) GB0026876D0 (de)
HK (1) HK1058799A1 (de)
HU (1) HUP0303907A3 (de)
IL (2) IL155078A0 (de)
MX (1) MXPA03003925A (de)
NO (1) NO325180B1 (de)
NZ (1) NZ525168A (de)
PL (1) PL206539B1 (de)
PT (1) PT1335930E (de)
SI (1) SI1335930T1 (de)
WO (1) WO2002046207A2 (de)
ZA (1) ZA200302560B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100503193B1 (ko) 2002-08-19 2005-07-25 한미약품 주식회사 3-옥소-4-아자-5α-안드로스탄 화합물의 선택적인 제조방법
WO2005075497A1 (en) * 2004-01-07 2005-08-18 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF 17ß-SUBSTITUTED-3-OXO-4-AZA-5ALPHA-ANDROSTANE DERIVATIVES
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法
AR070313A1 (es) 2008-01-03 2010-03-31 Gador Sa Un procedimiento para preparar una forma solida y cristalina de dutasteride, una forma polimorfica del compuesto (forma iii) y una composicion farmaceutica que incluye dicha forma
HU230730B1 (hu) 2011-06-30 2017-12-28 Richter Gedeon Nyrt Eljárás (5alfa,17béta)-N-[2,5-bisz-(trifluormetil)-fenil]-3-oxo-4-aza-5-androszt-1-én-17-karbonsavamid előállítására
CN103059097A (zh) * 2011-10-20 2013-04-24 连云港润众制药有限公司 一种度他雄胺中间体的制备方法
CN103254268A (zh) * 2013-05-16 2013-08-21 寿光市富康化学工业有限公司 一种制备度他雄胺的工艺
CN104231033B (zh) * 2014-09-17 2016-08-24 广东众生药业股份有限公司 一种度他雄胺的制备方法
CN108051513B (zh) * 2017-11-27 2020-09-29 重庆华邦制药有限公司 Hplc法分离测定度他雄胺起始原料sm2及其相关杂质的方法
CN109438549B (zh) * 2018-12-13 2022-01-04 湖北葛店人福药业有限责任公司 一种制备N-叔丁基-3-氧代-4-氮杂-5α-雄甾-17β-甲酰胺的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB2264494A (en) * 1992-02-25 1993-09-01 Merck & Co Inc 17b-n-monosubstituted carbamoyl-11-oxo-4-aza-5-a-androst-1-en-3-one testosterone-5-alpha reductase inhibitors
TW408127B (en) * 1993-09-17 2000-10-11 Glaxo Inc Androstenones

Also Published As

Publication number Publication date
CN1473165A (zh) 2004-02-04
KR100821018B1 (ko) 2008-04-08
WO2002046207A2 (en) 2002-06-13
HUP0303907A2 (hu) 2004-03-01
EP1335930B1 (de) 2004-10-13
AU2002241624B2 (en) 2004-10-28
US20040049042A1 (en) 2004-03-11
SI1335930T1 (en) 2005-04-30
ZA200302560B (en) 2004-04-01
BR0115089A (pt) 2003-10-07
ATE279429T1 (de) 2004-10-15
JP4257117B2 (ja) 2009-04-22
ES2230383T3 (es) 2005-05-01
WO2002046207A3 (en) 2003-03-20
NO20031995L (no) 2003-05-02
CA2427709A1 (en) 2002-06-13
KR20030081326A (ko) 2003-10-17
DE60106482T2 (de) 2005-10-13
IL155078A (en) 2009-06-15
HUP0303907A3 (en) 2012-09-28
PL365705A1 (en) 2005-01-10
HK1058799A1 (en) 2004-06-04
PL206539B1 (pl) 2010-08-31
DK1335930T3 (da) 2005-02-14
NO20031995D0 (no) 2003-05-02
PT1335930E (pt) 2005-01-31
MXPA03003925A (es) 2003-08-19
NZ525168A (en) 2005-03-24
CN1313480C (zh) 2007-05-02
AU4162402A (en) 2002-06-18
EP1335930A2 (de) 2003-08-20
GB0026876D0 (en) 2000-12-20
US6794508B2 (en) 2004-09-21
IL155078A0 (en) 2003-10-31
NO325180B1 (no) 2008-02-11
JP2004515505A (ja) 2004-05-27

Similar Documents

Publication Publication Date Title
BRPI0113670B8 (pt) composição farmacêutica e método para tratar hipogonadismo
DE60204322D1 (de) Stickstoffmonoxid bildende zusammensetzungen zur behandlung von nagelbettinfektionen
DE60029799D1 (de) Verbindungen, verfahren und pharmazeutische zubereitungen zur behandlung von zellschäden wie zum beispiel schäden an nerven- oder kerzgefässgewebe
DE60106482D1 (de) Verfahren zur Herstellung von 3-Oxo-4-azasteroiden
DE50310614D1 (de) Verfahren zur herstellung von c13-alkoholgemischen
ATE276235T1 (de) Verfahren zur herstellung von thiocarbonsäuren
DE60138804D1 (de) Verfahren zur herstellung von physiologisch aktiven substanzen enthaltenden dispersionen unter anwendung von hochdruck und hochscherkraft
ATE288264T1 (de) Kombinationspräparate zur behandlung von erkrankungen, die mit angiogenese verbunden sind
DE60136826D1 (de) Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs
DE60021381D1 (de) Chinonverbindungen zur behandlung von krankheiten
DE60021113D1 (de) Albumin-bindende verbindungen die die nichtenzymatische glycosylierung verhindern und die zur behandlung von glycosylierungsbedingten erkrankungen verwendet werden können
DE50112206D1 (de) Gelzusammensetzung auf alkoholischer basis zur behandlung von hypogonadismus durch transskrotale applikation
DE602004028574D1 (de) Zusammensetzungen und verfahren zur behandlung des reizdarmsyndroms und von nichtulzeröser dyspepsie
DE60322852D1 (de) Verfahren zur herstellung von eplerenon
BR0115359A (pt) Método para a preparação de uma composição catalisadora e seu uso em um processo de polimerização
DE69911430D1 (de) Verfahren zur herstellung von 1-(1h)-benzoquinolizin-3-on derivaten
DE60213874D1 (de) Verfahren zur herstellung von protease hemmenden zwischenprodukten
ATE197144T1 (de) Verfahren zur herstellung von alkoholen und/oder aldehyden aus olefinen
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
ATE229519T1 (de) Neue cis-3,4-chromanderivate zur vorbeugung oder behandlung von oestrogenbezogenen krankheiten oder syndromen
DE60004850D1 (de) Verfahren zur herstellung von (r) und (s)-aminocarnitin und deren derivative aus d- und l-aspargin säure
ATE293587T1 (de) Verfahren zur herstellung von cis-2-tertiär butylcyclohexanol durch katalytische hydrierung von 2-tertiär-butylphenol
ATE397615T1 (de) 6-o-alkyl-2-nor-2-substituierte ketolidderivate
DE50012229D1 (de) Verfahren zur herstellung von 2-halo-6-nitrobenzoesäuren
DE602004027401D1 (de) Verfahren zur herstellung von polymorphen von sertralin hydrochlorid

Legal Events

Date Code Title Description
8364 No opposition during term of opposition