DE60025958T2 - 14,15-beta-methylen substituierte androgene - Google Patents

14,15-beta-methylen substituierte androgene Download PDF

Info

Publication number
DE60025958T2
DE60025958T2 DE60025958T DE60025958T DE60025958T2 DE 60025958 T2 DE60025958 T2 DE 60025958T2 DE 60025958 T DE60025958 T DE 60025958T DE 60025958 T DE60025958 T DE 60025958T DE 60025958 T2 DE60025958 T2 DE 60025958T2
Authority
DE
Germany
Prior art keywords
worden
ist
grams
gramm
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60025958T
Other languages
German (de)
English (en)
Other versions
DE60025958D1 (de
Inventor
Dirk Leysen
Jaap Van Der Louw
Roberta Buma Bursi
Evert Marcel DE GOOYER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Publication of DE60025958D1 publication Critical patent/DE60025958D1/de
Application granted granted Critical
Publication of DE60025958T2 publication Critical patent/DE60025958T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
DE60025958T 1999-12-02 2000-11-29 14,15-beta-methylen substituierte androgene Expired - Lifetime DE60025958T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99204080 1999-12-02
EP99204080 1999-12-02
PCT/EP2000/012009 WO2001040255A2 (en) 1999-12-02 2000-11-29 14,15-beta-methylene substituted androgens

Publications (2)

Publication Number Publication Date
DE60025958D1 DE60025958D1 (de) 2006-04-20
DE60025958T2 true DE60025958T2 (de) 2006-07-27

Family

ID=8240955

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60025958T Expired - Lifetime DE60025958T2 (de) 1999-12-02 2000-11-29 14,15-beta-methylen substituierte androgene

Country Status (27)

Country Link
US (1) US6706700B2 (cg-RX-API-DMAC7.html)
EP (1) EP1237904B1 (cg-RX-API-DMAC7.html)
JP (1) JP2003515543A (cg-RX-API-DMAC7.html)
CN (1) CN1166680C (cg-RX-API-DMAC7.html)
AR (1) AR026655A1 (cg-RX-API-DMAC7.html)
AT (1) ATE317396T1 (cg-RX-API-DMAC7.html)
AU (1) AU778017B2 (cg-RX-API-DMAC7.html)
CA (1) CA2390226A1 (cg-RX-API-DMAC7.html)
CO (1) CO5251441A1 (cg-RX-API-DMAC7.html)
CY (1) CY1106086T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ301376B6 (cg-RX-API-DMAC7.html)
DE (1) DE60025958T2 (cg-RX-API-DMAC7.html)
DK (1) DK1237904T3 (cg-RX-API-DMAC7.html)
ES (1) ES2258037T3 (cg-RX-API-DMAC7.html)
HK (1) HK1047596B (cg-RX-API-DMAC7.html)
HU (1) HUP0203611A3 (cg-RX-API-DMAC7.html)
IL (1) IL149424A (cg-RX-API-DMAC7.html)
MX (1) MXPA02004939A (cg-RX-API-DMAC7.html)
NO (1) NO322422B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ518753A (cg-RX-API-DMAC7.html)
PE (1) PE20011033A1 (cg-RX-API-DMAC7.html)
PL (1) PL202999B1 (cg-RX-API-DMAC7.html)
RU (1) RU2242479C2 (cg-RX-API-DMAC7.html)
SK (1) SK287095B6 (cg-RX-API-DMAC7.html)
TW (1) TWI275593B (cg-RX-API-DMAC7.html)
WO (1) WO2001040255A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200203536B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059920A2 (en) * 1999-04-06 2000-10-12 Akzo Nobel N.V. Orally active 7.alpha.-alkyl androgens
PL208163B1 (pl) * 2002-01-21 2011-03-31 Organon Nv Sposób wytwarzania 7 α-metylosteroidów
US20080293683A1 (en) * 2007-05-24 2008-11-27 University Of Kansas Medical Center Hormone Replacement Therapy
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
EA024003B1 (ru) * 2011-10-07 2016-08-31 Эстетра С.П.Р.Л. Способ получения эстетрола
PT3310333T (pt) 2015-06-18 2020-06-08 Estetra Sprl Dose unitária orodispersível contendo um composto de estetrol
JP6866561B2 (ja) 2015-06-18 2021-04-28 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠
CA2988362C (en) 2015-06-18 2022-07-19 Mithra Pharmaceuticals S.A. Orodispersible tablet containing estetrol
TN2017000499A1 (en) 2015-06-18 2019-04-12 Mithra Pharmaceuticals S A Orodispersible dosage unit containing an estetrol component
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
CN111621141B (zh) * 2020-06-12 2022-04-08 广西大学 一种缓释型二氧化氯-水性聚氨酯抗菌膜及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3086027A (en) * 1960-01-22 1963-04-16 Lilly Co Eli 19-nor-4, 9(10)-steroids and process
IE60780B1 (en) * 1987-01-23 1994-08-10 Akzo Nv New 11-aryl steroid derivatives
DE19537626A1 (de) * 1995-10-10 1997-04-17 Jenapharm Gmbh Steroide mit einer 14, 15-Methylengruppe
DE19827522A1 (de) 1998-06-22 1999-12-23 Jenapharm Gmbh 14,15-Cyclopropanosteroide der 19-Nor-Androstanreihe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
CA2359218A1 (en) 1999-03-08 2000-09-14 Akzo Nobel N.V. 14.beta., 17-alpha-hydroxymethylandrostane derivatives as androgens

Also Published As

Publication number Publication date
ZA200203536B (en) 2003-08-04
AU778017B2 (en) 2004-11-11
CY1106086T1 (el) 2011-06-08
SK287095B6 (sk) 2009-12-07
PL355689A1 (en) 2004-05-17
CZ301376B6 (cs) 2010-02-03
AR026655A1 (es) 2003-02-19
DE60025958D1 (de) 2006-04-20
NO20022564L (no) 2002-05-30
US6706700B2 (en) 2004-03-16
NO20022564D0 (no) 2002-05-30
RU2242479C2 (ru) 2004-12-20
ATE317396T1 (de) 2006-02-15
HUP0203611A3 (en) 2004-07-28
CN1402735A (zh) 2003-03-12
DK1237904T3 (da) 2006-06-06
EP1237904B1 (en) 2006-02-08
NZ518753A (en) 2004-05-28
MXPA02004939A (es) 2003-05-23
HK1047596B (en) 2006-04-21
TWI275593B (en) 2007-03-11
HK1047596A1 (en) 2003-02-28
US20030100543A1 (en) 2003-05-29
CZ20021894A3 (cs) 2002-08-14
IL149424A0 (en) 2002-11-10
SK7582002A3 (en) 2002-09-10
WO2001040255A2 (en) 2001-06-07
AU2838301A (en) 2001-06-12
IL149424A (en) 2007-05-15
EP1237904A2 (en) 2002-09-11
CO5251441A1 (es) 2003-02-28
JP2003515543A (ja) 2003-05-07
CN1166680C (zh) 2004-09-15
ES2258037T3 (es) 2006-08-16
CA2390226A1 (en) 2001-06-07
WO2001040255A3 (en) 2001-11-15
HUP0203611A2 (hu) 2003-03-28
PL202999B1 (pl) 2009-08-31
NO322422B1 (no) 2006-10-02
PE20011033A1 (es) 2001-10-11

Similar Documents

Publication Publication Date Title
DE60025958T2 (de) 14,15-beta-methylen substituierte androgene
JP2010529153A (ja) １７β−シアノ−１９−ノル−アンドロスタ−４−エン誘導体、その使用、及び当該誘導体を含む医薬
DE60000826T2 (de) 14.beta.,17-alpha-hydroxymethylandrostan derivate als androgene
EP1343806B1 (en) Methylene steroids as novel androgens
KR100730010B1 (ko) 신규 안드로겐
US20040059140A1 (en) 14(15)-unsaturated 15- and/or 16-substituted androgens with mixed androgen-progrestational profile
AU2002224923A1 (en) Methylene steroids as novel androgens
WO1995011915A1 (de) 10,11β-C2-ÜBERBRÜCKTE STEROIDE
DE19535851A1 (de) 18-Norsteroide mit gestagener Wirkung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL