ATE276235T1 - Verfahren zur herstellung von thiocarbonsäuren - Google Patents
Verfahren zur herstellung von thiocarbonsäurenInfo
- Publication number
- ATE276235T1 ATE276235T1 AT01916231T AT01916231T ATE276235T1 AT E276235 T1 ATE276235 T1 AT E276235T1 AT 01916231 T AT01916231 T AT 01916231T AT 01916231 T AT01916231 T AT 01916231T AT E276235 T1 ATE276235 T1 AT E276235T1
- Authority
- AT
- Austria
- Prior art keywords
- acids
- thiocarboxic
- producing
- carbothiolates
- androstane
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- QZLYKIGBANMMBK-UGCZWRCOSA-N 5α-Androstane Chemical compound C([C@@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CCC[C@@]2(C)CC1 QZLYKIGBANMMBK-UGCZWRCOSA-N 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 229960000289 fluticasone propionate Drugs 0.000 abstract 1
- WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/02—Monothiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/513,399 US20020133032A1 (en) | 2000-02-25 | 2000-02-25 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods |
| PCT/US2001/006055 WO2001062722A2 (en) | 2000-02-25 | 2001-02-23 | Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE276235T1 true ATE276235T1 (de) | 2004-10-15 |
Family
ID=24043095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01916231T ATE276235T1 (de) | 2000-02-25 | 2001-02-23 | Verfahren zur herstellung von thiocarbonsäuren |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20020133032A1 (de) |
| EP (1) | EP1257531B1 (de) |
| JP (1) | JP3986313B2 (de) |
| AT (1) | ATE276235T1 (de) |
| CA (1) | CA2400919C (de) |
| DE (1) | DE60105555T2 (de) |
| DK (1) | DK1257531T3 (de) |
| ES (1) | ES2228832T3 (de) |
| MX (1) | MXPA02008275A (de) |
| PT (1) | PT1257531E (de) |
| WO (1) | WO2001062722A2 (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0017988D0 (en) * | 2000-07-21 | 2000-09-13 | Glaxo Group Ltd | Novel process |
| JP4436041B2 (ja) | 2000-08-05 | 2010-03-24 | グラクソ グループ リミテッド | 抗炎症剤としての６α，９α−ジフルオロ−１７α−［（２−フラニルカルボキシル）オキシ］−１１β−ヒドロキシ−１６α−メチル−３−オキソ−アンドロスト−１，４−ジエン−１７−チオカルボン酸Ｓ−フルオロメチルエステル |
| US6750210B2 (en) | 2000-08-05 | 2004-06-15 | Smithkline Beecham Corporation | Formulation containing novel anti-inflammatory androstane derivative |
| GB0019172D0 (en) | 2000-08-05 | 2000-09-27 | Glaxo Group Ltd | Novel compounds |
| US6759398B2 (en) | 2000-08-05 | 2004-07-06 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative |
| US6858593B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6777399B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6777400B2 (en) | 2000-08-05 | 2004-08-17 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| US6787532B2 (en) | 2000-08-05 | 2004-09-07 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivatives |
| US6858596B2 (en) | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Formulation containing anti-inflammatory androstane derivative |
| UA77656C2 (en) | 2001-04-07 | 2007-01-15 | Glaxo Group Ltd | S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent |
| BR0209271A (pt) | 2001-04-30 | 2004-06-15 | Glaxo Group Ltd | Composto, uso de um composto composição farmacêutica, formulação em aerossol farmacêutica, método para o tratamento de um paciente humano ou animal com uma condição inflamatória e/ou alérgica, e, processo para a preparação de um composto |
