WO2002080841A3 - Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine - Google Patents

Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine Download PDF

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Publication number
WO2002080841A3
WO2002080841A3 PCT/GB2002/001615 GB0201615W WO02080841A3 WO 2002080841 A3 WO2002080841 A3 WO 2002080841A3 GB 0201615 W GB0201615 W GB 0201615W WO 02080841 A3 WO02080841 A3 WO 02080841A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulphilimine
sulphoximine
cyclic
alkyl
hydrogen
Prior art date
Application number
PCT/GB2002/001615
Other languages
French (fr)
Other versions
WO2002080841A2 (en
Inventor
Michael John Betts
Michael Lingard Swain
Neil James Hales
Hoan Khai Huynh
Original Assignee
Astrazeneca Ab
Astrazeneca Uk Ltd
Michael John Betts
Michael Lingard Swain
Neil James Hales
Hoan Khai Huynh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Astrazeneca Uk Ltd, Michael John Betts, Michael Lingard Swain, Neil James Hales, Hoan Khai Huynh filed Critical Astrazeneca Ab
Priority to AU2002308000A priority Critical patent/AU2002308000A1/en
Publication of WO2002080841A2 publication Critical patent/WO2002080841A2/en
Publication of WO2002080841A3 publication Critical patent/WO2002080841A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example; T is selected, for example, from a group of formula (TA1) or (TA2), wherein, for example, X1m is O= and X2m is R2s-(E)ms-N-; wherein E is an electron withdrawing group, for example, -SO2- or -CO-; and, for example, R2s is hydrogen or (1-6C)alkyl; and, for example, HET(AR) is a 5 or 6 membered aromatic or heteroaromatic ring; and Y is NH and , for example, Z is hydrogen or -COR5 or CSR5, wherein R5 is, for example (1-6C)alkyl; are useful as pharmaceutical agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
PCT/GB2002/001615 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine WO2002080841A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002308000A AU2002308000A1 (en) 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108764.2A GB0108764D0 (en) 2001-04-07 2001-04-07 Chemical compounds
GB0108764.2 2001-04-07

Publications (2)

Publication Number Publication Date
WO2002080841A2 WO2002080841A2 (en) 2002-10-17
WO2002080841A3 true WO2002080841A3 (en) 2003-02-27

Family

ID=9912442

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001615 WO2002080841A2 (en) 2001-04-07 2002-04-03 Antibacterial oxazolidinones with a cyclic sulphilimine or sulphoximine

Country Status (3)

Country Link
AU (1) AU2002308000A1 (en)
GB (1) GB0108764D0 (en)
WO (1) WO2002080841A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0401005A3 (en) 2001-09-11 2007-11-28 Astrazeneca Ab Oxazolidinone and/or isoxazoline antibacterials, process for their preparation, their use and pharmaceutical compositions containing them
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials
MXPA04008312A (en) 2002-02-28 2004-11-26 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents.
CA2477379A1 (en) 2002-02-28 2003-09-04 Astrazeneca Ab Oxazolidinone derivatives, processes for their preparation, and pharmaceutical compositions containing them
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
SG2009082793A (en) 2003-06-03 2015-03-30 Rib X Pharmaceuticals Inc Biaryl heterocyclic compounds and methods of making and using the same
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
US7265140B2 (en) * 2003-09-23 2007-09-04 Pfizer Inc Acyloxymethylcarbamate prodrugs of oxazolidinones
AR046782A1 (en) 2003-12-17 2005-12-21 Rib X Pharmaceuticals Inc HALEROCICLY COMPOUNDS OF HALOGENATED BIARILO, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, METHODS FOR THEIR ELABORATION AND ITS USE AS MEDICATIONS.
CN102816194A (en) 2004-02-27 2012-12-12 瑞伯-X医药品有限公司 Macrocyclic compounds and methods of making and using the same
EP1904489B1 (en) 2005-06-08 2011-01-26 Rib-X Pharmaceuticals, Inc. Process for the synthesis of triazoles
CN112543756A (en) 2018-07-25 2021-03-23 卡迪拉保健有限公司 Substituted oxazolidinones for the treatment of mammalian infections
WO2020234636A1 (en) 2019-05-17 2020-11-26 Cadila Healthcare Limited Novel compounds for the treatment of mammalian infections
WO2021184339A1 (en) * 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1997009328A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
WO1997030995A1 (en) * 1996-02-24 1997-08-28 Zeneca Limited Antibiotic oxazolidinone derivatives
WO2001046185A1 (en) * 1999-12-21 2001-06-28 Pharmacia & Upjohn Company Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007271A1 (en) * 1993-09-09 1995-03-16 The Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
WO1997009328A1 (en) * 1995-09-01 1997-03-13 Pharmacia & Upjohn Company Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings
WO1997030995A1 (en) * 1996-02-24 1997-08-28 Zeneca Limited Antibiotic oxazolidinone derivatives
WO2001046185A1 (en) * 1999-12-21 2001-06-28 Pharmacia & Upjohn Company Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents

Also Published As

Publication number Publication date
GB0108764D0 (en) 2001-05-30
WO2002080841A2 (en) 2002-10-17
AU2002308000A1 (en) 2002-10-21

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