CA2254528A1 - Treatment of ischemia reperfusion injury and treatment of cellular dysfunction including arrhythmia and heart failure subsequent to myocardial infarction - Google Patents

Treatment of ischemia reperfusion injury and treatment of cellular dysfunction including arrhythmia and heart failure subsequent to myocardial infarction Download PDF

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Publication number
CA2254528A1
CA2254528A1 CA 2254528 CA2254528A CA2254528A1 CA 2254528 A1 CA2254528 A1 CA 2254528A1 CA 2254528 CA2254528 CA 2254528 CA 2254528 A CA2254528 A CA 2254528A CA 2254528 A1 CA2254528 A1 CA 2254528A1
Authority
CA
Canada
Prior art keywords
treatment
reperfusion injury
heart failure
ischemia reperfusion
myocardial infarction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2254528
Other languages
French (fr)
Other versions
CA2254528C (en
Inventor
Naranjan S. Dhalla
Rajat Sethi
Krishnamurti Dakshinamurti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manitoba
Medicure Inc
Original Assignee
University of Manitoba
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Manitoba filed Critical University of Manitoba
Publication of CA2254528A1 publication Critical patent/CA2254528A1/en
Application granted granted Critical
Publication of CA2254528C publication Critical patent/CA2254528C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compositions and methods for treatment and prevention of ischemia-related conditions, such as ischemia reperfusion injury and cellular dysfunction, are disclosed.
The methods are directed to administering pharmaceutical compositions containing at least one compound derived from vitamin B6, such as pyridoxal-5'-phosphate, pyridoxine, pyridoxal, and pyridoxamine.
CA 2254528 1998-07-09 1998-11-26 Treatment of ischemia reperfusion injury and treatment of cellular dysfunction including arrhythmia and heart failure subsequent to myocardial infarction Expired - Fee Related CA2254528C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11227798A 1998-07-09 1998-07-09
US09/112,277 1998-07-09

Publications (2)

Publication Number Publication Date
CA2254528A1 true CA2254528A1 (en) 2000-01-09
CA2254528C CA2254528C (en) 2007-07-17

Family

ID=22343046

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2254528 Expired - Fee Related CA2254528C (en) 1998-07-09 1998-11-26 Treatment of ischemia reperfusion injury and treatment of cellular dysfunction including arrhythmia and heart failure subsequent to myocardial infarction

Country Status (4)

Country Link
JP (1) JP2000026295A (en)
AU (2) AU759824B2 (en)
CA (1) CA2254528C (en)
NZ (1) NZ333023A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1531157A1 (en) * 2000-02-29 2005-05-18 Medicure International Inc. Cardioprotective phosphonates

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001237185B2 (en) * 2000-02-29 2006-02-02 Medicure International Inc. Cardioprotective phosphonates and malonates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ222664A (en) * 1986-11-29 1990-06-26 Vesta Med Pty Ltd Pharmaceutical compositions containing pyridoxal as a source of vitamin b6
JPH09221425A (en) * 1996-02-13 1997-08-26 Taiho Yakuhin Kogyo Kk Thiol protease inhibitor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1531157A1 (en) * 2000-02-29 2005-05-18 Medicure International Inc. Cardioprotective phosphonates

Also Published As

Publication number Publication date
AU2007202621A1 (en) 2007-06-28
JP2000026295A (en) 2000-01-25
NZ333023A (en) 2000-08-25
AU759824B2 (en) 2003-05-01
CA2254528C (en) 2007-07-17
AU9421098A (en) 2000-02-03

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed