DE60006685D1 - Rot-emittierende [8,9]benzophenoxazin-nukleinsäurefarbstoffe und verfahren zu deren verwendung - Google Patents

Rot-emittierende [8,9]benzophenoxazin-nukleinsäurefarbstoffe und verfahren zu deren verwendung

Info

Publication number
DE60006685D1
DE60006685D1 DE60006685T DE60006685T DE60006685D1 DE 60006685 D1 DE60006685 D1 DE 60006685D1 DE 60006685 T DE60006685 T DE 60006685T DE 60006685 T DE60006685 T DE 60006685T DE 60006685 D1 DE60006685 D1 DE 60006685D1
Authority
DE
Germany
Prior art keywords
red
nucleic acid
benzophenoxazine
emittering
acid dyes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60006685T
Other languages
English (en)
Other versions
DE60006685T2 (de
Inventor
Xiongwui Yan
Sheri Miraglia
Pau Miau Yuan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Biosystems LLC
Original Assignee
Applera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applera Corp filed Critical Applera Corp
Application granted granted Critical
Publication of DE60006685D1 publication Critical patent/DE60006685D1/de
Publication of DE60006685T2 publication Critical patent/DE60006685T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B19/00Oxazine dyes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Coloring (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60006685T 1999-09-03 2000-09-01 Rot-emittierende [8,9]benzophenoxazin-nukleinsäurefarbstoffe und verfahren zu deren verwendung Expired - Lifetime DE60006685T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/389,918 US6140500A (en) 1999-09-03 1999-09-03 Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use
US389918 1999-09-03
PCT/US2000/024057 WO2001018124A1 (en) 1999-09-03 2000-09-01 Red-emitting [8,9]benzophenoxazine nucleic acid dyes and methods for their use

Publications (2)

Publication Number Publication Date
DE60006685D1 true DE60006685D1 (de) 2003-12-24
DE60006685T2 DE60006685T2 (de) 2004-10-14

Family

ID=23540303

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60006685T Expired - Lifetime DE60006685T2 (de) 1999-09-03 2000-09-01 Rot-emittierende [8,9]benzophenoxazin-nukleinsäurefarbstoffe und verfahren zu deren verwendung

Country Status (8)

Country Link
US (1) US6140500A (de)
EP (1) EP1208160B1 (de)
JP (1) JP2003509528A (de)
AT (1) ATE254648T1 (de)
AU (1) AU753608B2 (de)
CA (1) CA2382593C (de)
DE (1) DE60006685T2 (de)
WO (1) WO2001018124A1 (de)

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CN101189520A (zh) * 2005-05-03 2008-05-28 亚佩瑞股份有限公司 荧光检测系统和供其使用的染料组
US8362250B2 (en) 2005-05-24 2013-01-29 Enzo Biochem, Inc. Fluorescent dyes and compounds, methods and kits useful for identifying specific organelles and regions in cells of interest
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
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EP2198050A1 (de) 2007-09-14 2010-06-23 Asuragen, INC. Mikrornas mit unterschiedlicher expression bei zervikalkarzinom und verwendungen davon
US8071562B2 (en) 2007-12-01 2011-12-06 Mirna Therapeutics, Inc. MiR-124 regulated genes and pathways as targets for therapeutic intervention
WO2009137807A2 (en) 2008-05-08 2009-11-12 Asuragen, Inc. Compositions and methods related to mirna modulation of neovascularization or angiogenesis
US8715944B2 (en) * 2008-09-08 2014-05-06 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
US9250249B2 (en) 2008-09-08 2016-02-02 Enzo Biochem, Inc. Autophagy and phospholipidosis pathway assays
US9334281B2 (en) * 2008-09-08 2016-05-10 Enzo Life Sciences, Inc. Fluorochromes for organelle tracing and multi-color imaging
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EP2634266B1 (de) 2009-05-22 2015-10-14 Asuragen, INC. miRNA-Biomarker für Erkrankungen der Prostata
EP2775300A3 (de) 2009-08-28 2015-04-01 Asuragen, INC. miRNA-Biomarker für Lungenerkrankungen
JP6081366B2 (ja) 2010-10-29 2017-02-15 アスラジェン, インコーポレイテッド リピート配列を分析するためのmPCR法
CN103597093A (zh) 2010-12-29 2014-02-19 生命技术公司 作为荧光参考标准品的ddao化合物
WO2013040251A2 (en) 2011-09-13 2013-03-21 Asurgen, Inc. Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
EP2929050A1 (de) 2012-12-10 2015-10-14 AdvanDx, Inc. Verwendung von sonden zur massenspektrometrischen identifizierung von mikroorganismen oder zellen und relevanten erkrankungen von interesse
CA2935789A1 (en) 2014-01-05 2015-07-09 Biomirna Holdings Ltd. Lung cancer determinations using mirna
US10619210B2 (en) 2014-02-07 2020-04-14 The Johns Hopkins University Predicting response to epigenetic drug therapy
CN107109474B (zh) 2014-08-19 2021-03-19 豪夫迈·罗氏有限公司 用于核酸检测的方法和组合物
WO2016094330A2 (en) 2014-12-08 2016-06-16 20/20 Genesystems, Inc Methods and machine learning systems for predicting the liklihood or risk of having cancer
WO2016177774A1 (en) 2015-05-04 2016-11-10 Academisch Medisch Centrum Method of quantifying mirnas using normalization
WO2017015543A1 (en) 2015-07-23 2017-01-26 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
WO2018045162A1 (en) 2016-09-01 2018-03-08 Biogen Ma Inc. Biomarkers predictive of primary progressive multiple sclerosis and uses thereof
CN107602498B (zh) * 2017-07-26 2020-07-28 华南理工大学 一种荧光探针及其制备方法与在酪氨酸酶检测中的应用
EP3774747A1 (de) * 2018-04-04 2021-02-17 Universidade do Minho Benzophenoxazinderivate zur diagnose von neoplasien oder infektionen
WO2020090294A1 (ja) * 2018-10-31 2020-05-07 日立化成株式会社 イオン性化合物、有機エレクトロニクス材料、インク組成物、及び有機エレクトロニクス素子
EP3719144A1 (de) 2019-04-05 2020-10-07 Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) Mir-151a-3p als universelle endogene steuerung zur exosomenladungsnormalisierung
US20220267857A1 (en) 2019-07-19 2022-08-25 Fundación Para La Investigación Biomédikca Del Hospital Universitario La Paz (Fibhulp) Method for determining the response to treatment of a patient affected by non-small cell lung carcinoma (nsclc)

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Also Published As

Publication number Publication date
CA2382593A1 (en) 2001-03-15
JP2003509528A (ja) 2003-03-11
CA2382593C (en) 2008-04-08
US6140500A (en) 2000-10-31
EP1208160B1 (de) 2003-11-19
AU753608B2 (en) 2002-10-24
DE60006685T2 (de) 2004-10-14
WO2001018124A1 (en) 2001-03-15
AU7101500A (en) 2001-04-10
EP1208160A1 (de) 2002-05-29
ATE254648T1 (de) 2003-12-15

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Legal Events

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Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US

8380 Miscellaneous part iii

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8380 Miscellaneous part iii

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