DE60042931D1 - Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe - Google Patents

Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe

Info

Publication number
DE60042931D1
DE60042931D1 DE60042931T DE60042931T DE60042931D1 DE 60042931 D1 DE60042931 D1 DE 60042931D1 DE 60042931 T DE60042931 T DE 60042931T DE 60042931 T DE60042931 T DE 60042931T DE 60042931 D1 DE60042931 D1 DE 60042931D1
Authority
DE
Germany
Prior art keywords
carotenoids
levels
diagnostic information
tissue
raman signal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60042931T
Other languages
English (en)
Inventor
Werner Gellermann
Robert W Mcclane
Nikita B Katz
Paul S Bernstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
University of Utah Research Foundation UURF
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation UURF filed Critical University of Utah Research Foundation UURF
Application granted granted Critical
Publication of DE60042931D1 publication Critical patent/DE60042931D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/44Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/443Evaluating skin constituents, e.g. elastin, melanin, water
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N2021/653Coherent methods [CARS]
    • G01N2021/656Raman microprobe
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65Raman scattering
    • G01N21/658Raman scattering enhancement Raman, e.g. surface plasmons
DE60042931T 1999-06-18 2000-03-22 Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe Expired - Lifetime DE60042931D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/335,932 US6205354B1 (en) 1999-06-18 1999-06-18 Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue
PCT/US2000/007745 WO2000078217A1 (en) 1999-06-18 2000-03-22 Method and apparatus for noninvasive measurement of carotenoids and related chemical substances in biological tissue

Publications (1)

Publication Number Publication Date
DE60042931D1 true DE60042931D1 (de) 2009-10-22

Family

ID=23313845

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60042931T Expired - Lifetime DE60042931D1 (de) 1999-06-18 2000-03-22 Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe

Country Status (9)

Country Link
US (1) US6205354B1 (de)
EP (1) EP1196088B1 (de)
JP (2) JP3786873B2 (de)
KR (3) KR100845640B1 (de)
AT (1) ATE442079T1 (de)
AU (1) AU3914400A (de)
CA (1) CA2371886C (de)
DE (1) DE60042931D1 (de)
WO (1) WO2000078217A1 (de)

Families Citing this family (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6389306B1 (en) * 1998-04-24 2002-05-14 Lightouch Medical, Inc. Method for determining lipid and protein content of tissue
US7398119B2 (en) * 1998-07-13 2008-07-08 Childrens Hospital Los Angeles Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals
TWI220926B (en) * 2000-03-24 2004-09-11 Ind Tech Res Inst Sieving apparatus for a bio-chip
GB2361994B (en) * 2000-05-06 2004-12-08 Astron Clinica Ltd Apparatus and methods for analysing skin histology
US6473174B1 (en) * 2000-09-01 2002-10-29 Advanced Micro Devices, Inc. Resist removal monitoring by raman spectroscopy
US6961599B2 (en) * 2001-01-09 2005-11-01 Childrens Hospital Los Angeles Identifying or measuring selected substances or toxins in a subject using resonant raman signals
US7215420B2 (en) * 2001-03-22 2007-05-08 Werner Gellerman Optical method and apparatus for determining status of agricultural products
US7596404B2 (en) * 2001-06-28 2009-09-29 Chemimage Corporation Method of chemical imaging to determine tissue margins during surgery
US8078268B2 (en) 2001-06-28 2011-12-13 Chemimage Corporation System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery
US6965793B2 (en) * 2001-06-28 2005-11-15 Chemimage Corporation Method for Raman chemical imaging of endogenous chemicals to reveal tissue lesion boundaries in tissue
US20030018271A1 (en) * 2001-07-02 2003-01-23 Kimble Allan Wayne Simplified and lightweight system for enhanced visualization of subcutaneous hemoglobin-containing structures
US7039452B2 (en) * 2002-12-19 2006-05-02 The University Of Utah Research Foundation Method and apparatus for Raman imaging of macular pigments
US7656522B2 (en) 2002-02-28 2010-02-02 River Diagnostics B.V. Depth selective pH measurement and UV exposure measurement
FR2840686B1 (fr) * 2002-06-10 2008-11-14 Oreal Procede pour determiner l'aptitude a diffuser et/ou a absorber la lumiere d'un produit cosmetique
AU2003255248A1 (en) * 2002-08-09 2004-02-25 Emerge Interactive, Inc. Real-time monitoring of factors relating to transmissible spongiform encephalopathies
US7192783B2 (en) * 2003-02-05 2007-03-20 Research Foundation Of The City University Of New York Stokes shift emission spectroscopy for detection of disease and physiological state of specimen
WO2004071286A1 (en) * 2003-02-05 2004-08-26 Childrens Hospital Los Angeles Research Institute Non-invasive in vivo measurement of macular carotenoids
US20040254479A1 (en) 2003-02-20 2004-12-16 John Fralick Bio-photonic feedback control software and database
JP2006527018A (ja) * 2003-06-06 2006-11-30 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 血液のpH特定のための装置および方法
US8326404B2 (en) * 2003-11-28 2012-12-04 British Columbia Cancer Agency Branch Multimodal detection of tissue abnormalities based on raman and background fluorescence spectroscopy
WO2005059526A1 (en) * 2003-12-16 2005-06-30 Koninklijke Philips Electronics N. V. Method and apparatus for optical spectroscopy
KR100686659B1 (ko) * 2004-02-19 2007-02-27 너스킨 인터어내셔날 인코포레이팃드 바이오 광 피드백 제어 장치 및 방법
US20050197581A1 (en) * 2004-02-19 2005-09-08 Scott Ferguson Bio-photonic-scanning calibration method
US20050278184A1 (en) 2004-06-10 2005-12-15 John Fralick Bio-photonic feedback control software and database
US7445600B1 (en) 2004-03-01 2008-11-04 Futrex, Inc. Multi-function, self-service health kiosk
AU2004201242B2 (en) * 2004-03-26 2010-10-28 Nuskin International Inc Bio-photonic feedback control software
US7697576B2 (en) * 2004-05-05 2010-04-13 Chem Image Corporation Cytological analysis by raman spectroscopic imaging
US20060281068A1 (en) * 2005-06-09 2006-12-14 Chemimage Corp. Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US7403281B2 (en) * 2004-05-07 2008-07-22 University Of Wyoming Raman spectrometer
