ATE246703T1 - Oral wirksame 7-alpha-alkyl androgene - Google Patents
Oral wirksame 7-alpha-alkyl androgeneInfo
- Publication number
- ATE246703T1 ATE246703T1 AT00936686T AT00936686T ATE246703T1 AT E246703 T1 ATE246703 T1 AT E246703T1 AT 00936686 T AT00936686 T AT 00936686T AT 00936686 T AT00936686 T AT 00936686T AT E246703 T1 ATE246703 T1 AT E246703T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- androgens
- alpha
- hydrogen
- oral active
- Prior art date
Links
- 239000003098 androgen Substances 0.000 title abstract 2
- 229940030486 androgens Drugs 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- YSGQGNQWBLYHPE-CFUSNLFHSA-N (7r,8r,9s,10r,13s,14s,17s)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-one Chemical class C1C[C@]2(C)[C@@H](O)CC[C@H]2[C@@H]2[C@H](C)CC3=CC(=O)CC[C@@H]3[C@H]21 YSGQGNQWBLYHPE-CFUSNLFHSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99201070 | 1999-04-06 | ||
| PCT/EP2000/002851 WO2000059920A2 (en) | 1999-04-06 | 2000-03-31 | Orally active 7.alpha.-alkyl androgens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE246703T1 true ATE246703T1 (de) | 2003-08-15 |
Family
ID=8240066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00936686T ATE246703T1 (de) | 1999-04-06 | 2000-03-31 | Oral wirksame 7-alpha-alkyl androgene |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6756366B1 (https=) |
| EP (1) | EP1212345B1 (https=) |
| JP (1) | JP2002541153A (https=) |
| AT (1) | ATE246703T1 (https=) |
| AU (1) | AU5209600A (https=) |
| CO (1) | CO5160345A1 (https=) |
| DE (1) | DE60004377T2 (https=) |
| ES (1) | ES2204613T3 (https=) |
| PE (1) | PE20010029A1 (https=) |
| WO (1) | WO2000059920A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1212345B1 (en) * | 1999-04-06 | 2003-08-06 | Akzo Nobel N.V. | Orally active 7-alpha-alkyl androgens |
| DE10104327A1 (de) * | 2001-01-24 | 2002-07-25 | Schering Ag | 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate |
| US20050090476A1 (en) * | 2002-01-21 | 2005-04-28 | Arnoldus Maria Van Buggenum Patrick | Process for the preparation of 7alpha-methylsteroids |
| GB0304927D0 (en) | 2003-03-04 | 2003-04-09 | Resolution Chemicals Ltd | Process for the production of tibolone |
| PE20050677A1 (es) | 2003-12-22 | 2005-10-04 | Akzo Nobel Nv | Esteroides con perfil androgenico y progestagenico mixto |
| EP2278880B1 (en) * | 2008-04-09 | 2012-10-10 | Pherin Pharmaceuticals, Inc. | Steroid treatment for hot flashes |
| CN103347525A (zh) * | 2010-12-15 | 2013-10-09 | 哈博生物科学公司 | 制备3α-氧取代的甾族化合物的方法及化合物 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE755689A (fr) * | 1969-09-03 | 1971-03-03 | Upjohn Co | Procede de fabrication de nouvelles 7 beta-alkyl-19- nortestosterones |
| US5342834A (en) * | 1989-04-07 | 1994-08-30 | The Population Council, Inc. | Method for androgen supplementation |
| US5395627A (en) * | 1992-09-04 | 1995-03-07 | Akzo N.V. | Pharmaceutical granulate |
| US6037339A (en) * | 1993-02-08 | 2000-03-14 | Akzo Nobel N.V. | C-11 substituted steroids for treating menopausal complaints |
| EP0613687B1 (en) * | 1993-03-05 | 1999-06-02 | Akzo Nobel N.V. | Use of a pregnane derivatives for the treatment of tumours |
| IL113816A (en) * | 1994-06-08 | 1998-12-06 | Akzo Nobel Nv | Pharmaceutical compositions containing desogestrel their preparation and use |
| CA2159419C (en) * | 1994-10-17 | 2006-07-04 | Pieter De Haan | Solid pharmaceutical composition comprising an excipient capable of binding water |
| DE69620607T2 (de) * | 1995-06-22 | 2002-09-19 | Akzo Nobel N.V., Arnheim/Arnhem | Trockengranulierte gepresste tabletten enthaltend desogestrel |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| IL119468A (en) * | 1995-11-06 | 2000-02-29 | Akzo Nobel Nv | Method of isomerisation of equilin or derivatives thereof |
