DE60008352D1 - Pyridoxin-derivate in der behandlung von kardiovaskulären beschwerden - Google Patents
Pyridoxin-derivate in der behandlung von kardiovaskulären beschwerdenInfo
- Publication number
- DE60008352D1 DE60008352D1 DE60008352T DE60008352T DE60008352D1 DE 60008352 D1 DE60008352 D1 DE 60008352D1 DE 60008352 T DE60008352 T DE 60008352T DE 60008352 T DE60008352 T DE 60008352T DE 60008352 D1 DE60008352 D1 DE 60008352D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- pyridoxine
- pyridoxal
- pyridoxine derivatives
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Electrotherapy Devices (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US276280 | 1999-03-25 | ||
US09/276,280 US6043259A (en) | 1998-07-09 | 1999-03-25 | Treatment of cardiovascular and related pathologies |
PCT/IB2000/000340 WO2000057863A2 (en) | 1999-03-25 | 2000-03-22 | Use of pyridoxine compounds for treatment of cardiovascular and related pathologies |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60008352D1 true DE60008352D1 (de) | 2004-03-25 |
DE60008352T2 DE60008352T2 (de) | 2004-12-23 |
Family
ID=23055999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60008352T Expired - Fee Related DE60008352T2 (de) | 1999-03-25 | 2000-03-22 | Pyridoxin-derivate in der behandlung von kardiovaskulären beschwerden |
Country Status (13)
Country | Link |
---|---|
US (1) | US6043259A (de) |
EP (1) | EP1162980B1 (de) |
JP (1) | JP2002540144A (de) |
AT (1) | ATE259643T1 (de) |
AU (1) | AU779238B2 (de) |
BR (1) | BR0009292A (de) |
CA (1) | CA2368775C (de) |
DE (1) | DE60008352T2 (de) |
DK (1) | DK1162980T3 (de) |
ES (1) | ES2215618T3 (de) |
NZ (1) | NZ514767A (de) |
PT (1) | PT1162980E (de) |
WO (1) | WO2000057863A2 (de) |
Families Citing this family (55)
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US6716858B1 (en) | 1995-08-28 | 2004-04-06 | Kansas University Medical Center | Methods for inhibiting diabetic complications |
US6265391B1 (en) | 1995-10-17 | 2001-07-24 | Upsher-Smith Laboratories, Inc. | Method for preventing peripheral nerve damage |
AU5840200A (en) * | 1999-07-13 | 2001-01-30 | Medicure Inc. | Treatment of diabetes and related pathologies |
EP1872797A3 (de) * | 1999-08-24 | 2008-04-02 | Medicure International Inc. | Behandlung kardiovaskulärer und verwandter Leiden |
EP1531157B1 (de) * | 2000-02-29 | 2008-03-19 | Medicure International Inc. | Cardioprotektive Phosphonate |
WO2001064692A1 (en) | 2000-02-29 | 2001-09-07 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
US6586414B2 (en) | 2000-03-28 | 2003-07-01 | Medicure International Inc. | Treatment of cerebrovascular disease |
US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
US6897228B2 (en) | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
ATE364595T1 (de) * | 2000-07-07 | 2007-07-15 | Medicure Int Inc | Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika |
AU2002237667A1 (en) | 2000-11-20 | 2002-05-27 | University Of Kansas Medical Center | Methods for the treatment and prevention of urinary stone disease |
US6864242B2 (en) * | 2001-03-05 | 2005-03-08 | Stephen P. Ernest | Enteral formulation |
US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
SE0101854L (sv) * | 2001-05-28 | 2002-11-29 | Bioneris Ab | Användning av en förening med en negativt laddad region av grupper för behandling av restenos. |
US20050026874A1 (en) * | 2002-07-29 | 2005-02-03 | Lockwood Samuel Fournier | Carotenoid ether analogs or derivatives for the inhibition and amelioration of liver disease |
US7763649B2 (en) | 2002-07-29 | 2010-07-27 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for controlling connexin 43 expression |
US20050049248A1 (en) * | 2002-07-29 | 2005-03-03 | Lockwood Samuel Fournier | Carotenoid ether analogs or derivatives for controlling C-reactive protein levels |
US7521584B2 (en) * | 2002-07-29 | 2009-04-21 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of disease |
US20050004235A1 (en) * | 2002-07-29 | 2005-01-06 | Lockwood Samuel Fournier | Carotenoid analogs or derivatives for the inhibition and amelioration of liver disease |
US20050059659A1 (en) * | 2002-07-29 | 2005-03-17 | Lockwood Samuel Fournier | Carotenoid analogs or derivatives for controlling C-reactive protein levels |
US7320997B2 (en) * | 2002-07-29 | 2008-01-22 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease |
US20050143475A1 (en) * | 2002-07-29 | 2005-06-30 | Lockwood Samuel F. | Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury |
US20050148517A1 (en) * | 2002-07-29 | 2005-07-07 | Lockwood Samuel F. | Carotenoid ether analogs or derivatives for controlling connexin 43 expression |
US7723327B2 (en) * | 2002-07-29 | 2010-05-25 | Cardax Pharmaceuticals, Inc. | Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease |
US20050059635A1 (en) * | 2002-07-29 | 2005-03-17 | Lockwood Samuel Fournier | Carotenoid ester analogs or derivatives for controlling C-reactive protein levels |
US20050009788A1 (en) * | 2002-07-29 | 2005-01-13 | Lockwood Samuel Fournier | Carotenoid ester analogs or derivatives for controlling connexin 43 expression |
