ATE236442T1 - Fluoreszierende cyaninfarbstoffe - Google Patents
Fluoreszierende cyaninfarbstoffeInfo
- Publication number
- ATE236442T1 ATE236442T1 AT98903434T AT98903434T ATE236442T1 AT E236442 T1 ATE236442 T1 AT E236442T1 AT 98903434 T AT98903434 T AT 98903434T AT 98903434 T AT98903434 T AT 98903434T AT E236442 T1 ATE236442 T1 AT E236442T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanine dyes
- fluorescent cyanine
- fluorescent
- useful
- reporter groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Luminescent Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/781,326 US6027709A (en) | 1997-01-10 | 1997-01-10 | Fluorescent cyanine dyes |
PCT/US1998/000475 WO1998030992A2 (en) | 1997-01-10 | 1998-01-08 | Fluorescent cyanine dyes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE236442T1 true ATE236442T1 (de) | 2003-04-15 |
Family
ID=25122364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98903434T ATE236442T1 (de) | 1997-01-10 | 1998-01-08 | Fluoreszierende cyaninfarbstoffe |
Country Status (8)
Country | Link |
---|---|
US (1) | US6027709A (de) |
EP (1) | EP1019887B1 (de) |
JP (1) | JP4361138B2 (de) |
AT (1) | ATE236442T1 (de) |
AU (1) | AU739930B2 (de) |
CA (1) | CA2278313C (de) |
DE (1) | DE69812982T2 (de) |
WO (1) | WO1998030992A2 (de) |
Families Citing this family (84)
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US20030223935A1 (en) * | 2001-03-05 | 2003-12-04 | Gray Brian D. | Fluorescent membrane intercalating probes and methods for their use |
ATE429932T1 (de) * | 2000-03-03 | 2009-05-15 | Phanos Tech Inc | Fluoreszierende im membran interkalierende proben und verfahren zu deren verwendung |
WO2001074950A2 (en) * | 2000-04-03 | 2001-10-11 | Sun Chemical Corporation | Mono- and bis-hydrazone pigments |
JP2001288197A (ja) * | 2000-04-10 | 2001-10-16 | Fuji Photo Film Co Ltd | 蛍光ヌクレオチド |
DE10018199A1 (de) | 2000-04-12 | 2001-10-31 | Few Chemicals Gmbh | Fluoreszenzmarker |
CN100462433C (zh) * | 2000-07-07 | 2009-02-18 | 维西根生物技术公司 | 实时序列测定 |
US20070172866A1 (en) * | 2000-07-07 | 2007-07-26 | Susan Hardin | Methods for sequence determination using depolymerizing agent |
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JP4989013B2 (ja) * | 2000-09-19 | 2012-08-01 | リ−コール インコーポレーティッド | シアニン色素 |
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DE10046215B4 (de) * | 2000-09-19 | 2004-04-15 | Institut für Chemo- und Biosensorik Münster e.V. i.Ins. | Fluorochrome und deren Verwendung |
ATE352586T2 (de) | 2000-09-29 | 2007-02-15 | Molecular Probes Inc | Modifizierte carbocyaninfarbstoffe und deren konjugate |
EP1317464B1 (de) * | 2000-10-11 | 2009-05-13 | Applera Corporation | Fluoreszierende nukleobasekonjugate mit anionische linker |
US6663847B1 (en) * | 2000-10-13 | 2003-12-16 | Mallinckrodt Inc. | Dynamic organ function monitoring agents |
AU2002236683A1 (en) * | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
US6331632B1 (en) * | 2000-11-09 | 2001-12-18 | Beckman Coulter, Inc. | Cyanine dye phosphoramidites |
WO2002044425A2 (en) * | 2000-12-01 | 2002-06-06 | Visigen Biotechnologies, Inc. | Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity |
EP1221465A1 (de) * | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetrische, monofunktionalisierte Polymethinfarbstoffe als Markierungsreagenzien |
US6887690B2 (en) * | 2001-06-22 | 2005-05-03 | Pe Corporation | Dye-labeled ribonucleotide triphosphates |
US7668697B2 (en) * | 2006-02-06 | 2010-02-23 | Andrei Volkov | Method for analyzing dynamic detectable events at the single molecule level |
JP4676654B2 (ja) * | 2001-07-19 | 2011-04-27 | 富士フイルム株式会社 | 蛍光ヌクレオチド及びそれを用いた標識法 |
US6533396B2 (en) | 2001-08-16 | 2003-03-18 | Benq Corporation | Printhead cartridge with asymmetrical contacts |
US20050032060A1 (en) * | 2001-08-31 | 2005-02-10 | Shishir Shah | Arrays comprising pre-labeled biological molecules and methods for making and using these arrays |
JP2005519634A (ja) | 2001-10-12 | 2005-07-07 | スペクトラル ジェノミクス、インク. | 核酸組成物及びアレイ及びそれらを用いる方法 |
US7439346B2 (en) * | 2001-10-12 | 2008-10-21 | Perkinelmer Las Inc. | Nucleic acids arrays and methods of use therefor |
