ATE415962T1 - Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs - Google Patents

Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs

Info

Publication number
ATE415962T1
ATE415962T1 AT01920974T AT01920974T ATE415962T1 AT E415962 T1 ATE415962 T1 AT E415962T1 AT 01920974 T AT01920974 T AT 01920974T AT 01920974 T AT01920974 T AT 01920974T AT E415962 T1 ATE415962 T1 AT E415962T1
Authority
AT
Austria
Prior art keywords
asiaticoside
asiatic acid
treat cancer
cancer
acid
Prior art date
Application number
AT01920974T
Other languages
English (en)
Inventor
Se-Kyung Oh
Chokyun Rha
Kadir Azizol Abdul
Lean Teik Ng
Original Assignee
Government Of Malaysia
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Government Of Malaysia, Massachusetts Inst Technology filed Critical Government Of Malaysia
Application granted granted Critical
Publication of ATE415962T1 publication Critical patent/ATE415962T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/739—Lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01920974T 2000-08-29 2001-02-14 Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs ATE415962T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI20003987A MY138883A (en) 2000-08-29 2000-08-29 Use of asiatic acid for treatment of cencer

Publications (1)

Publication Number Publication Date
ATE415962T1 true ATE415962T1 (de) 2008-12-15

Family

ID=19749475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01920974T ATE415962T1 (de) 2000-08-29 2001-02-14 Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs

Country Status (9)

Country Link
US (1) US20040097463A1 (de)
EP (1) EP1313462B1 (de)
JP (2) JP2004507496A (de)
AT (1) ATE415962T1 (de)
AU (1) AU2001247968A1 (de)
DE (1) DE60136826D1 (de)
DK (1) DK1313462T3 (de)
MY (1) MY138883A (de)
WO (1) WO2002017904A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144312A1 (en) * 2001-10-30 2003-07-31 Schoenhard Grant L. Inhibitors of ABC drug transporters in multidrug resistant cancer cells
KR100571886B1 (ko) 2004-02-23 2006-04-17 학교법인 영남학원 아시아틱산을 포함하는 피부암 예방 또는 치료용 조성물
JP2007523956A (ja) 2004-02-25 2007-08-23 ダナ−ファーバー キャンサー インスティテュート インク． 腫瘍細胞増殖を阻害するための方法
WO2006012015A2 (en) * 2004-06-29 2006-02-02 Oregon Health And Science University Methods and compositions for nerve regeneration
US20070010459A1 (en) * 2005-01-14 2007-01-11 Ying Liu Application of asiatic acid and its derivatives to treat pulmonary fibrosis
US20090018146A1 (en) * 2005-01-27 2009-01-15 Research Development Corporation Combination Therapy with Triterpenoid Compounds and Proteasome Inhibitors
JP5539224B2 (ja) * 2008-01-11 2014-07-02 シャンハイ・インスティチュート・オブ・ファーマシューティカル・インダストリー（エスアイピーアイ） アジアティック酸（ａｓｉａｔｉｃａｃｉｄ）及びその選択される塩に基づく治療用製剤
US9146238B2 (en) 2008-04-16 2015-09-29 The Johns Hopkins University Compositions and methods for treating or preventing prostate cancer and for detecting androgen receptor variants
US8835506B2 (en) 2008-06-05 2014-09-16 Stc.Unm Methods and related compositions for the treatment of cancer
MX341872B (es) 2009-12-21 2016-09-06 Pirelli Proceso y planta para construir llantas.
AU2010354973B2 (en) * 2010-06-10 2015-01-22 Indus Biotech Private Limited A method for preparation of highly pure asiaticoside composition from Centella asiatica and a method of use thereof
TR201816243T4 (tr) * 2011-01-31 2018-11-21 Lucolas M D Ltd Aromataz inhibitörlerinin ve antioksidanların kombinasyonları.
US20140194368A1 (en) * 2013-01-04 2014-07-10 Beech Tree Labs, Inc. Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70)
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
US10357483B2 (en) 2013-05-03 2019-07-23 Selecta Biosciences, Inc. Methods comprising dosing combinations for reducing undesired humoral immune responses
EP3033088A4 (de) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarker zur behandlung neoplastischer störungen mit androgen-anzielenden therapien
WO2015179404A1 (en) 2014-05-19 2015-11-26 The Johns Hopkins University Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer
EP3186393A4 (de) * 2014-08-25 2018-01-10 The Johns Hopkins University Verfahren und zusammensetzungen im zusammenhang mit prostatakrebstherapeutika
EP3124047A1 (de) * 2015-07-28 2017-02-01 Merz Pharma GmbH & Co. KGaA Pentacyclische triterpene zur injektionslipolyse
US20180228815A1 (en) * 2016-11-09 2018-08-16 The Chinese University Of Hong Kong Naringenin and asiatic acid combination treatment of cancers
CA3055936A1 (en) 2017-03-11 2018-09-20 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
WO2019200585A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Naringenin and asiatic acid combination treatment of cancers
WO2020078453A1 (en) * 2018-10-18 2020-04-23 Sinomab Bioscience Limited Methods of treating rheumatoid arthritis
CN109528735B (zh) * 2019-01-30 2021-03-12 中国药科大学 积雪草苷在制备治疗皮肤癌药物中的新用途
CN110200981A (zh) * 2019-06-06 2019-09-06 中国药科大学 五环三萜皂苷的医药用途及其药物组合物
US20240034788A1 (en) * 2020-08-20 2024-02-01 The Board Of Trustees Of The Leland Stanford Junior University Abscopal therapy for cancer
WO2025188669A1 (en) * 2024-03-04 2025-09-12 Cardiff Oncology, Inc. Use of plk1 inhibitor as monotherapy and in combination with cetuximab in treating ras wild-type colorectal cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB923414A (en) * 1960-04-13 1963-04-10 Laroche Navarron Lab Therapeutic compositions comprising asiatic and arjunolic acids
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
EP0383171A3 (de) * 1989-02-11 1991-07-24 Hoechst Aktiengesellschaft 2,3,23-Trihydroxy-urs-12-en Derivate zur Behandlung von Kognitiven Störungen
FR2714598B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition amincissante à deux types de liposomes pour traitement topique, son utilisation.
JPH08133952A (ja) * 1994-11-07 1996-05-28 Shiseido Co Ltd 皮膚外用剤
EP0944571B1 (de) * 1996-11-27 2001-06-13 Dong Kook Pharmaceutical Co., Ltd. Derivate der asiatica-saeure mit einem modifizierten a-ring
IT1288257B1 (it) * 1996-11-29 1998-09-11 Paoli Ambrosi Gianfranco De Composizione per uso cosmetico,farmaceutico o dietetico a base di un aminozucchero e/o di un acido poliidrossilico
FR2763336B1 (fr) * 1997-05-14 1999-08-06 Lvmh Rech Esters de tocopherol et leurs utilisations en cosmetique et pharmacie
AU2005251463A1 (en) * 2004-06-14 2005-12-22 Zoser B. Salama Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody

Also Published As

Publication number Publication date
JP2004507496A (ja) 2004-03-11
EP1313462A1 (de) 2003-05-28
DK1313462T3 (da) 2009-03-30
AU2001247968A1 (en) 2002-03-13
DE60136826D1 (de) 2009-01-15
WO2002017904A1 (en) 2002-03-07
MY138883A (en) 2009-08-28
US20040097463A1 (en) 2004-05-20
JP2012092110A (ja) 2012-05-17
EP1313462B1 (de) 2008-12-03
JP5421340B2 (ja) 2014-02-19

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