|
US5773435A
(en)
*
|
1987-08-04 |
1998-06-30 |
Bristol-Myers Squibb Company |
Prodrugs for β-lactamase and uses thereof
|
|
NZ225599A
(en)
*
|
1987-08-04 |
1991-09-25 |
Bristol Myers Co |
Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells
|
|
US5851527A
(en)
*
|
1988-04-18 |
1998-12-22 |
Immunomedics, Inc. |
Method for antibody targeting of therapeutic agents
|
|
US5632990A
(en)
*
|
1988-04-22 |
1997-05-27 |
Cancer Research Campaign Tech. Ltd. |
Treatment for tumors comprising conjugated antibody A5B7 and a prodrug
|
|
GB8809616D0
(en)
*
|
1988-04-22 |
1988-05-25 |
Cancer Res Campaign Tech |
Further improvements relating to drug delivery systems
|
|
AU633867B2
(en)
*
|
1989-02-02 |
1993-02-11 |
Eli Lilly And Company |
Delivery of cytotoxic agents
|
|
GB8920011D0
(en)
*
|
1989-09-05 |
1989-10-18 |
Mann J |
New route of synthesis for tertiary butyl esters
|
|
US6610299B1
(en)
|
1989-10-19 |
2003-08-26 |
Aventis Pharma Deutschland Gmbh |
Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
|
|
DE3935016A1
(de)
*
|
1989-10-20 |
1991-04-25 |
Behringwerke Ag |
Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten
|
|
DE4106389A1
(de)
*
|
1991-02-28 |
1992-09-03 |
Behringwerke Ag |
Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung
|
|
US7241595B2
(en)
|
1989-10-20 |
2007-07-10 |
Sanofi-Aventis Pharma Deutschland Gmbh |
Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
|
|
US6475486B1
(en)
|
1990-10-18 |
2002-11-05 |
Aventis Pharma Deutschland Gmbh |
Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
|
|
AU649952B2
(en)
*
|
1989-12-11 |
1994-06-09 |
Immunomedics Inc. |
Method for antibody targeting of diagnostic or therapeutic agents
|
|
WO1991009134A1
(en)
*
|
1989-12-15 |
1991-06-27 |
Takeda Chemical Industries, Ltd. |
Biospecific antibody to cancer cell and enzyme with prodrug-activating characteristics
|
|
GB9001641D0
(en)
*
|
1990-01-24 |
1990-03-21 |
Imp Cancer Res Tech |
Compounds
|
|
DE4002888A1
(de)
*
|
1990-02-01 |
1991-08-08 |
Behringwerke Ag |
Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten
|
|
FR2676058B1
(fr)
*
|
1991-04-30 |
1994-02-25 |
Hoechst Lab |
Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
|
|
GB9200417D0
(en)
*
|
1992-01-09 |
1992-02-26 |
Bagshawe Kenneth D |
Cytotoxic drug therapy
|
|
GB9200415D0
(en)
*
|
1992-01-09 |
1992-02-26 |
Bagshawe Kenneth D |
Inactivation of cytotoxic drugs
|
|
GB9314960D0
(en)
*
|
1992-07-23 |
1993-09-01 |
Zeneca Ltd |
Chemical compounds
|
|
DE4233152A1
(de)
|
1992-10-02 |
1994-04-07 |
Behringwerke Ag |
Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung
|
|
DE4236237A1
(de)
*
|
1992-10-27 |
1994-04-28 |
Behringwerke Ag |
Prodrugs, ihre Herstellung und Verwendung als Arzneimittel
|
|
GB9308166D0
(en)
*
|
1993-04-20 |
1993-06-02 |
Cancer Res Campaign Tech |
Cancer therapy
|
|
US6461643B2
(en)
|
1993-04-22 |
2002-10-08 |
Emisphere Technologies, Inc. |
Oral drug delivery compositions and methods
|
|
US20010003001A1
(en)
|
1993-04-22 |
2001-06-07 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
GB9308957D0
(en)
*
|
1993-04-30 |
1993-06-16 |
Cancer Res Campaign Tech |
Novel produgs
|
|
US5502037A
(en)
*
|
1993-07-09 |
1996-03-26 |
Neuromed Technologies, Inc. |
Pro-cytotoxic drug conjugates for anticancer therapy
|
|
GB9323429D0
(en)
*
|
1993-11-12 |
1994-01-05 |
Wellcome Found |
Therapy
|
|
GB9324807D0
(en)
*
|
1993-12-03 |
1994-01-19 |
Cancer Res Campaign Tech |
Tumour antibody
|
|
GB9415167D0
(en)
|
1994-07-27 |
1994-09-14 |
Springer Caroline J |
Improvements relating to cancer therapy
|
|
DE69527805T2
(de)
*
|
1994-12-23 |
2003-04-24 |
Astrazeneca Ab, Soedertaelje |
Chemische mittel
|
|
GB9501052D0
(en)
*
|
1995-01-19 |
1995-03-08 |
Cancer Res Campaign Tech |
Improvements relating to prodrugs
|
|
US6001347A
(en)
|
1995-03-31 |
1999-12-14 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
AU707689B2
(en)
|
1995-08-16 |
1999-07-15 |
Astrazeneca Ab |
Mutated Carboxypeptidase B enzyme conjugated to a tumour targeted antibody for use in Antibody Directed Enzyme Prodrug Therapy
|
|
GB9516943D0
(en)
*
|
1995-08-18 |
1995-10-18 |
Cancer Soc Auckland Div Nz Inc |
Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
|
|
GB9517001D0
(en)
*
|
1995-08-18 |