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US7222059B2 (en) * | 2001-11-15 | 2007-05-22 | Siemens Medical Solutions Diagnostics | Electrophoretic trace simulator |
EP1485716A1 (de) * | 2002-03-11 | 2004-12-15 | Visen Medical, Inc. | Sonden zur erzeugung von optischen bildern |
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US8188116B2 (en) * | 2002-09-04 | 2012-05-29 | Vanderbilt University | Agents for therapy efficacy monitoring and deep tissue imaging |
US7754884B2 (en) * | 2005-01-03 | 2010-07-13 | Vanderbilt University | Targeted, NIR imaging agents for therapy efficacy monitoring, deep tissue disease demarcation and deep tissue imaging |
US7005518B2 (en) * | 2002-10-25 | 2006-02-28 | Li-Cor, Inc. | Phthalocyanine dyes |
US20040132092A1 (en) * | 2003-01-03 | 2004-07-08 | Stetson Christopher M. | Determining the density of functional moieties on polymer reagents |
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EP2284278A1 (de) | 2003-04-04 | 2011-02-16 | Roche Diagnostics GmbH | Verbessertes System für Mehrfarben-Echtzeit-PCR |
US7572581B2 (en) * | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
US7619059B2 (en) * | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
CA2445420A1 (en) * | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
US7727752B2 (en) * | 2003-07-29 | 2010-06-01 | Life Technologies Corporation | Kinase and phosphatase assays |
US7271265B2 (en) * | 2003-08-11 | 2007-09-18 | Invitrogen Corporation | Cyanine compounds and their application as quenching compounds |
EP1671128B1 (de) * | 2003-09-12 | 2010-02-17 | Life Technologies Corporation | Anwendungen des Resonanzenergietransfers zwischen Terbium und GFP |
JP2007515947A (ja) * | 2003-10-30 | 2007-06-21 | タフツ−ニュー イングランド メディカル センター | 羊水中の無細胞胎児dnaを使用する出生前診断 |
WO2005056687A2 (en) | 2003-12-05 | 2005-06-23 | Molecular Probes, Inc. | Methine-substituted cyanine dye compounds |
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US7776529B2 (en) | 2003-12-05 | 2010-08-17 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
JP4127204B2 (ja) * | 2003-12-17 | 2008-07-30 | セイコーエプソン株式会社 | 液晶表示装置の製造方法 |
US7230117B2 (en) * | 2004-07-12 | 2007-06-12 | Beckman Coulter, Inc. | Stable cyanine dye phosphoramidites |
EP1885718B1 (de) | 2005-05-11 | 2017-03-15 | Life Technologies Corporation | Chemische fluoreszente verbindungen mit hoher selektivität für doppelstrang-dna sowie verfahren zu ihrer verwendung |
US7569695B2 (en) * | 2005-05-24 | 2009-08-04 | Enzo Life Sciences, Inc. | Dyes for the detection or quantification of desirable target molecules |
US7737281B2 (en) * | 2005-05-24 | 2010-06-15 | Enzo Life Sciences, Inc. C/O Enzo Biochem, Inc. | Purine based fluorescent dyes |
US8227621B2 (en) * | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
FR2889700B1 (fr) * | 2005-08-11 | 2012-11-23 | Synthinnove Lab | Marqueurs, leur procede de fabrication et leurs applications |
EP1934211B1 (de) | 2005-09-02 | 2017-01-11 | Visen Medical, Inc. | Biologisch kompatible fluoreszente farbstoffmarker, die n,n-disubstituierte sulfonamide enthalten |
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JP5416970B2 (ja) * | 2005-09-02 | 2014-02-12 | ビセン メディカル, インコーポレイテッド | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
US20080241938A1 (en) * | 2006-07-20 | 2008-10-02 | Visigen Biotechnologies, Inc. | Automated synthesis or sequencing apparatus and method for making and using same |
US20080091005A1 (en) * | 2006-07-20 | 2008-04-17 | Visigen Biotechnologies, Inc. | Modified nucleotides, methods for making and using same |
US20080241951A1 (en) * | 2006-07-20 | 2008-10-02 | Visigen Biotechnologies, Inc. | Method and apparatus for moving stage detection of single molecular events |
PL2202516T3 (pl) * | 2007-09-27 | 2015-02-27 | Sysmex Corp | Zestaw odczynników do analizy próbek i sposób analizy próbek |
US20090214436A1 (en) * | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
CA2723315A1 (en) | 2008-04-30 | 2009-11-05 | Ben-Gurion University Of The Negev Research And Development Authority | Vascular delivery systems |
JP5500875B2 (ja) * | 2009-01-30 | 2014-05-21 | キヤノン株式会社 | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 |
US9155471B2 (en) * | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
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WO2011151814A2 (en) | 2010-05-29 | 2011-12-08 | Ben-Gurion University Of The Negev Research And Development Authority | Caged cell penetrating peptide-polymer conjugates for diagnostic and therapeutic applications |
WO2012054784A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
US9314304B2 (en) | 2010-12-08 | 2016-04-19 | Lumicell, Inc. | Methods and system for image guided cell ablation with microscopic resolution |
EP2806781B1 (de) | 2012-01-23 | 2018-03-21 | Washington University | Brillenbildgebungssysteme und -verfahren |
KR20160037834A (ko) | 2013-03-14 | 2016-04-06 | 루미셀, 아이엔씨. | 의료 이미징 장치 및 사용 방법 |
JP6580552B2 (ja) | 2013-03-15 | 2019-09-25 | ビセン メディカル, インコーポレイテッド | 4,4−二置換シクロヘキシル架橋ヘプタメチンシアニン色素およびその使用 |
AR102743A1 (es) | 2014-11-26 | 2017-03-22 | Li Cor Inc | Medios de contraste ir para imágenes por fluorescencia |
US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
US10300153B2 (en) | 2015-11-30 | 2019-05-28 | Asthra, Llc | Immunological detection of altered cells |
CN106280533B (zh) * | 2016-08-17 | 2018-03-09 | 赣南师范大学 | 一种近红外荧光染料及其合成方法和用于寄生虫荧光标记 |
CA3059733A1 (en) | 2017-04-11 | 2018-10-18 | Li-Cor, Inc. | Solid cyanine dyes |
WO2019213543A1 (en) | 2018-05-04 | 2019-11-07 | Li-Cor, Inc. | 2-[2-[4-[bis(2-sulfoethyl)amino]phenyl]ethenyl]-1-butyl-3,3-dimethyl-3h-indolium hemicyanine dyes for the detection of antibodies and other biomolecules |
EP3891225A1 (de) * | 2018-12-06 | 2021-10-13 | Futuresynthesis Spólka z o.o. | Verfahren zur fluoreszenzmarkierung biologischer materialien, thermisch entfernbare fluoreszenzmarker für dieses verfahren und verfahren zu deren herstellung und verwendung |
EP4072598A4 (de) | 2019-12-13 | 2024-02-21 | Washington University St Louis | Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren |
CN117999481A (zh) | 2021-10-26 | 2024-05-07 | 卡里布生物科学公司 | 核酸外切酶偶联实时核酸内切酶活性测定 |
Family Cites Families (19)
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US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
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DE3912046B4 (de) * | 1988-09-02 | 2004-03-25 | Carnegie Mellon University | Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt |
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DE69407467T2 (de) * | 1993-04-12 | 1998-04-16 | Ibiden Co Ltd | Harzzusammensetzungen und diese verwendende Leiterplatten |
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JP3399598B2 (ja) * | 1993-09-17 | 2003-04-21 | イビデン株式会社 | N−部分置換アミノグリカンを用いた免疫測定用標識試薬 |
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US5622821A (en) * | 1994-06-29 | 1997-04-22 | The Regents Of The University Of California | Luminescent lanthanide chelates and methods of use |
DE69632244T2 (de) * | 1995-01-30 | 2005-04-14 | Daiichi Pure Chemicals Co. Ltd. | Diagnostisches Markierungsmittel |
-
1997
- 1997-01-10 US US08/781,326 patent/US6027709A/en not_active Expired - Lifetime
-
1998
- 1998-01-08 EP EP98903434A patent/EP1019887B1/de not_active Expired - Lifetime
- 1998-01-08 WO PCT/US1998/000475 patent/WO1998030992A2/en active IP Right Grant
- 1998-01-08 DE DE69812982T patent/DE69812982T2/de not_active Expired - Lifetime
- 1998-01-08 CA CA002278313A patent/CA2278313C/en not_active Expired - Lifetime
- 1998-01-08 JP JP53116298A patent/JP4361138B2/ja not_active Expired - Lifetime
- 1998-01-08 AU AU60206/98A patent/AU739930B2/en not_active Ceased
- 1998-01-08 AT AT98903434T patent/ATE236442T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2001511195A (ja) | 2001-08-07 |
EP1019887A2 (de) | 2000-07-19 |
CA2278313C (en) | 2008-03-18 |
EP1019887B1 (de) | 2003-04-02 |
AU6020698A (en) | 1998-08-03 |
DE69812982T2 (de) | 2003-11-13 |
US6027709A (en) | 2000-02-22 |
DE69812982D1 (de) | 2003-05-08 |
WO1998030992A3 (en) | 1998-11-12 |
WO1998030992A2 (en) | 1998-07-16 |
AU739930B2 (en) | 2001-10-25 |
CA2278313A1 (en) | 1998-07-16 |
JP4361138B2 (ja) | 2009-11-11 |
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