EP1532108B1 (de) * | 2002-07-29 | 2016-06-29 | Cardax Pharma, Inc. | Astaxanthinester zur vermeidung und verbesserung von krankheiten |
US7375133B2 (en) * | 2002-07-29 | 2008-05-20 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
US7345091B2 (en) * | 2002-07-29 | 2008-03-18 | Cardax Pharmaceuticals, Inc. | Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
US20070167411A1 (en) * | 2003-03-27 | 2007-07-19 | Medicure International Inc. | Compositions for treating angina |
JP2006523206A (ja) * | 2003-03-27 | 2006-10-12 | メディキュア インコーポレーテッド | 細胞死の調節 |
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US20060058269A1 (en) * | 2004-04-14 | 2006-03-16 | Lockwood Samuel F | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
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US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
JP2008514552A (ja) * | 2004-09-24 | 2008-05-08 | メディキュア・インターナショナル・インコーポレーテッド | アテローム性動脈硬化症および再狭窄を治療および予防するためのピリドキサール−5’−リン酸並びにステント |
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CA2528191A1 (en) * | 2004-11-26 | 2006-05-26 | Medicure International Inc. | Novel formulation of pyridoxal 5'-phosphate and method of preparation |
WO2006072172A1 (en) * | 2005-01-05 | 2006-07-13 | Medicure International Inc. | Compounds and methods for regulating triglyceride levels |
CA2503087A1 (en) * | 2005-03-30 | 2006-09-30 | Medicure International Inc. | Intravenous formulations of pyridoxal 5'-phosphate and method of preparation |
EP1879594A2 (de) * | 2005-04-07 | 2008-01-23 | Unilever N.V. | Verwendung einer kombination aus vitaminen b und phytosterolen zur senkung des blutdrucks |
CA2632090A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
EP1790331A1 (de) * | 2005-11-28 | 2007-05-30 | Medicure International Inc. | Verwendung von Pyridoxal-5-Phosphat zur Behandlung von kardiovaskulären und verwandten Krankheiten |
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IT1263957B (it) * | 1993-02-23 | 1996-09-05 | Impiego terapeutico del pirrolidon carbossilato di piridossina | |
TW268948B (de) * | 1993-04-02 | 1996-01-21 | Senju Pharma Co | |
DE4344751A1 (de) * | 1993-12-28 | 1995-06-29 | Carl Heinrich Dr Weischer | Neue Vitamin B6-Derivate und deren Herstellung und Verwendung als Arzneimittel und als Kosmetika |
US5504090A (en) * | 1994-03-30 | 1996-04-02 | Trustees Of The University Of Pennsylvania | Compositions and methods for the prevention and treatment of ischemia-reperfusion organ injury |
EP1609477B1 (de) * | 1994-12-12 | 2011-11-09 | Omeros Corporation | Bespüllungslösung und deren Verwendung zur perioperativen Hemmung von Schmerzen, Entzündungen und/oder Spasmen an einer Gefässstruktur |
US5569459A (en) * | 1995-02-15 | 1996-10-29 | Bio-Virus Research Incorporated | Pharmaceutical compositions for the management of premenstrual syndrome and alleviation of menopausal disorders |
US5733916A (en) * | 1995-03-24 | 1998-03-31 | The Trustees Of The University Of Pennsylvania | Prevention and treatment of ischemia-reperfusion and endotoxin-related injury using adenosine and purino receptor antagonists |
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EP0891719A1 (de) * | 1997-07-14 | 1999-01-20 | N.V. Nutricia | Narungszusammensetzungen mit Gehalt an Methionin |
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-
1999
- 1999-03-25 US US09/276,280 patent/US6043259A/en not_active Expired - Fee Related
-
2000
- 2000-03-22 EP EP00911153A patent/EP1162980B1/de not_active Expired - Lifetime
- 2000-03-22 ES ES00911153T patent/ES2215618T3/es not_active Expired - Lifetime
- 2000-03-22 DK DK00911153T patent/DK1162980T3/da active
- 2000-03-22 JP JP2000607614A patent/JP2002540144A/ja active Pending
- 2000-03-22 PT PT00911153T patent/PT1162980E/pt unknown
- 2000-03-22 DE DE60008352T patent/DE60008352T2/de not_active Expired - Fee Related
- 2000-03-22 BR BR0009292-4A patent/BR0009292A/pt not_active Application Discontinuation
- 2000-03-22 AU AU33147/00A patent/AU779238B2/en not_active Ceased
- 2000-03-22 WO PCT/IB2000/000340 patent/WO2000057863A2/en active IP Right Grant
- 2000-03-22 NZ NZ514767A patent/NZ514767A/xx unknown
- 2000-03-22 CA CA002368775A patent/CA2368775C/en not_active Expired - Fee Related
- 2000-03-22 AT AT00911153T patent/ATE259643T1/de not_active IP Right Cessation
Also Published As
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WO2000057863A3 (en) | 2001-04-05 |
WO2000057863A2 (en) | 2000-10-05 |
CA2368775A1 (en) | 2000-10-05 |
CA2368775C (en) | 2008-07-08 |
US6043259A (en) | 2000-03-28 |
BR0009292A (pt) | 2001-12-26 |
AU779238B2 (en) | 2005-01-13 |
DK1162980T3 (da) | 2004-06-14 |
ATE259643T1 (de) | 2004-03-15 |
EP1162980A2 (de) | 2001-12-19 |
EP1162980B1 (de) | 2004-02-18 |
ES2215618T3 (es) | 2004-10-16 |
NZ514767A (en) | 2004-02-27 |
DE60008352T2 (de) | 2004-12-23 |
AU3314700A (en) | 2000-10-16 |
PT1162980E (pt) | 2004-06-30 |
JP2002540144A (ja) | 2002-11-26 |
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