ES2204613T3 - Androgenos 7-alfa alquilo oralmente activos. - Google Patents

Androgenos 7-alfa alquilo oralmente activos.

Info

Publication number
ES2204613T3
ES2204613T3 ES00936686T ES00936686T ES2204613T3 ES 2204613 T3 ES2204613 T3 ES 2204613T3 ES 00936686 T ES00936686 T ES 00936686T ES 00936686 T ES00936686 T ES 00936686T ES 2204613 T3 ES2204613 T3 ES 2204613T3
Authority
ES
Spain
Prior art keywords
alkyl
ethyl
compound
ethenyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00936686T
Other languages
English (en)
Spanish (es)
Inventor
Jaap Louw Van Der
Dirk Leysen
Roberta Buma Bursi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of ES2204613T3 publication Critical patent/ES2204613T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0074—Esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ES00936686T 1999-04-06 2000-03-31 Androgenos 7-alfa alquilo oralmente activos. Expired - Lifetime ES2204613T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99201070 1999-04-06
EP99201070 1999-04-06

Publications (1)

Publication Number Publication Date
ES2204613T3 true ES2204613T3 (es) 2004-05-01

Family

ID=8240066

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00936686T Expired - Lifetime ES2204613T3 (es) 1999-04-06 2000-03-31 Androgenos 7-alfa alquilo oralmente activos.

Country Status (10)

Country Link
US (2) US6756366B1 (https=)
EP (1) EP1212345B1 (https=)
JP (1) JP2002541153A (https=)
AT (1) ATE246703T1 (https=)
AU (1) AU5209600A (https=)
CO (1) CO5160345A1 (https=)
DE (1) DE60004377T2 (https=)
ES (1) ES2204613T3 (https=)
PE (1) PE20010029A1 (https=)
WO (1) WO2000059920A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
DE10104327A1 (de) * 2001-01-24 2002-07-25 Schering Ag 11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
US20050090476A1 (en) * 2002-01-21 2005-04-28 Arnoldus Maria Van Buggenum Patrick Process for the preparation of 7alpha-methylsteroids
GB0304927D0 (en) 2003-03-04 2003-04-09 Resolution Chemicals Ltd Process for the production of tibolone
PE20050677A1 (es) 2003-12-22 2005-10-04 Akzo Nobel Nv Esteroides con perfil androgenico y progestagenico mixto
EP2278880B1 (en) * 2008-04-09 2012-10-10 Pherin Pharmaceuticals, Inc. Steroid treatment for hot flashes
CN103347525A (zh) * 2010-12-15 2013-10-09 哈博生物科学公司 制备3α-氧取代的甾族化合物的方法及化合物

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE755689A (fr) * 1969-09-03 1971-03-03 Upjohn Co Procede de fabrication de nouvelles 7 beta-alkyl-19- nortestosterones
US5342834A (en) * 1989-04-07 1994-08-30 The Population Council, Inc. Method for androgen supplementation
US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
US6037339A (en) * 1993-02-08 2000-03-14 Akzo Nobel N.V. C-11 substituted steroids for treating menopausal complaints
EP0613687B1 (en) * 1993-03-05 1999-06-02 Akzo Nobel N.V. Use of a pregnane derivatives for the treatment of tumours
IL113816A (en) * 1994-06-08 1998-12-06 Akzo Nobel Nv Pharmaceutical compositions containing desogestrel their preparation and use
CA2159419C (en) * 1994-10-17 2006-07-04 Pieter De Haan Solid pharmaceutical composition comprising an excipient capable of binding water
DE69620607T2 (de) * 1995-06-22 2002-09-19 Akzo Nobel N.V., Arnheim/Arnhem Trockengranulierte gepresste tabletten enthaltend desogestrel
IL118974A (en) * 1995-08-17 2001-09-13 Akzo Nobel Nv History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
IL119468A (en) * 1995-11-06 2000-02-29 Akzo Nobel Nv Method of isomerisation of equilin or derivatives thereof
US5998639A (en) * 1995-11-06 1999-12-07 Akzo Nobel, N.V. Sulfatation of estrogen mixtures
CA2200423C (en) * 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
US6506390B2 (en) * 1996-06-25 2003-01-14 Akzo Nobel Progestogen-anti-progestogen regimens
IL123195A (en) * 1997-02-21 2002-11-10 Akzo Nobel Nv Steroid compounds with anti-pregnancy activity and against bone thinning, preparation and pharmaceutical preparations containing them
WO1998052965A1 (en) * 1997-05-16 1998-11-26 Akzo Nobel N.V. 20-ARALKYL-5α-PREGNANE DERIVATIVES
TR199902873T2 (xx) * 1997-06-04 2000-04-21 Akzo Nobel N.V. Miyozun mod�lasyonu i�in 17�-aliloksi(tiyo)alkil-androstan t�revleri.
DE69702985T2 (de) * 1997-09-23 2001-02-15 Akzo Nobel N.V., Arnheim/Arnhem Steroid enthaltende Dosierungsformen mit einer steroiddichten Umhüllung
US6080773A (en) * 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
TR200001334T2 (tr) * 1997-11-14 2000-09-21 Akzo Nobel N.V. Progestojen-anti-progestojen rejimleri.
JP2001526293A (ja) * 1997-12-18 2001-12-18 アクゾ・ノベル・エヌ・ベー １７β−アリール（アリールメチル）オキシ（チオ）アルキル−アンドロスタン誘導体
RU2198873C2 (ru) * 1998-02-26 2003-02-20 Акцо Нобель Н.В. Производные азетидина и пирролидина
DE69901250T2 (de) * 1998-06-19 2002-10-17 Akzo Nobel N.V., Arnheim/Arnhem 7.alpha.-methyl 19-nortestosteron undecanoat mit androgenischer aktivität
US6528501B1 (en) * 1998-12-11 2003-03-04 Akzo Nobel N.V. 22s-hydroxycholesta-8, 14-diene derivatives with meiosis regulating activity
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
WO2000053618A1 (en) * 1999-03-09 2000-09-14 Akzo Nobel N.V. 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
EP1212345B1 (en) * 1999-04-06 2003-08-06 Akzo Nobel N.V. Orally active 7-alpha-alkyl androgens
TW548277B (en) * 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
CZ2002831A3 (cs) * 1999-09-06 2002-05-15 Akzo Nobel N. V. Nearomatické estrogenní steroidy
ES2258037T3 (es) * 1999-12-02 2006-08-16 Akzo Nobel N.V. Androgenos sustituidos con 14,15-beta-metilen.
JP2003528858A (ja) * 2000-03-27 2003-09-30 アクゾ・ノベル・エヌ・ベー エストロゲン関連治療用のノンステロイド系四環式化合物
CZ2003514A3 (cs) * 2000-08-23 2003-10-15 Akzo Nobel N. V. Fluorenové deriváty a jejich analogy

Also Published As

Publication number Publication date
DE60004377T2 (de) 2004-06-09
WO2000059920A3 (en) 2001-02-15
JP2002541153A (ja) 2002-12-03
US6756366B1 (en) 2004-06-29
ATE246703T1 (de) 2003-08-15
CO5160345A1 (es) 2002-05-30
EP1212345A2 (en) 2002-06-12
PE20010029A1 (es) 2001-01-26
AU5209600A (en) 2000-10-23
US20040209853A1 (en) 2004-10-21
EP1212345B1 (en) 2003-08-06
WO2000059920A2 (en) 2000-10-12
DE60004377D1 (de) 2003-09-11

Similar Documents

Publication Publication Date Title
ES2213596T3 (es) Androgenos con una actividad oral.
US7196074B2 (en) Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof
ES2204613T3 (es) Androgenos 7-alfa alquilo oralmente activos.
JP2010529153A (ja) １７β−シアノ−１９−ノル−アンドロスタ−４−エン誘導体、その使用、及び当該誘導体を含む医薬
US6677329B1 (en) Non-aromatic estrogenic steroids with a hydrocarbon substituent in position 11
US6881728B1 (en) 14-β, 17-α-hydroxymethylandrostane derivatives as androgens
HUT73238A (en) 15,15-dialkyl-substituted derivatives of estradiol and pharmaceutical compositions containing the same
EP1846434B1 (en) NANDROLONE 17ß-CARBONATES
JP4279552B2 (ja) 新規アンドロゲンとしてのメチレンステロイド
AU2002258664B2 (en) Methods of making, using and pharmaceutical formulations comprising 7alpha, 11beta-dimethyl-17beta-hydroxyestra-4, 14-dien-3-one and 17-esters thereof
CN1481388A (zh) 具有雄激素-孕激素混合活性的14(15)-不饱和的15-和/或16-取代的雄激素类