DE60018425T2 - Elastomerische Mikropumpen- oder Mikroventilsysteme - Google Patents

Elastomerische Mikropumpen- oder Mikroventilsysteme Download PDF

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Publication number
DE60018425T2
DE60018425T2 DE2000618425 DE60018425T DE60018425T2 DE 60018425 T2 DE60018425 T2 DE 60018425T2 DE 2000618425 DE2000618425 DE 2000618425 DE 60018425 T DE60018425 T DE 60018425T DE 60018425 T2 DE60018425 T2 DE 60018425T2
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DE
Germany
Prior art keywords
flow
elastomeric
channel
layer
elastomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE2000618425
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German (de)
English (en)
Other versions
DE60018425D1 (de
Inventor
Marc A. South San Francisco Unger
Axel Laguna Beach Scherer
Stephen R. San Marino Quake
Hou-Pu Chou
Todd A. Pasadena Thorsen
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California Institute of Technology
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California Institute of Technology
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Publication of DE60018425T2 publication Critical patent/DE60018425T2/de
Anticipated expiration legal-status Critical
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B5/00—Devices comprising elements which are movable in relation to each other, e.g. comprising slidable or rotatable elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Programme devices
    • F15C1/06—Constructional details; Selection of specified materials ; Constructional realisation of one single element; Canal shapes; Jet nozzles; Assembling an element with other devices, only if the element forms the main part
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K1/00—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
    • F16K1/16—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members
    • F16K1/18—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps
    • F16K1/20—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
    • F16K11/10—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit
    • F16K11/20—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by separate actuating members
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K13/00—Other constructional types of cut-off apparatus; Arrangements for cutting-off
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K31/00—Actuating devices; Operating means; Releasing devices
    • F16K31/12—Actuating devices; Operating means; Releasing devices actuated by fluid
    • F16K31/126—Actuating devices; Operating means; Releasing devices actuated by fluid the fluid acting on a diaphragm, bellows, or the like
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
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    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0048—Electric operating means therefor using piezoelectric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0051—Electric operating means therefor using electrostatic means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/046—Chemical or electrochemical formation of bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0655—Valves, specific forms thereof with moving parts pinch valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B81C2201/01—Manufacture or treatment of microstructural devices or systems in or on a substrate
    • B81C2201/0174—Manufacture or treatment of microstructural devices or systems in or on a substrate for making multi-layered devices, film deposition or growing
    • B81C2201/019—Bonding or gluing multiple substrate layers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0073—Fabrication methods specifically adapted for microvalves
    • F16K2099/0074—Fabrication methods specifically adapted for microvalves using photolithography, e.g. etching
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16K2099/0076—Fabrication methods specifically adapted for microvalves using electrical discharge machining [EDM], milling or drilling
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16K2099/0078—Fabrication methods specifically adapted for microvalves using moulding or stamping
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0094—Micropumps
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes
    • Y10T137/0402—Cleaning, repairing, or assembling
    • Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/0318—Processes
    • Y10T137/0402—Cleaning, repairing, or assembling
    • Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
    • Y10T137/0497—Fluid actuated or retarded
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87249—Multiple inlet with multiple outlet
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/8593—Systems
    • Y10T137/87917—Flow path with serial valves and/or closures
    • Y10T137/87981—Common actuator
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24744—Longitudinal or transverse tubular cavity or cell

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  • Physical Or Chemical Processes And Apparatus (AREA)
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  • Closures For Containers (AREA)
  • Valve Housings (AREA)
DE2000618425 1999-06-28 2000-06-27 Elastomerische Mikropumpen- oder Mikroventilsysteme Expired - Lifetime DE60018425T2 (de)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155871B2 (en) 2010-11-19 2015-10-13 C. Miethke Gmbh & Co Kg Electrically operable, in one possible embodiment programmable hydrocephalus valve

Families Citing this family (776)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US7052594B2 (en) 2002-01-31 2006-05-30 Sri International Devices and methods for controlling fluid flow using elastic sheet deflection
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
RU2234894C2 (ru) 1999-04-26 2004-08-27 Джи-Эм-Пи Вижн Солюшнз, Инк. Расширительное устройство и способ лечения глаукомы
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) * 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US8052792B2 (en) 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US7217321B2 (en) 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US7052545B2 (en) 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
EP1065378B1 (en) 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7195670B2 (en) * 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US7501245B2 (en) 1999-06-28 2009-03-10 Helicos Biosciences Corp. Methods and apparatuses for analyzing polynucleotide sequences
CA2290731A1 (en) 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
AU2001249071B2 (en) * 2000-02-23 2005-09-08 Caliper Life Sciences, Inc. Multi-reservoir pressure control system
WO2001067369A2 (en) * 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002000343A2 (en) 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US7236831B2 (en) * 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US6669669B2 (en) * 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1322936A2 (en) * 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
US20030196695A1 (en) * 2000-11-06 2003-10-23 Nanostream, Inc. Microfluidic flow control devices
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US8097471B2 (en) * 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
EP1345698A4 (en) * 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUID DEVICES FOR THE INTRODUCTION AND DISPOSAL OF FLUIDS FROM MICROFLUID SYSTEMS
FR2817974B1 (fr) * 2000-12-12 2003-09-12 Commissariat Energie Atomique Micro-actionneur optique, composant optique utilisant le micro-actionneur, et procede de realisation d'un micro-actionneur optique
CA2697026A1 (en) * 2000-12-12 2002-06-12 Bayer Healthcare Llc Method of making a capillary channel
JP4248238B2 (ja) * 2001-01-08 2009-04-02 プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ マイクロ流体システム用の弁およびポンプならびにマイクロ流体システムを作製するための方法
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6904784B2 (en) * 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
CA2440754A1 (en) 2001-03-12 2002-09-19 Stephen Quake Methods and apparatus for analyzing polynucleotide sequences by asynchronous base extension
WO2002075312A1 (en) 2001-03-19 2002-09-26 Gyros Ab Characterization of reaction variables
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
EP1679121A3 (en) * 2001-04-06 2006-07-26 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
ATE500051T1 (de) 2001-04-06 2011-03-15 Fluidigm Corp Polymeroberflächenmodifikation
EP1661623A3 (en) * 2001-04-06 2006-06-07 Fluidigm Corporation Microfluidic delivery system
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
CA2442652C (en) 2001-04-07 2011-01-04 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US20040023310A1 (en) * 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
US20030124516A1 (en) * 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US7318912B2 (en) * 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US7247313B2 (en) 2001-06-27 2007-07-24 Advanced Cardiovascular Systems, Inc. Polyacrylates coatings for implantable medical devices
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
KR100421359B1 (ko) 2001-07-24 2004-03-06 엘지전자 주식회사 탄성 재질의 기판 내에서 유체를 이송하는 방법 및 이를위한 장치
US6734436B2 (en) 2001-08-07 2004-05-11 Sri International Optical microfluidic devices and methods
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7075162B2 (en) 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
SG106631A1 (en) * 2001-08-31 2004-10-29 Agency Science Tech & Res Liquid delivering device
DE20115733U1 (de) * 2001-09-25 2001-12-20 FESTO AG & Co., 73734 Esslingen Ventileinrichtung
US20030073961A1 (en) * 2001-09-28 2003-04-17 Happ Dorrie M. Medical device containing light-protected therapeutic agent and a method for fabricating thereof
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US8440093B1 (en) * 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
AU2002359329A1 (en) * 2001-10-30 2003-05-12 The Texas A And M University System Method and apparatus for temperature gradient microfluidics
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US6848462B2 (en) 2001-12-06 2005-02-01 Nanostream, Inc. Adhesiveless microfluidic device fabrication
US6622746B2 (en) 2001-12-12 2003-09-23 Eastman Kodak Company Microfluidic system for controlled fluid mixing and delivery
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
GB2383546B (en) * 2001-12-28 2006-03-01 Norchip As Fluid manipulation in a microfabricated reaction chamber system
WO2003060157A2 (en) * 2001-12-28 2003-07-24 Norchip As Fluid manipulation in a microfabricated reaction chamber system
US7289132B1 (en) * 2003-12-19 2007-10-30 Apple Inc. Method and apparatus for image acquisition, organization, manipulation, and publication
US6568799B1 (en) 2002-01-23 2003-05-27 Eastman Kodak Company Drop-on-demand ink jet printer with controlled fluid flow to effect drop ejection
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US6561224B1 (en) * 2002-02-14 2003-05-13 Abbott Laboratories Microfluidic valve and system therefor
GB0204009D0 (en) * 2002-02-20 2002-04-03 Xaar Technology Ltd Actuation device and use thereof in droplet deposition
US20030180711A1 (en) * 2002-02-21 2003-09-25 Turner Stephen W. Three dimensional microfluidic device having porous membrane
US6958119B2 (en) * 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
WO2003072765A1 (en) 2002-02-27 2003-09-04 The Regents Of The University Of Michigan Process for sorting motile particles from lesser-motile particles and apparatus suitable therefor
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US6637476B2 (en) 2002-04-01 2003-10-28 Protedyne Corporation Robotically manipulable sample handling tool
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
US6872645B2 (en) * 2002-04-02 2005-03-29 Nanosys, Inc. Methods of positioning and/or orienting nanostructures
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6808075B2 (en) 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
DE10220371A1 (de) * 2002-05-07 2003-11-27 Fraunhofer Ges Forschung Freistrahldosiermodul und Verfahren zu seiner Herstellung
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US7059348B2 (en) * 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
US7125510B2 (en) * 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US7396539B1 (en) 2002-06-21 2008-07-08 Advanced Cardiovascular Systems, Inc. Stent coatings with engineered drug release rate
US7005137B1 (en) 2002-06-21 2006-02-28 Advanceed Cardiovascular Systems, Inc. Coating for implantable medical devices
AU2003277853A1 (en) * 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7491233B1 (en) 2002-07-19 2009-02-17 Advanced Cardiovascular Systems Inc. Purified polymers for coatings of implantable medical devices
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
DE10241294A1 (de) * 2002-09-04 2004-03-18 Basf Ag Hybriddispersionen aus Polyadditionsprodukten und radikalischen Polymerisaten
US20060099135A1 (en) * 2002-09-10 2006-05-11 Yodh Arjun G Carbon nanotubes: high solids dispersions and nematic gels thereof
EP1403209A1 (en) * 2002-09-24 2004-03-31 The Technology Partnership Limited Fluid routing device
US8220494B2 (en) 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
JP2006501056A (ja) * 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
WO2004032228A2 (de) * 2002-09-30 2004-04-15 Siemens Aktiengesellschaft Substrat mit einem planen oberflächenabschnitt, verfahren zum herstellen eines materialfilms auf dem oberflächenabschnitt des substrats und verwendung des substrats
JP5695287B2 (ja) 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
GB0224121D0 (en) * 2002-10-16 2002-11-27 Microemissive Displays Ltd Method of patterning a functional material on to a substrate
DE10254312B4 (de) * 2002-11-21 2005-04-21 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Variabler Flußwiderstand
ATE362586T1 (de) * 2002-11-21 2007-06-15 California Inst Of Techn Hydroimpedanzpumpe
US7086288B2 (en) * 2002-11-27 2006-08-08 Northwestern University Thin membrane transducer
US6920203B2 (en) * 2002-12-02 2005-07-19 General Electric Company Method and apparatus for selectively attenuating a radiation source
CN100380034C (zh) 2002-12-04 2008-04-09 斯宾克斯公司 流体的可程控微量控制用装置和方法
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
KR101216828B1 (ko) 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
US6866233B2 (en) * 2003-01-03 2005-03-15 Orbital Research Inc. Reconfigurable porous technology for fluid flow control and method of controlling flow
US7090471B2 (en) * 2003-01-15 2006-08-15 California Institute Of Technology Integrated electrostatic peristaltic pump method and apparatus
JP2006527093A (ja) * 2003-03-10 2006-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン プログラム可能な触覚アクチュエータを用いた集積化したマイクロ流体コントロール
US6844953B2 (en) * 2003-03-12 2005-01-18 Hewlett-Packard Development Company, L.P. Micro-mirror device including dielectrophoretic liquid
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7279027B2 (en) * 2003-03-21 2007-10-09 Air Products And Chemicals, Inc. Planar ceramic membrane assembly and oxidation reactor system
US7249529B2 (en) 2003-03-28 2007-07-31 Protedyne Corporation Robotically manipulable sample handling tool
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
WO2006102264A1 (en) 2005-03-18 2006-09-28 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
WO2004091763A2 (en) 2003-04-10 2004-10-28 President And Fellows Of Harvard College Formation and control of fluidic species
US6929969B2 (en) * 2003-04-23 2005-08-16 Taiwan Semiconductor Manufacturing Company Reflective spatial light modulator mirror device manufacturing process and layout method
US7563454B1 (en) 2003-05-01 2009-07-21 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices
US8791171B2 (en) * 2003-05-01 2014-07-29 Abbott Cardiovascular Systems Inc. Biodegradable coatings for implantable medical devices
US7074327B2 (en) * 2003-05-08 2006-07-11 Nanostream, Inc. Sample preparation for parallel chromatography
US20050002025A1 (en) * 2003-05-15 2005-01-06 Toshiba Ceramics Co., Ltd. Channel structure and process for production thereof
US7695683B2 (en) 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
US6962658B2 (en) * 2003-05-20 2005-11-08 Eksigent Technologies, Llc Variable flow rate injector
FR2855076B1 (fr) * 2003-05-21 2006-09-08 Inst Curie Dispositif microfluidique
US7115230B2 (en) * 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
US7381361B2 (en) * 2003-06-26 2008-06-03 Intel Corporation Fabricating structures in micro-fluidic channels based on hydrodynamic focusing
EP1641944B1 (en) * 2003-07-09 2011-06-29 Genvault Corporation Room temperature elution of nucleic acids
WO2005007223A2 (en) * 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
JP4996248B2 (ja) 2003-07-31 2012-08-08 ハンディーラブ インコーポレイテッド 粒子含有サンプルの処理
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
CN1867795B (zh) * 2003-08-11 2010-12-08 加州理工学院 微流体的大规模集成
US20050051489A1 (en) * 2003-08-20 2005-03-10 California Institute Of Technology IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it
EP2662136A3 (en) 2003-08-27 2013-12-25 President and Fellows of Harvard College Method for handling and mixing droplets
CA2536360C (en) * 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US7247778B2 (en) * 2003-08-29 2007-07-24 Spencer Chase Addressable pneumatic valve system
US7296592B2 (en) 2003-09-16 2007-11-20 Eksigent Technologies, Llc Composite polymer microfluidic control device
US8277760B2 (en) * 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US20050226782A1 (en) * 2003-09-19 2005-10-13 Reed Mark T High density plate filler
US7998435B2 (en) * 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US7407630B2 (en) * 2003-09-19 2008-08-05 Applera Corporation High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US20060272738A1 (en) * 2003-09-19 2006-12-07 Gary Lim High density plate filler
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20060233673A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US20060233671A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
JP4586021B2 (ja) 2003-09-23 2010-11-24 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル マイクロ流体装置の新規な材料として使用するための光硬化性ペルフルオロポリエーテル
US20050232817A1 (en) * 2003-09-26 2005-10-20 The University Of Cincinnati Functional on-chip pressure generator using solid chemical propellant
US7284966B2 (en) * 2003-10-01 2007-10-23 Agency For Science, Technology & Research Micro-pump
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20050100712A1 (en) * 2003-11-12 2005-05-12 Simmons Blake A. Polymerization welding and application to microfluidics
EP1542074A1 (en) * 2003-12-11 2005-06-15 Heptagon OY Manufacturing a replication tool, sub-master or replica
US7351380B2 (en) * 2004-01-08 2008-04-01 Sandia Corporation Microfluidic structures and methods for integrating a functional component into a microfluidic device
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
WO2005072353A2 (en) 2004-01-25 2005-08-11 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
US20050182312A1 (en) * 2004-02-12 2005-08-18 Medtronic Xomed, Inc. Contact tonometer using MEMS technology
WO2007021762A2 (en) 2005-08-09 2007-02-22 The University Of North Carolina At Chapel Hill Methods and materials for fabricating microfluidic devices
SG150506A1 (en) * 2004-02-13 2009-03-30 Univ North Carolina State Functional materials and novel methods for the fabrication of microfluidic devices
DE602005020421D1 (de) 2004-02-19 2010-05-20 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US20050196321A1 (en) * 2004-03-03 2005-09-08 Zhili Huang Fluidic programmable array devices and methods
US20060004422A1 (en) * 2004-03-11 2006-01-05 Dirk De Ridder Electrical stimulation system and method for stimulating tissue in the brain to treat a neurological condition
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
CN102778432A (zh) * 2004-05-02 2012-11-14 弗卢丁公司 热反应设备及使用其的方法
CN101811074B (zh) * 2004-05-02 2012-09-12 弗卢丁公司 热反应设备及使用其的方法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
CA2994321C (en) 2004-05-03 2023-08-08 Handylab, Inc. A microfluidic device and methods for processing polynucleotide-containing samples
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7419639B2 (en) * 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
KR101506727B1 (ko) 2004-05-13 2015-04-03 나노바이오심 인크. 나노-ｐｃｒ: 핵산 증폭 및 검출을 위한 방법 및 장치
JP2008509226A (ja) * 2004-05-24 2008-03-27 ジェンボールト コーポレイション 回収可能な形式での安定なタンパク質保管および安定な核酸保管
US7476734B2 (en) 2005-12-06 2009-01-13 Helicos Biosciences Corporation Nucleotide analogs
US8197234B2 (en) * 2004-05-25 2012-06-12 California Institute Of Technology In-line actuator for electromagnetic operation
DE602005027700D1 (de) 2004-05-25 2011-06-09 Helicos Biosciences Corp Verfahren zur nukleinsäureimmobilisierung
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
US7307802B2 (en) 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
US7686040B2 (en) 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
JP4412081B2 (ja) * 2004-07-07 2010-02-10 株式会社日立製作所 ガスタービンとガスタービンの冷却方法
US20060018795A1 (en) * 2004-07-23 2006-01-26 General Electric Company Fabrication methods and multifunctional substrate materials for chemical and biological analysis in microfluidic systems
US7244443B2 (en) 2004-08-31 2007-07-17 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
DE102004042578A1 (de) * 2004-09-02 2006-03-23 Roche Diagnostics Gmbh Mikropumpe zur Förderung von Flüssigkeiten mit niedrigen Förderraten im Druck/Saug-Betrieb
DE102004042987A1 (de) * 2004-09-06 2006-03-23 Roche Diagnostics Gmbh Push-Pull betriebene Pumpe für ein mikrofluidisches System
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US20060073035A1 (en) * 2004-09-30 2006-04-06 Narayan Sundararajan Deformable polymer membranes
JP3922280B2 (ja) * 2004-09-30 2007-05-30 セイコーエプソン株式会社 配線パターンの形成方法及びデバイスの製造方法
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
DE102004051394B4 (de) * 2004-10-21 2006-08-17 Advalytix Ag Verfahren zur Bewegung von kleinen Flüssigkeitsmengen in Mikrokanälen und Mikrokanalsystem
US20060088449A1 (en) * 2004-10-26 2006-04-27 Massachusetts Institute Of Technology Systems and methods for transferring a fluid sample
KR100661347B1 (ko) * 2004-10-27 2006-12-27 삼성전자주식회사 미소 박막 구조물 및 이를 이용한 ｍｅｍｓ 스위치 그리고그것들을 제조하기 위한 방법
JP2008522795A (ja) * 2004-12-03 2008-07-03 カリフォルニア インスティチュート オブ テクノロジー 化学反応回路を有するマイクロ流体装置
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
US20080264863A1 (en) * 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
WO2006072383A1 (de) 2005-01-05 2006-07-13 Advalytix Ag Verfahren und vorrichtung zur dosierung und durchmischung kleiner flüssigkeitsmengen
DE102005000835B3 (de) * 2005-01-05 2006-09-07 Advalytix Ag Verfahren und Vorrichtung zur Dosierung kleiner Flüssigkeitsmengen
US7328882B2 (en) * 2005-01-06 2008-02-12 Honeywell International Inc. Microfluidic modulating valve
US7469987B2 (en) * 2005-01-10 2008-12-30 Silverbrook Research Pty Ltd MST device for attachment to an adhesive surface
US7482120B2 (en) 2005-01-28 2009-01-27 Helicos Biosciences Corporation Methods and compositions for improving fidelity in a nucleic acid synthesis reaction
US7465545B2 (en) * 2005-01-29 2008-12-16 Samsung Electronics Co., Ltd. Microfluidic chip and manipulating apparatus having the same
US7235750B1 (en) 2005-01-31 2007-06-26 United States Of America As Represented By The Secretary Of The Air Force Radio frequency MEMS switch contact metal selection
US7601554B1 (en) 2005-01-31 2009-10-13 The United States Of America As Represented By The Secretary Of The Air Force Shaped MEMS contact
DE102005005121A1 (de) * 2005-02-04 2006-08-17 Forschungszentrum Jülich GmbH Verfahren zur Herstellung eines Elastomers und Elastomer
US20080009835A1 (en) * 2005-02-17 2008-01-10 Kriesel Marshall S Fluid dispensing apparatus with flow rate control
US20070054119A1 (en) * 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
EP1861194A2 (en) * 2005-03-04 2007-12-05 The President and Fellows of Harvard College Method and apparatus for forming multiple emulsions
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
WO2006113492A2 (en) * 2005-04-14 2006-10-26 President And Fellows Of Harvard College Adjustable solubility in sacrificial layers for microfabrication
EP1882189A2 (en) 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US7618391B2 (en) * 2005-04-20 2009-11-17 Children's Medical Center Corporation Waveform sensing and regulating fluid flow valve
US8140745B2 (en) 2005-09-09 2012-03-20 The Invention Science Fund I, Llc Data retrieval methods
US7512959B2 (en) * 2005-05-09 2009-03-31 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US7596073B2 (en) * 2005-05-09 2009-09-29 Searete Llc Method and system for fluid mediated disk activation and deactivation
US8121016B2 (en) 2005-05-09 2012-02-21 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US7694316B2 (en) * 2005-05-09 2010-04-06 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
US8159925B2 (en) 2005-08-05 2012-04-17 The Invention Science Fund I, Llc Limited use memory device with associated information
US7916615B2 (en) 2005-06-09 2011-03-29 The Invention Science Fund I, Llc Method and system for rotational control of data storage devices
US8462605B2 (en) * 2005-05-09 2013-06-11 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device
US8220014B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Modifiable memory devices having limited expected lifetime
US7770028B2 (en) * 2005-09-09 2010-08-03 Invention Science Fund 1, Llc Limited use data storing device
US7748012B2 (en) * 2005-05-09 2010-06-29 Searete Llc Method of manufacturing a limited use data storing device
US7907486B2 (en) 2006-06-20 2011-03-15 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US7519980B2 (en) * 2005-05-09 2009-04-14 Searete Llc Fluid mediated disk activation and deactivation mechanisms
US9396752B2 (en) 2005-08-05 2016-07-19 Searete Llc Memory device activation and deactivation
US8099608B2 (en) 2005-05-09 2012-01-17 The Invention Science Fund I, Llc Limited use data storing device
US7668068B2 (en) * 2005-06-09 2010-02-23 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US7668069B2 (en) * 2005-05-09 2010-02-23 Searete Llc Limited use memory device with associated information
US8218262B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device including structured data and primary and secondary read-support information
US7916592B2 (en) 2005-05-09 2011-03-29 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
US7565596B2 (en) 2005-09-09 2009-07-21 Searete Llc Data recovery systems
EP2477029A1 (en) * 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
CA2610875A1 (en) 2005-06-06 2006-12-14 Decision Biomarkers, Inc. Assays based on liquid flow over arrays
TWI288116B (en) * 2005-06-07 2007-10-11 Chien-Chung Fu Method of manufacturing a LIGA mold by backside exposure
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
KR101264673B1 (ko) * 2005-06-24 2013-05-20 엘지디스플레이 주식회사 소프트 몰드를 이용한 미세 패턴 형성방법
TWI256905B (en) * 2005-06-29 2006-06-21 Univ Nat Cheng Kung Method of forming micro-droplets and chips thereof
US8628055B2 (en) 2005-07-27 2014-01-14 The Board Of Trustees Of The University Of Illinois Bi-direction rapid action electrostatically actuated microvalve
US20070048192A1 (en) * 2005-08-10 2007-03-01 Emil Kartalov Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US8480053B2 (en) * 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
WO2007030755A2 (en) * 2005-09-09 2007-03-15 Eksigent Technologies, Llc Variable flow rate system for column chromatography
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7390377B1 (en) * 2005-09-22 2008-06-24 Sandia Corporation Bonding thermoplastic polymers
US7611673B2 (en) * 2005-09-28 2009-11-03 California Institute Of Technology PMDS microfluidic components and methods of operation of the same
US8075851B2 (en) * 2005-09-29 2011-12-13 Siemens Medical Solutions Usa, Inc. Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography
US8123834B2 (en) * 2005-10-06 2012-02-28 The Board Of Trustees Of The University Of Illinois High gain selective metal organic framework preconcentrators
WO2007044888A2 (en) * 2005-10-11 2007-04-19 The Johns Hopkins Univerisity Microfluidic device and method for high-throughput cellular gradient and dose response studies
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8206975B2 (en) * 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US7913928B2 (en) 2005-11-04 2011-03-29 Alliant Techsystems Inc. Adaptive structures, systems incorporating same and related methods
US20070106200A1 (en) * 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
WO2007056561A2 (en) * 2005-11-09 2007-05-18 Liquidia Technologies, Inc. Medical device, materials, and methods
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US9028467B2 (en) 2005-11-09 2015-05-12 The Invention Science Fund I, Llc Osmotic pump with remotely controlled osmotic pressure generation
US20070106277A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Remote controller for substance delivery system
US7942867B2 (en) * 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US20070106275A1 (en) 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Reaction device controlled by RF control signal
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US7986686B2 (en) 2005-11-25 2011-07-26 Cisco Technology, Inc. Techniques for distributing network provider digital content to customer premises nodes
EP1790861A1 (en) 2005-11-25 2007-05-30 Bonsens AB Microfluidic system
EP3913375A1 (en) * 2006-01-11 2021-11-24 Bio-Rad Laboratories, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
DE102006002924B3 (de) 2006-01-20 2007-09-13 Albert-Ludwigs-Universität Freiburg Fluidhandhabungsvorrichtung und Verfahren zum Handhaben eines Fluids
US8021582B2 (en) * 2006-01-23 2011-09-20 National Cheng Kung University Method for producing microparticles in a continuous phase liquid
US20070248971A1 (en) * 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
DE602007009811D1 (de) * 2006-01-27 2010-11-25 Harvard College Koaleszenz fluider tröpfchen
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
US7862000B2 (en) * 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
EP1979079A4 (en) 2006-02-03 2012-11-28 Integenx Inc MICROFLUIDIC DEVICES
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US7397546B2 (en) 2006-03-08 2008-07-08 Helicos Biosciences Corporation Systems and methods for reducing detected intensity non-uniformity in a laser beam
EP1998829B1 (en) 2006-03-14 2011-02-09 University Of Southern California Mems device for delivery of therapeutic agents
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
US8883490B2 (en) 2006-03-24 2014-11-11 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9862984B2 (en) * 2006-04-21 2018-01-09 Nanobiosym, Inc. Single-molecule platform for drug discovery: methods and apparatuses for drug discovery, including discovery of anticancer and antiviral agents
US8828661B2 (en) * 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
WO2007125468A2 (en) * 2006-05-01 2007-11-08 Koninklijke Philips Electronics N.V. Fluid sample transport device with reduced dead volume for processing, controlling and/or detecting a fluid sample
US20070260174A1 (en) * 2006-05-05 2007-11-08 Searete Llc Detecting a failure to maintain a regimen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
EP2021113A2 (en) 2006-05-11 2009-02-11 Raindance Technologies, Inc. Microfluidic devices
JP4721227B2 (ja) * 2006-05-22 2011-07-13 アイダエンジニアリング株式会社 マイクロ流路チップ及びその製造方法
WO2007140417A2 (en) 2006-05-31 2007-12-06 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
JP2009539625A (ja) * 2006-06-02 2009-11-19 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ イリノイ ソフトｍｅｍｓデバイス
US20090016333A1 (en) * 2006-06-14 2009-01-15 Derek Wang Content-based adaptive jitter handling
US8264928B2 (en) 2006-06-19 2012-09-11 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
US8432777B2 (en) 2006-06-19 2013-04-30 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
DE102006030068A1 (de) 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
CA2657435A1 (en) 2006-07-10 2008-07-03 Medipacs, Inc. Super elastic epoxy hydrogel
TWI336781B (en) * 2006-07-17 2011-02-01 Ind Tech Res Inst Fluidic device and controlling method thereof
US7959876B2 (en) * 2006-07-17 2011-06-14 Industrial Technology Research Institute Fluidic device
US20080021364A1 (en) * 2006-07-17 2008-01-24 Industrial Technology Research Institute Fluidic device
US7794665B2 (en) * 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
US7966898B2 (en) * 2006-07-28 2011-06-28 California Institute Of Technology Polymer NEMS for cell physiology and microfabricated cell positioning system for micro-biocalorimeter
EP2047157A1 (en) * 2006-08-02 2009-04-15 The Regents of the University of Michigan Multiplexed microfluidic valve activator
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US7817698B2 (en) * 2006-08-11 2010-10-19 California Institute Of Technology Mechanically tunable elastomeric optofluidic distributed feedback dye lasers
TW200808957A (en) * 2006-08-15 2008-02-16 Univ Nat Cheng Kung Chip for cell culture
US8050516B2 (en) 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US20080131327A1 (en) * 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
RU2456618C2 (ru) * 2006-10-12 2012-07-20 Конинклейке Филипс Электроникс Н.В. Система и способ обнаружения с помощью магнитной и/или электрической метки
US8123192B2 (en) * 2006-10-18 2012-02-28 California Institute Of Technology Control arrangement for microfluidic devices and related methods and systems
US7790118B2 (en) * 2006-10-18 2010-09-07 California Institute Of Technology Microfluidic devices and related methods and systems
US8841116B2 (en) 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
DE602006009405D1 (de) * 2006-10-28 2009-11-05 Sensirion Holding Ag Mehrzellenpumpe
US8540677B2 (en) * 2006-11-02 2013-09-24 Becton, Dickinson And Company Vascular access device chamber venting
AU2007319383A1 (en) 2006-11-10 2008-05-22 Glaukos Corporation Uveoscleral shunt and methods for implanting same
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
US20100171054A1 (en) * 2006-11-28 2010-07-08 Astc Aerospace Ab Micromechanical slow acting valve system
WO2008067552A2 (en) 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
US8128393B2 (en) 2006-12-04 2012-03-06 Liquidia Technologies, Inc. Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
EP1931158B1 (en) * 2006-12-08 2013-04-10 Samsung Electronics Co., Ltd. Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
US20080163946A1 (en) * 2006-12-28 2008-07-10 The Trustees Of California State University Magnetically controlled valve for flow manipulation in polymer microfluidic devices
US20080160603A1 (en) * 2006-12-28 2008-07-03 Narayan Sundararajan Flow stabilization in micro-and nanofluidic devices
GB2445739A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
US7829032B2 (en) * 2007-01-23 2010-11-09 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
CN101715483A (zh) 2007-02-05 2010-05-26 微芯片生物工艺学股份有限公司 微流体和纳米流体装置、系统和应用
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US7871570B2 (en) * 2007-02-23 2011-01-18 Joseph Zhili Huang Fluidic array devices and systems, and related methods of use and manufacturing
JPWO2008108481A1 (ja) * 2007-03-05 2010-06-17 日本電気株式会社 マイクロチップの流体制御機構
US7776927B2 (en) * 2007-03-28 2010-08-17 President And Fellows Of Harvard College Emulsions and techniques for formation
US20080258036A1 (en) * 2007-03-30 2008-10-23 Labrador Research Llc System for dimensional stability of elastomeric microdevices
WO2008124781A1 (en) 2007-04-09 2008-10-16 Auburn University A microfluidic array system for biological, chemical, and biochemical assessments
US8071035B2 (en) * 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
WO2008130623A1 (en) 2007-04-19 2008-10-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
WO2008141183A2 (en) 2007-05-09 2008-11-20 Fluidigm Corporation Method and system for crystallization and x-ray diffraction screening
WO2009006318A1 (en) 2007-06-29 2009-01-08 Artificial Muscle, Inc. Electroactive polymer transducers for sensory feedback applications
WO2009009131A2 (en) 2007-07-11 2009-01-15 California Institute Of Technology Cardiac assist system using helical arrangement of contractile bands and helically-twisting cardiac assist device
ES2648798T3 (es) 2007-07-13 2018-01-08 Handylab, Inc. Materiales de captura de polinucleótidos y métodos de utilización de los mismos
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
AU2013205252B8 (en) * 2007-07-13 2015-10-22 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8105783B2 (en) * 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8016260B2 (en) * 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
WO2009015296A1 (en) 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
US8206025B2 (en) * 2007-08-07 2012-06-26 International Business Machines Corporation Microfluid mixer, methods of use and methods of manufacture thereof
KR101321912B1 (ko) * 2007-08-28 2013-10-30 삼성전자주식회사 탄성 밸브 및 이를 구비한 미세유동 장치
EP2195452B1 (en) 2007-08-29 2012-03-14 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
CN101821619B (zh) 2007-09-07 2015-02-11 弗卢丁公司 拷贝数变化确定、方法和系统
US8557582B2 (en) * 2007-09-28 2013-10-15 Christopher MORAES System, apparatus and method for applying mechanical force to a material
EP2212437A4 (en) 2007-11-07 2011-09-28 Univ British Columbia MICROFLUIDIC DEVICE AND METHOD OF USING THE DEVICE
JP2009128037A (ja) * 2007-11-20 2009-06-11 Canon Inc マイクロ流体装置
US8152136B2 (en) * 2007-11-26 2012-04-10 The Hong Kong Polytechnic University Polymer microvalve with actuators and devices
DE102007060352A1 (de) 2007-12-12 2009-06-18 Richter, Andreas, Dr. Ansteuerung für integrierte aktive Mikrosysteme auf Hydrogelbasis
US8561963B2 (en) * 2007-12-19 2013-10-22 Palo Alto Research Center Incorporated Electrostatically addressable microvalves
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US8123841B2 (en) 2008-01-16 2012-02-28 The Board Of Trustees Of The University Of Illinois Column design for micro gas chromatograph
WO2009091934A1 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Single molecule nucleic acid sequence analysis processes and compositions
WO2009092106A1 (en) * 2008-01-18 2009-07-23 The Regents Of The University Of California Accurate and rapid micromixer for integrated microfluidic devices
WO2009108260A2 (en) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
WO2009100449A1 (en) 2008-02-08 2009-08-13 Fluidigm Corporation Dynamic array assay methods
KR100952056B1 (ko) * 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
EP2271772B1 (en) 2008-03-11 2014-07-16 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP2259072A4 (en) * 2008-03-24 2016-03-30 Nec Corp FLOW PASSAGE CONTROL MECHANISM FOR MICROCHIP
US8269029B2 (en) 2008-04-08 2012-09-18 The Board Of Trustees Of The University Of Illinois Water repellent metal-organic frameworks, process for making and uses regarding same
EP2280905B1 (en) 2008-04-11 2016-07-06 Fluidigm Corporation Multilevel microfluidic systems and methods
US8096784B2 (en) * 2008-04-16 2012-01-17 National Taiwan Ocean University Bi-directional continuous peristaltic micro-pump
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2898911A1 (en) 2008-05-08 2015-07-29 MiniPumps, LLC Implantable pumps and cannulas therefor
CN102202708B (zh) 2008-05-08 2015-01-21 迷你泵有限责任公司 药物输送泵及其制造方法
EP2286125B1 (en) 2008-05-16 2015-07-08 President and Fellows of Harvard College Valves and other flow control in fluidic systems including microfluidic systems
TWI350891B (en) * 2008-05-27 2011-10-21 Ying Chyi Chou Omnibus quasi-hydrosystem
US7999257B2 (en) * 2008-06-02 2011-08-16 Taiwan Semiconductor Manufacturing Company, Ltd. Process for eliminating delamination between amorphous silicon layers
DE102008002336A1 (de) 2008-06-10 2009-12-24 Robert Bosch Gmbh Quetschventil und Verfahren zu dessen Herstellung
WO2009152520A2 (en) * 2008-06-13 2009-12-17 Decode Biostructures, Inc. Nanovolume microcapillary crystallization system
US20090314368A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Pinch Valve and On-Chip MEMS Pump
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
US20090315126A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidic System Comprising Thermal Bend Actuated Valve
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010004721A1 (ja) * 2008-07-08 2010-01-14 パナソニック株式会社 導電性高分子を用いた流体搬送装置
EP2143492A1 (en) * 2008-07-11 2010-01-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method and microfluidic device for combining reaction components contained in liquids
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
WO2010009365A1 (en) 2008-07-18 2010-01-21 Raindance Technologies, Inc. Droplet libraries
US7976789B2 (en) * 2008-07-22 2011-07-12 The Board Of Trustees Of The University Of Illinois Microfluidic device for preparing mixtures
US9579830B2 (en) 2008-07-25 2017-02-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
DE102008038462B4 (de) * 2008-08-20 2010-06-17 Advanced Display Technology Ag Vorrichtung zur fluidischen Anzeige und Verfahren dazu
US20100059120A1 (en) * 2008-09-11 2010-03-11 General Electric Company Microfluidic device and methods for droplet generation and manipulation
CN102177237B (zh) 2008-09-12 2013-10-30 金沃特公司 用于贮存和稳定生物分子的基质和介质
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
AU2009293232B2 (en) 2008-09-16 2015-05-14 Sequenom Center For Molecular Medicine Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8082810B2 (en) * 2008-09-29 2011-12-27 Ysi Incorporated Microfluidic elastic micro-aliquotter
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
US20100102261A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Microfluidic valve mechanism
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
JP4824743B2 (ja) * 2008-12-26 2011-11-30 アイダエンジニアリング株式会社 マイクロ流路チップ
US8672532B2 (en) 2008-12-31 2014-03-18 Integenx Inc. Microfluidic methods
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
EP3722810A3 (en) 2009-02-11 2021-01-13 Caris MPI, Inc. Molecular profiling of tumors
US8989230B2 (en) 2009-02-20 2015-03-24 Vixar Method and apparatus including movable-mirror mems-tuned surface-emitting lasers
US9700038B2 (en) 2009-02-25 2017-07-11 Genea Limited Cryopreservation of biological cells and tissues
CA2755615A1 (en) * 2009-03-18 2010-09-23 Sequenom, Inc. Use of thermostable endonucleases for generating reporter molecules
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
EP2414547B1 (en) 2009-04-02 2014-03-12 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
EP3211095B1 (en) 2009-04-03 2019-01-02 Sequenom, Inc. Nucleic acid preparation compositions and methods
EP2239793A1 (de) 2009-04-11 2010-10-13 Bayer MaterialScience AG Elektrisch schaltbarer Polymerfilmaufbau und dessen Verwendung
JP5937004B2 (ja) 2009-05-18 2016-06-22 ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ 薬剤溶出眼内インプラント
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2012071476A2 (en) 2010-11-24 2012-05-31 David Haffner Drug eluting ocular implant
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
DE102009023430B4 (de) * 2009-05-29 2013-07-25 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Steuern von Fluidströmen in Lab-on-a-Chip-Systemen sowie Verfahren zum Herstellen der Vorrichtung
DE102009023429B4 (de) * 2009-05-29 2013-08-14 Siemens Aktiengesellschaft Ventil für Lab-on-a-Chip-Systeme, Verfahren zum Betätigen und zur Herstellung des Ventils
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
WO2010141131A1 (en) 2009-06-04 2010-12-09 Lockheed Martin Corporation Multiple-sample microfluidic chip for dna analysis
BRPI1010169A2 (pt) 2009-06-05 2016-03-29 Integenx Inc sistema que se ajusta dentro de um invólucro de não mais que 10 pés3, cartucho, artigo em forma legível por computador, método, sistema configurado para realizar um método, sistema óptico, instrumento e dispositivo.
US8623288B1 (en) 2009-06-29 2014-01-07 Nanosys, Inc. Apparatus and methods for high density nanowire growth
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
CN102576385B (zh) 2009-08-18 2016-02-24 迷你泵有限责任公司 具有自适应控制的电解药物输送泵
KR101274113B1 (ko) * 2009-09-01 2013-06-13 한국전자통신연구원 금속볼을 이용한 자기력 마이크로밸브 및 그 제조방법
EP2473263B1 (en) 2009-09-02 2022-11-02 President and Fellows of Harvard College Multiple emulsions created using jetting and other techniques
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
KR101252829B1 (ko) * 2009-10-06 2013-04-11 한국전자통신연구원 단일세포 분주용 어레이 장치
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
WO2011056688A2 (en) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Molecular profiling for personalized medicine
US8145114B2 (en) 2009-10-29 2012-03-27 Eastman Kodak Company Digital manufacture of a microfluidic device
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9229001B2 (en) 2009-11-23 2016-01-05 Cyvek, Inc. Method and apparatus for performing assays
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
WO2011066588A1 (en) 2009-11-30 2011-06-03 Fluidigm Corporation Microfluidic device regeneration
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
IT1397819B1 (it) * 2009-12-17 2013-02-04 Silicon Biosystems Spa Sistema microfluidico
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
EP2517025B1 (en) 2009-12-23 2019-11-27 Bio-Rad Laboratories, Inc. Methods for reducing the exchange of molecules between droplets
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP4484577A3 (en) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
KR101177981B1 (ko) * 2010-03-04 2012-08-28 전북대학교산학협력단 3차원 나선형 액추에이터의 제조방법
IT1399361B1 (it) * 2010-03-31 2013-04-16 Milano Politecnico Metodo per la realizzazione di un dispositivo microfluidico e dispositivo derivante dallo stesso
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
CA2797429C (en) 2010-04-26 2018-09-18 National Research Council Of Canada Semipermanently closed microfluidic valve
US9267618B2 (en) 2010-05-18 2016-02-23 Samsung Electronics Co., Ltd. Microvalve device and method of manufacturing the same
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
HUE062745T2 (hu) 2010-05-28 2023-12-28 Genea Ip Holdings Pty Ltd Továbbfejlesztett mikromanipulációs és tároló készülék és eljárások
KR20110136629A (ko) 2010-06-15 2011-12-21 삼성전자주식회사 마이크로 밸브를 갖는 미세 유체 소자
CN103081195B (zh) 2010-06-18 2015-12-02 myFC股份公司 电化学致动阀
GB2481425A (en) 2010-06-23 2011-12-28 Iti Scotland Ltd Method and device for assembling polynucleic acid sequences
US9125655B2 (en) 2010-07-16 2015-09-08 California Institute Of Technology Correction and optimization of wave reflection in blood vessels
WO2012024658A2 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Integrated analysis system
EP2606242A4 (en) 2010-08-20 2016-07-20 Integenx Inc MICROFLUIDIC DEVICES WITH MECHANICALLY SEALED MEMBRANE VALVES
EP2622103B2 (en) 2010-09-30 2022-11-16 Bio-Rad Laboratories, Inc. Sandwich assays in droplets
WO2012051529A1 (en) 2010-10-15 2012-04-19 Lockheed Martin Corporation Micro fluidic optic design
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
WO2012109600A2 (en) 2011-02-11 2012-08-16 Raindance Technologies, Inc. Methods for forming mixed droplets
US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
KR20120096175A (ko) * 2011-02-22 2012-08-30 엘지전자 주식회사 태양전지 모듈용 프레임 시스템
JP2014513510A (ja) 2011-03-01 2014-05-29 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 変形可能なポリマー装置及び変形可能なポリマーフィルムを作るための自動化された製造プロセス
US9195058B2 (en) 2011-03-22 2015-11-24 Parker-Hannifin Corporation Electroactive polymer actuator lenticular system
CN103649759B (zh) 2011-03-22 2016-08-31 西维克公司 微流体装置以及制造方法和用途
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
CA3082652A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
WO2012145301A2 (en) * 2011-04-20 2012-10-26 California Institute Of Technology Single-layer pcb microfluidics
US8460872B2 (en) 2011-04-29 2013-06-11 Sequenom, Inc. Quantification of a minority nucleic acid species
US8857275B2 (en) 2011-05-02 2014-10-14 California Institute Of Technology NEMS sensors for cell force application and measurement
EP2705130B1 (en) 2011-05-04 2016-07-06 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
WO2012154876A1 (en) 2011-05-09 2012-11-15 Fluidigm Corporation Probe based nucleic acid detection
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012162296A2 (en) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Control of emulsions, including multiple emulsions
JP4934750B1 (ja) * 2011-05-31 2012-05-16 株式会社メトラン ポンプユニット、呼吸補助装置
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
WO2013006661A2 (en) 2011-07-06 2013-01-10 President And Fellows Of Harvard College Multiple emulsions and techniques for the formation of multiple emulsions
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
WO2013016676A2 (en) 2011-07-27 2013-01-31 MYTEK, LLC (doing business as VIXAR) Method and apparatus including improved vertical-cavity surface-emitting lasers
CN103959070B (zh) 2011-09-30 2017-05-10 贝克顿·迪金森公司 组合试剂条
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
EP2786019B1 (en) 2011-11-16 2018-07-25 International Business Machines Corporation Microfluidic device with deformable valve
ES2978107T3 (es) 2012-02-03 2024-09-05 Becton Dickinson Co Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas
EP2834425A4 (en) * 2012-02-21 2016-05-11 Fluidigm Corp METHOD AND SYSTEMS FOR MICROFLUIDIC LOGIC ELEMENTS
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
FR2987282B1 (fr) 2012-02-24 2017-12-29 Fonds De L'espci Georges Charpak Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage
US9304065B2 (en) 2012-02-29 2016-04-05 Fluidigm Corporation Methods, systems and devices for multiple single-cell capturing and processing using microfluidics
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013133792A1 (en) 2012-03-05 2013-09-12 Empire Technology Development Llc Flexible circuits
EP2847249A4 (en) 2012-03-14 2016-12-28 Medipacs Inc Smart polymer materials with excess reactive molecules
WO2013142552A1 (en) 2012-03-21 2013-09-26 Bayer Materialscience Ag Roll-to-roll manufacturing processes for producing self-healing electroactive polymer devices
WO2013148275A2 (en) 2012-03-26 2013-10-03 Glaukos Corporation System and method for delivering multiple ocular implants
CN104204523A (zh) * 2012-03-26 2014-12-10 美艾利尔圣地亚哥公司 微流体泵
PL4201327T3 (pl) 2012-03-30 2024-11-04 Insulet Corporation Urządzenie do dostarczania płynu z narzędziem dostępu przezskórnego, mechanizmem wprowadzającym i monitorowaniem poziomu glukozy we krwi do stosowania z nim
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
US9238833B2 (en) 2012-04-17 2016-01-19 California Institute Of Technology Thermally controlled chamber with optical access for high-performance PCR
US9080941B2 (en) 2012-04-27 2015-07-14 General Electric Company Microfluidic flow cell assemblies for imaging and method of use
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
CN104471077B (zh) 2012-05-21 2017-05-24 富鲁达公司 颗粒群的单颗粒分析
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US9761790B2 (en) 2012-06-18 2017-09-12 Parker-Hannifin Corporation Stretch frame for stretching process
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
EP2872648B1 (en) 2012-07-13 2019-09-04 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8519644B1 (en) * 2012-08-15 2013-08-27 Transmute, Inc. Accelerator having acceleration channels formed between covalently bonded chips
US20150247790A1 (en) * 2012-09-14 2015-09-03 President And Fellows Of Harvard College Microfluidic Assisted Cell Screening
AU2013326980B2 (en) 2012-10-04 2019-08-15 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
GB2506630A (en) * 2012-10-04 2014-04-09 Univ Leiden Method and apparatus for processing a liquid
CN105008895B (zh) 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
EP2912182B1 (en) 2012-10-23 2021-12-08 Caris Science, Inc. Aptamers and uses thereof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US9590193B2 (en) 2012-10-24 2017-03-07 Parker-Hannifin Corporation Polymer diode
US9857333B2 (en) 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9549666B2 (en) 2012-11-10 2017-01-24 Curvo Medical, Inc. Coaxial micro-endoscope
US9233225B2 (en) 2012-11-10 2016-01-12 Curvo Medical, Inc. Coaxial bi-directional catheter
US20140142438A1 (en) * 2012-11-19 2014-05-22 Biosense Webster (Israel), Ltd. Using location and force measurements to estimate tissue thickness
WO2014100434A1 (en) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions and methods for aptamer screening
EP2934751B1 (en) 2012-12-21 2019-05-29 Micronics, Inc. Low elasticity films for microfluidic use
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
KR102102123B1 (ko) 2012-12-21 2020-04-20 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 유체 공학 회로 및 관련 제조 방법
PL2941124T3 (pl) 2013-01-07 2023-12-27 Genea Ip Holdings Pty Limited Metoda, system i urządzenie do ulepszonej mikromanipulacji i przechowywania danych
US20150352752A1 (en) * 2013-01-16 2015-12-10 General Electric Company An aqueous -solvent based process for continuous manufacturing of supported ion selective membranes
JP6335926B2 (ja) 2013-02-01 2018-05-30 スウエイジロク・カンパニー 溶接されたダイヤフラム弁座担体を有するダイヤフラム弁
DE102013202623A1 (de) * 2013-02-19 2014-08-21 Robert Bosch Gmbh Ventil mit verbesserter Kaltstartfähigkeit
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
CN105164246B (zh) 2013-03-15 2018-09-25 富鲁达公司 用于分析定义的多细胞组合的方法和设备
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
CN105189750B (zh) 2013-05-07 2020-07-28 珀金埃尔默健康科学有限公司 使用粘土矿物和碱性溶液制备含核酸样品的方法
JP6484222B2 (ja) 2013-05-07 2019-03-13 マイクロニクス， インコーポレイテッド 核酸の調製および分析のためのデバイス
EP2994750B1 (en) 2013-05-07 2020-08-12 PerkinElmer Health Sciences, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
ITTO20130447A1 (it) * 2013-05-31 2014-12-01 St Microelectronics Srl Valvola microfluidica a membrana e procedimento per fabbricare una valvola microfluidica a membrana
US20160319361A1 (en) 2013-08-28 2016-11-03 Caris Life Sciences Switzerland Holdings Gmbh Oligonucleotide probes and uses thereof
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US10136636B2 (en) 2013-10-15 2018-11-27 The Regents Of The University Of Michigan Vitrification of biological material
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
CA2927701C (en) 2013-10-22 2020-10-13 Berkeley Lights, Inc. Microfluidic devices having sequestration pens and methods of testing biological micro-objects with same
EP3783094B1 (en) 2013-10-22 2023-10-11 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
WO2015073999A1 (en) 2013-11-18 2015-05-21 Integenx Inc. Cartridges and instruments for sample analysis
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
US11193176B2 (en) 2013-12-31 2021-12-07 Bio-Rad Laboratories, Inc. Method for detecting and quantifying latent retroviral RNA species
US10344753B2 (en) 2014-02-28 2019-07-09 Encite Llc Micro pump systems
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015148808A1 (en) 2014-03-26 2015-10-01 Zhenyu Li Handheld fluid handling systems and methods
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
EP3148491B1 (en) 2014-05-29 2020-07-01 Glaukos Corporation Implants with controlled drug delivery features and manufacturing method for said implants
US20150352547A1 (en) 2014-06-06 2015-12-10 Berkeley Lights, Inc. Isolating Microfluidic Structures and Trapping Bubbles
US10081816B1 (en) 2014-07-03 2018-09-25 Nant Holdings Ip, Llc Mechanical transfection devices and methods
US10760040B1 (en) 2014-07-03 2020-09-01 NanoCav, LLC Mechanical transfection devices and methods
CN107106983B (zh) 2014-10-22 2021-04-16 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
US10330095B2 (en) 2014-10-31 2019-06-25 Encite Llc Microelectromechanical systems fabricated with roll to roll processing
CN107249742B (zh) 2014-12-08 2019-12-06 伯克利之光生命科技公司 微流体装置中定向流动的致动微流体结构及使用它的方法
EP3230718B1 (en) * 2014-12-09 2022-03-02 Berkeley Lights, Inc. Automated detection of assay-positive areas or of analyte quantities in microfluidic devices
WO2016145128A1 (en) 2015-03-09 2016-09-15 Caris Science, Inc. Oligonucleotide probes and uses thereof
AU2016250689B2 (en) 2015-04-22 2021-07-08 Berkeley Lights, Inc. Microfluidic cell culture
WO2016172623A1 (en) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
NL2014801B1 (en) * 2015-05-13 2017-01-27 Berkin Bv Fluid flow device, comprising a valve unit, as well as method of manufacturing the same.
US10136563B2 (en) 2015-06-25 2018-11-20 International Business Machines Corporation Active perforation for advanced server cooling
US9907210B2 (en) * 2015-06-25 2018-02-27 International Business Machines Corporation Active perforation for advanced server cooling
US10590425B2 (en) 2015-06-29 2020-03-17 Caris Science, Inc. Therapeutic oligonucleotides
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
WO2017040856A1 (en) * 2015-09-01 2017-03-09 The Regents Of The Univesity Of California Reconfigurable microvalve optical waveguide
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10598166B2 (en) 2015-09-09 2020-03-24 Massachusetts Institute Of Technology Atherofluidics-on-chip
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
AU2016361413B2 (en) 2015-11-23 2022-04-14 Berkeley Lights, Inc. In situ-generated microfluidic isolation structures, kits and methods of use thereof
CN105258738B (zh) * 2015-11-26 2018-01-30 黑龙江大学 一种压力/二维磁场单片集成传感器
US10203604B2 (en) * 2015-11-30 2019-02-12 Applied Materials, Inc. Method and apparatus for post exposure processing of photoresist wafers
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
CN108603878A (zh) 2015-12-08 2018-09-28 伯克利之光生命科技公司 微流体设备和试剂盒及其使用方法
KR20230042540A (ko) 2015-12-30 2023-03-28 버클리 라잇츠, 인크. 광학적으로 구동되는 대류 및 변위를 위한 미세유체 디바이스들, 키트들 및 그 방법들
WO2017119902A1 (en) 2016-01-08 2017-07-13 Hewlett-Packard Development Company, L.P. Polymerase chain reaction device
CN105510101B (zh) * 2016-01-28 2018-02-13 哈尔滨理工大学 一种用于研究干式空心电抗器匝间绝缘老化过程的试样的制作方法及片状试样
EP3429753A4 (en) 2016-03-16 2019-11-06 Berkeley Lights, Inc. METHODS, SYSTEMS AND DEVICES FOR SELECTION AND PRODUCTION OF GENERICALLY WORKED CLONES
KR102423945B1 (ko) 2016-03-17 2022-07-22 버클리 라잇츠, 인크. 미세유체 디바이스에서의 t 림프구들의 선택 및 클로닝
AU2017235661B2 (en) 2016-03-18 2023-06-08 Caris Science, Inc. Oligonucleotide probes and uses thereof
KR102038116B1 (ko) * 2016-03-21 2019-12-02 주식회사 엘지화학 플렉서블 디스플레이용 보호 필름
AU2017248822B2 (en) 2016-04-15 2022-09-15 Berkeley Lights, Inc. Methods, systems and kits for in-pen assays
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
US11293017B2 (en) 2016-05-25 2022-04-05 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017205816A1 (en) 2016-05-26 2017-11-30 Insulet Corporation Single dose drug delivery device
AU2017271673B2 (en) 2016-05-26 2022-04-14 Berkeley Lights, Inc. Covalently modified surfaces, kits, and methods of preparation and use
JP6953513B2 (ja) * 2016-08-05 2021-10-27 スティーブン アラン マーシュ， マイクロ圧力センサ
EP3496789A1 (en) 2016-08-14 2019-06-19 Insulet Corporation Automatic drug delivery device with trigger mechanism
WO2018051242A1 (en) 2016-09-14 2018-03-22 Ecole Polytechnique Federale De Lausanne (Epfl) Device for high throughput single-cell studies
EP3522951A1 (en) 2016-10-07 2019-08-14 Insulet Corporation Multi-stage delivery system
US10780217B2 (en) 2016-11-10 2020-09-22 Insulet Corporation Ratchet drive for on body delivery system
PL3538665T3 (pl) 2016-11-14 2024-05-06 PPB Technology Pty Ltd Cząsteczki czujnika proteazy
AT15707U1 (de) 2016-11-18 2018-04-15 Secop Gmbh Kältemittelkompressor
CN106767551A (zh) * 2016-11-18 2017-05-31 合肥工业大学 一种微纳米测量设备用高精度高灵敏弹性簧片的制作方法
US10767742B2 (en) * 2016-12-08 2020-09-08 Ford Global Technologies, Llc Transaxle having chain final drive
US10732712B2 (en) 2016-12-27 2020-08-04 Facebook Technologies, Llc Large scale integration of haptic devices
TWI621794B (zh) * 2017-01-05 2018-04-21 研能科技股份有限公司 流體控制裝置
WO2018136699A1 (en) 2017-01-19 2018-07-26 Insulet Corporation Cartridge hold-up volume reduction
US20200011795A1 (en) 2017-02-28 2020-01-09 The Regents Of The University Of California Optofluidic analyte detection systems using multi-mode interference waveguides
US10695485B2 (en) 2017-03-07 2020-06-30 Insulet Corporation Very high volume user filled drug delivery device
CA3055565A1 (en) 2017-03-08 2018-09-13 The Regents Of The University Of Michigan Analyte detection
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
EP3558540A4 (en) 2017-04-23 2020-08-12 Hewlett-Packard Development Company, L.P. PARTICLE SEPARATION
CN111315485B (zh) * 2017-05-16 2023-05-23 凯恩生物科学股份有限公司 用于精密培养、控制和监测活细胞的微流体启用式多孔细胞培养设备和系统
US11754579B2 (en) 2017-06-06 2023-09-12 The Regents Of The University Of California Systems and methods for rapid generation of droplet libraries
JP2020528747A (ja) 2017-07-21 2020-10-01 バークレー ライツ，インコーポレイテッド 抗原提示合成表面、共有結合官能化表面、活性化ｔ細胞及びそれらの使用
EP4375504A3 (en) 2017-08-03 2024-06-26 Insulet Corporation Micro piston pump
US10973978B2 (en) 2017-08-03 2021-04-13 Insulet Corporation Fluid flow regulation arrangements for drug delivery devices
SG11202001121WA (en) 2017-08-08 2020-03-30 Commw Scient Ind Res Org Carbohydrate sensors
US11007523B2 (en) * 2017-09-01 2021-05-18 Mgi Tech Co., Ltd. Injection molded microfluidic/fluidic cartridge integrated with silicon-based sensor
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
WO2019075476A2 (en) 2017-10-15 2019-04-18 Berkeley Lights, Inc. METHODS, SYSTEMS AND KITS FOR ENCLOSED TESTS
US11046575B2 (en) 2017-10-31 2021-06-29 Encite Llc Broad range micro pressure sensor
US20190142111A1 (en) * 2017-11-10 2019-05-16 Head Technology Gmbh Liner for sports shoes
CN110678414A (zh) * 2017-11-10 2020-01-10 Nok株式会社 微流控芯片及微流控器件
CN111247089A (zh) * 2017-11-22 2020-06-05 惠普发展公司，有限责任合伙企业 具有用于装载流体的盖的微流体装置
WO2019116306A1 (en) 2017-12-13 2019-06-20 Ecole Polytechnique Federale De Lausanne (Epfl) System for capture or immunoprecipitation of a protein-dna complex
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
WO2019169060A1 (en) * 2018-03-02 2019-09-06 President And Fellows Of Harvard College Layered microfluidic devices and techniques
WO2019167031A1 (en) * 2018-03-02 2019-09-06 National Research Council Of Canada Polymeric microfluidic valve
US11971377B2 (en) 2018-03-12 2024-04-30 The Penn State Research Foundation Method and apparatus for temperature gradient microfluidics
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
WO2019186569A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Use of electric field gradients to control gene expression
DE102018109314A1 (de) * 2018-04-19 2019-10-24 Eisenhuth Gmbh & Co. Kg Elektrochemischer Fällungsreaktor mit bewegter Elektrode
US11376589B2 (en) 2018-04-30 2022-07-05 Protein Fluidics, Inc. Valveless fluidic switching flowchip and uses thereof
JP7410935B2 (ja) 2018-05-24 2024-01-10 ザ リサーチ ファウンデーション フォー ザ ステイト ユニバーシティー オブ ニューヨーク 容量性センサ
SG11202011180UA (en) 2018-05-31 2020-12-30 Berkeley Lights Inc Automated detection and characterization of micro-objects in microfluidic devices
US10874803B2 (en) 2018-05-31 2020-12-29 Insulet Corporation Drug cartridge with drive system
WO2019236818A1 (en) 2018-06-06 2019-12-12 Insulet Corporation Linear shuttle pump for drug delivery
WO2020018687A1 (en) 2018-07-17 2020-01-23 Insulet Corporation Semi-rigid and flexible elements for wearable drug delivery device reservoir
US11815507B2 (en) 2018-08-15 2023-11-14 Deepcell, Inc. Systems and methods for particle analysis
US10611995B2 (en) 2018-08-15 2020-04-07 Deepcell, Inc. Systems and methods for particle analysis
CN108843855B (zh) * 2018-08-31 2024-03-12 湖南乐准智芯生物科技有限公司 一种微流控系统及常闭微阀、控制方法
JP7485653B2 (ja) 2018-09-07 2024-05-16 セクエノム， インコーポレイテッド 移植片拒絶を検出する方法およびシステム
US20200139362A1 (en) 2018-10-18 2020-05-07 Berkeley Lights, Inc. Proto-Antigen-Presenting Synthetic Surfaces, Activated T Cells, and Uses Thereof
JP7449876B2 (ja) 2018-11-16 2024-03-14 イルミナ インコーポレイテッド 流体カートリッジ用積層流体回路
US12258551B2 (en) 2018-11-16 2025-03-25 Cairn Biosciences, Inc. Methods for dynamic evolution and monitoring of characteristics in living cells using a microfluidic-enabled multi-well cell culture devices and systems
JP7161618B2 (ja) 2018-11-28 2022-10-26 インスレット コーポレイション 薬物送達シャトルポンプシステムと弁アセンブリ
IL311084A (en) 2018-11-30 2024-04-01 Caris Mpi Inc New generation molecular characterization
WO2020131103A1 (en) * 2018-12-21 2020-06-25 Sri International Apparatuses and methods involving protein exploration through proteolysis and nanopore translocation
CN109718875B (zh) * 2018-12-24 2021-08-24 东南大学 一种基于pdms微流体结构上集成聚氨酯薄膜的方法
WO2020168258A1 (en) 2019-02-15 2020-08-20 Berkeley Lights, Inc. Laser-assisted repositioning of a micro-object and culturing of an attachment-dependent cell in a microfluidic environment
CA3128894A1 (en) 2019-02-19 2020-08-27 Sequenom, Inc. Compositions, methods, and systems to detect hematopoietic stem cell transplantation status
DE102019105191A1 (de) * 2019-02-28 2020-09-03 Prominent Gmbh Verdrängerpumpe mit strömungsbegünstigten Oberflächen
USD919833S1 (en) 2019-03-06 2021-05-18 Princeton Biochemicals, Inc Micro valve for controlling path of fluids in miniaturized capillary connections
CN114126762B (zh) 2019-04-30 2023-01-03 伯克利之光生命科技公司 用于包封和测定细胞的方法
EP3990285A4 (en) 2019-06-25 2023-04-19 Hewlett-Packard Development Company, L.P. Molded structures with channels
WO2021030271A2 (en) 2019-08-09 2021-02-18 Nutcracker Therapeutics, Inc. Methods and apparatuses for manufacturing for removing material from a therapeutic composition
GB201913529D0 (en) * 2019-09-19 2019-11-06 Tanriverdi Ugur Method And Apparatus
IL269674B (en) 2019-09-25 2020-08-31 Roy Bar Ziv Assembling protein complexes on a chip
CN114829626A (zh) 2019-10-10 2022-07-29 1859公司 用于微流体筛选的方法和系统
CN110586216A (zh) * 2019-10-16 2019-12-20 陕西优博特生物科技有限公司 一种用于微控流芯片实验的试样采加样系统
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump
WO2021092524A1 (en) 2019-11-07 2021-05-14 Smylio Inc. Saliva collection and testing system
TW202142856A (zh) 2019-11-17 2021-11-16 美商伯克利之光生命科技公司 用於生物樣本之分析的系統及方法
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
EP3845790B1 (en) * 2019-12-30 2024-04-17 Imec VZW Microfluidic device for controlling pneumatic microvalves
EP4090464A1 (en) 2020-01-17 2022-11-23 F. Hoffmann-La Roche AG Microfluidic device and method for automated split-pool synthesis
US20230039014A1 (en) 2020-01-22 2023-02-09 Roche Sequencing Solutions, Inc. Microfluidic bead trapping devices and methods for next generation sequencing library preparation
JP7759883B2 (ja) 2020-02-20 2025-10-24 スタンダード バイオツールズ インコーポレイテッド 並列化サンプル処理とライブラリー調製
US12416043B2 (en) 2020-02-20 2025-09-16 Standard BioTools Inc. Parallelized sample processing and library prep
JP2023516299A (ja) 2020-02-28 2023-04-19 ラボラトリー コーポレイション オブ アメリカ ホールディングス 父子判定のための組成物、方法、およびシステム
CA3170874A1 (en) 2020-03-09 2021-09-16 Phillip J. M. ELMS Methods, systems and kits for in-pen assays
JP7477378B2 (ja) * 2020-06-19 2024-05-01 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ
TW202223389A (zh) 2020-09-07 2022-06-16 美商伯克利之光生命科技公司 檢測生物細胞之方法
CN116490239A (zh) 2020-11-09 2023-07-25 敏捷设备有限公司 用于操纵导管的装置
CN112452365B (zh) * 2020-11-23 2021-12-07 无锡市夸克微智造科技有限责任公司 微加工流体装置
CN116782966A (zh) 2021-01-08 2023-09-19 英赛罗公司 单致动精确剂量中间泵送室
US12440617B2 (en) 2021-01-11 2025-10-14 Insulet Corporation Linear activated drug dosing pump system
EP4346945A1 (en) 2021-05-28 2024-04-10 Insulet Corporation Spring-based status sensors
US12090498B2 (en) 2021-08-19 2024-09-17 Insulet Corporation Low-friction rolling plunger for a wearable drug delivery device
US20240299945A1 (en) 2021-09-03 2024-09-12 Elegen Corporation Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
DE102022107894A1 (de) * 2022-04-01 2023-10-05 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Verfahren zum Herstellen eines Reaktors, Reaktoren und Anordnungen
EP4504925A1 (en) 2022-04-04 2025-02-12 The Broad Institute, Inc. Cas9 variants having non-canonical pam specificities and uses thereof
US12194464B1 (en) * 2022-04-04 2025-01-14 Corporation For National Research Initiatives Integrated microfluidic system and method of fabrication
USD1024314S1 (en) 2022-06-01 2024-04-23 Insulet Corporation Automated drug delivery device
EP4536402A1 (en) 2022-06-07 2025-04-16 Yeda Research and Development Co., Ltd. Microfluidic device for analyzing steady state biological reactions
US12452991B2 (en) 2022-06-25 2025-10-21 EvansWerks, Inc. Cooling system and methods
US12363864B2 (en) 2022-06-25 2025-07-15 EvansWerks, Inc. Cooling system and methods
US12490411B2 (en) 2022-06-25 2025-12-02 EvansWerks, Inc. Cooling system and methods
US12133365B2 (en) 2022-06-25 2024-10-29 EvansWerks, Inc. Cooling system and methods
US12101909B2 (en) 2022-06-25 2024-09-24 EvansWerks, Inc. Cooling system and methods
US12453048B2 (en) 2022-06-25 2025-10-21 EvansWerks, Inc. Cooling system and methods
ES2958141B2 (es) * 2022-07-07 2025-02-27 Univ Madrid Carlos Iii Material conductivo autorreparable
CN115445678B (zh) * 2022-08-23 2023-08-01 电子科技大学 一种驱动磁流体水平运动的方法、装置及应用
DE102022132929A1 (de) * 2022-12-12 2024-06-13 Gemü Gebr. Müller Apparatebau Gmbh & Co. Kommanditgesellschaft Verfahren, Prozessarmatur, Armaturanordnung
NL2036035B1 (en) * 2023-09-21 2025-03-26 Deepcell Inc Cartridge for fluid with particles
WO2025104733A1 (en) 2023-11-14 2025-05-22 Yeda Research And Development Co. Ltd. Chips for determining binding affinities of biomolecules
TWI886903B (zh) * 2024-04-12 2025-06-11 臺北醫學大學 微流體晶片和微流體晶片操作系統
CN119641992B (zh) * 2024-12-10 2025-10-21 南京航空航天大学 一种基于电制动pvc凝胶的微型流体泄压阀

Family Cites Families (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US186856A (en) 1877-01-30 Improvement in sheet-metal cans
US147199A (en) 1874-02-03 Improvement in revolving horse hay-rakes
US409832A (en) * 1889-08-27 Compound fire-proof column
US499312A (en) * 1893-06-13 Alonzo g
US141503A (en) 1873-08-05 Improvement in treating cotton-seed oil to render it drying
US2260938A (en) * 1940-06-24 1941-10-28 Standard Railway Equipment Mfg Hatch construction
US2620938A (en) 1949-09-02 1952-12-09 Package Devices Inc Container closure
US3495608A (en) 1967-05-04 1970-02-17 Pitney Bowes Inc Fluidic elements and devices thereof
US3570515A (en) 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
GB1362952A (en) 1970-07-21 1974-08-07 Rasmussen O B Conjugate fibre and method of manufacturing same
NL7102074A (enExample) 1971-02-17 1972-08-21
DE2138491B1 (de) * 1971-07-31 1973-02-15 Hoffman-Rheem Maschinen Gmbh, 5000 Koeln Hand Dampf und Bugelplatte
GB1520402A (en) * 1974-07-30 1978-08-09 Mitsubishi Electric Corp Combustion apparatus
FR2287606A1 (fr) 1974-10-08 1976-05-07 Pegourie Jean Pierre Circuits logiques pneumatiques et leurs circuits integres
JPS5941169B2 (ja) 1975-12-25 1984-10-05 シチズン時計株式会社 エラストマ−ヒヨウジソウチ
US4153655A (en) * 1976-07-23 1979-05-08 Minnick Leonard J Products from molten fly ash and scrubber sludge including fly ash
US4153855A (en) 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4434704A (en) 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
US4581624A (en) * 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4990216A (en) 1987-10-27 1991-02-05 Fujitsu Limited Process and apparatus for preparation of single crystal of biopolymer
US4852851A (en) * 1987-12-11 1989-08-01 Integrated Fluidics, Inc. Valve with flexible sheet member
US4848722A (en) 1987-12-11 1989-07-18 Integrated Fluidics, Inc. Valve with flexible sheet member
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
EP0374313B2 (en) 1988-12-20 1997-07-02 E.I. Du Pont De Nemours And Company Polyester resin filled with low-adhesive glass fibre
US4992312A (en) 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (enExample) 1989-04-11 1992-03-13 Westonbridge Int Ltd
DE3917396A1 (de) 1989-05-29 1990-12-06 Buerkert Gmbh Mikroventil
JPH04501449A (ja) 1989-06-14 1992-03-12 ウエストンブリッジ　インターナショナル　リミティド マイクロポンプ
US5238223A (en) * 1989-08-11 1993-08-24 Robert Bosch Gmbh Method of making a microvalve
JP2555193B2 (ja) 1989-08-22 1996-11-20 ファナック株式会社 オルダム継手
US5171132A (en) 1989-12-27 1992-12-15 Seiko Epson Corporation Two-valve thin plate micropump
DE4006152A1 (de) 1990-02-27 1991-08-29 Fraunhofer Ges Forschung Mikrominiaturisierte pumpe
US6054034A (en) * 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
US5429856A (en) 1990-03-30 1995-07-04 Minnesota Mining And Manufacturing Company Composite materials and process
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
US5259737A (en) 1990-07-02 1993-11-09 Seiko Epson Corporation Micropump with valve structure
US5108682A (en) 1990-07-24 1992-04-28 Bridgestone/Firestone, Inc. Coextrusion apparatus and method using an elastic die for varying the outer profile of a tubular extrudate
US5164558A (en) 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (ja) * 1991-07-18 2002-09-24 アイシン精機株式会社 流体制御装置
DE4143343C2 (de) 1991-09-11 1994-09-22 Fraunhofer Ges Forschung Mikrominiaturisierte, elektrostatisch betriebene Mikromembranpumpe
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
DE4220077A1 (de) 1992-06-19 1993-12-23 Bosch Gmbh Robert Mikropumpe
US5364742A (en) 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
JP2812629B2 (ja) 1992-11-25 1998-10-22 宇宙開発事業団 結晶成長セル
US5290240A (en) 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5670102A (en) 1993-02-11 1997-09-23 Minnesota Mining And Manufacturing Company Method of making thermoplastic foamed articles using supercritical fluid
US5387329A (en) * 1993-04-09 1995-02-07 Ciba Corning Diagnostics Corp. Extended use planar sensors
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
US5681024A (en) 1993-05-21 1997-10-28 Fraunhofer-Gesellschaft zur Forderung der angerwanden Forschung e.V. Microvalve
SE501713C2 (sv) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
US5642015A (en) * 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5417235A (en) * 1993-07-28 1995-05-23 Regents Of The University Of Michigan Integrated microvalve structures with monolithic microflow controller
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
DE4332720C2 (de) 1993-09-25 1997-02-13 Karlsruhe Forschzent Mikromembranpumpe
US5423267A (en) * 1993-12-30 1995-06-13 Eklund; Byron G. Pocket rerailer
CH689836A5 (fr) 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropompe.
US5538223A (en) * 1994-04-21 1996-07-23 Scace; Gregory Single line multiple purchase block and tackle system
US5472053A (en) * 1994-09-14 1995-12-05 Halliburton Company Leakproof floating apparatus and method for fabricating said apparatus
DE4433894A1 (de) * 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Ansteuerung einer Mikropumpe
DE69531430T2 (de) * 1994-10-07 2004-07-01 Bayer Corp. Entlastungsventil
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5788468A (en) 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
EP0791238B1 (en) 1994-11-10 2004-09-22 Orchid BioSciences, Inc. Liquid distribution system
JP3094880B2 (ja) 1995-03-01 2000-10-03 住友金属工業株式会社 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
CA2183478C (en) 1995-08-17 2004-02-24 Stephen A. Carter Digital gas metering system using tri-stable and bi-stable solenoids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5598033A (en) 1995-10-16 1997-01-28 Advanced Micro Devices, Inc. Micro BGA stacking scheme
US5958344A (en) 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (ko) 1995-12-19 1999-07-15 전주범 광로 조절 장치의 제조방법
US5660370A (en) 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5724677A (en) 1996-03-08 1998-03-10 Minnesota Mining And Manufacturing Company Multi-part headband and respirator mask assembly and process for making same
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5810325A (en) 1996-06-25 1998-09-22 Bcam International, Inc. Microvalve
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
CA2259395C (en) 1996-07-15 2002-03-05 Sumitomo Metal Industries, Ltd. Equipment for crystal growth and crystal-growing method using the same
US5876157A (en) * 1996-07-17 1999-03-02 Wethered; William Drill centering jig and forming tool guide
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US5738799A (en) 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US5788488A (en) * 1996-09-23 1998-08-04 Precision Dental International, Inc. Dental reamer stop dispenser
US6221654B1 (en) * 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5865417A (en) 1996-09-27 1999-02-02 Redwood Microsystems, Inc. Integrated electrically operable normally closed valve
US5839722A (en) * 1996-11-26 1998-11-24 Xerox Corporation Paper handling system having embedded control structures
US6123316A (en) * 1996-11-27 2000-09-26 Xerox Corporation Conduit system for a valve array
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
FR2757906A1 (fr) * 1996-12-31 1998-07-03 Westonbridge Int Ltd Micropompe avec piece intermediaire integree
US6436529B1 (en) 1997-01-21 2002-08-20 3M Innovative Properties Company Elatomeric laminates and composites
US6376971B1 (en) * 1997-02-07 2002-04-23 Sri International Electroactive polymer electrodes
US5882496A (en) * 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
US6069392A (en) 1997-04-11 2000-05-30 California Institute Of Technology Microbellows actuator
US6116863A (en) * 1997-05-30 2000-09-12 University Of Cincinnati Electromagnetically driven microactuated device and method of making the same
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US6304364B1 (en) 1997-06-11 2001-10-16 President & Fellows Of Harvard College Elastomeric light valves
WO1999000655A2 (en) 1997-06-27 1999-01-07 Immunetics, Inc. Rapid flow-through binding assay apparatus and method
AU8492998A (en) 1997-07-16 1999-02-10 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5999307A (en) 1997-09-04 1999-12-07 The University Of British Columbia Method and apparatus for controllable frustration of total internal reflection
US20020092767A1 (en) * 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6540895B1 (en) * 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5836750A (en) 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6345502B1 (en) * 1997-11-12 2002-02-12 California Institute Of Technology Micromachined parylene membrane valve and pump
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
ATE364148T1 (de) 1998-01-20 2007-06-15 Invensys Sys Inc Elektromagnet- vorrichtung mit zwei von drei elektromagneten die immer betätigt sind
US6790526B2 (en) * 1998-01-30 2004-09-14 Integument Technologies, Inc. Oxyhalopolymer protective multifunctional appliqués and paint replacement films
US6451674B1 (en) * 1998-02-18 2002-09-17 Matsushita Electronics Corporation Method for introducing impurity into a semiconductor substrate without negative charge buildup phenomenon
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
WO1999052633A1 (en) 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
WO2000000678A1 (en) 1998-06-26 2000-01-06 University Of Washington Crystallization media
US6225243B1 (en) 1998-08-03 2001-05-01 Bba Nonwovens Simpsonville, Inc. Elastic nonwoven fabric prepared from bi-component filaments
US6221483B1 (en) 1998-09-10 2001-04-24 Avery Dennison Corporation Reversibly extensible film
US6482306B1 (en) * 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
RU2143343C1 (ru) * 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Микроинжектор и способ изготовления микроинжектора
US6958865B1 (en) * 1998-11-12 2005-10-25 California Institute Of Technology Microlicensing particles and applications
JP3535831B2 (ja) 1998-11-16 2004-06-07 カリフォルニア インスティテュート オヴ テクノロジー パリレン製マイクロ逆止め弁およびその製造方法
AU3508600A (en) * 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
JP2000314381A (ja) * 1999-03-03 2000-11-14 Ngk Insulators Ltd ポンプ
DE60034033T2 (de) 1999-04-06 2007-12-06 University of Alabama, Birmingham Research Foundation, Birmingham Vorrichtung zum screening von kristallisierungsbedingungen in lösungen zur kristallzüchtung
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US6406605B1 (en) * 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
EP1065378B1 (en) 1999-06-28 2002-04-03 California Institute of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
WO2001006575A1 (en) * 1999-07-20 2001-01-25 Sri International Improved electroactive polymers
WO2001009595A2 (en) 1999-08-02 2001-02-08 Emerald Biostructures, Inc. Method and system for creating a crystallization results database
US7255506B2 (en) * 2000-06-02 2007-08-14 The Procter & Gamble Company Semi-enclosed applicator for distributing a substance onto a target surface
US20020112961A1 (en) * 1999-12-02 2002-08-22 Nanostream, Inc. Multi-layer microfluidic device fabrication
WO2001067369A2 (en) 2000-03-03 2001-09-13 California Institute Of Technology Combinatorial array for nucleic acid analysis
EP1285106A2 (en) 2000-03-31 2003-02-26 Micronics, Inc. Protein crystallization in microfluidic structures
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
JP2003533681A (ja) * 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体装置および細胞ベースの分析を実行する方法
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6885982B2 (en) * 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
WO2002000343A2 (en) * 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
US6301055B1 (en) * 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
AU2001290879A1 (en) 2000-09-15 2002-03-26 California Institute Of Technology Microfabricated crossflow devices and methods
EP1322936A2 (en) * 2000-10-03 2003-07-02 California Institute Of Technology Microfluidic devices and methods of use
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US7678547B2 (en) * 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1336097A4 (en) 2000-10-13 2006-02-01 Fluidigm Corp SAMPLE INJECTION SYSTEM BASED ON A MICROFLUIDIC EQUIPMENT FOR ANALYTICAL EQUIPMENT
US7232109B2 (en) * 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
EP1345698A4 (en) 2000-11-16 2006-05-17 Fluidigm Corp MICROFLUID DEVICES FOR THE INTRODUCTION AND DISPOSAL OF FLUIDS FROM MICROFLUID SYSTEMS
AU2002230524A1 (en) 2000-11-16 2002-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
WO2002081729A2 (en) 2001-04-06 2002-10-17 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
ATE500051T1 (de) * 2001-04-06 2011-03-15 Fluidigm Corp Polymeroberflächenmodifikation
US7075162B2 (en) 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
WO2003031163A2 (en) 2001-10-08 2003-04-17 California Institute Of Technology Microfabricated lenses, methods of manufacture thereof, and applications therefor
WO2003031066A1 (en) * 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
AU2002351187A1 (en) 2001-11-30 2003-06-17 Fluidigm Corporation Microfluidic device and methods of using same
AU2003224817B2 (en) * 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
US7059348B2 (en) 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
AU2003277853A1 (en) 2002-06-24 2004-01-06 Fluidigm Corporation Recirculating fluidic network and methods for using the same
JP2006501056A (ja) * 2002-09-25 2006-01-12 カリフォルニア インスティテュート オブ テクノロジー ミクロ流体大規模集積
JP5695287B2 (ja) * 2002-10-02 2015-04-01 カリフォルニア インスティテュート オブ テクノロジー 微小流体の核酸解析
GB0302302D0 (en) 2003-01-31 2003-03-05 Glaxo Group Ltd Microfluidic apparatus and method
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
AU2004228678A1 (en) 2003-04-03 2004-10-21 Fluidigm Corp. Microfluidic devices and methods of using same
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) * 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
WO2004094020A2 (en) 2003-04-17 2004-11-04 Fluidigm Corporation Crystal growth devices and systems, and methods for using same
US7695683B2 (en) * 2003-05-20 2010-04-13 Fluidigm Corporation Method and system for microfluidic device and imaging thereof
CA2532530A1 (en) 2003-07-28 2005-02-10 Fluidigm Corporation Image processing method and system for microfluidic devices
US7042649B2 (en) 2003-08-11 2006-05-09 California Institute Of Technology Microfabricated rubber microscope using soft solid immersion lenses
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
WO2005054441A2 (en) 2003-12-01 2005-06-16 California Institute Of Technology Device for immobilizing chemical and biomedical species and methods of using same
US7407799B2 (en) * 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
US7307802B2 (en) 2004-06-07 2007-12-11 Fluidigm Corporation Optical lens system and method for microfluidic devices
ATE384310T1 (de) * 2004-07-07 2008-02-15 Koninkl Philips Electronics Nv System und verfahren zur korrektur zeitlicher artefakte in tomographischen bildern
JP2008522795A (ja) 2004-12-03 2008-07-03 カリフォルニア インスティチュート オブ テクノロジー 化学反応回路を有するマイクロ流体装置
US20080264863A1 (en) 2004-12-03 2008-10-30 California Institute Of Technology Microfluidic Sieve Valves
EP1882189A2 (en) 2005-04-20 2008-01-30 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US20070048192A1 (en) * 2005-08-10 2007-03-01 Emil Kartalov Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same
US20070054293A1 (en) 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US8206975B2 (en) * 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US20070248971A1 (en) 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
US8039269B2 (en) 2006-01-26 2011-10-18 California Institute Of Technology Mechanically induced trapping of molecular interactions
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8828661B2 (en) * 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8055034B2 (en) * 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
EP2074341A4 (en) 2006-10-04 2013-04-10 Fluidigm Corp MICROFLUIDIC CHECK VALVES
WO2008067552A2 (en) * 2006-11-30 2008-06-05 Fluidigm Corporation Method and apparatus for biological sample analysis
EP2125219B1 (en) 2007-01-19 2016-08-10 Fluidigm Corporation High precision microfluidic devices and methods
WO2008141183A2 (en) * 2007-05-09 2008-11-20 Fluidigm Corporation Method and system for crystallization and x-ray diffraction screening
CN101821619B (zh) * 2007-09-07 2015-02-11 弗卢丁公司 拷贝数变化确定、方法和系统
WO2009100449A1 (en) 2008-02-08 2009-08-13 Fluidigm Corporation Dynamic array assay methods
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US9579830B2 (en) 2008-07-25 2017-02-28 Fluidigm Corporation Method and system for manufacturing integrated fluidic chips
WO2010017210A1 (en) 2008-08-07 2010-02-11 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
CN105964316A (zh) 2008-12-08 2016-09-28 富鲁达公司 可编程微流体数字阵列
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155871B2 (en) 2010-11-19 2015-10-13 C. Miethke Gmbh & Co Kg Electrically operable, in one possible embodiment programmable hydrocephalus valve

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