1995-10-18 |
Denny William |
Enediyne compounds
|
|
GB9524942D0
(en)
*
|
1995-12-06 |
1996-02-07 |
Aepact Ltd |
Drug therapy
|
|
EP0885299B1
(de)
|
1996-01-08 |
2005-10-26 |
Genentech, Inc. |
Ob-rezeptor und liganden
|
|
AU2595697A
(en)
|
1996-03-29 |
1997-10-22 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
WO1998000173A2
(en)
*
|
1996-07-03 |
1998-01-08 |
Pharmacia & Upjohn Company |
Targeted drug delivery using sulfonamide derivatives
|
|
US6130237A
(en)
*
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
EP0886471A4
(de)
|
1996-11-18 |
2002-07-17 |
Emisphere Tech Inc |
Verfahren und zusammensetzungen zur induzierung oraler toleranz in saugetieren
|
|
GB9625913D0
(en)
*
|
1996-12-13 |
1997-01-29 |
Cancer Soc Auckland Div Nz Inc |
Novel cyclopropylindoles and their seco precursors,and their use as prodrugs
|
|
US6251933B1
(en)
|
1996-12-13 |
2001-06-26 |
The Cancer Research Campaign Technology Limited |
Seco precursors of cyclopropylindolines and their use as prodrugs
|
|
US6358504B1
(en)
|
1997-02-07 |
2002-03-19 |
Emisphere Technologies, Inc. |
Compounds and compositions for delivering active agents
|
|
IL132240A0
(en)
|
1997-04-07 |
2001-03-19 |
Genentech Inc |
Anti-vegf antibodies
|
|
DE69832970T2
(de)
|
1997-04-07 |
2006-08-10 |
Genentech, Inc., South San Francisco |
Humanisierte antikörper und verfahren zu ihrer herstellung
|
|
GB9712370D0
(en)
|
1997-06-14 |
1997-08-13 |
Aepact Ltd |
Therapeutic systems
|
|
EP1947119A3
(de)
|
1997-12-12 |
2012-12-19 |
Genentech, Inc. |
Krebsbehandlung mit Antikörpern gegen ERBB2 und einem chemotherapeutischen Mittel
|
|
EP3112468A1
(de)
|
1998-05-15 |
2017-01-04 |
Genentech, Inc. |
Il-17-homologe polypeptide und therapeutische verwendung davon
|
|
AU740405B2
(en)
|
1998-05-15 |
2001-11-01 |
Genentech Inc. |
IL-17 homologous polypeptides and therapeutic uses thereof
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
PT1109812E
(pt)
|
1998-08-27 |
2005-09-30 |
Spirogen Ltd |
Pirrolobenzodiazepinas
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB2348203B
(en)
|
1998-11-04 |
2002-06-19 |
Imp College Innovations Ltd |
Solube beta-forms of prion proteins, methods of preparation and use
|
|
EP1950300A3
(de)
|
1998-11-18 |
2011-03-23 |
Genentech, Inc. |
Antikörpervarianten mit höherer Bindungsaffinität im Vergleich zu verwandten Antikörpern
|
|
GB9907414D0
(en)
|
1999-03-31 |
1999-05-26 |
Cancer Res Campaign Tech |
Improvements relating to prodrugs
|
|
NZ534409A
(en)
|
1999-04-05 |
2006-03-31 |
Emisphere Tech Inc |
Disodium salts, monohydrates, and ethanol solvates for delivering active agents
|
|
AT500848B1
(de)
|
1999-06-25 |
2008-01-15 |
Genentech Inc |
Humanisierte anti-erbb2-antikörper
|
|
PL202369B1
(pl)
|
1999-08-27 |
2009-06-30 |
Genentech Inc |
Zastosowanie przeciwciała skierowanego przeciw ErbB2, zastosowanie przeciwciała skierowanego przeciw ErbB oraz zestaw zawierający to przeciwciało
|
|
US7129274B1
(en)
|
1999-11-05 |
2006-10-31 |
Emisphere Technologies Inc. |
Phenoxy carboxylic acid compounds and compositions for delivering active agents
|
|
US7279597B1
(en)
|
1999-11-05 |
2007-10-09 |
Emisphere Technologies, Inc. |
Phenyl amine carboxylic acid compounds and compositions for delivering active agents
|
|
EP1237872B1
(de)
|
1999-12-16 |
2008-02-27 |
Emisphere Technologies, Inc. |
Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
|
|
DE60137829D1
(de)
|
2000-01-13 |
2009-04-16 |
Genentech Inc |
Menschliche stra6 polypeptide
|
|
AU2001247616B2
(en)
|
2000-04-11 |
2007-06-14 |
Genentech, Inc. |
Multivalent antibodies and uses therefor
|
|
WO2001093826A1
(fr)
*
|
2000-06-06 |
2001-12-13 |
Sumitomo Pharmaceuticals Company, Limited |
Preparations polymere synthetiques biocompatibles
|
|
AU6836301A
(en)
|
2000-06-20 |
2002-01-02 |
Idec Pharma Corp |
Treatment of b-cell associated diseases such as malignancies and autoimmune diseases using a cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination
|
|
GB0016162D0
(en)
|
2000-06-30 |
2000-08-23 |
Cancer Res Campaign Tech |
Indole-3-acetic acid derivatives
|
|
US6656718B2
(en)
|
2000-07-07 |
2003-12-02 |
Cancer Research Technology Limited |
Modified carboxypeptidase enzymes and their use
|
|
ATE415978T1
(de)
|
2000-07-27 |
2008-12-15 |
