DE60004377T2 - Oral wirksame 7-alpha-alkyl androgene - Google Patents

Oral wirksame 7-alpha-alkyl androgene Download PDF

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Publication number
DE60004377T2
DE60004377T2 DE60004377T DE60004377T DE60004377T2 DE 60004377 T2 DE60004377 T2 DE 60004377T2 DE 60004377 T DE60004377 T DE 60004377T DE 60004377 T DE60004377 T DE 60004377T DE 60004377 T2 DE60004377 T2 DE 60004377T2
Authority
DE
Germany
Prior art keywords
alkyl
ethyl
compound
ethenyl
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60004377T
Other languages
German (de)
English (en)
Other versions
DE60004377D1 (de
Inventor
Jaap Louw Van Der
Dirk Leysen
Roberta Buma Bursi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE60004377D1 publication Critical patent/DE60004377D1/de
Publication of DE60004377T2 publication Critical patent/DE60004377T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DE60004377T 1999-04-06 2000-03-31 Oral wirksame 7-alpha-alkyl androgene Expired - Lifetime DE60004377T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99201070 1999-04-06
EP99201070 1999-04-06
PCT/EP2000/002851 WO2000059920A2 (en) 1999-04-06 2000-03-31 Orally active 7.alpha.-alkyl androgens

Publications (2)

Publication Number Publication Date
DE60004377D1 DE60004377D1 (de) 2003-09-11
DE60004377T2 true DE60004377T2 (de) 2004-06-09

Family

ID=8240066

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60004377T Expired - Lifetime DE60004377T2 (de) 1999-04-06 2000-03-31 Oral wirksame 7-alpha-alkyl androgene

Country Status (10)

Country Link
US (2) US6756366B1 (https=)
EP (1) EP1212345B1 (https=)
JP (1) JP2002541153A (https=)
AT (1) ATE246703T1 (https=)
AU (1) AU5209600A (https=)
CO (1) CO5160345A1 (https=)
DE (1) DE60004377T2 (https=)
ES (1) ES2204613T3 (https=)
PE (1) PE20010029A1 (https=)
WO (1) WO2000059920A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
US20050090476A1 (en) * 2002-01-21 2005-04-28 Arnoldus Maria Van Buggenum Patrick Process for the preparation of 7alpha-methylsteroids
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
EP2278880B1 (en) * 2008-04-09 2012-10-10 Pherin Pharmaceuticals, Inc. Steroid treatment for hot flashes
CN103347525A (zh) * 2010-12-15 2013-10-09 哈博生物科学公司 制备3α-氧取代的甾族化合物的方法及化合物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755689A (fr) * 1969-09-03 1971-03-03 Upjohn Co Procede de fabrication de nouvelles 7 beta-alkyl-19- nortestosterones
US5342834A (en) * 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
US6037339A (en) * 1993-02-08 2000-03-14 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
EP0613687B1 (en) * 1993-03-05 1999-06-02 Akzo Nobel N.V. Use of a pregnane derivatives for the treatment of tumours
IL113816A (en) * 1994-06-08 1998-12-06 Akzo Nobel Nv Pharmaceutical compositions containing desogestrel their preparation and use
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
DE69620607T2 (de) * 1995-06-22 2002-09-19 Akzo Nobel N.V., Arnheim/Arnhem Trockengranulierte gepresste tabletten enthaltend desogestrel
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
IL119468A (en) * 1995-11-06 2000-02-29 Akzo Nobel Nv Method of isomerisation of equilin or derivatives thereof
US5998639A (en) * 1995-11-06 1999-12-07 Akzo Nobel, N.V. Sulfatation of estrogen mixtures
CA2200423C (en) * 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
IL123195A (en) * 1997-02-21 2002-11-10 Akzo Nobel Nv Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them
WO1998052965A1 (en) * 1997-05-16 1998-11-26 Akzo Nobel N.V. 20-ARALKYL-5α-PREGNANE DERIVATIVES
TR199902873T2 (xx) * 1997-06-04 2000-04-21 Akzo Nobel N.V. Miyozun mod�lasyonu i�in 17�-aliloksi(tiyo)alkil-androstan t�revleri.
DE69702985T2 (de) * 1997-09-23 2001-02-15 Akzo Nobel N.V., Arnheim/Arnhem Steroid enthaltende Dosierungsformen mit einer steroiddichten Umhüllung
US6080773A (en) * 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
TR200001334T2 (tr) * 1997-11-14 2000-09-21 Akzo Nobel N.V. Progestojen-anti-progestojen rejimleri.
JP2001526293A (ja) * 1997-12-18 2001-12-18 アクゾ・ノベル・エヌ・ベー １７β−アリール（アリールメチル）オキシ（チオ）アルキル−アンドロスタン誘導体
RU2198873C2 (ru) * 1998-02-26 2003-02-20 Акцо Нобель Н.В. Производные азетидина и пирролидина
DE69901250T2 (de) * 1998-06-19 2002-10-17 Akzo Nobel N.V., Arnheim/Arnhem 7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität
US6528501B1 (en) * 1998-12-11 2003-03-04 Akzo Nobel N.V. 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
WO2000053618A1 (en) * 1999-03-09 2000-09-14 Akzo Nobel N.V. 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
TW548277B (en) * 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
CZ2002831A3 (cs) * 1999-09-06 2002-05-15 Akzo Nobel N. V. Nearomatické estrogenní steroidy
ES2258037T3 (es) * 1999-12-02 2006-08-16 Akzo Nobel N.V. Androgenos sustituidos con 14,15-beta-metilen.
JP2003528858A (ja) * 2000-03-27 2003-09-30 アクゾ・ノベル・エヌ・ベー エストロゲン関連治療用のノンステロイド系四環式化合物
CZ2003514A3 (cs) * 2000-08-23 2003-10-15 Akzo Nobel N. V. Fluorenové deriváty a jejich analogy

Also Published As

Publication number Publication date
ES2204613T3 (es) 2004-05-01
WO2000059920A3 (en) 2001-02-15
JP2002541153A (ja) 2002-12-03
US6756366B1 (en) 2004-06-29
ATE246703T1 (de) 2003-08-15
CO5160345A1 (es) 2002-05-30
EP1212345A2 (en) 2002-06-12
PE20010029A1 (es) 2001-01-26
AU5209600A (en) 2000-10-23
US20040209853A1 (en) 2004-10-21
EP1212345B1 (en) 2003-08-06
WO2000059920A2 (en) 2000-10-12
DE60004377D1 (de) 2003-09-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: N.V. ORGANON, OSS, NL