| AU2002321884A1 (en) * | 2001-08-03 | 2003-02-24 | Smithkline Beecham Corporation | A method for preparing fluticasone derivatives |
| GB2389530B (en) | 2002-06-14 | 2007-01-10 | Cipla Ltd | Pharmaceutical compositions |
| EP1534733A2 (de) * | 2002-06-20 | 2005-06-01 | Sun Pharmaceuticals Industries Ltd. | Einfache synthese von s-fluormethyl-6alpha, 9alpha-difluor-11beta-hydroxy-16alpha-methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-dien-17beta-carbothioat |
| IL153462A0 (en) * | 2002-12-16 | 2003-07-06 | Chemagis Ltd | Thiocarboxylic acid organic salts and processes utilizing the same |
| EP1611149A1 (de) * | 2003-04-04 | 2006-01-04 | Alpharma APS | Verfahren zur herstellung von steroidal 17 beta-carbothioates und zwischenprodukten |
| EP1466920A1 (de) * | 2003-04-04 | 2004-10-13 | Alpharma APS | Verfahren zur Herstellung von steroidal 17 beta-carbothioates |
| EP1526139A1 (de) * | 2003-10-24 | 2005-04-27 | S.N.I.F.F. Italia S.P.A. | Verfahren zur Herstellung von hochreinen Androstan-17-beta-carbonsäuren und Androstan-17-beta-fluoromethyl-thiocarbonsäureestern |
| PT103202B (pt) | 2004-10-19 | 2011-01-27 | Hovione Farmaciencia S A | Processo para a esterificação de um ácido carbotiótico |
| CN100560598C (zh) | 2005-07-26 | 2009-11-18 | 上海奥锐特国际贸易有限公司 | 氟替卡松丙酸酯的合成方法 |
| EP2044099B1 (de) * | 2006-06-14 | 2012-05-23 | Generics [UK] Limited | Verfahren zur herstellung von s-fluormethyl-6,9-difluor-11-hydroxy-16-methyl-17-propionyloxy-3-oxoandrosta-1,4-dien-17-carbothioat und zwischenprodukten |
| US7265247B1 (en) | 2006-07-28 | 2007-09-04 | Im&T Research, Inc. | Substituted phenylsulfur trifluoride and other like fluorinating agents |
| US8399720B2 (en) * | 2007-03-23 | 2013-03-19 | Ube Industries, Ltd. | Methods for producing fluorinated phenylsulfur pentafluorides |
| KR101421921B1 (ko) * | 2007-03-23 | 2014-07-22 | 우베 인더스트리즈 리미티드 | 아릴설퍼 펜타플루오라이드의 제조공정 |
| US8030516B2 (en) * | 2007-10-19 | 2011-10-04 | Ube Industries, Ltd. | Methods for producing perfluoroalkanedi(sulfonyl chloride) |
| WO2009076345A1 (en) * | 2007-12-11 | 2009-06-18 | Im & T Research, Inc. | Methods and compositions for producing difluoromethylene-and trifluoromethyl-containing compounds |
| TW201006787A (en) * | 2008-03-07 | 2010-02-16 | Im & T Res Inc | Fluorination processes with arylsulfur halotetrafluorides |
| WO2010022001A1 (en) * | 2008-08-18 | 2010-02-25 | Im&T Research, Inc. | Methods for preparing fluoroalkyl arylsulfinyl compounds and fluorinated compounds thereto |
| US8653302B2 (en) * | 2008-09-22 | 2014-02-18 | Ube Industries, Ltd. | Processes for preparing poly(pentafluorosulfanyl)aromatic compounds |
| US20100174096A1 (en) * | 2009-01-05 | 2010-07-08 | Im&T Research, Inc. | Methods for Production of Optically Active Fluoropyrrolidine Derivatives |
| US8203003B2 (en) | 2009-01-09 | 2012-06-19 | Ube Industries, Ltd. | 4-fluoropyrrolidine-2-carbonyl fluoride compounds and their preparative methods |
| WO2012029077A2 (en) | 2010-09-01 | 2012-03-08 | Cadila Healthcare Limited | Process for preparing fluticasone propionate/furoate |