Genentech Inc |
Sequentielle verabreichung von cpt-11 und apo-2l polypeptid
|
|
US7220824B1
(en)
|
2000-08-28 |
2007-05-22 |
Bayer Aktiengesellschaft |
Integrin-mediated drug targeting
|
|
JP4340062B2
(ja)
|
2000-10-12 |
2009-10-07 |
ジェネンテック・インコーポレーテッド |
粘度の減少した濃縮タンパク質製剤
|
|
US7087726B2
(en)
|
2001-02-22 |
2006-08-08 |
Genentech, Inc. |
Anti-interferon-α antibodies
|
|
EP1238678A1
(de)
|
2001-03-08 |
2002-09-11 |
Bayer Aktiengesellschaft |
Enzymaktivierte cytostatische Prodrugverbindungen mit Integrin Liganden
|
|
KR100576674B1
(ko)
|
2001-06-20 |
2006-05-10 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
|
|
ES2431929T3
(es)
|
2001-09-18 |
2013-11-28 |
Genentech, Inc. |
Composiciones y procedimientos para el diagnóstico y el tratamiento de tumores
|
|
EP2067472A1
(de)
|
2002-01-02 |
2009-06-10 |
Genentech, Inc. |
Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Tumoren
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
DE10210427A1
(de)
|
2002-03-09 |
2003-10-09 |
Hans Konrad Mueller-Hermelink |
Humaner monoklonaler Antikörper
|
|
CN1646160A
(zh)
|
2002-03-13 |
2005-07-27 |
拜奥根Idec马萨诸塞公司 |
抗αvβ6抗体
|
|
CA2481507A1
(en)
|
2002-04-16 |
2003-10-30 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US7232888B2
(en)
|
2002-07-01 |
2007-06-19 |
Massachusetts Institute Of Technology |
Antibodies against tumor surface antigens
|
|
CA2491669A1
(en)
|
2002-07-04 |
2004-01-15 |
Oncomab Gmbh |
Neoplasm specific antibodies and uses thereof
|
|
HUP0600340A3
(en)
|
2002-07-15 |
2011-06-28 |
Genentech Inc |
Methods for identifying tumors that are responsive to treatment with anti-erbb2 antibodies
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
NZ521851A
(en)
|
2002-10-08 |
2005-02-25 |
Auckland Uniservices Ltd |
Nitroaniline-based unsymmetrical mustard alkylating agents for gene dependent enzyme prodrug therapy
|
|
GB0226593D0
(en)
|
2002-11-14 |
2002-12-24 |
Consultants Ltd |
Compounds
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
AU2004229335C1
(en)
|
2003-04-04 |
2010-06-17 |
Genentech, Inc. |
High concentration antibody and protein formulations
|
|
SI1613350T1
(sl)
|
2003-04-09 |
2009-08-31 |
Genentech Inc |
Zdravljenje avtoimunske bolezni pri bolniku z neustreznim odzivom na inhibitor TNF-alfa
|
|
NZ621449A
(en)
|
2003-05-30 |
2015-07-31 |
Genentech Inc |
Treatment with anti-vegf antibodies
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
US20070148170A1
(en)
|
2005-10-03 |
2007-06-28 |
Desjarlais John R |
Fc Variants With Optimized Fc Receptor Binding Properties
|
|
US9714282B2
(en)
|
2003-09-26 |
2017-07-25 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
|
EP1742969A2
(de)
|
2003-11-12 |
2007-01-17 |
OncoMab GmbH |
Verfahren zur identifizierung neoplasmaspezifischer antikörper und verwendungen davon
|
|
EP1531162A1
(de)
|
2003-11-14 |
2005-05-18 |
Heinz Vollmers |
Antikörper SAM-6, der spezifisch von Adenocarzinom ist, und dessen Verwendungen
|
|
PL2295073T3
(pl)
|
2003-11-17 |
2014-09-30 |
Genentech Inc |
Przeciwciało przeciwko CD22 do leczenia nowotworu pochodzącego z układu krwiotwórczego
|
|
AU2005205533B2
(en)
|
2004-01-07 |
2012-03-22 |
Novartis Vaccines And Diagnostics, Inc. |
M-CSF-specific monoclonal antibody and uses thereof
|
|
CA2555820C
(en)
|
2004-02-19 |
2016-01-19 |
Genentech, Inc. |
Cdr-repaired antibodies
|
|
CA2561686C
(en)
|
2004-03-31 |
2014-12-02 |
Genentech, Inc. |
Humanized anti-tgf-beta antibodies
|
|
US20150017671A1
(en)
|
2004-04-16 |
2015-01-15 |
Yaping Shou |
Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
|
|
EP1753455A2
(de)
|
2004-06-04 |
2007-02-21 |
Genentech, Inc. |
Verfahren zur behandlung von multipler sklerose
|
|
CN102532321B
(zh)
|
2004-06-18 |
2018-10-12 |
Ambrx公司 |
新颖抗原结合多肽和其用途
|
|
EP3342782B1
(de)
|
2004-07-15 |
2022-08-17 |
Xencor, Inc. |
Optimierte fc-varianten
|
|
CA2577938C
(en)
|
2004-08-26 |
2013-04-16 |
Himanshu Brahmbhatt |
Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells
|
|
BRPI0517837A
(pt)
|
2004-11-12 |
2008-10-21 |
Xencor Inc |
variantes fc com ligação alterada a fcrn
|
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
ES2343746T3
(es)
|
2005-01-07 |
2010-08-09 |
Diadexus, Inc. |
Composiciones de anticuerpo ovr110 y metodos de uso.
|
|
US8029783B2
(en)
|
2005-02-02 |
2011-10-04 |
Genentech, Inc. |
DR5 antibodies and articles of manufacture containing same
|
|
HUE025945T2
(en)
|
2005-02-15 |
2016-07-28 |
Univ Duke |
Anti-CD19 antibodies and their applications in oncology
|
|
CA2604885A1
(en)
|
2005-04-07 |
2006-10-19 |
Guoying Yu |
Cacna1e in cancer diagnosis, detection and treatment
|
|
EP2083088A3
(de)
|
2005-04-07 |
2009-10-14 |
Novartis Vaccines and Diagnostics, Inc. |
Gene in Verbindung mit Krebs
|
|
AU2006244445B2
(en)
|
2005-05-05 |
2013-04-18 |
Duke University |
Anti-CD19 antibody therapy for autoimmune disease
|
|
CN102875681A
(zh)
|
2005-07-08 |
2013-01-16 |
拜奥根Idec马萨诸塞公司 |
抗-αvβ6抗体及其用途
|
|
EP2004695A2
(de)
|
2005-07-08 |
2008-12-24 |
Xencor, Inc. |
Optimierte anti-ep-cam-antikörper
|
|
WO2007016285A2
(en)
|
2005-07-28 |
2007-02-08 |
Novartis Ag |
M-csf specific monoclonal antibody and uses thereof
|
|
GB0517957D0
(en)
|
2005-09-03 |
2005-10-12 |
Morvus Technology Ltd |
Method of combating infection
|
|
EP3023497A1
(de)
|
2005-11-18 |
2016-05-25 |
Glenmark Pharmaceuticals S.A. |
Anti-alpha2-integrin-antikörper und deren verwendungen
|
|
GB0526552D0
(en)
|
2005-12-29 |
2006-02-08 |
Morvus Technology Ltd |
New use
|
|
WO2007103469A2
(en)
|
2006-03-06 |
2007-09-13 |
Aeres Biomedical Ltd. |
Humanized anti-cd22 antibodies and their use in treatment of oncology, transplantation and autoimmune disease
|
|
EP2010569A4
(de)
|
2006-03-20 |
2009-09-09 |
Xoma Technology Ltd |
Für gastrin spezifische humane antikörper, materialien und methoden
|
|
US20100278821A1
(en)
|
2006-03-21 |
2010-11-04 |
The Regents Of The University Of California |
N-cadherin: target for cancer diagnosis and therapy
|
|
AU2007227195A1
(en)
|
2006-03-21 |
2007-09-27 |
The Regents Of The University Of California |
N-cadherin and Ly6 E: targets for cancer diagnosis and therapy
|
|
CN101437536A
(zh)
|
2006-03-23 |
2009-05-20 |
诺华有限公司 |
抗肿瘤细胞抗原抗体治疗
|
|
AU2007243946B2
(en)
|
2006-04-05 |
2012-11-29 |
Curis, Inc. |
Method for using BOC/CDO to modulate hedgehog signaling
|
|
TW200813231A
(en)
|
2006-04-13 |
2008-03-16 |
Novartis Vaccines & Diagnostic |
Methods of treating, diagnosing or detecting cancer
|
|
ES2611975T3
(es)
|
2006-06-20 |
2017-05-11 |
Transgene S.A. |
Procedimiento para producir poxvirus y composiciones de poxvirus
|
|
US9878043B2
(en)
|
2006-06-23 |
2018-01-30 |
Engeneic Molecular Delivery Pty Ltd |
Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
|
|
SG173364A1
(en)
|
2006-07-10 |
2011-08-29 |
Biogen Idec Inc |
Compositions and methods for inhibiting growth of smad4-deficient cancers
|
|
CA2657934C
(en)
|
2006-07-19 |
2017-04-04 |
The Trustees Of The University Of Pennsylvania |
Wsx-1/p28 as a target for anti-inflammatory responses
|
|
PL2383297T3
(pl)
|
2006-08-14 |
2013-06-28 |
Xencor Inc |
Zoptymalizowane przeciwciała ukierunkowane na CD19
|
|
EP3018144A1
(de)
|
2006-08-18 |
2016-05-11 |
XOMA Technology Ltd. |
Prlr-spezifischer antikörper und verwendungen davon
|
|
US20100292090A1
(en)
|
2006-08-25 |
2010-11-18 |
Oncotherapy Science, Inc. |
Prognostic markers and therapeutic targets for lung cancer
|
|
GB2442202A
(en)
|
2006-09-30 |
2008-04-02 |
Morvus Technology Ltd |
Vermin poison
|
|
JP5391073B2
(ja)
|
2006-11-27 |
2014-01-15 |
ディアデクサス インコーポレーテッド |
Ovr110抗体組成物および使用方法
|
|
JP2010521180A
(ja)
|
2007-03-14 |
2010-06-24 |
ノバルティス アーゲー |
癌を処置、診断または検出するためのapcdd1阻害剤
|
|
PT2145002E
(pt)
|
2007-03-30 |
2015-04-29 |
Engeneic Molecular Delivery Pty Ltd |
Mínicélulas derivadas de bactérias, intactas, que compreendem ácidos nucleicos funcionais livres de plasmídeos, para administração in vivo em células de mamíferos
|
|
SG10201507845PA
(en)
|
2007-05-03 |
2015-10-29 |
Agency Science Tech & Res |
Antibodies binding to an intracellular prl-1 or prl-3 polypeptide
|
|
EP2703011A3
(de)
|
2007-05-07 |
2014-03-26 |
MedImmune, LLC |
Anti-Icos-Antikörper und ihre Verwendung bei der Behandlung von Krebs, Transplantationen und Autoimmunerkrankungen
|
|
AU2008260498B2
(en)
|
2007-05-30 |
2012-11-29 |
Xencor, Inc. |
Methods and compositions for inhibiting CD32b expressing cells
|
|
ATE543835T1
(de)
|
2007-07-16 |
2012-02-15 |
Genentech Inc |
Anti-cd79b-antikörper und immunkonjugate und anwendungsverfahren
|
|
ES2528922T3
(es)
|
2007-07-16 |
2015-02-13 |
Genentech, Inc. |
Anticuerpos anti-CD79b humanizados e inmunoconjugados y métodos de uso
|
|
US8709731B2
(en)
|
2007-08-24 |
2014-04-29 |
Oncotherapy Science, Inc. |
DKK1 oncogene as therapeutic target for cancer and a diagnosing marker
|
|
AU2008345242B2
(en)
|
2007-10-31 |
2014-02-27 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
|
EP2220116B1
(de)
|
2007-11-12 |
2012-09-05 |
Theraclone Sciences, Inc. |
Zusammensetzungen und verfahren zur therapie und diagnose von grippe
|
|
WO2010135521A2
(en)
|
2009-05-20 |
2010-11-25 |
Theraclone Sciences, Inc. |
Compositions and methods for the therapy and diagnosis of influenza
|
|
AR070141A1
(es)
|
2008-01-23 |
2010-03-17 |
Glenmark Pharmaceuticals Sa |
Anticuerpos humanizados especificos para el factor von willebrand
|
|
PT2247620T
(pt)
|
2008-01-31 |
2016-08-23 |
Genentech Inc |
Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
|
|
US12492253B1
(en)
|
2008-02-25 |
2025-12-09 |
Xencor, Inc. |
Anti-human C5 antibodies
|
|
ES2542308T3
(es)
|
2008-03-10 |
2015-08-04 |
Theraclone Sciences, Inc. |
Composiciones y métodos para la terapia y diagnóstico de infecciones por citomegalovirus
|
|
WO2010001585A1
(en)
|
2008-06-30 |
2010-01-07 |
Oncotherapy Science, Inc. |
Anti-cdh3 antibodies labeled with radioisotope label and uses thereof
|
|
TW201438738A
(zh)
|
2008-09-16 |
2014-10-16 |
建南德克公司 |
治療進展型多發性硬化症之方法
|
|
NZ592436A
(en)
|
2008-11-06 |
2012-10-26 |
Glenmark Pharmaceuticals Sa |
Treatment with anti-alpha2 integrin antibodies
|
|
JP5933975B2
(ja)
|
2008-11-12 |
2016-06-15 |
メディミューン,エルエルシー |
抗体製剤
|
|
WO2010060920A1
(en)
|
2008-11-27 |
2010-06-03 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Cxcl4l1 as a biomarker of pancreatic cancer
|
|
EP4209510B1
(de)
|
2008-12-09 |
2024-01-31 |
F. Hoffmann-La Roche AG |
Anti-pd-l1-antikörper und deren verwendung zur verbesserung der t-zellfunktion
|
|
SI3260136T1
(sl)
|
2009-03-17 |
2021-05-31 |
Theraclone Sciences, Inc. |
Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa
|
|
CA2757382A1
(en)
|
2009-04-01 |
2010-10-21 |
Kristi Elkins |
Anti-fcrh5 antibodies and immunoconjugates
|
|
SG175305A1
(en)
|
2009-04-23 |
2011-11-28 |
Theraclone Sciences Inc |
Granulocyte-macrophage colony-stimulating factor (gm-csf) neutralizing antibodies
|
|
NZ596595A
(en)
|
2009-05-12 |
2013-05-31 |
Transgene Sa |
Method for orthopoxvirus production and purification
|
|
IN2012DN01577A
(de)
|
2009-07-21 |
2015-06-05 |
Transgene Sa |
|
|
AU2010292897B2
(en)
|
2009-08-06 |
2016-01-07 |
Genentech, Inc. |
Method to improve virus removal in protein purification
|
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
US8926976B2
(en)
|
2009-09-25 |
2015-01-06 |
Xoma Technology Ltd. |
Modulators
|
|
WO2011038301A2
(en)
|
2009-09-25 |
2011-03-31 |
Xoma Technology Ltd. |
Screening methods
|
|
BR112012009409A2
(pt)
|
2009-10-22 |
2017-02-21 |
Genentech Inc |
método de identificação de uma substância inibidora, molécula antagonista, ácido nucleico isolado, vetor, célula hospedeira, método para fabricar a molécula, composição, artigo de fabricação, método de inibição de uma atividade biológica, método de tratamento de uma condição patológica, método para detectar msp em uma amostra e método para detectar hepsina em uma amostra
|
|
WO2011062997A2
(en)
|
2009-11-17 |
2011-05-26 |
Musc Foundation For Research Development |
Human monoclonal antibodies to human nucleolin
|
|
PE20121584A1
(es)
|
2009-11-30 |
2012-11-29 |
Genentech Inc |
Composiciones y metodos para el diagnostico y el tratamiento de tumores
|
|
WO2011076922A1
(en)
|
2009-12-23 |
2011-06-30 |
Synimmune Gmbh |
Anti-flt3 antibodies and methods of using the same
|
|
DK2519542T3
(en)
|
2009-12-28 |
2019-01-14 |
Onco Therapy Science Inc |
ANTI-CDH3 ANTIBODIES AND APPLICATIONS THEREOF.
|
|
WO2011089211A1
(en)
|
2010-01-22 |
2011-07-28 |
Synimmune Gmbh |
Anti-cd133 antibodies and methods of using the same
|
|
MX2012009809A
(es)
|
2010-02-23 |
2012-11-23 |
Sanofi Sa |
Anticuerpos anti - integrina alfa2 y sus usos.
|
|
NZ601293A
(en)
|
2010-02-23 |
2014-10-31 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor
|
|
JP2013528357A
(ja)
|
2010-03-29 |
2013-07-11 |
ザイムワークス,インコーポレイテッド |
強化又は抑制されたエフェクター機能を有する抗体
|
|
NZ602020A
(en)
|
2010-03-31 |
2014-05-30 |
Boehringer Ingelheim Int |
Anti-cd40 antibodies
|
|
CN102958941A
(zh)
|
2010-05-03 |
2013-03-06 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
|
WO2012021786A2
(en)
|
2010-08-12 |
2012-02-16 |
Theraclone Sciences, Inc. |
Anti-hemagglutinin antibody compositions and methods of use thereof
|
|
EP3556396B1
(de)
|
2010-08-31 |
2022-04-20 |
Theraclone Sciences, Inc. |
Antikörper zur neutralisierung des humanen immundefizienzvirus (hiv)
|
|
EP2614085B1
(de)
|
2010-09-10 |
2016-04-20 |
Apexigen, Inc. |
Anti-il-1-antikörper und verfahren zu ihrer verwendung
|
|
SG190006A1
(en)
|
2010-11-04 |
2013-06-28 |
Boehringer Ingelheim Int |
Anti-il-23 antibodies
|
|
JP5766296B2
(ja)
|
2010-12-23 |
2015-08-19 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
ポリペプチド−ポリヌクレオチド複合体、およびエフェクター成分の標的化された送達におけるその使用
|
|
CA2827170A1
(en)
|
2011-02-11 |
2012-08-16 |
David M. Hilbert |
Monovalent and multivalent multispecific complexes and uses thereof
|
|
EP2675478A4
(de)
|
2011-02-14 |
2015-06-10 |
Theraclone Sciences Inc |
Zusammensetzungen und verfahren zur therapie und diagnose von grippe
|
|
JP6097702B2
(ja)
|
2011-03-03 |
2017-03-15 |
アペクシジェン, インコーポレイテッド |
抗il−6受容体抗体およびその使用方法
|
|
JP5832559B2
(ja)
|
2011-03-10 |
2015-12-16 |
オメロス コーポレーション |
exvivoにおける加速された抗体進化による抗FN14モノクローナル抗体の生成
|
|
AU2012229188A1
(en)
|
2011-03-15 |
2013-09-26 |
Theraclone Sciences, Inc. |
Compositions and methods for the therapy and diagnosis of influenza
|
|
ES2709654T3
(es)
|
2011-04-29 |
2019-04-17 |
Apexigen Inc |
Anticuerpos anti-CD40 y métodos de uso
|
|
EP2714738B1
(de)
|
2011-05-24 |
2018-10-10 |
Zyngenia, Inc. |
Multivalente und monovalente multispezifische komplexe und ihre verwendungen
