DE4112440C1 - - Google Patents

Info

Publication number
DE4112440C1
DE4112440C1 DE4112440A DE4112440A DE4112440C1 DE 4112440 C1 DE4112440 C1 DE 4112440C1 DE 4112440 A DE4112440 A DE 4112440A DE 4112440 A DE4112440 A DE 4112440A DE 4112440 C1 DE4112440 C1 DE 4112440C1
Authority
DE
Germany
Prior art keywords
selection
nucleic acid
mutagenesis
cycle
acid sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE4112440A
Other languages
German (de)
English (en)
Inventor
Karsten Dr. 4006 Erkrath De Henco
Manfred Prof. Dr. 3400 Goettingen De Eigen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Diagen Institut fur Molekularbiologische Diagnostik 4000 Duesseldorf De GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6429722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE4112440(C1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diagen Institut fur Molekularbiologische Diagnostik 4000 Duesseldorf De GmbH filed Critical Diagen Institut fur Molekularbiologische Diagnostik 4000 Duesseldorf De GmbH
Priority to DE4112440A priority Critical patent/DE4112440C1/de
Priority to PCT/EP1992/000840 priority patent/WO1992018645A1/de
Priority to AT92908537T priority patent/ATE171479T1/de
Priority to JP50798892A priority patent/JP3504658B2/ja
Priority to EP92908537A priority patent/EP0583265B1/de
Priority to DE59209506T priority patent/DE59209506D1/de
Publication of DE4112440C1 publication Critical patent/DE4112440C1/de
Application granted granted Critical
Priority to US08/507,190 priority patent/US5795747A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ecology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE4112440A 1991-04-16 1991-04-16 Expired - Lifetime DE4112440C1 (show.php)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE4112440A DE4112440C1 (show.php) 1991-04-16 1991-04-16
EP92908537A EP0583265B1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren
AT92908537T ATE171479T1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren
JP50798892A JP3504658B2 (ja) 1991-04-16 1992-04-14 新規生体高分子の製造方法
PCT/EP1992/000840 WO1992018645A1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren
DE59209506T DE59209506D1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren
US08/507,190 US5795747A (en) 1991-04-16 1995-06-26 Process for manufacturing new biopolymers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4112440A DE4112440C1 (show.php) 1991-04-16 1991-04-16

Publications (1)

Publication Number Publication Date
DE4112440C1 true DE4112440C1 (show.php) 1992-10-22

Family

ID=6429722

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4112440A Expired - Lifetime DE4112440C1 (show.php) 1991-04-16 1991-04-16
DE59209506T Expired - Lifetime DE59209506D1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59209506T Expired - Lifetime DE59209506D1 (de) 1991-04-16 1992-04-14 Verfahren zur herstellung von neuen biopolymeren

Country Status (5)

Country Link
EP (1) EP0583265B1 (show.php)
JP (1) JP3504658B2 (show.php)
AT (1) ATE171479T1 (show.php)
DE (2) DE4112440C1 (show.php)
WO (1) WO1992018645A1 (show.php)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010572A1 (de) * 1992-11-05 1994-05-11 Evotec Biosystems Gmbh Trägermaterial zur simultanen bindung genotypischer und phänotypischer substanzen
US7235386B2 (en) 2001-02-02 2007-06-26 Large Scale Biology Corporation Method of increasing complementarity in a heteroduplex
US7273739B2 (en) 2002-02-01 2007-09-25 Padgett Hal S Nucleic acid molecules encoding endonucleases and methods of use thereof
US7582423B2 (en) 2001-02-02 2009-09-01 Novici Biotech Llc Population of polynucleotide sequence variants
US7838219B2 (en) 2001-02-02 2010-11-23 Novici Biotech Llc Method of increasing complementarity in a heteroduplex

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849545A (en) * 1992-05-11 1998-12-15 Evotec Biosystems Gmbh Substrate material for simultaneously binding genotypic and phenotypic substances
DE4343591A1 (de) * 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6995017B1 (en) 1994-02-17 2006-02-07 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US6165793A (en) * 1996-03-25 2000-12-26 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) * 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6309883B1 (en) 1994-02-17 2001-10-30 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
WO1996017056A1 (en) * 1994-12-02 1996-06-06 Institut Pasteur Hypermutagenesis
EP0714980A1 (en) * 1994-12-02 1996-06-05 Institut Pasteur Hypermutagenesis
US6406723B1 (en) 1997-04-09 2002-06-18 Danisco A/S Method for preparing flour doughs and products made from such doughs using glycerol oxidase and lipase
US6936289B2 (en) 1995-06-07 2005-08-30 Danisco A/S Method of improving the properties of a flour dough, a flour dough improving composition and improved food products
JPH1066577A (ja) * 1996-08-07 1998-03-10 Novo Nordisk As 核酸プールおよびその製造方法
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US6258558B1 (en) 1997-01-21 2001-07-10 The General Hospital Corporation Method for selection of proteins using RNA-protein fusions
US8207093B2 (en) 1997-01-21 2012-06-26 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US6153410A (en) * 1997-03-25 2000-11-28 California Institute Of Technology Recombination of polynucleotide sequences using random or defined primers
US6927025B1 (en) 1997-09-03 2005-08-09 Biovation Limited Methods for protein screening
AU754377B2 (en) * 1997-09-03 2002-11-14 Merck Patent Gesellschaft Mit Beschrankter Haftung Methods for protein screening
CA2302147C (en) * 1997-09-03 2008-05-13 Biovation Limited Methods for protein screening
EP2270234B1 (en) 1997-12-08 2013-03-06 California Institute of Technology Method for creating polynucleotide and polypeptide sequences
US7153655B2 (en) 1998-06-16 2006-12-26 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence
WO1999065927A2 (en) * 1998-06-17 1999-12-23 Maxygen, Inc. Method for producing polynucleotides with desired properties
US6846655B1 (en) 1998-06-29 2005-01-25 Phylos, Inc. Methods for generating highly diverse libraries
WO2000005396A1 (en) 1998-07-21 2000-02-03 Danisco A/S Foodstuff
CA2337490C (en) 1998-08-17 2012-01-03 Phylos, Inc. Identification of compound-protein interactions using libraries of protein-nucleic acid fusion molecules
DE19953854C2 (de) 1999-11-09 2002-01-17 Max Planck Gesellschaft Verfahren zur Herstellung von Biopolymeren mit veränderten Eigenschaften
DE60118527D1 (de) 2000-01-24 2006-05-18 Compound Therapeutics Inc Sensible und multiplexe diagnostische tests zur proteinanalyse
US7022479B2 (en) 2000-01-24 2006-04-04 Compound Therapeutics, Inc. Sensitive, multiplexed diagnostic assays for protein analysis
US6958213B2 (en) 2000-12-12 2005-10-25 Alligator Bioscience Ab Method for in vitro molecular evolution of protein function
US20020086292A1 (en) 2000-12-22 2002-07-04 Shigeaki Harayama Synthesis of hybrid polynucleotide molecules using single-stranded polynucleotide molecules
BR0209154A (pt) 2001-05-18 2004-07-20 Danisco Processo de preparação de uma massa com uma enzima
EP1840211A1 (en) 2001-10-31 2007-10-03 Danisco A/S Pyranosone dehydratase from phanerochaete chrysosporium
CA2485506C (en) 2002-05-17 2012-02-28 Alligator Bioscience Ab A method for in vitro molecular evolution of protein function
CN1668274B (zh) * 2002-07-17 2010-06-16 荷兰联合利华有限公司 包含支链醇的羧烷基化物和/或其烷氧基化物的皮肤护理美容组合物
MXPA05007653A (es) 2003-01-17 2005-09-30 Danisco Metodo.
JP4778887B2 (ja) 2003-01-17 2011-09-21 ダニスコ エイ／エス 脂質アシルトランスフェラーゼの使用
US20050196766A1 (en) 2003-12-24 2005-09-08 Soe Jorn B. Proteins
US7955814B2 (en) 2003-01-17 2011-06-07 Danisco A/S Method
AU2004249903B2 (en) 2003-06-18 2009-06-04 Bayer Schering Pharma Aktiengesellschaft New biological entities and the use thereof
KR101169265B1 (ko) 2003-12-24 2012-08-02 대니스코 에이/에스 단백질
US7718408B2 (en) 2003-12-24 2010-05-18 Danisco A/S Method
