DE60019457D1 - Substituierte isoxazoline und ihre verwendung als antibakterielle wirkstoffe - Google Patents

Substituierte isoxazoline und ihre verwendung als antibakterielle wirkstoffe

Info

Publication number
DE60019457D1
DE60019457D1 DE60019457T DE60019457T DE60019457D1 DE 60019457 D1 DE60019457 D1 DE 60019457D1 DE 60019457 T DE60019457 T DE 60019457T DE 60019457 T DE60019457 T DE 60019457T DE 60019457 D1 DE60019457 D1 DE 60019457D1
Authority
DE
Germany
Prior art keywords
sup
alkyl
optionally substituted
active substances
antibacterial active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60019457T
Other languages
English (en)
Other versions
DE60019457T2 (de
Inventor
Barry Gravestock
Michael John Betts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE60019457D1 publication Critical patent/DE60019457D1/de
Publication of DE60019457T2 publication Critical patent/DE60019457T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/12—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60019457T 1999-12-03 2000-11-28 Substituierte isoxazoline und ihre verwendung als antibakterielle wirkstoffe Expired - Fee Related DE60019457T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9928568 1999-12-03
GBGB9928568.6A GB9928568D0 (en) 1999-12-03 1999-12-03 Chemical compounds
PCT/GB2000/004516 WO2001040222A1 (en) 1999-12-03 2000-11-28 Substituted isoxazolines and their use as antibacterial agents

Publications (2)

Publication Number Publication Date
DE60019457D1 true DE60019457D1 (de) 2005-05-19
DE60019457T2 DE60019457T2 (de) 2006-01-26

Family

ID=10865622

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60019457T Expired - Fee Related DE60019457T2 (de) 1999-12-03 2000-11-28 Substituierte isoxazoline und ihre verwendung als antibakterielle wirkstoffe

Country Status (8)

Country Link
US (2) US7081538B1 (de)
EP (1) EP1242416B1 (de)
JP (1) JP2003515607A (de)
AT (1) ATE293110T1 (de)
AU (1) AU1714801A (de)
DE (1) DE60019457T2 (de)
GB (1) GB9928568D0 (de)
WO (1) WO2001040222A1 (de)

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US20110046101A1 (en) * 2008-03-17 2011-02-24 Dmitrienko Gary I Bate-lactamase inhibitors
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CN101781294B (zh) * 2010-03-10 2012-02-01 天津药物研究院 一类咪唑的衍生物、其制备方法和用途
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JP6938545B2 (ja) 2016-05-20 2021-09-22 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用
JP7022751B2 (ja) 2016-12-09 2022-02-18 ゼノン・ファーマシューティカルズ・インコーポレイテッド ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用
EP3807281A1 (de) 2018-06-13 2021-04-21 Xenon Pharmaceuticals Inc. Benzolsulfonamidverbindungen und deren verwendung als arzneimittel
BR112021000209A2 (pt) 2018-08-31 2021-08-24 Xenon Pharmaceuticals Inc. Compostos de sulfonamida substituída por heteroarila e seu uso como agentes terapêuticos
JP7383012B2 (ja) 2018-08-31 2023-11-17 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヘテロアリール置換スルホンアミド化合物、およびナトリウムチャネル阻害剤としてのその使用

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Also Published As

Publication number Publication date
DE60019457T2 (de) 2006-01-26
EP1242416B1 (de) 2005-04-13
EP1242416A1 (de) 2002-09-25
US20070281916A1 (en) 2007-12-06
US7081538B1 (en) 2006-07-25
AU1714801A (en) 2001-06-12
WO2001040222A1 (en) 2001-06-07
JP2003515607A (ja) 2003-05-07
GB9928568D0 (en) 2000-02-02
ATE293110T1 (de) 2005-04-15

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