| CN102558273B (zh) * | 2010-12-14 | 2014-07-02 | 浙江省天台县奥锐特药业有限公司 | 氟替卡松糠酸酯的制备方法 |
| US9303060B1 (en) * | 2014-10-03 | 2016-04-05 | Amphaster Pharmaceuticals, Inc. | Methods of preparing intermediate of fluticasone propionate |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4188385A (en) | 1978-04-05 | 1980-02-12 | Syntex (U.S.A.) Inc. | Thioetianic acid derivatives |
| US4263289A (en) * | 1978-04-05 | 1981-04-21 | Syntex (U.S.A.) Inc. | Thio etianic acid derivatives |
| US4198403A (en) | 1978-04-05 | 1980-04-15 | Syntex (U.S.A.) Inc. | 17 Beta-thiocarboxylic acid esters of 4-halo-3-oxoandrost-4-enes |
| JPS56138200A (en) * | 1980-02-15 | 1981-10-28 | Glaxo Group Ltd | Androstane carbothioate compound |
| CY1291A (en) | 1980-02-15 | 1985-10-18 | Glaxo Group Ltd | Androstane 17 beta carbothioates |
| GB2137206B (en) | 1980-02-15 | 1985-04-03 | Glaxo Group Ltd | Androstane 17-carbothioc acid derivatives |
| US4578221A (en) | 1980-04-23 | 1986-03-25 | Glaxo Group Limited | Androstane carbothioic acids |
| IL109656A (en) | 1994-05-15 | 1998-02-22 | Chemagis Ltd | Process for the manufacture of androstane - 17 - carbothioates and androstane - 17 - carbothioates prepared thereby |
| GB9622173D0 (en) * | 1996-10-24 | 1996-12-18 | Glaxo Group Ltd | Particulate Products |
| US6858593B2 (en) * | 2000-08-05 | 2005-02-22 | Smithkline Beecham Corporation | Anti-inflammatory androstane derivative compositions |
| IL150654A (en) * | 2002-07-09 | 2006-12-10 | Ori Lerman | Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate |
-
2000
- 2000-02-25 US US09/513,399 patent/US20020133032A1/en not_active Abandoned
-
2001
- 2001-02-23 MX MXPA02008275A patent/MXPA02008275A/es active IP Right Grant
- 2001-02-23 CA CA002400919A patent/CA2400919C/en not_active Expired - Fee Related
- 2001-02-23 ES ES01916231T patent/ES2228832T3/es not_active Expired - Lifetime
- 2001-02-23 JP JP2001561731A patent/JP3986313B2/ja not_active Expired - Fee Related
- 2001-02-23 WO PCT/US2001/006055 patent/WO2001062722A2/en not_active Ceased
- 2001-02-23 PT PT01916231T patent/PT1257531E/pt unknown
- 2001-02-23 AT AT01916231T patent/ATE276235T1/de active
- 2001-02-23 EP EP01916231A patent/EP1257531B1/de not_active Expired - Lifetime
- 2001-02-23 DK DK01916231T patent/DK1257531T3/da active
- 2001-02-23 DE DE60105555T patent/DE60105555T2/de not_active Expired - Lifetime
-
2004
- 2004-05-18 US US10/847,846 patent/US7214807B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2400919A1 (en) | 2001-08-30 |
| US20020133032A1 (en) | 2002-09-19 |
| US7214807B2 (en) | 2007-05-08 |
| EP1257531A2 (de) | 2002-11-20 |
| EP1257531B1 (de) | 2004-09-15 |
| JP2003529564A (ja) | 2003-10-07 |
| PT1257531E (pt) | 2005-01-31 |
| DE60105555D1 (de) | 2004-10-21 |
| CA2400919C (en) | 2009-01-20 |
| ES2228832T3 (es) | 2005-04-16 |
| MXPA02008275A (es) | 2003-01-28 |
| JP3986313B2 (ja) | 2007-10-03 |
| WO2001062722A3 (en) | 2002-05-16 |
| DE60105555T2 (de) | 2005-09-29 |
| DK1257531T3 (da) | 2005-01-17 |
| WO2001062722A2 (en) | 2001-08-30 |
| US20040209854A1 (en) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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