US20120252050A1 (en) 2004-06-22 2012-10-04 Crescent Diagnostics Limited Methods for assessing risk of bone fracture
BRPI0512336A (pt) 2004-06-22 2008-03-04 Crescent Diagnostics Ireland L métodos de diagnósticos para osteoporose
EP1766349A4 (de) * 2004-06-30 2010-01-20 Chemimage Corp Dynamische chemische abbildung biologischer zellen und anderer objekte
US20060063991A1 (en) * 2004-08-09 2006-03-23 Dejin Yu Method and apparatus for non-invasive measurement of blood analytes with dynamic spectral calibration
US20060063992A1 (en) * 2004-08-09 2006-03-23 Dejin Yu Method and apparatus for non-invasive measurement of blood analytes
US7145651B2 (en) * 2004-09-17 2006-12-05 B & W Property Inc. Apparatus for fluorescence subtracted Raman spectroscopy
CN1762303B (zh) * 2004-10-22 2010-09-01 如新国际公司 生物光电反馈控制方法和装置
US7365839B2 (en) * 2004-11-03 2008-04-29 Nu Skin International, Inc. Process and compositions for synthetic calibration of bio-photonic scanners
US7899636B2 (en) * 2004-12-15 2011-03-01 Koninklijke Philips Electronics N.V. Calibration of optical analysis making use of multivariate optical elements
US20060244913A1 (en) * 2004-12-21 2006-11-02 Werner Gellermann Imaging of macular pigment distributions
US20060134004A1 (en) * 2004-12-21 2006-06-22 The University Of Utah Methods and apparatus for detection of carotenoids in macular tissue
US20060211926A1 (en) * 2005-03-21 2006-09-21 Dejin Yu Non-invasive Raman measurement apparatus with broadband spectral correction
WO2006130921A1 (en) * 2005-06-08 2006-12-14 Monash University Investigating biological cells using enhanced raman spectroscopy
US8253936B2 (en) * 2008-08-08 2012-08-28 Chemimage Corporation Raman characterization of transplant tissue
US7558619B2 (en) * 2005-10-04 2009-07-07 Nu Skin International, Inc. Raman instrument for measuring weak signals in the presence of strong background fluorescence
US7557915B2 (en) 2005-10-24 2009-07-07 Chemimage Corporation Automated acquisition of spectral data and image data
US20070166354A1 (en) 2005-10-26 2007-07-19 Bridget Barrett-Reis Method of reducing the risk of retinopathy of prematurity in preterm infants
KR100862637B1 (ko) 2006-05-30 2008-10-09 (주) 인텍플러스 광학식 검사 방법
JP2008043396A (ja) * 2006-08-11 2008-02-28 Olympus Corp 内視鏡システム
JP2008148791A (ja) * 2006-12-14 2008-07-03 Olympus Corp 内視鏡システム
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
US8652040B2 (en) 2006-12-19 2014-02-18 Valencell, Inc. Telemetric apparatus for health and environmental monitoring
RU2010114587A (ru) 2007-09-13 2011-10-20 Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури (Us) Компоненты оптического устройства
WO2009036396A1 (en) * 2007-09-14 2009-03-19 Light Sciences Oncology, Inc. Systems, devices, and methods for photoactive assisted resection
SE531527C2 (sv) * 2007-10-01 2009-05-12 Bioresonator Ab Förfarande vid och en anordning för opåverkad materialundersökning
JP2010540955A (ja) * 2007-10-02 2010-12-24 インテクプラス カンパニー、リミテッド 光学式検査方法
CN101903757B (zh) * 2007-10-04 2012-08-29 密苏里大学董事会 光学装置组件
US7961305B2 (en) * 2007-10-23 2011-06-14 The Curators Of The University Of Missouri Optical device components
US8251903B2 (en) 2007-10-25 2012-08-28 Valencell, Inc. Noninvasive physiological analysis using excitation-sensor modules and related devices and methods
WO2009120600A2 (en) 2008-03-25 2009-10-01 The Curators Of The University Of Missouri Method and system for non-invasive blood glucose detection utilizing spectral data of one or more components other than glucose
US7914147B2 (en) * 2008-03-26 2011-03-29 Image Technologies Corporation Systems and methods for optical detection of lipofuscin concentrations in a subject's eye
WO2010042253A2 (en) * 2008-04-30 2010-04-15 Board Of Regents, The University Of Texas System An apparatus and method for noninvasive evalution of a target versus a non- target
EP2285272A4 (de) * 2008-04-30 2017-01-04 Board of Regents, The University of Texas System Integriertes patientenbettsystem
CN102015020A (zh) * 2008-05-09 2011-04-13 休·贝克曼 用于诊断和治疗异常组织的医疗设备及其使用方法
US9042967B2 (en) 2008-05-20 2015-05-26 University Health Network Device and method for wound imaging and monitoring
CN102961146B (zh) 2008-05-22 2015-09-23 密苏里大学董事会 用光谱数据分析进行无创的光学血糖检测的方法和系统
US8260402B2 (en) * 2008-06-06 2012-09-04 Longevity Link, Inc. Noninvasive measurement of carotenoids in biological tissue
US8416405B2 (en) * 2008-08-08 2013-04-09 Chemimage Corporation Raman chemical imaging of implantable drug delivery devices
US9814417B2 (en) * 2009-01-13 2017-11-14 Longevity Link Corporation Noninvasive measurement of flavonoid compounds in biological tissue
DE102009007398A1 (de) 2009-01-30 2010-08-05 Laser- und Medizin-Technologie GmbH, Berlin (LMTB) Korrektur von Raman- oder Fluoreszenzmessungen bezüglich des Einflusses der optischen Eigenschaften des untersuchten Mediums
US8700111B2 (en) 2009-02-25 2014-04-15 Valencell, Inc. Light-guiding devices and monitoring devices incorporating same
US9750462B2 (en) 2009-02-25 2017-09-05 Valencell, Inc. Monitoring apparatus and methods for measuring physiological and/or environmental conditions
US8788002B2 (en) 2009-02-25 2014-07-22 Valencell, Inc. Light-guiding devices and monitoring devices incorporating same
JP2012522579A (ja) * 2009-04-01 2012-09-27 ザ・キュレーターズ・オブ・ザ・ユニバーシティ・オブ・ミズーリ 血糖を非侵襲的に検出するための光分光デバイスと関連する使用方法
WO2011079126A2 (en) * 2009-12-23 2011-06-30 Laser Biopsy, Inc. Method and apparatus for microscopic imaging system with wide field of view and high collection efficiency
US8665433B2 (en) * 2010-08-17 2014-03-04 Exelis Inc. Standoff explosives detector using deep-UV Raman spectroscopy
US8888701B2 (en) 2011-01-27 2014-11-18 Valencell, Inc. Apparatus and methods for monitoring physiological data during environmental interference
RO126898B1 (ro) 2011-02-08 2016-05-30 Staden Raluca Ioana Van Sistem de scanare pentru analize biomedicale
WO2013016007A2 (en) 2011-07-25 2013-01-31 Valencell, Inc. Apparatus and methods for estimating time-state physiological parameters
US9801552B2 (en) 2011-08-02 2017-10-31 Valencell, Inc. Systems and methods for variable filter adjustment by heart rate metric feedback
CA2843752A1 (en) * 2011-08-22 2013-02-28 Spectral Platforms, Inc. Rapid detection of metabolic activity
CN104066372A (zh) * 2012-01-27 2014-09-24 皇家飞利浦有限公司 用于对相关联组织进行光学分析的装置
US9155473B2 (en) * 2012-03-21 2015-10-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
US20140058224A1 (en) * 2012-08-21 2014-02-27 Opticks, Inc. Systems and methods for detection of carotenoid-related compounds in biological tissue
US20140104597A1 (en) * 2012-10-12 2014-04-17 Hamilton Sundstrand Space Systems International, Inc. Dual-spectroscopy detection apparatus and method
US20140200419A1 (en) * 2013-01-17 2014-07-17 Igor V. Ermakov Optical detection of carotenoid-related compounds in human bone and surrounding tissues
CN110013239A (zh) 2013-01-28 2019-07-16 瓦伦赛尔公司 具有与身体运动脱开的感测元件的生理监测装置
US20150201840A1 (en) * 2013-03-18 2015-07-23 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus for skin autofluorescence
US9888855B2 (en) * 2013-03-18 2018-02-13 Korea Electrotechnology Research Institute Reflection detection type measurement apparatus and method for skin autofluorescence
JP6288936B2 (ja) * 2013-04-22 2018-03-07 ローム株式会社 癌診断装置
WO2014175223A1 (ja) 2013-04-22 2014-10-30 ローム株式会社 癌診断装置、診断システム、診断装置
CN103267746B (zh) * 2013-04-23 2016-01-20 武汉新瑞达激光工程有限责任公司 一种宏观与微区集成式激光探针成分分析仪
CN103398999B (zh) * 2013-08-08 2015-11-04 浙江大学 基于拉曼光谱技术的等鞭金藻中胡萝卜素分布的检测方法
KR101594523B1 (ko) 2013-09-02 2016-02-16 한국광기술원 가시광 광학영상 및 비가시광 형광영상의 동시구현이 가능한 광대역 영상 획득투사장치
CN103499560B (zh) * 2013-09-29 2015-08-05 浙江大学 一种结合拉曼光谱技术和谱峰比值法的藻种鉴别方法