|
|
PH12013502489B1
(en)
|
2011-06-03 |
2019-04-24 |
Xoma Technology Ltd |
Antibodies specific for tgf-beta
|
|
CA2844289C
(en)
|
2011-08-12 |
2020-01-14 |
Omeros Corporation |
Anti-fzd10 monoclonal antibodies and methods for their use
|
|
WO2013033069A1
(en)
|
2011-08-30 |
2013-03-07 |
Theraclone Sciences, Inc. |
Human rhinovirus (hrv) antibodies
|
|
KR102027603B1
(ko)
|
2011-11-02 |
2019-10-01 |
아펙시젠, 인코포레이티드 |
항-kdr 항체 및 사용 방법
|
|
RS67639B1
(sr)
|
2011-11-16 |
2026-02-27 |
Boehringer Ingelheim Int |
Anti il-36r antitela
|
|
WO2013101771A2
(en)
|
2011-12-30 |
2013-07-04 |
Genentech, Inc. |
Compositions and method for treating autoimmune diseases
|
|
US20130243750A1
(en)
|
2012-01-31 |
2013-09-19 |
Genentech, Inc. |
Anti-ige antibodies and methods using same
|
|
CN104507497B
(zh)
|
2012-05-03 |
2018-10-19 |
勃林格殷格翰国际有限公司 |
抗IL-23p19抗体
|
|
FR2994390B1
(fr)
|
2012-08-10 |
2014-08-15 |
Adocia |
Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee
|
|
US20150210758A1
(en)
|
2012-08-14 |
2015-07-30 |
Nanyang Technological University |
Angiopoietin-like 4 antibody and a method of its use in cancer treatment
|
|
CN105051004B
(zh)
|
2012-08-23 |
2017-12-05 |
健康创新企业私人有限责任公司 |
新型前体药物及其使用方法
|
|
US10202408B2
(en)
|
2012-08-23 |
2019-02-12 |
Health Innovation Ventures B.V. |
Prodrugs and methods of use thereof
|
|
CN104918957B
(zh)
|
2012-10-30 |
2018-11-16 |
埃派斯进有限公司 |
抗-cd40抗体及其使用方法
|
|
HRP20170743T1
(hr)
|
2012-11-20 |
2017-07-28 |
Sanofi |
Anti-ceacam5 protutijela i njihova uporaba
|
|
EP3400961B1
(de)
|
2012-12-27 |
2021-02-24 |
Sanofi |
Anti-lamp1 antikörper und antikörper-konjugate und deren verwendung
|
|
WO2014143739A2
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Anti-alpha v beta 6 antibodies and uses thereof
|
|
WO2014144466A1
(en)
|
2013-03-15 |
2014-09-18 |
Biogen Idec Ma Inc. |
Anti-alpha v beta 6 antibodies and uses thereof
|
|
US20140283157A1
(en)
|
2013-03-15 |
2014-09-18 |
Diadexus, Inc. |
Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
|
|
CR20160132A
(es)
|
2013-08-12 |
2016-08-25 |
Genentech Inc |
Composiciones y método para tratar condiciones asociadas con el complemento
|
|
WO2016039801A1
(en)
|
2014-01-31 |
2016-03-17 |
Boehringer Ingelheim International Gmbh |
Novel anti-baff antibodies
|
|
US10328149B2
(en)
|
2014-06-13 |
2019-06-25 |
Tenboron Oy |
Conjugates comprising an anti-EGFR1 antibody
|
|
WO2016038609A1
(en)
|
2014-09-08 |
2016-03-17 |
Yeda Research And Development Co. Ltd. |
Anti-her3 antibodies and uses of same
|
|
AU2015357225B2
(en)
|
2014-12-01 |
2020-04-09 |
Transgene Sa |
Stable liquid vaccinia virus formulations
|
|
SG10202103879YA
(en)
|
2015-02-04 |
2021-05-28 |
Boehringer Ingelheim Int |
Methods of treating inflammatory diseases
|
|
WO2016141111A1
(en)
|
2015-03-03 |
2016-09-09 |
Xoma (Us) Llc |
Treatment of post-prandial hyperinsulinemia and hypoglycemia after bariatric surgery
|
|
CN116327915A
(zh)
|
2015-04-03 |
2023-06-27 |
佐马技术有限公司 |
使用TGF-β抑制剂和PD-1抑制剂治疗癌症
|
|
ES2810700T3
(es)
|
2015-05-29 |
2021-03-09 |
Hoffmann La Roche |
Metilación del promotor de PD-L1 en cáncer
|
|
WO2017024285A2
(en)
|
2015-08-06 |
2017-02-09 |
Xoma (Us) Llc |
Antibody fragments against the insulin receptor and uses thereof to treat hypoglycemia
|
|
IL324412A
(en)
|
2015-10-06 |
2026-01-01 |
Genentech Inc |
A method for treating multiple sclerosis
|
|
EP3383497A4
(de)
|
2015-12-04 |
2019-06-12 |
The Regents of The University of California |
Neuartige antikörper zur behandlung von krebserkrankungen
|
|
GB201604458D0
(en)
|
2016-03-16 |
2016-04-27 |
Immatics Biotechnologies Gmbh |
Peptides and combination of peptides for use in immunotherapy against cancers
|
|
TW201808336A
(zh)
|
2016-05-11 |
2018-03-16 |
賽諾菲公司 |
用抗muc1類美登素免疫綴合物抗體治療腫瘤的治療方案
|
|
PL3468997T3
(pl)
|
2016-06-08 |
2024-12-16 |
Xencor, Inc. |
Leczenie chorób związanych z lgG4 przeciwciałami anty-CD19 wiążącymi się krzyżowo z CD32b
|
|
EP3490600A1
(de)
|
2016-08-01 |
2019-06-05 |
Xoma (Us) Llc |
Parathormon-rezeptor 1 (pth1r)-antikörper und verwendungen davon
|
|
US20180273627A1
(en)
|
2017-03-27 |
2018-09-27 |
Boehringer Ingelheim International Gmbh |
Anti il-36r antibodies combination therapy
|
|
CA3068634A1
(en)
|
2017-06-30 |
2019-01-03 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for adoptive cell therapy for cancer
|
|
AU2019291890A1
(en)
|
2018-06-29 |
2020-12-17 |
Boehringer Ingelheim International Gmbh |
Anti-CD40 antibodies for use in treating autoimmune disease
|
|
EP3876993A1
(de)
|
2018-11-05 |
2021-09-15 |
Bayer Pharma Aktiengesellschaft |
Cytostatische konjugate mit integrinliganden
|
|
EP3693023A1
(de)
|
2019-02-11 |
2020-08-12 |
Sanofi |
Verwendung von anti-ceacam5-immunkonjugaten zur behandlung von lungenkrebs
|
|
SG11202107843WA
(en)
|
2019-02-07 |
2021-08-30 |
Sanofi Sa |
Use of anti-ceacam5 immunoconjugates for treating lung cancer
|
|
US20210032370A1
(en)
|
2019-08-02 |
2021-02-04 |
Immatics Biotechnologies Gmbh |
Recruiting agent further binding an mhc molecule
|
|
DE102019121007A1
(de)
|
2019-08-02 |
2021-02-04 |
Immatics Biotechnologies Gmbh |
Antigenbindende Proteine, die spezifisch an MAGE-A binden
|
|
TW202123965A
(zh)
|
2019-09-09 |
2021-07-01 |
德商百靈佳殷格翰國際股份有限公司 |
抗-il-23p19抗體調配物
|
|
JP2023525423A
(ja)
|
2020-01-15 |
2023-06-16 |
イマティクス バイオテクノロジーズ ゲーエムベーハー |
Prameに特異的に結合する抗原結合タンパク質
|
|
CN115515643A
(zh)
|
2020-02-28 |
2022-12-23 |
建新公司 |
用于优化的药物缀合的经修饰的结合多肽
|
|
MX2023002330A
(es)
|
2020-09-04 |
2023-03-21 |
Merck Patent Gmbh |
Anticuerpos anti molecula de adhesion celular 5 relacionada con el antigeno carcinoembrionario (ceacam5) y conjugados y usos de los mismos.
|
|
US12564642B2
(en)
|
2020-11-10 |
2026-03-03 |
Sanofi |
CEACAM5 antibody-drug conjugate formulation
|
|
WO2022170008A2
(en)
|
2021-02-05 |
2022-08-11 |
Boehringer Ingelheim International Gmbh |
Anti-il1rap antibodies
|
|
BR112023022765A2
(pt)
|
2021-05-05 |
2024-01-02 |
Immatics Biotechnologies Gmbh |
Proteínas de ligação ao antígeno que ligam especificamente o prame
|
|
JP2024529467A
(ja)
|
2021-07-27 |
2024-08-06 |
イマティクス バイオテクノロジーズ ゲーエムベーハー |
Ct45に特異的に結合する抗原結合タンパク質
|
|
CN118556062A
(zh)
|
2021-10-04 |
2024-08-27 |
文赛克斯制药有限责任公司 |
用于治疗、预防或管理过度增殖病症的化合物、药物组合物和方法
|
|
US20240408222A1
(en)
|
2021-10-04 |
2024-12-12 |
Vincerx Pharma Gmbh |
Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorder
|
|
JP2024536628A
(ja)
|
2021-10-04 |
2024-10-04 |
ヴィンセルクス ファーマ ゲーエムベーハー |
過剰増殖性障害の処置、予防、または管理のための化合物、医薬組成物、および方法
|
|
JP2024545428A
(ja)
|
2021-12-02 |
2024-12-06 |
サノフイ |
癌治療における患者選択のためのceaアッセイ
|
|
JP2024545427A
(ja)
|
2021-12-02 |
2024-12-06 |
サノフイ |
Ceacam5 adc-抗pd1/pd-l1組み合わせ療法
|
|
EP4489791A1
(de)
|
2022-03-09 |
2025-01-15 |
Merck Patent GmbH |
Anti-gd2-antikörper, immunkonjugate und therapeutische verwendungen davon
|
|
CN119487076A
(zh)
|
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