DE60136826D1 - Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs - Google Patents

Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs

Info

Publication number
DE60136826D1
DE60136826D1 DE60136826T DE60136826T DE60136826D1 DE 60136826 D1 DE60136826 D1 DE 60136826D1 DE 60136826 T DE60136826 T DE 60136826T DE 60136826 T DE60136826 T DE 60136826T DE 60136826 D1 DE60136826 D1 DE 60136826D1
Authority
DE
Germany
Prior art keywords
cancer
treatment
acid
asicic
asicaticoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136826T
Other languages
English (en)
Inventor
Se-Kyung Oh
Chokyun Rha
Kadir Azizol Abdul
Lean Teik Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Government of Malaysia
Massachusetts Institute of Technology
Original Assignee
Government of Malaysia
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government of Malaysia, Massachusetts Institute of Technology filed Critical Government of Malaysia
Application granted granted Critical
Publication of DE60136826D1 publication Critical patent/DE60136826D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DE60136826T 2000-08-29 2001-02-14 Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs Expired - Lifetime DE60136826D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MYPI20003987A MY138883A (en) 2000-08-29 2000-08-29 Use of asiatic acid for treatment of cencer
PCT/US2001/040103 WO2002017904A1 (en) 2000-08-29 2001-02-14 Use of asiatic acid or asiaticoside for treatment of cancer

Publications (1)

Publication Number Publication Date
DE60136826D1 true DE60136826D1 (de) 2009-01-15

Family

ID=19749475

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60136826T Expired - Lifetime DE60136826D1 (de) 2000-08-29 2001-02-14 Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs

Country Status (9)

Country Link
US (1) US20040097463A1 (de)
EP (1) EP1313462B1 (de)
JP (2) JP2004507496A (de)
AT (1) ATE415962T1 (de)
AU (1) AU2001247968A1 (de)
DE (1) DE60136826D1 (de)
DK (1) DK1313462T3 (de)
MY (1) MY138883A (de)
WO (1) WO2002017904A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144312A1 (en) * 2001-10-30 2003-07-31 Schoenhard Grant L. Inhibitors of ABC drug transporters in multidrug resistant cancer cells
KR100571886B1 (ko) 2004-02-23 2006-04-17 학교법인 영남학원 아시아틱산을 포함하는 피부암 예방 또는 치료용 조성물
JP2007523956A (ja) 2004-02-25 2007-08-23 ダナ−ファーバー キャンサー インスティテュート インク． 腫瘍細胞増殖を阻害するための方法
WO2006012015A2 (en) * 2004-06-29 2006-02-02 Oregon Health And Science University Methods and compositions for nerve regeneration
US20070010459A1 (en) * 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
CA2595749A1 (en) * 2005-01-27 2006-08-03 Research Development Foundation Combination therapy with triterpenoid compounds and proteasome inhibitors
ES2535088T3 (es) * 2008-01-11 2015-05-05 Shanghai Institute Of Pharmaceutical Industry Formulaciones terapéuticas basadas en ácido asiático y sales seleccionadas del mismo
EP2300041B1 (de) 2008-04-16 2016-01-27 The Johns Hopkins University Verfahren zur bestimmung des risikos für wiederauftreten von prostatakrebs
US8835506B2 (en) 2008-06-05 2014-09-16 Stc.Unm Methods and related compositions for the treatment of cancer
KR101808750B1 (ko) 2009-12-21 2017-12-13 피렐리 타이어 소시에떼 퍼 아찌오니 타이어를 제조하는 공정 및 장치
RU2565410C2 (ru) * 2010-06-10 2015-10-20 Индус Биотек Прайвит Лимитед СПОСОБ ПОЛУЧЕНИЯ ВЫСОКООЧИЩЕННОЙ АЗИАТИКОЗИДНОЙ КОМПОЗИЦИИ ИЗ Centella asiatica И СПОСОБ ЕЕ ПРИМЕНЕНИЯ
JP6091431B2 (ja) * 2011-01-31 2017-03-15 ルコラス−エム．ディー．リミテッド 医薬的使用
US20140194368A1 (en) * 2013-01-04 2014-07-10 Beech Tree Labs, Inc. Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70)
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
CN105636594A (zh) 2013-08-12 2016-06-01 托凯药业股份有限公司 使用雄激素靶向疗法用于治疗肿瘤性疾病的生物标记物
US10774387B2 (en) 2014-05-19 2020-09-15 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
EP3186393A4 (de) 2014-08-25 2018-01-10 The Johns Hopkins University Verfahren und zusammensetzungen im zusammenhang mit prostatakrebstherapeutika
EP3124047A1 (de) * 2015-07-28 2017-02-01 Merz Pharma GmbH & Co. KGaA Pentacyclische triterpene zur injektionslipolyse
US20180228815A1 (en) * 2016-11-09 2018-08-16 The Chinese University Of Hong Kong Naringenin and asiatic acid combination treatment of cancers
WO2019200585A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Naringenin and asiatic acid combination treatment of cancers
CN109528735B (zh) * 2019-01-30 2021-03-12 中国药科大学 积雪草苷在制备治疗皮肤癌药物中的新用途
CN110200981A (zh) * 2019-06-06 2019-09-06 中国药科大学 五环三萜皂苷的医药用途及其药物组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923414A (en) * 1960-04-13 1963-04-10 Laroche Navarron Lab Therapeutic compositions comprising asiatic and arjunolic acids
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
EP0383171A3 (de) * 1989-02-11 1991-07-24 Hoechst Aktiengesellschaft 2,3,23-Trihydroxy-urs-12-en Derivate zur Behandlung von Kognitiven Störungen
FR2714598B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition amincissante à deux types de liposomes pour traitement topique, son utilisation.
JPH08133952A (ja) * 1994-11-07 1996-05-28 Shiseido Co Ltd 皮膚外用剤
CN1075802C (zh) * 1996-11-27 2001-12-05 东国制药株式会社 A环被修饰的积雪草酸衍生物
IT1288257B1 (it) * 1996-11-29 1998-09-11 Paoli Ambrosi Gianfranco De Composizione per uso cosmetico,farmaceutico o dietetico a base di un aminozucchero e/o di un acido poliidrossilico
FR2763336B1 (fr) * 1997-05-14 1999-08-06 Lvmh Rech Esters de tocopherol et leurs utilisations en cosmetique et pharmacie
AU2005251463A1 (en) * 2004-06-14 2005-12-22 Zoser B. Salama Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody

Also Published As

Publication number Publication date
JP2004507496A (ja) 2004-03-11
JP5421340B2 (ja) 2014-02-19
EP1313462A1 (de) 2003-05-28
AU2001247968A1 (en) 2002-03-13
US20040097463A1 (en) 2004-05-20
ATE415962T1 (de) 2008-12-15
JP2012092110A (ja) 2012-05-17
MY138883A (en) 2009-08-28
DK1313462T3 (da) 2009-03-30
WO2002017904A1 (en) 2002-03-07
EP1313462B1 (de) 2008-12-03

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