CN104749156B (zh) * 2013-12-27 2017-08-29 同方威视技术股份有限公司 拉曼光谱检测方法
EP3013217B1 (de) 2014-01-07 2017-02-22 Opsolution GmbH Vorrichtung und verfahren zur bestimmung einer konzentration in einer probe
US20180303347A1 (en) * 2014-06-18 2018-10-25 The Regents Of The University Of California Raman Imaging Systems and Methods
PT3171765T (pt) 2014-07-24 2021-10-27 Univ Health Network Recolha e análise de dados para fins diagnósticos
US20160029898A1 (en) 2014-07-30 2016-02-04 Valencell, Inc. Physiological Monitoring Devices and Methods Using Optical Sensors
WO2016022295A1 (en) 2014-08-06 2016-02-11 Valencell, Inc. Optical physiological sensor modules with reduced signal noise
US9794653B2 (en) 2014-09-27 2017-10-17 Valencell, Inc. Methods and apparatus for improving signal quality in wearable biometric monitoring devices
US10517477B2 (en) 2015-02-13 2019-12-31 The Regents Of The University Of California Scanning method for uniform, normal-incidence imaging of spherical surface with a single beam
CN104749162B (zh) * 2015-04-17 2018-03-27 江苏天瑞仪器股份有限公司 共聚焦拉曼光谱仪及其光路装置
KR102396249B1 (ko) * 2015-10-14 2022-05-09 삼성전자주식회사 라만 스펙트럼을 이용한 사용자 인증 장치 및 방법
US10610158B2 (en) 2015-10-23 2020-04-07 Valencell, Inc. Physiological monitoring devices and methods that identify subject activity type
US10945618B2 (en) 2015-10-23 2021-03-16 Valencell, Inc. Physiological monitoring devices and methods for noise reduction in physiological signals based on subject activity type
US20170281077A1 (en) * 2016-04-04 2017-10-05 Speclipse, Inc. System with disease diagnosis and skin age measurement functions and handpiece used therewith
KR101640202B1 (ko) * 2016-04-04 2016-07-21 스페클립스 주식회사 레이저 조사 장치를 이용한 질병 진단 장치 및 질병 진단용 탈부착 핸드피스
US11660012B2 (en) 2016-04-15 2023-05-30 The Regents Of The University Of California Assessment of wound status and tissue viability via analysis of spatially resolved THz reflectometry maps
US10939844B2 (en) 2016-04-15 2021-03-09 The Regents Of The University Of California THz sensing of corneal tissue water content
CN108603839A (zh) 2016-04-18 2018-09-28 惠普发展公司,有限责任合伙企业 散射辐射的多重光谱的同时检测
LU93098B1 (de) * 2016-06-03 2018-01-22 Leica Microsystems Verfahren zum Einstellen der Intensität eines Lichtstrahls in einer optischen Anordnung und zugehörige optische Anordnung
CA3028105A1 (en) * 2016-06-16 2017-12-21 Valisure Llc Methods and systems for spectroscopic analysis
WO2018009736A1 (en) 2016-07-08 2018-01-11 Valencell, Inc. Motion-dependent averaging for physiological metric estimating systems and methods
CN106290292B (zh) * 2016-07-25 2018-12-28 浙江大学 一种利用共聚焦显微拉曼检测茶叶中类胡萝卜素含量的方法
EP3544492A4 (de) * 2016-11-23 2020-05-27 General Electric Company Bildgebungsprotokollmanager
JP2020139735A (ja) * 2017-06-26 2020-09-03 株式会社ニコン 測定方法、測定装置
KR102544670B1 (ko) 2018-07-27 2023-06-16 삼성전자주식회사 항산화 센서, 항산화 신호 측정 방법 및 항산화 레벨 판단 방법
US11555742B2 (en) 2018-09-04 2023-01-17 Provincial Health Services Authority Image guided micro-Raman spectroscopy
CN109481851A (zh) * 2018-09-14 2019-03-19 合肥泓博医学科技有限公司 一种咽喉护理器
KR102279688B1 (ko) 2019-03-22 2021-07-20 스페클립스 주식회사 레이저 유도 붕괴 스펙트럼 분석을 이용하는 진단 방법 및 이를 수행하는 진단 장치
KR20210022319A (ko) 2019-08-20 2021-03-03 삼성전자주식회사 생체정보 추정 장치 및 방법
KR20210047540A (ko) 2019-10-22 2021-04-30 삼성전자주식회사 항산화 센서 및 항산화 수치 측정 방법
CN110910506B (zh) * 2019-12-03 2021-02-09 江苏集萃华科智能装备科技有限公司 基于法线检测的三维重建方法、装置、检测装置及系统
KR20210069945A (ko) 2019-12-04 2021-06-14 삼성전자주식회사 생체정보 추산 장치 및 방법
WO2021150808A1 (en) * 2020-01-23 2021-07-29 Precision Healing, Inc. Skin diagnostics using optical signatures
CN111912828A (zh) * 2020-08-19 2020-11-10 河南省农业科学院农副产品加工研究中心 一种快速检测玉米中类胡萝卜素含量的方法
JP7256910B2 (ja) * 2020-12-21 2023-04-12 カゴメ株式会社 野菜摂取量改善システム、野菜摂取食データベース、及び野菜摂取量改善プログラム
CN113484303A (zh) * 2021-07-01 2021-10-08 农业农村部食物与营养发展研究所 基于拉曼光谱检测小米类胡萝卜素的方法

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563233A (en) 1969-03-17 1971-02-16 Albert G Bodine Sonic dental tool for massaging gums
US4144464A (en) 1978-01-25 1979-03-13 The United States Of America As Represented By The United States Department Of Energy Device and method for noresonantly Raman shifting ultraviolet radiation
US4318057A (en) 1979-06-04 1982-03-02 The United States Of America As Represented By The United States Department Of Energy Optically pumped isotopic ammonia laser system
US4519400A (en) 1983-04-01 1985-05-28 Biosonics, Inc. Method for stimulating salivation
US4500995A (en) 1983-05-02 1985-02-19 At&T Bell Laboratories Bromine anti-stokes raman laser
US4665921A (en) 1984-05-28 1987-05-19 Teranishi Electric Works, Ltd. High potential generating toothbrush
US5346488A (en) 1985-04-08 1994-09-13 The General Hospital Corporation Laser-induced ablation of atherosclerotic plaque
US4758081A (en) 1985-07-18 1988-07-19 Bausch & Lomb Incorporated Control of laser photocoagulation using Raman radiation
FR2591105B1 (fr) 1985-12-11 1989-03-24 Moet Hennessy Rech Composition pharmaceutique, notamment dermatologique, ou cosmetique, a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un retinoide ou un analogue structural dudit retinoide tel qu'un carotenoide.
CN87101867A (zh) 1987-03-09 1988-09-21 王龄 电离子口腔治疗微电器
US4852579A (en) 1987-04-20 1989-08-01 Karl Storz Endoscopy Gmbh And Company Photocharacterization and treatment of normal abnormal and ectopic endometrium
US4832483A (en) 1987-09-03 1989-05-23 New England Medical Center Hospitals, Inc. Method of using resonance raman spectroscopy for detection of malignancy disease
US4807240A (en) 1988-01-11 1989-02-21 Rockwell International Corporation Frequency adding lasers and optical amplifiers
US4858238A (en) 1988-01-14 1989-08-15 The United States Of America As Represented By The Secretary Of The Air Force Stimulated Raman scattering enhancer
US5421337A (en) 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5124313A (en) 1989-06-02 1992-06-23 Schaeffer Hans A Methods of improved skin care and the treatment of dermatological conditions
US5290605A (en) 1989-06-29 1994-03-01 Niva Shapira Sun-exposure nutritional supporting composition
US5376556A (en) 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
US5243983A (en) 1990-12-14 1993-09-14 Georgia Tech Research Corporation Non-invasive blood glucose measurement system and method using stimulated raman spectroscopy
US5261410A (en) * 1991-02-07 1993-11-16 Alfano Robert R Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy
US5303026A (en) 1991-02-26 1994-04-12 The Regents Of The University Of California Los Alamos National Laboratory Apparatus and method for spectroscopic analysis of scattering media
CA2104960C (en) 1991-02-26 2005-04-05 Richard P. Rava Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue
US5275168A (en) 1992-03-31 1994-01-04 The United States Of America As Represented By The Secretary Of The Navy Time-gated imaging through dense-scattering materials using stimulated Raman amplification
US5452723A (en) 1992-07-24 1995-09-26 Massachusetts Institute Of Technology Calibrated spectrographic imaging
US5418797A (en) 1993-01-15 1995-05-23 The United States Of America As Represented By The Secretary Of The Navy Time gated imaging through scattering material using polarization and stimulated raman amplification
US5304170A (en) 1993-03-12 1994-04-19 Green Howard A Method of laser-induced tissue necrosis in carotenoid-containing skin structures
US5553616A (en) 1993-11-30 1996-09-10 Florida Institute Of Technology Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator
US5556612A (en) 1994-03-15 1996-09-17 The General Hospital Corporation Methods for phototherapeutic treatment of proliferative skin diseases
US5451785A (en) 1994-03-18 1995-09-19 Sri International Upconverting and time-gated two-dimensional infrared transillumination imaging
US5590660A (en) 1994-03-28 1997-01-07 Xillix Technologies Corp. Apparatus and method for imaging diseased tissue using integrated autofluorescence
US5432610A (en) 1994-04-15 1995-07-11 Hewlett-Packard Company Diode-pumped power build-up cavity for chemical sensing
US5579773A (en) 1994-09-30 1996-12-03 Martin Marietta Energy Systems, Inc. Laser-induced differential normalized fluorescence method for cancer diagnosis
US5553617A (en) 1995-01-20 1996-09-10 Hughes Aircraft Company Noninvasive method and apparatus for determining body chemistry
US5697373A (en) 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5615673A (en) * 1995-03-27 1997-04-01 Massachusetts Institute Of Technology Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes
US5733507A (en) 1995-06-07 1998-03-31 Inphocyte, Inc. Biological cell sample holder for use in infrared and/or Raman spectroscopy analysis holder
US5643623A (en) 1995-06-07 1997-07-01 Mars Incorporated Health food product and its uses
US5657754A (en) 1995-07-10 1997-08-19 Rosencwaig; Allan Apparatus for non-invasive analyses of biological compounds
US5873831A (en) 1997-03-13 1999-02-23 The University Of Utah Technology Transfer Office Method and system for measurement of macular carotenoid levels