GB0716126D0 (en) 2007-08-17 2007-09-26 Danisco Process
GB0405637D0 (en) 2004-03-12 2004-04-21 Danisco Protein
CA2571694C (en) 2004-07-16 2014-09-02 Danisco A/S Enzymatic oil-degumming method
GB0421598D0 (en) 2004-09-29 2004-10-27 Cambridge Advanced Tech Modification of plant development and morphology
GB0422052D0 (en) 2004-10-04 2004-11-03 Dansico As Enzymes
GB0423139D0 (en) 2004-10-18 2004-11-17 Danisco Enzymes
US8846366B2 (en) 2006-12-14 2014-09-30 Dsm Ip Assets Bv R-hydroxynitrile lyase (R-HNL) random variants and their use for preparing optically pure, sterically hindered cyanohydrins
CA2673954C (en) 2007-01-25 2015-09-15 Danisco A/S Production of a lipid acyltransferase from transformed bacillus licheniformis cells
US8143046B2 (en) 2007-02-07 2012-03-27 Danisco Us Inc., Genencor Division Variant Buttiauxella sp. phytases having altered properties
US20080220498A1 (en) 2007-03-06 2008-09-11 Cervin Marguerite A Variant Buttiauxella sp. phytases having altered properties
WO2008150376A1 (en) 2007-05-21 2008-12-11 Danisco Us, Inc., Genencor Division Use of an aspartic protease (nsp24) signal sequence for heterologous protein expression
CA2721691C (en) 2008-04-18 2019-07-09 Danisco Us Inc. Buttiauxella sp. phytase variants
CN102083996A (zh) 2008-04-30 2011-06-01 丹尼斯科公司 氧化方法
GB0908770D0 (en) 2009-04-24 2009-07-01 Danisco Method
CN102428177B (zh) 2009-05-19 2015-01-14 杜邦营养生物科学有限公司 提高面包耐码垛性的方法及其产品
AR077042A1 (es) 2009-06-12 2011-07-27 Danisco Metodo para tratar una composicion que contiene pirofiofitina
GB0920089D0 (en) 2009-11-17 2009-12-30 Danisco Method
JP5795331B2 (ja) 2010-01-13 2015-10-14 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 新規マンナナーゼ変異体
AR080293A1 (es) 2010-03-12 2012-03-28 Danisco Proceso de refinamiento de un aceite vegetal
WO2011114251A1 (en) 2010-03-18 2011-09-22 Danisco A/S Foodstuff
US20130085287A1 (en) 2010-06-17 2013-04-04 Dupont Nutrition Biosciences Aps Process
GB201011513D0 (en) 2010-07-08 2010-08-25 Danisco Method
WO2012114232A1 (en) 2011-02-23 2012-08-30 Dupont Nutrition Biosciences Aps Process
EP2678438B1 (en) 2011-02-23 2017-07-05 DuPont Nutrition Biosciences ApS Enzymatic treatment of chlorophyll in plant oils
AR085253A1 (es) 2011-02-23 2013-09-18 Danisco Metodo para producir una clorofilasa
KR20140024365A (ko) 2011-04-08 2014-02-28 다니스코 유에스 인크. 조성물
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
WO2013104659A2 (en) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Process
WO2013104660A1 (en) 2012-01-13 2013-07-18 Dupont Nutrition Biosciences Aps Process for treating a plant oil comprising hydrolysing chlorophyll or a chlorophyll derivative and involving partial caustic neutralisation
WO2013160374A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for refining crude plant oil involving enzymatic hydrolysis and gum recycling
WO2013160372A1 (en) 2012-04-27 2013-10-31 Dupont Nutrition Biosciences Aps Process for treating plant oil involving addition of serial doses of chlorophyll or chlorophyll derivative degrading enzyme
EP2909230B1 (en) 2012-10-19 2019-05-22 Danisco US Inc. Stabilization of biomimetic membranes
EP3083936B1 (en) 2013-12-19 2018-07-04 Danisco US Inc. Use of hydrophobins to increase gas transfer in aerobic fermentation processes
EP3126509A1 (en) 2014-04-01 2017-02-08 DuPont Nutrition Biosciences ApS Method for increasing crude palm oil yields
EP3172329A1 (en) 2014-10-24 2017-05-31 Danisco US Inc. Method for producing alcohol by use of a tripeptidyl peptidase
CA2965423A1 (en) 2014-10-24 2016-04-28 Dupont Nutrition Biosciences Aps Proline tolerant tripeptidyl peptidases and uses thereof
JP2018518976A (ja) 2015-06-26 2018-07-19 デュポン ニュートリション バイオサイエンシス エーピーエス タンパク質加水分解用アミノペプチダーゼ
EP3420097A1 (en) 2016-02-25 2019-01-02 DuPont Nutrition Biosciences ApS Method for producing a protein hydrolysate employing an aspergillus fumigatus tripeptidyl peptidase
DE102023001827A1 (de) 2023-04-19 2024-10-24 Horst Wochnowski Verfahren und dazugehörige Vorrichtung zum Züchten von in Gewässern Mikroplastik zersetzenden und abbauenden Mikroorganismenstämme durch einen künstlich herbeigeführten und beschleunigten Evolutions- und Selektionsprozess

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0285123A3 (en) * 1987-04-03 1989-02-01 Stabra AG A method for complete mutagenesis of nucleic acids
KR0185192B1 (ko) * 1989-10-05 1999-04-01 제임스 더블유. 데이비 신규의 유전자 및 폴리펩티드의 무세포 합성 및 분리
WO1992002536A1 (en) * 1990-08-02 1992-02-20 The Regents Of The University Of Colorado Systematic polypeptide evolution by reverse translation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS ERMITTELT *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010572A1 (de) * 1992-11-05 1994-05-11 Evotec Biosystems Gmbh Trägermaterial zur simultanen bindung genotypischer und phänotypischer substanzen
US7235386B2 (en) 2001-02-02 2007-06-26 Large Scale Biology Corporation Method of increasing complementarity in a heteroduplex
US7582423B2 (en) 2001-02-02 2009-09-01 Novici Biotech Llc Population of polynucleotide sequence variants
US7833759B2 (en) 2001-02-02 2010-11-16 Novici Biotech Llc Method of increasing complementarity in a heteroduplex
US7838219B2 (en) 2001-02-02 2010-11-23 Novici Biotech Llc Method of increasing complementarity in a heteroduplex
US7273739B2 (en) 2002-02-01 2007-09-25 Padgett Hal S Nucleic acid molecules encoding endonucleases and methods of use thereof

Also Published As

Publication number Publication date
ATE171479T1 (de) 1998-10-15
EP0583265A1 (de) 1994-02-23
WO1992018645A1 (de) 1992-10-29
DE59209506D1 (de) 1998-10-29
JP3504658B2 (ja) 2004-03-08
JPH06506355A (ja) 1994-07-21
EP0583265B1 (de) 1998-09-23

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Legal Events

Date Code Title Description
8100 Publication of patent without earlier publication of application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: EVOTEC BIOSYSTEMS GMBH, 22529 HAMBURG, DE

8327 Change in the person/name/address of the patent owner

Owner name: EVOTEC BIOSYSTEMS AG, 22525 HAMBURG, DE

8327 Change in the person/name/address of the patent owner

Owner name: EVOTEC OAI AG, 22525 HAMBURG, DE

8327 Change in the person/name/address of the patent owner

Owner name: DIREVO BIOTECH, 50829 KOELN, DE

R071 Expiry of right