DE60017888T2 - Dinatrium-salze, monohydrate und ethanol-solvate - Google Patents

Dinatrium-salze, monohydrate und ethanol-solvate Download PDF

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Publication number
DE60017888T2
DE60017888T2 DE60017888T DE60017888T DE60017888T2 DE 60017888 T2 DE60017888 T2 DE 60017888T2 DE 60017888 T DE60017888 T DE 60017888T DE 60017888 T DE60017888 T DE 60017888T DE 60017888 T2 DE60017888 T2 DE 60017888T2
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DE
Germany
Prior art keywords
disodium salt
agent
substituted
ethanol
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017888T
Other languages
German (de)
English (en)
Other versions
DE60017888D1 (de
Inventor
E. William BAY
K. Rajesh AGARWAL
Kiran Chaudhary
Shingai Majuru
M. Michael GOLDBERG
P. JoAnne RUSSO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emisphere Technologies Inc
Original Assignee
Emisphere Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emisphere Technologies Inc filed Critical Emisphere Technologies Inc
Application granted granted Critical
Publication of DE60017888D1 publication Critical patent/DE60017888D1/de
Publication of DE60017888T2 publication Critical patent/DE60017888T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
DE60017888T 1999-04-05 2000-04-05 Dinatrium-salze, monohydrate und ethanol-solvate Expired - Lifetime DE60017888T2 (de)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US12775499P 1999-04-05 1999-04-05
US127754P 1999-04-05
US18614300P 2000-03-01 2000-03-01
US18614200P 2000-03-01 2000-03-01
US186143P 2000-03-01
US186142P 2000-03-01
US19128600P 2000-03-21 2000-03-21
US191286P 2000-03-21
PCT/US2000/009390 WO2000059863A1 (en) 1999-04-05 2000-04-05 Disodium salts, monohydrates, and ethanol solvates

Publications (2)

Publication Number Publication Date
DE60017888D1 DE60017888D1 (de) 2005-03-10
DE60017888T2 true DE60017888T2 (de) 2006-01-19

Family

ID=27494697

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017888T Expired - Lifetime DE60017888T2 (de) 1999-04-05 2000-04-05 Dinatrium-salze, monohydrate und ethanol-solvate

Country Status (12)

Country Link
US (6) US20020065255A1 (US07384982-20080610-C00001.png)
EP (1) EP1175390B1 (US07384982-20080610-C00001.png)
JP (2) JP4588221B2 (US07384982-20080610-C00001.png)
AT (1) ATE288415T1 (US07384982-20080610-C00001.png)
AU (1) AU4216700A (US07384982-20080610-C00001.png)
CA (1) CA2369591C (US07384982-20080610-C00001.png)
DE (1) DE60017888T2 (US07384982-20080610-C00001.png)
ES (1) ES2235854T3 (US07384982-20080610-C00001.png)
HK (1) HK1045680A1 (US07384982-20080610-C00001.png)
IL (4) IL145546A0 (US07384982-20080610-C00001.png)
NZ (1) NZ534409A (US07384982-20080610-C00001.png)
WO (1) WO2000059863A1 (US07384982-20080610-C00001.png)

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IL180118A (en) 2010-12-30
JP4588221B2 (ja) 2010-11-24
WO2000059863A1 (en) 2000-10-12
DE60017888D1 (de) 2005-03-10
ATE288415T1 (de) 2005-02-15
US20020065255A1 (en) 2002-05-30
US8658695B2 (en) 2014-02-25
IL145546A (en) 2007-10-31
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US8003697B2 (en) 2011-08-23
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US8207227B2 (en) 2012-06-26
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US20110251125A1 (en) 2011-10-13
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