Also Published As

Publication number Publication date
KR20020035007A (ko) 2002-05-09
JP4336673B2 (ja) 2009-09-30
JP2003507088A (ja) 2003-02-25
CA2371886A1 (en) 2000-12-28
KR100825521B1 (ko) 2008-04-25
WO2000078217A1 (en) 2000-12-28
AU3914400A (en) 2001-01-09
EP1196088A1 (de) 2002-04-17
KR20060134230A (ko) 2006-12-27
ATE442079T1 (de) 2009-09-15
KR20070004144A (ko) 2007-01-05
US6205354B1 (en) 2001-03-20
KR100788536B1 (ko) 2007-12-24
EP1196088B1 (de) 2009-09-09
JP2006078497A (ja) 2006-03-23
CA2371886C (en) 2012-01-03
KR100845640B1 (ko) 2008-07-10
JP3786873B2 (ja) 2006-06-14
EP1196088A4 (de) 2003-08-06

Similar Documents

Publication Publication Date Title
DE60042931D1 (de) Verfahren zum nicht invasiven messen von karotenoiden und verwandten chemischen substanzen in biologischem gewebe
Lieber et al. Automated method for subtraction of fluorescence from biological Raman spectra
Calin et al. Optical techniques for the noninvasive diagnosis of skin cancer
Choo‐Smith et al. Medical applications of Raman spectroscopy: from proof of principle to clinical implementation
Moreira et al. Raman spectroscopy: A powerful technique for biochemical analysis and diagnosis
Dancik et al. Use of multiphoton tomography and fluorescence lifetime imaging to investigate skin pigmentation in vivo
DE69836979D1 (de) Verfahren zur nicht invasiven analytenmessung
ES2185374T3 (es) Procedimiento de modulacion tisular para el analisis espectroscopico cuantitativo in vivo, no invasor de tejidos.
WO2009149266A3 (en) Noninvasive measurement of carotenoids in biological tissue
Wabnitz et al. Time-resolved near-infrared spectroscopy and imaging of the adult human brain
Sekar et al. Broadband diffuse optical characterization of elastin for biomedical applications
Schulmerich et al. Transcutaneous Raman spectroscopy of bone tissue using a non-confocal fiber optic array probe
EP3056141A1 (de) Verfahren zur nichtinvasiven messung des blutzuckers und optoelektronisches system zur nichtinvasiven messung des blutzuckers
Kopola et al. Two-channel fiber optic skin erythema meter
Kanemura et al. Assessment of skin inflammation using near-infrared Raman spectroscopy combined with artificial intelligence analysis in an animal model
WO2013123950A1 (en) Analytical method for common and specific characterization of skin carcinogenesis by ftir microspectroscopy
JPH07120384A (ja) 光計測方法および装置
TWI588492B (zh) 陣列式近場光學高散射材料檢測方法
Prince et al. Analysis of spectroscopic diffuse reflectance plots for different skin conditions
KR20100075553A (ko) 생체 조직으로부터 분광 시험 신호를 수집하는 방법 및 측정 장치
Wei et al. Comparison of hair from rectum cancer patients and from healthy persons by Raman microspectroscopy and imaging
Pinzaru et al. Cancer tissue screening using surface enhanced Raman scattering
Prince et al. Functional optical imaging of a tissue based on diffuse reflectance with fibre spectrometer
Kohl-Bareis NIRS: Theoretical background and practical aspects
Skrebova et al. Noninvasive quantification of cutaneous oedema in patch test reactions by fiber optic near-infrared Fourier transform Raman spectroscopy

Legal Events

Date Code Title Description
8364 No opposition during term of opposition