| US5998639A (en) * | 1995-11-06 | 1999-12-07 | Akzo Nobel, N.V. | Sulfatation of estrogen mixtures |
| CA2200423C (en) * | 1996-03-26 | 2006-12-19 | Sietse Mosselman | Novel estrogen receptor |
| US6506390B2 (en) * | 1996-06-25 | 2003-01-14 | Akzo Nobel | Progestogen-anti-progestogen regimens |
| IL123195A (en) * | 1997-02-21 | 2002-11-10 | Akzo Nobel Nv | Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them |
| WO1998052965A1 (en) * | 1997-05-16 | 1998-11-26 | Akzo Nobel N.V. | 20-ARALKYL-5α-PREGNANE DERIVATIVES |
| TR199902873T2 (xx) * | 1997-06-04 | 2000-04-21 | Akzo Nobel N.V. | Miyozun mod�lasyonu i�in 17�-aliloksi(tiyo)alkil-androstan t�revleri. |
| DE69702985T2 (de) * | 1997-09-23 | 2001-02-15 | Akzo Nobel N.V., Arnheim/Arnhem | Steroid enthaltende Dosierungsformen mit einer steroiddichten Umhüllung |
| US6080773A (en) * | 1997-10-14 | 2000-06-27 | Akzo Nobel, N.V. | Benzylamine derivatives which are useful in treating psychiatric disorders |
| TR200001334T2 (tr) * | 1997-11-14 | 2000-09-21 | Akzo Nobel N.V. | Progestojen-anti-progestojen rejimleri. |
| JP2001526293A (ja) * | 1997-12-18 | 2001-12-18 | アクゾ・ノベル・エヌ・ベー | １７β−アリール（アリールメチル）オキシ（チオ）アルキル−アンドロスタン誘導体 |
| RU2198873C2 (ru) * | 1998-02-26 | 2003-02-20 | Акцо Нобель Н.В. | Производные азетидина и пирролидина |
| DE69901250T2 (de) * | 1998-06-19 | 2002-10-17 | Akzo Nobel N.V., Arnheim/Arnhem | 7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität |
| US6528501B1 (en) * | 1998-12-11 | 2003-03-04 | Akzo Nobel N.V. | 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity |
| US6498153B1 (en) * | 1998-12-31 | 2002-12-24 | Akzo Nobel N.V. | Extended release growth promoting two component composition |
| WO2000053618A1 (en) * | 1999-03-09 | 2000-09-14 | Akzo Nobel N.V. | 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis |
| EP1212345B1 (en) * | 1999-04-06 | 2003-08-06 | Akzo Nobel N.V. | Orally active 7-alpha-alkyl androgens |
| TW548277B (en) * | 1999-07-16 | 2003-08-21 | Akzo Nobel Nv | Orally active androgens |
| CZ2002831A3 (cs) * | 1999-09-06 | 2002-05-15 | Akzo Nobel N. V. | Nearomatické estrogenní steroidy |
| ES2258037T3 (es) * | 1999-12-02 | 2006-08-16 | Akzo Nobel N.V. | Androgenos sustituidos con 14,15-beta-metilen. |
| JP2003528858A (ja) * | 2000-03-27 | 2003-09-30 | アクゾ・ノベル・エヌ・ベー | エストロゲン関連治療用のノンステロイド系四環式化合物 |
| CZ2003514A3 (cs) * | 2000-08-23 | 2003-10-15 | Akzo Nobel N. V. | Fluorenové deriváty a jejich analogy |
-
2000
- 2000-03-31 EP EP00936686A patent/EP1212345B1/en not_active Expired - Lifetime
- 2000-03-31 US US09/937,274 patent/US6756366B1/en not_active Expired - Fee Related
- 2000-03-31 JP JP2000609430A patent/JP2002541153A/ja active Pending
- 2000-03-31 WO PCT/EP2000/002851 patent/WO2000059920A2/en not_active Ceased
- 2000-03-31 AT AT00936686T patent/ATE246703T1/de not_active IP Right Cessation
- 2000-03-31 ES ES00936686T patent/ES2204613T3/es not_active Expired - Lifetime
- 2000-03-31 DE DE60004377T patent/DE60004377T2/de not_active Expired - Lifetime
- 2000-03-31 AU AU52096/00A patent/AU5209600A/en not_active Abandoned
- 2000-04-06 CO CO00025244A patent/CO5160345A1/es unknown
- 2000-04-06 PE PE2000000309A patent/PE20010029A1/es not_active Application Discontinuation
-
2004
- 2004-04-29 US US10/837,061 patent/US20040209853A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2204613T3 (es) | 2004-05-01 |
| DE60004377T2 (de) | 2004-06-09 |
| WO2000059920A3 (en) | 2001-02-15 |
| JP2002541153A (ja) | 2002-12-03 |
| US6756366B1 (en) | 2004-06-29 |
| CO5160345A1 (es) | 2002-05-30 |
| EP1212345A2 (en) | 2002-06-12 |
| PE20010029A1 (es) | 2001-01-26 |
| AU5209600A (en) | 2000-10-23 |
| US20040209853A1 (en) | 2004-10-21 |
| EP1212345B1 (en) | 2003-08-06 |
| WO2000059920A2 (en) | 2000-10-12 |
| DE60004377D1 (de) | 2003-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |