DE4035961A1 - Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung - Google Patents

Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Info

Publication number
DE4035961A1
DE4035961A1 DE4035961A DE4035961A DE4035961A1 DE 4035961 A1 DE4035961 A1 DE 4035961A1 DE 4035961 A DE4035961 A DE 4035961A DE 4035961 A DE4035961 A DE 4035961A DE 4035961 A1 DE4035961 A1 DE 4035961A1
Authority
DE
Germany
Prior art keywords
group
carbon atoms
alkyl
substituted
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE4035961A
Other languages
German (de)
English (en)
Inventor
Frank Dipl Chem Dr Himmelsbach
Volkhard Dipl Chem Dr Austel
Helmut Dipl Chem Dr Pieper
Wolfgang Prof Dr Dr Dr Eisert
Thomas Dipl Chem Dr Mueller
Johannes Dipl Che Weisenberger
Guenter Dipl Chem Dr Linz
Gerd Dipl Chem Dr Krueger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE4035961A priority Critical patent/DE4035961A1/de
Priority to DK91118148T priority patent/DK0483667T3/da
Priority to ES91118148T priority patent/ES2113867T3/es
Priority to AT91118148T priority patent/ATE163008T1/de
Priority to EP91118148A priority patent/EP0483667B1/de
Priority to SG9601241A priority patent/SG81852A1/en
Priority to DE59108930T priority patent/DE59108930D1/de
Priority to PT99402A priority patent/PT99402B/pt
Priority to FI915136A priority patent/FI107606B/fi
Priority to CA002054850A priority patent/CA2054850C/en
Priority to NO914294A priority patent/NO174806B/no
Priority to JP3313154A priority patent/JP2937589B2/ja
Priority to AU86926/91A priority patent/AU650488C/en
Priority to HU913455A priority patent/HUT67288A/hu
Priority to IE382291A priority patent/IE913822A1/en
Priority to SU915001905A priority patent/RU2040519C1/ru
Priority to IL9992691A priority patent/IL99926A/en
Priority to KR1019910019458A priority patent/KR100223135B1/ko
Priority to NZ240463A priority patent/NZ240463A/en
Priority to ZA918734A priority patent/ZA918734B/xx
Publication of DE4035961A1 publication Critical patent/DE4035961A1/de
Priority to MX9203677A priority patent/MX9203677A/es
Priority to BG098416A priority patent/BG62025B2/bg
Priority to EE9400438A priority patent/EE03099B1/xx
Priority to US08/365,336 priority patent/US5541343A/en
Priority to US08/458,096 priority patent/US5591769A/en
Priority to HU95P/P00156P priority patent/HU211563A9/hu
Priority to BR1100445-2A priority patent/BR1100445A/pt
Priority to GR980400691T priority patent/GR3026508T3/el
Priority to HK98109250.9A priority patent/HK1008742B/xx
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Detergent Compositions (AREA)
DE4035961A 1990-11-02 1990-11-02 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung Ceased DE4035961A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE4035961A DE4035961A1 (de) 1990-11-02 1990-11-02 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DK91118148T DK0483667T3 (da) 1990-11-02 1991-10-24 Cykliske iminoderivater, lægemidler indholdende disse forbindelser og fremgangsmåde til fremstilling deraf
ES91118148T ES2113867T3 (es) 1990-11-02 1991-10-24 Imino-derivados ciclicos, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
AT91118148T ATE163008T1 (de) 1990-11-02 1991-10-24 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP91118148A EP0483667B1 (de) 1990-11-02 1991-10-24 Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
SG9601241A SG81852A1 (en) 1990-11-02 1991-10-24 Cyclic imino derivatives, pharmaceutical compositions containing these compounds and process for preparing them
DE59108930T DE59108930D1 (de) 1990-11-02 1991-10-24 Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PT99402A PT99402B (pt) 1990-11-02 1991-10-31 Processo para a preparacao de derivados de imino ciclicos e de composicoes farmaceuticas que os contem
FI915136A FI107606B (fi) 1990-11-02 1991-10-31 Menetelmä valmistaa farmaseuttisesti arvokkaita 1-, 3-, 5-substituoituja pyrrolidin-2-oneja
IE382291A IE913822A1 (en) 1990-11-02 1991-11-01 Cyclic imino derivatives
IL9992691A IL99926A (en) 1990-11-02 1991-11-01 Cyclo imino derivatives their preparation and pharmaceutical compositions containing them
NO914294A NO174806B (no) 1990-11-02 1991-11-01 Analogifremgangsmåte for fremstilling av cykliske iminoderivater
JP3313154A JP2937589B2 (ja) 1990-11-02 1991-11-01 環状イミノ誘導体、これらの化合物を含む製薬組成物及びそれらの調製方法
AU86926/91A AU650488C (en) 1990-11-02 1991-11-01 Cyclic imino derivatives
HU913455A HUT67288A (en) 1990-11-02 1991-11-01 Process for producing cyclic imino derivatives and pharmaceutical compositions comprising them
CA002054850A CA2054850C (en) 1990-11-02 1991-11-01 Cyclic imino derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
SU915001905A RU2040519C1 (ru) 1990-11-02 1991-11-01 Циклические иминопроизводные, их смеси изомеров, энантиомеры, диастереомеры или физиологически переносимые соли, обладающие противотромботическим действием
KR1019910019458A KR100223135B1 (ko) 1990-11-02 1991-11-02 사이클릭아미노유도체,이를함유하는약제학적조성물및이의제조방법
NZ240463A NZ240463A (en) 1990-11-02 1991-11-04 Cyclic imino derivatives, especially pyrrolidine derivatives, and pharmaceutical compositions
ZA918734A ZA918734B (en) 1990-11-02 1991-11-04 Cyclic imino derivatives, pharmaceutical compositions containing these compounds and processes for preparing them.
MX9203677A MX9203677A (es) 1990-11-02 1992-06-29 Derivados ciclicos, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
BG098416A BG62025B2 (bg) 1990-11-02 1994-01-25 Циклични иминопроизводни,лекарствени средства,съдържащи тези съединения,и метод за тяхното получаване
EE9400438A EE03099B1 (et) 1990-11-02 1994-11-23 Tsüklilised iminoderivaadid, neid ühendeid sisaldavad ravimid ja meetodid nende saamiseks
US08/365,336 US5541343A (en) 1990-11-02 1994-12-28 Cyclic imino derivatives and pharmaceutical compositions containing them
US08/458,096 US5591769A (en) 1990-11-02 1995-06-01 Cyclic imino derivatives and pharmaceutical compositions containing them
HU95P/P00156P HU211563A9 (en) 1990-11-02 1995-06-02 5-membered cyclic alkyleneimino derivatives
BR1100445-2A BR1100445A (pt) 1990-11-02 1997-05-06 Derivados imino cìclicos, composições farmacêuticas contendo estes compostos e processo para sua preparação
GR980400691T GR3026508T3 (en) 1990-11-02 1998-04-03 Cyclic imino derivatives, process for their preparation and drugs containing them
HK98109250.9A HK1008742B (en) 1990-11-02 1998-07-17 Cyclic imino derivatives, process for their preparation and drugs containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4035961A DE4035961A1 (de) 1990-11-02 1990-11-02 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
DE4035961A1 true DE4035961A1 (de) 1992-05-07

Family

ID=6418111

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4035961A Ceased DE4035961A1 (de) 1990-11-02 1990-11-02 Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE59108930T Expired - Lifetime DE59108930D1 (de) 1990-11-02 1991-10-24 Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59108930T Expired - Lifetime DE59108930D1 (de) 1990-11-02 1991-10-24 Cyclische Iminoderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Country Status (24)

Country Link
US (2) US5541343A (enExample)
EP (1) EP0483667B1 (enExample)
JP (1) JP2937589B2 (enExample)
KR (1) KR100223135B1 (enExample)
AT (1) ATE163008T1 (enExample)
BG (1) BG62025B2 (enExample)
BR (1) BR1100445A (enExample)
CA (1) CA2054850C (enExample)
DE (2) DE4035961A1 (enExample)
DK (1) DK0483667T3 (enExample)
EE (1) EE03099B1 (enExample)
ES (1) ES2113867T3 (enExample)
FI (1) FI107606B (enExample)
GR (1) GR3026508T3 (enExample)
HU (2) HUT67288A (enExample)
IE (1) IE913822A1 (enExample)
IL (1) IL99926A (enExample)
MX (1) MX9203677A (enExample)
NO (1) NO174806B (enExample)
NZ (1) NZ240463A (enExample)
PT (1) PT99402B (enExample)
RU (1) RU2040519C1 (enExample)
SG (1) SG81852A1 (enExample)
ZA (1) ZA918734B (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0567967B1 (de) * 1992-04-28 1996-07-10 Dr. Karl Thomae GmbH Tritiumarkierte Fibrinogen-Rezeptor-Antagonisten, deren Verwendung und Verfahren zur ihrer Herstellung
DE4213931A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4241632A1 (de) * 1992-12-10 1994-06-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5314902A (en) * 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
ATE195117T1 (de) * 1993-03-31 2000-08-15 Searle & Co 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
DE4424975A1 (de) * 1994-07-15 1996-01-18 Thomae Gmbh Dr K 2-Piperidinone, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
PL321003A1 (en) * 1994-12-23 1997-11-24 Thomae Gmbh Dr K Derivatives of piperasine, drugs containing them, their application and methods of obtaining them
CA2216162A1 (en) * 1995-04-26 1996-10-31 Takeda Chemical Industries, Ltd. Piperazinones useful as inhibitors of platelet aggregation
DE19515500A1 (de) * 1995-04-27 1996-10-31 Thomae Gmbh Dr K Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
DE19604191A1 (de) * 1996-02-06 1997-08-07 Hoechst Schering Agrevo Gmbh 2,4-Diamino-1,3,5-triazine, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19621483A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 2-Naphthoylguanidine, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19621482A1 (de) 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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WO1999011658A1 (en) * 1997-08-29 1999-03-11 Proteus Molecular Design Ltd. Meta-benzamidine derivatives as serin protease inhibitors
US6740682B2 (en) 1997-08-29 2004-05-25 Tularik Limited Meta-benzamidine derivatives as serine protease inhibitors
US5962504A (en) 1997-09-08 1999-10-05 Georgetown University Substituted 2-pyrrolidinone activators of PKC
KR20010032175A (ko) 1997-11-20 2001-04-16 야스이 쇼사꾸 비페닐아미딘 유도체
JP2003504301A (ja) 1998-04-01 2003-02-04 ブリストル−マイヤーズ スクイブ ファーマ カンパニー インテグリンアンタゴニスト
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
HUP0101137A3 (en) 1998-04-10 2003-03-28 Japan Tobacco Inc Anticoagulant amidines and their pharmaceutical use
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
CA2329422A1 (en) * 1998-04-23 1999-10-28 Abbott Laboratories Pyrrolidines as inhibitors of neuraminidases
ES2219033T3 (es) * 1998-07-22 2004-11-16 Daiichi Suntory Pharma Co., Ltd. Inhibidores de nf-kappa b que contienen derivados de indano como ingrediente activo.
US6284796B1 (en) * 1998-08-06 2001-09-04 Abbott Laboratories Ukokinase inhibitors
DE19844787A1 (de) * 1998-09-30 2000-04-13 Boehringer Ingelheim Pharma Disubstituierte Pyrrolidinone, diese Verbindung enthaltende Arzneimittel und deren Verwendung sowie ihre Herstellung
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US6489354B1 (en) 1999-03-02 2002-12-03 Merck & Co., Inc. 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity
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US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
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EP0483667A3 (en) 1992-09-16
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AU650488B2 (en) 1994-06-23
HK1008742A1 (en) 1999-05-14
EE03099B1 (et) 1998-06-15
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US5591769A (en) 1997-01-07
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PT99402A (pt) 1992-09-30
US5541343A (en) 1996-07-30
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IL99926A (en) 1996-06-18
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